Gracilaria birdiae is a tropical agarophytes species of red seaweed that is rich in carbohydrates... more Gracilaria birdiae is a tropical agarophytes species of red seaweed that is rich in carbohydrates and presents a great potential for mariculture and economic use. However, it is still understudied as a potential renewable resource. In this study, the hydrolysis conditions of G. birdiae algal biomass, reaction time, and sulfuric acid concentration for obtaining monosaccharides, organic acids, and furanic compounds were optimized. Glucose and galactose concentrations were found to be more affected by algal biomass concentration, while the production of 5-hydroxymethylfurfural (5-HMF) and organic acid were most affected by sulfuric acid concentration. The most suitable conditions to produce glucose (28.56 ± 0.72 g⋅L − 1) and galactose (108.03 ± 1.32 g⋅L − 1) were at 121 • C, with sulfuric acid 1.3 mol⋅L − 1 , 841.59 g⋅L − 1 of algal biomass and time of 20 min. For cellobiose (25.39 ± 0.43 g⋅L − 1), the condition was sulfuric acid 0.6 mol⋅L − 1 , 680 g⋅L − 1 of biomass, and 10 min. For 5-HMF (19.82 ± 0.43 g⋅L − 1), it was sulfuric acid 0.6 mol⋅L − 1 , 680 g⋅L − 1 of biomass and 30 min. Finally, for levulinic (38.88 ± 0.58 g⋅L − 1) and formic acids (26.75 ± 0.54 g⋅L − 1) and, the best conditions were sulfuric acid 2.0 mol⋅L − 1 , 680 g⋅L − 1 of biomass and 30 min. Thus being, Gracilaria birdiae is a promising renewable resource to produce fine chemicals and fermentable compounds by optimizing its acid hydrolysis conditions.
International journal of biological macromolecules, Jan 7, 2018
This study assessed the antioxidant, antimicrobial, cytotoxic, anticancer and neuroprotective act... more This study assessed the antioxidant, antimicrobial, cytotoxic, anticancer and neuroprotective activities of the kappa(k)-carrageenan isolated from the red alga Hypnea musciformis (Hm-SP). As expected, the chemical spectrum of the k-carrageenan from Hm-SP was confirmed by Fourier transform infrared (FT-IR) spectroscopy. Hm-SP revealed an antibacterial and antifungal action against Staphylococcus aureus and Candida albicans, respectively. Hm-SP did not promoted cytotoxic effects against Human breast cancer (MCF-7) and Human neuroblastoma (SH-SY5Y). However, it was observed a significant reduction of the cellular proliferation capacity in these cancer cells in presence of the Hm-SP. Furthermore, Hm-SP showed neuroprotective activity in 6-hydroxydopamine-induced neurotoxicity on SH-SY5Y cells by modulation of the mitochondria transmembrane potential and reducing Caspase 3 activity. In addition, Hm-SP demonstrates low antioxidant potential and did not induce significant cytotoxic effects...
Gracilaria birdiae is a tropical agarophytes species of red seaweed that is rich in carbohydrates... more Gracilaria birdiae is a tropical agarophytes species of red seaweed that is rich in carbohydrates and presents a great potential for mariculture and economic use. However, it is still understudied as a potential renewable resource. In this study, the hydrolysis conditions of G. birdiae algal biomass, reaction time, and sulfuric acid concentration for obtaining monosaccharides, organic acids, and furanic compounds were optimized. Glucose and galactose concentrations were found to be more affected by algal biomass concentration, while the production of 5-hydroxymethylfurfural (5-HMF) and organic acid were most affected by sulfuric acid concentration. The most suitable conditions to produce glucose (28.56 ± 0.72 g⋅L − 1) and galactose (108.03 ± 1.32 g⋅L − 1) were at 121 • C, with sulfuric acid 1.3 mol⋅L − 1 , 841.59 g⋅L − 1 of algal biomass and time of 20 min. For cellobiose (25.39 ± 0.43 g⋅L − 1), the condition was sulfuric acid 0.6 mol⋅L − 1 , 680 g⋅L − 1 of biomass, and 10 min. For 5-HMF (19.82 ± 0.43 g⋅L − 1), it was sulfuric acid 0.6 mol⋅L − 1 , 680 g⋅L − 1 of biomass and 30 min. Finally, for levulinic (38.88 ± 0.58 g⋅L − 1) and formic acids (26.75 ± 0.54 g⋅L − 1) and, the best conditions were sulfuric acid 2.0 mol⋅L − 1 , 680 g⋅L − 1 of biomass and 30 min. Thus being, Gracilaria birdiae is a promising renewable resource to produce fine chemicals and fermentable compounds by optimizing its acid hydrolysis conditions.
International journal of biological macromolecules, Jan 7, 2018
This study assessed the antioxidant, antimicrobial, cytotoxic, anticancer and neuroprotective act... more This study assessed the antioxidant, antimicrobial, cytotoxic, anticancer and neuroprotective activities of the kappa(k)-carrageenan isolated from the red alga Hypnea musciformis (Hm-SP). As expected, the chemical spectrum of the k-carrageenan from Hm-SP was confirmed by Fourier transform infrared (FT-IR) spectroscopy. Hm-SP revealed an antibacterial and antifungal action against Staphylococcus aureus and Candida albicans, respectively. Hm-SP did not promoted cytotoxic effects against Human breast cancer (MCF-7) and Human neuroblastoma (SH-SY5Y). However, it was observed a significant reduction of the cellular proliferation capacity in these cancer cells in presence of the Hm-SP. Furthermore, Hm-SP showed neuroprotective activity in 6-hydroxydopamine-induced neurotoxicity on SH-SY5Y cells by modulation of the mitochondria transmembrane potential and reducing Caspase 3 activity. In addition, Hm-SP demonstrates low antioxidant potential and did not induce significant cytotoxic effects...
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Papers by Edna Cordeiro