Papers by Dr. Mahesh Kumar Kataria
The drugs or biological products for the diagnosis, treatment, or prevention of a rare disease or... more The drugs or biological products for the diagnosis, treatment, or prevention of a rare disease or condition are orphan drugs. Even though the drugs intended to treat common disease where revenue is not expected by pharmaceutical manufacturer are as well categorized as orphan. United State of America (USA) was the first nation to propose a legal framework to encourage development and availability of orphan drugs. The Orphan Drug Act (ODA) was passed on January 28, 1983, which was an amendment of Federal Food, Drug and Cosmetic Act of 1938, to stimulate the research, development, and approval of products for orphan diseases. The regulation for orphan drugs varies in different countries. Several benefits are offered to the pharmaceutical manufacturer of orphan drug includes tax incentives for clinical research, exemption from application filing fees, grant for Phase I and II clinical trials and marketing exclusivity for a specific period of time. These benefits have motivated the pharm...
Ketoconazole is an imidazole derivative used for the treatment of local and systemic fungal infec... more Ketoconazole is an imidazole derivative used for the treatment of local and systemic fungal infection. The oral use of Ketoconazole is not recommended as it has many side effects. The present study was designed to formulate and evaluate different ratio of topical gel containing Ketoconazole for treatment of fungal infection of skin. Antifungal drug, Ketoconazole was encapsulated in liposomes for topical application. Ketoconazole liposomes were prepared by thin film hydration technique using soya lecithin, cholesterol and drug in different weight ratios. The prepared liposomes were characterized for entrapment efficiency, in-vitro drug release (by franz diffusion cell) and viscosity, Release kinetic. The studies demonstrated successful preparation of Ketoconazole liposomes and effect of soya lecithin cholesterol weight ratio on entrapment efficiency and on drug release.
Indo American Journal of Pharmaceutical Research, 2015
Ketoconazole is one of the most commonly used anti-fungal drug. Ketoconazole, is a member of imid... more Ketoconazole is one of the most commonly used anti-fungal drug. Ketoconazole, is a member of imidazole containing compound that is used as a broad spectrum antifungal agent for the treatment or prevention of fungal infections especially against thrush, gastrointestinal (GI) infections, and infections of the skin, nails and scalp. Ketoconazole is available as oral tablet, cream and dandruff shampoo formulations. Ketoconazole has a high permeability and its solubility in aqueous media is not sufficient for the whole dose to be dissolved in the GI fluids under normal conditions. Formulation techniques that accelerate drug dissolution can guarantee a parallel improvement in bioavailability. Now a days different techniques are available to enhance the solubility of drug like co-solvent, solid dispersion, chemical modification of drug, liquid solid technique etc. One of the favourable strategy to improve the solubility and hence bioavailability of poorly water soluble drugs is the formula...
The text book entitled “MATRIX TABLETS: AN APPROACH TOWARDS SUSTAINED RELEASE DRUG DELIVERY” emph... more The text book entitled “MATRIX TABLETS: AN APPROACH TOWARDS SUSTAINED RELEASE DRUG DELIVERY” emphasizes on the general introduction, approaches to sustained release drug delivery system, matrix tablets, method of preparation, drug release mechanism, evaluation of SRDDS and packaging of matrix tablets. An attempt has been made to cover various marketed preparation and patents related to of sustained release matrix tablets. The book may be beneficial for the pharmacy professional, students and research scholars for thorough knowledge, basics and updatation in the area till date.
Glipizide is one of the most commonly used anti-diabetic drugs for treatment of type 2 diabetes m... more Glipizide is one of the most commonly used anti-diabetic drugs for treatment of type 2 diabetes mellitus. It is effective in pancreatic secretion of insulin. Glipizide is used for patients with type 2 diabetes who have failed diet and exercise therapy and it appears to be the most effective in first phase insulin secretion. The poor aqueous solubility of the drug leads to the poor bioavailability. As it is antidiabetic drug it has to be absorbed rapidly, so enhancement of the solubility of drug is important. In order to improve solubility and dissolution of poorly water-soluble drug many methods are used. Enhancing the bioavailability of poorly water-soluble drug, selection of the carriers is of the most challenging aspect of drug development. Now a days different techniques are available to enhance the solubility of drug like co-solvent, solid dispersion, chemical modification of drug, liquisolid technique etc. The review article comprises of the research materialized in the field ...
Topical drug administration is a localized drug delivery system anywhere in the body through opht... more Topical drug administration is a localized drug delivery system anywhere in the body through ophthalmic, rectal, vaginal and skin as topical routes. Skin is one of the most readily accessible organs on human body for topical administration and is main route of topical drug delivery system. There are various skin infections caused by fungus. An antifungal medication is a pharmaceutical fungicide used to treat mycoses such as athlete’s foot ringworm, candidasis. Antifungal works by exploiting differences between mammalian and fungal cells to kill the fungal organism without dangerous effect on host. kitoconazole is an imidazoles antifungal derivative and used for the treatment of local and systemic fungal infection. When administered orally, ketoconazole is best absorbed at highly acidic levels, so antacids or other causes of decreased stomach acid levels will lower the drug's absorption. Absorption can be increased by taking it with an acidic beverage, such as cola. Ketoconazole ...
World Journal of Pharmaceutical Research
ABSTRACT
Journal of Biological & Scientific Opinion, 2013
Suspensions are solid-liquid dispersion and defined as heterogeneous biphasic liquid dosage form ... more Suspensions are solid-liquid dispersion and defined as heterogeneous biphasic liquid dosage form of medicaments in which continuous or external phase is usually a liquid or semisolid and the dispersed or internal phase is made up of particulate matter that is essentially insoluble in, but dispersed through, the continuous phase. They require suspending agents to suspend the fine particles of dispersed phase, proper wetting agents (surfactants), viscosity increasing agents to improve the stability of preparation and suitable preservatives in preparation. Suspensions are generally taken orally or by parenteral route and also used for external applications. Suspension should have heterogeneous nature and product should be resistant to microbial contamination. Various types of suspension are available in pharmaceuticals like oral, parenteral, ophthalmic and suspension for external uses. Several advancements in suspension technologies viz nanosuspension, taste masked suspension, sustained release suspension, aqueous suspension etc. are discussed in detail. Patents related to these advancements are also mentioned in this article of previous 39 years (from 2012 to 1975). This article emphasise on the general introduction of suspension, their types, recent advancements and patents related to these advancements.
Journal of Biological & Scientific Opinion, 2013
Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system.... more Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. About 40 % drugs from newly developed chemical entities are lipophilic and fail to reach market due to their poor water solubility. The solubility behavior of drugs remains one of the most challenging aspects in formulation development. The bioavailability of an orally administration drug depends on its solubility in aqueous media over different pH ranges. The insufficient dissolution rate of the drug is the limiting factor in the oral bioavailability of poorly water soluble compounds. Most of drugs are weakly acidic and weakly basic with poor aqueous solubility. Various techniques are used for the improvement of aqueous solubility, dissolution rate and bioavailability of poorly water soluble drugs include micronization, chemical modification, pH adjustment, solid dispersion, nanosuspension, superdisintegrant, liquisolid technique, complexation, co-solvency, micellar solubilization, hydrotrophy etc. The purpose of this review article is to describe the techniques of solubilizaton and research materialized for the attainment of effective absorption and improved bioavailability.
Journal of Biological & Scientific Opinion, 2013
Oral controlled release drug delivery system becomes a very promising approach for those drugs th... more Oral controlled release drug delivery system becomes a very promising approach for those drugs that are given orally but having the high dosing frequency and shorter half-life. Matrix tablets serves as an important tool for oral controlled release dosage forms. Problems like patient compliance, drug targeting, local side effects, frequent administration and fluctuations in blood concentration levels, associated with their counterparts, the conventional dosage forms were rectified. Many of the pharmaceutical dosage form are formulated as sustained release dosage form to retard the release of a therapeutic agent such that its appearance in the systemic circulation is prolonged and its plasma profile is sustained in duration. Tablets offer the lowest cost approach to controlled and sustained release dosage forms. Matrix tablet as controlled release has given a new breakthrough for novel drug delivery system in the field of pharmaceutical technology. This review focuses on the various types of matrix systems based on polymer used and porosity of matrix system i.e. hydrophilic, hydrophobic, fat wax, porous, non-porous, pH sensitive. An effort has been made to consolidate different types of patents granted across the globe for last thirty years in the field of matrix system viz. tablet, pellets etc.
Journal of Biological & Scientific Opinion, 2013
Aceclofenac is aceclofenacum (O-(2, 6-dichloroaniline) phenyl] acetate glycolic acid ester, 2-(2,... more Aceclofenac is aceclofenacum (O-(2, 6-dichloroaniline) phenyl] acetate glycolic acid ester, 2-(2, 6dichloraniline) phenyl acetoxy acetic acid. Aceclofenac is a Non-Steroidal Anti Inflammatory drug. It is used in the management of osteoarthritis, rheumatoid arthritis and ankylozing spondylitis. Aceclofenac when taken orally shows gastrointestinal disturbances such as GI discomfort, nausea, diarrhea due to its low solubility, in some patient's peptic ulceration and severe gastrointestinal bleeding may also occur. Thus various approaches have been used to overcome problems like gastric irritation and other side effects that are frequently experienced with NSAID drug therapy. Aceclofenac is practically insoluble in water leading to poor dissolution and variable bioavailability upon oral administration. Aceclofenac needs enhancement of solubility and dissolution rate to improve its oral bioavailability and therapeutic efficacy. In order to improve solubility and dissolution of poorly water-soluble drug several methods are used. Enhancing the bioavailability of poorly water-soluble drug, selection of the carriers is of the most challenging aspect of drug development. Now a days different techniques are available to enhance the solubility of drug like co-solvent, solid dispersion, chemical modification of drug, liquid solid technique etc. The review article comprises of the research materialized in the field of solubility and dissolution enhancement of aceclofenac.
and full-text of published articles. The journal is devoted to the promotion of health sciences a... more and full-text of published articles. The journal is devoted to the promotion of health sciences and related disciplines (including medicine, pharmacy, nursing, biotechnology, cell and molecular biology, and related engineering fields). It seeks particularly (but not exclusively) to encourage multidisciplinary research and collaboration among scientists, the industry and the healthcare professionals. It will also provide an international forum for the communication and evaluation of data, methods and findings in health sciences and related disciplines. The journal welcomes original research papers, reviews and case reports on current topics of special interest and relevance. All manuscripts will be subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication) will be published without delay. The maximum length of manuscripts should normally be 10,000 words (20 single-spaced typewritten pages) for review, 6,000 words for research articles, 3,000 for technical notes, case reports, commentaries and short communications.
International Journal of Health Research, 2010
and full-text of published articles. The journal is devoted to the promotion of health sciences a... more and full-text of published articles. The journal is devoted to the promotion of health sciences and related disciplines (including medicine, pharmacy, nursing, biotechnology, cell and molecular biology, and related engineering fields). It seeks particularly (but not exclusively) to encourage multidisciplinary research and collaboration among scientists, the industry and the healthcare professionals. It will also provide an international forum for the communication and evaluation of data, methods and findings in health sciences and related disciplines. The journal welcomes original research papers, reviews and case reports on current topics of special interest and relevance. All manuscripts will be subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication) will be published without delay. The maximum length of manuscripts should normally be 10,000 words (20 single-spaced typewritten pages) for review, 6,000 words for research articles, 3,000 for technical notes, case reports, commentaries and short communications.
Drug Discovery Today, 2007
To date, the most widely used method for measuring the taste characteristics of pharmaceutical pr... more To date, the most widely used method for measuring the taste characteristics of pharmaceutical preparations is psychophysical evaluation by a taste panel. However, conventional chemical analyses, on the basis of release studies, have been shown to be useful subsidiary methods. More recently, novel in vitro taste assessment apparatus and methodologies have been developed for high-throughput taste screening and quality control. Biomimetic taste sensing systems (BMTSSs), such as multichannel taste sensors or electronic tongues with global selectivity, have been welcomed by both pharmaceutical scientists and the industry as a whole. As we discuss here, the emerging in vitro approaches for assessing taste characteristics of taste masked drug and drug products will result in a decreased reliance on human panel tests. Reviews POST SCREEN
INTERNATIONAL RESEARCH JOURNAL OF PHARMACY, 2014
Emulsions are thermodynamically unstable heterogeneous biphasic system. There are certain paramet... more Emulsions are thermodynamically unstable heterogeneous biphasic system. There are certain parameters which if and emulsion follow considered as stable. There are lots of sign of physical and chemical instability of emulsion are creaming, cracking, phase inversion, flocculation. There are several methods of detect stability of prepared emulsion. Rheological assessment, macroscopic examination, globule size analysis and accelerated stability test. Many types of emulsifying agents are interfacial tension, film formation and electric potential and emulsion rheology. Emulgents form three types of films around dispersed phase globules are monomolecular, multimolecular and particulate film. Regard to the improvement in the effectiveness and stability several enhancements have been made in the emulsion technology micro emulsion, multiple emulsions, non aqueous emulsions, liposome emulsions, nanoemulsions and emulsions polymerization are few advances with the advancement in application of emulsion incorporate in this review.
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Papers by Dr. Mahesh Kumar Kataria