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Dr. Hui Tag

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I completed my Master in Botany in 2002 and obtained my PhD in Botany in 2008 from Rajiv Gandhi University, Rono Hills, Doimukh-791112, Arunachal Pradesh, India. I work on higher plant taxonomy, ethnobotany, medicinal floristics and pharmacognosy.Research Interest: Biodiversity, Araceae, Begoniaceae, ethnobotany and traditional knowledge

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Mohd Tariq Salman

Integral University

University of Wisconsin-Madison

Kansas State University

University of Aberdeen

Universidad de la Amazonia

North Bengal University

State University of Moldova

Ain Shams University

University of Padjadjaran (UNPAD)

Rajeev Kumar Singh

Botanical Survey of India

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Papers by Dr. Hui Tag

Two new records of Henckelia for India from Arunachal Pradesh

Vegetos/Vegetos - International journal of plant research, Apr 29, 2024

Didymocarpus medogensis (Gesneriaceae): a new record for India

Vegetos/Vegetos - International journal of plant research, Mar 5, 2024

Medicinal plants used by the Apatani and Tagin tribes of Arunachal Pradesh for the treatment of stomach disorders

Zenodo (CERN European Organization for Nuclear Research), Dec 30, 2021

Present study enumerated 16 species of medicinal plants effective against stomach related disorde... more Present study enumerated 16 species of medicinal plants effective against stomach related disorders popularly used by the traditional herbal healers of the Apatani and Tagin tribes of the Subansiri district of Arunachal Pradesh. We interviewed 35 key informants (15 from Apatani and 20 from Tagin tribes) from 6 villages who were specialized in treatment of digestive diseases. Of the total 16 species recorded, Houttuynia cordata, Paederia foetida and Thladiantha ziroensis have been reported as most potential species effective against severe dysentery, diarrhea and gastritis while rest 13 species were found used in traditional home remedies for constipation, indigestion, liver diseases and loss of appetite. The Allium hookeri, Diplazium esculentum, Houttuynia cordata and Acmella oleracea were frequently harvested and sold in the local market and have been found commercially viable species potential to ensure rural livelihood security. However, Thladiantha ziroensis was found rare in their natural habitat which need conservation attention.

帰化植物の渡来経路 : インド北東部アルナーチャル・プラデーシュ州の事例から

インド、アルナーチャル・プラデーシュ州における野生食用・薬用植物利用の特徴

帰化植物の渡来経路 : インド北東部アルナーチャル・プラデーシュ州の事例から

ヒマラヤ学誌 Himalayan Study Monographs, May 1, 2010

インド、アルナーチャル・プラデーシュ州における野生食用・薬用植物利用の特徴

ヒマラヤ学誌 Himalayan Study Monographs, May 1, 2011

Diversity and distribution of the genus Rhynchotechum Blume (Gesneriaceae) in Arunachal Pradesh, India

Zenodo (CERN European Organization for Nuclear Research), Jun 29, 2022

A taxonomic investigation on the genus Rhynchotechum Blume (Gesneriaceae) in the state of Arunach... more A taxonomic investigation on the genus Rhynchotechum Blume (Gesneriaceae) in the state of Arunachal Pradesh, India was carried out during 2018-2022. The present revisionary studies have reported 7 taxa from Arunachal Pradesh. All the recorded species are enumerated here with taxonomic keys and notes based on morphological characters of living plants, along with the distributional ranges and colored photographs.

Ethnomedicinal plants used by traditional healers of Bodo community in Udalguri district of BTAD, Assam for treatment of Jaundice

by ABHAYA P Das, Dr. Hui Tag, and Jenima Basumatary

Journal of Bioresources, 2024

Bodo community of Assam has been using plants as medicine since an unknown past. The traditional ... more Bodo community of Assam has been using plants as medicine since an unknown past. The traditional Bodo-healers, 'Ojha' are reported to have good knowledge in preparation of herbal medicines for curing several ailments of man and domesticated animals. Ethnomedicobotanical study in 40 villages of Udalguri district of Bodoland Territorial Area District (BTAD) of Assam during 2021-2022 and interaction with Ojhas and other knowledgeable people recorded 44 species of plants from 30 families and five formulations they use to treat Jaundice. The herbal formulations used to treat jaundice were found innovative and unique but the practitioners decline to share their detailed protocols to others. However, majority of the recorded plant species they use are commonly growing in the study area.

Antioxidant and Antidiabetic Properties of Extracts from Three Underutilized Food Plants of North East India

Chemistry & Biodiversity, Jan 10, 2023

Three underutilized leafy vegetables Sarcochlamys pulcherrima (Roxb.) Gaudich (SP), Ipomoea aquat... more Three underutilized leafy vegetables Sarcochlamys pulcherrima (Roxb.) Gaudich (SP), Ipomoea aquatica Forssk. (IA) and Zanthoxylum rhetsa (Roxb.) DC (ZR) were extracted with different solvents viz. 95 % ethyl alcohol, methanol and hot water. The extracts were evaluated for their antioxidant potential via DPPH, ABTS and FRAP assay along with electroanalytical studies using cyclic voltammetry. The antidiabetic potential was determined by recording their α‐amylase and α‐glucosidase inhibitory assay. The total phenolic content (TPC), total flavonoid content (TFC) and the liquid chromatography‐mass spectrometry (LC/MS) based phytochemical profiles of the extracts were also determined. All three extracts of SP exhibited significant antioxidant capacity. The antidiabetic potential of the IA and ZR extracts was found to be higher than or at par with that of standard acarbose. LC/MS studies reveal the presence of hitherto reported antioxidant and antidiabetic compounds like gamma‐aminobutyric acid, cinnamic acid, caffeic acid, α‐viniferin, piperlonguminine, niacin, kaempferol, etc., in the extracts.

Evaluation of the nutritional potential and GC-MS analysis of Acmella paniculata (Wall. ex DC.) R.K. Jansen from Arunachal Pradesh (Eastern Himalayas)

Journal of Plant Pathology & Microbiology, Jun 17, 2016

Wild Edible and Medicinal Plants Used by Apatani Community of Lower Subansiri District, Arunachal Pradesh, India

International Journal of Current Research in Biosciences and Plant Biology, Mar 6, 2017

Arunachal Pradesh, a part of North East India known for its rich plant diversity and cultural div... more Arunachal Pradesh, a part of North East India known for its rich plant diversity and cultural diversity. It has been recognized as the 25th biodiversity hotspot in the world. It is also among the 200 globally important ecoregion. The Lower Subansiri district of the state is well known for the unique tradition of wet rice cultivation. The district is dominated by the Apatani tribe. The use of plants in the form of medicine and other purposes is time immemorial especially the tribal people who are intimately connected with plant resources. The present study deals with some highly used wild edible and medicinal plant species including herbs, shrubs, climber and trees by the Apatani tribe of Lower Subansiri district, Arunachal Pradesh, which have been least explored in this region. Total 41 wild edibles and medicinal plant species have been recorded belonging to 33 families used by the Apatani community.

Traditional skill among the Adi tribes of Arunachal Pradesh

Indian Journal of Traditional Knowledge, 2008

The tribal people living in far flung areas dependent on rich biocultural resources have always b... more The tribal people living in far flung areas dependent on rich biocultural resources have always been curious in exploring the plant resources of their immediate surrounding in order to sustain their traditional livelihood system. After centuries of being in close association with nature, they have developed for themselves the indigenous skill and technology to use these resources in various parts of their life support system. In recent decades, rapid modernization and acculturation process developed in traditional livelihood system of tribal community has practically endangered their age-old biocultural heritage and traditional skills, knowledge and technology in alarming proportion. The paper based on ethnobotanical field work discusses some vital aspects of plant based traditional skills and technology practiced by the rural Adi community of East Siang district of Arunachal Pradesh. A number of traditional plant based technologies such as handicrafts, fishing and hunting tools, storage items, utensils used in kitchen and foods system, etc. are available among the Adis. While crafting these valuable and low-cost traditional handicraft technologies, the local people are dependent on locally available plant biodiversity conserved in jhum land, kitchen gardens and community forest. Integrated and holistic approach can revive and sustain traditional plant technology through entrepreneurship development, coupled with ecotourism and economic empowerment to the concerned indigenous community.

Molecular insights into genetic diversity and population dynamics of Paris polyphylla Smith in the Eastern Himalaya, India: a threatened anticancer medicinal herb of broad-spectrum therapeutic importance

Vegetos, May 24, 2022

GC-MS analysis of phytocomponents in the methanolic extract of Gynocardia odorata R.Br.- A poisonous plant from Arunachal Himalayan Region

Journal of Pharmacognosy and Phytochemistry, 2018

The present research was designed to investigate the bioactive phytochemicals present in the meta... more The present research was designed to investigate the bioactive phytochemicals present in the metabolic leaf extract of the species. The identification of the phytochemical compounds was confirmed based on the peak area, RT and molecular formula. In total 50 compounds of different molecular weight were detected from the methanolic extracts of Gynocardia odorata R.Br. leaf and the identification and the characterization of each known compound was done with the help of the Wiley and NIST library. Stigmast-5-En-3-Ol, (3.Beta.) had the highest abundance with (7.72% of peak area) with 414 D molecular mass. So, there is a need of proper investigation of the plants with the help of sophisticated instruments like HPLC, GC-MS, LCMS, NMR for the isolation and characterization of the active bioactive molecules.

Antioxidant and Antidiabetic Properties of Extracts from Three Underutilized Food Plants of North East India

Chemistry & Biodiversity

Three underutilized leafy vegetables Sarcochlamys pulcherrima (Roxb.) Gaudich (SP), Ipomoea aquat... more Three underutilized leafy vegetables Sarcochlamys pulcherrima (Roxb.) Gaudich (SP), Ipomoea aquatica Forssk. (IA) and Zanthoxylum rhetsa (Roxb.) DC (ZR) were extracted with different solvents viz. 95 % ethyl alcohol, methanol and hot water. The extracts were evaluated for their antioxidant potential via DPPH, ABTS and FRAP assay along with electroanalytical studies using cyclic voltammetry. The antidiabetic potential was determined by recording their α‐amylase and α‐glucosidase inhibitory assay. The total phenolic content (TPC), total flavonoid content (TFC) and the liquid chromatography‐mass spectrometry (LC/MS) based phytochemical profiles of the extracts were also determined. All three extracts of SP exhibited significant antioxidant capacity. The antidiabetic potential of the IA and ZR extracts was found to be higher than or at par with that of standard acarbose. LC/MS studies reveal the presence of hitherto reported antioxidant and antidiabetic compounds like gamma‐aminobutyric...

Computational Analysis of Bacopa monnieri (L.) Wettst. Compounds for Drug Development against Neurodegenerative Disorders

Current Computer-Aided Drug Design

Aim: With several experimental studies establishing the role of Bacopa monnieri as an effective n... more Aim: With several experimental studies establishing the role of Bacopa monnieri as an effective neurological medication, less focus has been employed to explore how effectively Bacopa monnieri brings about this property. The current work focuses on understanding the molecular interaction of the phytochemicals of the plant against different neurotrophic factors to explore their role and potential as potent anti-neurodegenerative drugs. Background: Neurotrophins play a crucial role in the development and regulation of neurons. Alterations in the functioning of these Neurotrophins lead to several Neurodegenerative Disorders. Albeit engineered medications are accessible for the treatment of Neurodegenerative Disorders, due to their numerous side effects, it becomes imperative to formulate and synthesize novel drug candidates. Objective: This study aims to investigate the potential of Bacopa monnieri phytochemicals as potent antineurodegenerative drugs by inspecting the interactions betw...

$Research paper thumbnail of Identification of phytocompounds from Paris polyphylla Smith as potential inhibitors against two breast cancer receptors (ER\a and EGFR tyrosine kinase) through chromatographic and In silico approaches$

Identification of phytocompounds from Paris polyphylla Smith as potential inhibitors against two breast cancer receptors (ER\a and EGFR tyrosine kinase) through chromatographic and In silico approaches

Journal of Applied Biology & Biotechnology

In the current decade, the potential side effects caused by synthetic kinase domain inhibitors ha... more In the current decade, the potential side effects caused by synthetic kinase domain inhibitors have paved the way for developing an alternative anti-breast cancer drug from botanical sources. Estrogen receptor-α (ERα) and epidermal growth factor receptor (EGFR) tyrosine kinase receptors play a key role in the activation of genomic and nongenomic related pathways of breast cancer progression. Paris polyphylla Smith (Melanthiaceae) is a rich source of steroidal saponins reported as an anti-breast cancer agent used among the local communities of Asian countries. In the present study, a total of 116 phytocompounds were characterized and identified from P. polyphylla rhizomes using gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry tools. They were subjected to virtual screening, molecular docking, and molecular simulation analysis with these two breast cancer receptors. Among them, only three steroidal saponins, namely, diosgenin, pennogenin, and 7-ketodiosgenin acetate binding affinity with target receptors were on the higher side when compared with natural ligands. The highest affinity for the receptors ERα and EGFR tyrosine kinase was shown by 7-ketodiosgenin acetate with docking scores of −10.4 Kcal/mol and −11.2 Kcal/mol, respectively, followed by diosgenin and pennogenin. LigPlot + analysis revealed that the selected three steroidal saponins utilized a combination of hydrogen bonding and hydrophobic interactions to align themselves more efficiently in the ligand-binding pocket of the target receptors. Molecular simulation analysis revealed a stable interaction between the phytocompounds and the target receptors. Lipinski's rule confirmed pennogenin as the best phytocompound that could be used as a potential inhibitor against the two target breast cancer receptors (ERα and EGFR tyrosine kinase).

On the introduction of paddy rice cultivation by swiddeners in Arunachal Pradesh, India

Tropics, 2015

The transformation of land from swidden based to permanent agriculture is an important issue rela... more The transformation of land from swidden based to permanent agriculture is an important issue related to the sustainable livelihood and land use system of people in mountain environments. This paper reports the introduction of paddy rice cultivation and its consequences in four swiddener communities in Arunachal Pradesh, India, by focusing on cultivation techniques. The Indian government introduced paddy rice cultivation to Arunachal Pradesh in the 1950 s by teaching the required techniques and supplying seed and agricultural tools. However, few swiddeners began rice cultivation because they disliked working in muddy paddies that could not produce non-rice crops. During the "green revolution" in the 1970 s, many people decided to create paddy fields after observing the remarkably high yield of new rice varieties. Over 60 years of trial and error, many swiddener communities have developed a unique cultivation system suited to their local environment, while often learning from their neighboring communities of Ahom and Apatani that already practiced paddy rice cultivation. The paddy field has become a symbol of wealth and social status because of the high and stable yield of paddy rice and escalating land prices. However, the communities usually continue some aspects of swidden cultivation, because only a limited amount of land is suitable for paddy rice, people need non-rice crops, or because older people prefer swidden cultivation work and the taste of upland rice. This case study shows the importance of local needs and knowledge of skilled farmers in swidden transformation.

Two new species of <i>Henckelia</i> (Gesneriaceae) from the Eastern Himalayan state Arunachal Pradesh, India

Feddes Repertorium, Aug 21, 2021

Two new species of Henckelia from the Eastern Himalayan state Arunachal Pradesh, India, are descr... more Two new species of Henckelia from the Eastern Himalayan state Arunachal Pradesh, India, are described and illustrated. The first, Henckelia dasii Taram, D.Borah, R.Kr.Singh &amp; Tag is allied to H. umbellata Kanthraj &amp; K.N.Nair, the second, H. lallanii Taram, D.Borah, Tag &amp; R.Kr.Singh is close to H. urticifolia (Buch.‐Ham. ex D.Don) A.Dietr. (type species of the former Chirita sect. Chirita). The differences are given in Table 1 and 2, respectively. A key is presented for the 21 Henckelia species presently known from N and NE India.

Two new records of Henckelia for India from Arunachal Pradesh

Vegetos/Vegetos - International journal of plant research, Apr 29, 2024

Didymocarpus medogensis (Gesneriaceae): a new record for India

Vegetos/Vegetos - International journal of plant research, Mar 5, 2024

Medicinal plants used by the Apatani and Tagin tribes of Arunachal Pradesh for the treatment of stomach disorders

Zenodo (CERN European Organization for Nuclear Research), Dec 30, 2021

Present study enumerated 16 species of medicinal plants effective against stomach related disorde... more Present study enumerated 16 species of medicinal plants effective against stomach related disorders popularly used by the traditional herbal healers of the Apatani and Tagin tribes of the Subansiri district of Arunachal Pradesh. We interviewed 35 key informants (15 from Apatani and 20 from Tagin tribes) from 6 villages who were specialized in treatment of digestive diseases. Of the total 16 species recorded, Houttuynia cordata, Paederia foetida and Thladiantha ziroensis have been reported as most potential species effective against severe dysentery, diarrhea and gastritis while rest 13 species were found used in traditional home remedies for constipation, indigestion, liver diseases and loss of appetite. The Allium hookeri, Diplazium esculentum, Houttuynia cordata and Acmella oleracea were frequently harvested and sold in the local market and have been found commercially viable species potential to ensure rural livelihood security. However, Thladiantha ziroensis was found rare in their natural habitat which need conservation attention.

帰化植物の渡来経路 : インド北東部アルナーチャル・プラデーシュ州の事例から

インド、アルナーチャル・プラデーシュ州における野生食用・薬用植物利用の特徴

帰化植物の渡来経路 : インド北東部アルナーチャル・プラデーシュ州の事例から

ヒマラヤ学誌 Himalayan Study Monographs, May 1, 2010

インド、アルナーチャル・プラデーシュ州における野生食用・薬用植物利用の特徴

ヒマラヤ学誌 Himalayan Study Monographs, May 1, 2011

Diversity and distribution of the genus Rhynchotechum Blume (Gesneriaceae) in Arunachal Pradesh, India

Zenodo (CERN European Organization for Nuclear Research), Jun 29, 2022

A taxonomic investigation on the genus Rhynchotechum Blume (Gesneriaceae) in the state of Arunach... more A taxonomic investigation on the genus Rhynchotechum Blume (Gesneriaceae) in the state of Arunachal Pradesh, India was carried out during 2018-2022. The present revisionary studies have reported 7 taxa from Arunachal Pradesh. All the recorded species are enumerated here with taxonomic keys and notes based on morphological characters of living plants, along with the distributional ranges and colored photographs.

Ethnomedicinal plants used by traditional healers of Bodo community in Udalguri district of BTAD, Assam for treatment of Jaundice

by ABHAYA P Das, Dr. Hui Tag, and Jenima Basumatary

Journal of Bioresources, 2024

Bodo community of Assam has been using plants as medicine since an unknown past. The traditional ... more Bodo community of Assam has been using plants as medicine since an unknown past. The traditional Bodo-healers, 'Ojha' are reported to have good knowledge in preparation of herbal medicines for curing several ailments of man and domesticated animals. Ethnomedicobotanical study in 40 villages of Udalguri district of Bodoland Territorial Area District (BTAD) of Assam during 2021-2022 and interaction with Ojhas and other knowledgeable people recorded 44 species of plants from 30 families and five formulations they use to treat Jaundice. The herbal formulations used to treat jaundice were found innovative and unique but the practitioners decline to share their detailed protocols to others. However, majority of the recorded plant species they use are commonly growing in the study area.

Antioxidant and Antidiabetic Properties of Extracts from Three Underutilized Food Plants of North East India

Chemistry & Biodiversity, Jan 10, 2023

Three underutilized leafy vegetables Sarcochlamys pulcherrima (Roxb.) Gaudich (SP), Ipomoea aquat... more Three underutilized leafy vegetables Sarcochlamys pulcherrima (Roxb.) Gaudich (SP), Ipomoea aquatica Forssk. (IA) and Zanthoxylum rhetsa (Roxb.) DC (ZR) were extracted with different solvents viz. 95 % ethyl alcohol, methanol and hot water. The extracts were evaluated for their antioxidant potential via DPPH, ABTS and FRAP assay along with electroanalytical studies using cyclic voltammetry. The antidiabetic potential was determined by recording their α‐amylase and α‐glucosidase inhibitory assay. The total phenolic content (TPC), total flavonoid content (TFC) and the liquid chromatography‐mass spectrometry (LC/MS) based phytochemical profiles of the extracts were also determined. All three extracts of SP exhibited significant antioxidant capacity. The antidiabetic potential of the IA and ZR extracts was found to be higher than or at par with that of standard acarbose. LC/MS studies reveal the presence of hitherto reported antioxidant and antidiabetic compounds like gamma‐aminobutyric acid, cinnamic acid, caffeic acid, α‐viniferin, piperlonguminine, niacin, kaempferol, etc., in the extracts.

Evaluation of the nutritional potential and GC-MS analysis of Acmella paniculata (Wall. ex DC.) R.K. Jansen from Arunachal Pradesh (Eastern Himalayas)

Journal of Plant Pathology & Microbiology, Jun 17, 2016

Wild Edible and Medicinal Plants Used by Apatani Community of Lower Subansiri District, Arunachal Pradesh, India

International Journal of Current Research in Biosciences and Plant Biology, Mar 6, 2017

Arunachal Pradesh, a part of North East India known for its rich plant diversity and cultural div... more Arunachal Pradesh, a part of North East India known for its rich plant diversity and cultural diversity. It has been recognized as the 25th biodiversity hotspot in the world. It is also among the 200 globally important ecoregion. The Lower Subansiri district of the state is well known for the unique tradition of wet rice cultivation. The district is dominated by the Apatani tribe. The use of plants in the form of medicine and other purposes is time immemorial especially the tribal people who are intimately connected with plant resources. The present study deals with some highly used wild edible and medicinal plant species including herbs, shrubs, climber and trees by the Apatani tribe of Lower Subansiri district, Arunachal Pradesh, which have been least explored in this region. Total 41 wild edibles and medicinal plant species have been recorded belonging to 33 families used by the Apatani community.

Traditional skill among the Adi tribes of Arunachal Pradesh

Indian Journal of Traditional Knowledge, 2008

The tribal people living in far flung areas dependent on rich biocultural resources have always b... more The tribal people living in far flung areas dependent on rich biocultural resources have always been curious in exploring the plant resources of their immediate surrounding in order to sustain their traditional livelihood system. After centuries of being in close association with nature, they have developed for themselves the indigenous skill and technology to use these resources in various parts of their life support system. In recent decades, rapid modernization and acculturation process developed in traditional livelihood system of tribal community has practically endangered their age-old biocultural heritage and traditional skills, knowledge and technology in alarming proportion. The paper based on ethnobotanical field work discusses some vital aspects of plant based traditional skills and technology practiced by the rural Adi community of East Siang district of Arunachal Pradesh. A number of traditional plant based technologies such as handicrafts, fishing and hunting tools, storage items, utensils used in kitchen and foods system, etc. are available among the Adis. While crafting these valuable and low-cost traditional handicraft technologies, the local people are dependent on locally available plant biodiversity conserved in jhum land, kitchen gardens and community forest. Integrated and holistic approach can revive and sustain traditional plant technology through entrepreneurship development, coupled with ecotourism and economic empowerment to the concerned indigenous community.

Molecular insights into genetic diversity and population dynamics of Paris polyphylla Smith in the Eastern Himalaya, India: a threatened anticancer medicinal herb of broad-spectrum therapeutic importance

Vegetos, May 24, 2022

GC-MS analysis of phytocomponents in the methanolic extract of Gynocardia odorata R.Br.- A poisonous plant from Arunachal Himalayan Region

Journal of Pharmacognosy and Phytochemistry, 2018

The present research was designed to investigate the bioactive phytochemicals present in the meta... more The present research was designed to investigate the bioactive phytochemicals present in the metabolic leaf extract of the species. The identification of the phytochemical compounds was confirmed based on the peak area, RT and molecular formula. In total 50 compounds of different molecular weight were detected from the methanolic extracts of Gynocardia odorata R.Br. leaf and the identification and the characterization of each known compound was done with the help of the Wiley and NIST library. Stigmast-5-En-3-Ol, (3.Beta.) had the highest abundance with (7.72% of peak area) with 414 D molecular mass. So, there is a need of proper investigation of the plants with the help of sophisticated instruments like HPLC, GC-MS, LCMS, NMR for the isolation and characterization of the active bioactive molecules.

Antioxidant and Antidiabetic Properties of Extracts from Three Underutilized Food Plants of North East India

Chemistry & Biodiversity

Three underutilized leafy vegetables Sarcochlamys pulcherrima (Roxb.) Gaudich (SP), Ipomoea aquat... more Three underutilized leafy vegetables Sarcochlamys pulcherrima (Roxb.) Gaudich (SP), Ipomoea aquatica Forssk. (IA) and Zanthoxylum rhetsa (Roxb.) DC (ZR) were extracted with different solvents viz. 95 % ethyl alcohol, methanol and hot water. The extracts were evaluated for their antioxidant potential via DPPH, ABTS and FRAP assay along with electroanalytical studies using cyclic voltammetry. The antidiabetic potential was determined by recording their α‐amylase and α‐glucosidase inhibitory assay. The total phenolic content (TPC), total flavonoid content (TFC) and the liquid chromatography‐mass spectrometry (LC/MS) based phytochemical profiles of the extracts were also determined. All three extracts of SP exhibited significant antioxidant capacity. The antidiabetic potential of the IA and ZR extracts was found to be higher than or at par with that of standard acarbose. LC/MS studies reveal the presence of hitherto reported antioxidant and antidiabetic compounds like gamma‐aminobutyric...

Computational Analysis of Bacopa monnieri (L.) Wettst. Compounds for Drug Development against Neurodegenerative Disorders

Current Computer-Aided Drug Design

Aim: With several experimental studies establishing the role of Bacopa monnieri as an effective n... more Aim: With several experimental studies establishing the role of Bacopa monnieri as an effective neurological medication, less focus has been employed to explore how effectively Bacopa monnieri brings about this property. The current work focuses on understanding the molecular interaction of the phytochemicals of the plant against different neurotrophic factors to explore their role and potential as potent anti-neurodegenerative drugs. Background: Neurotrophins play a crucial role in the development and regulation of neurons. Alterations in the functioning of these Neurotrophins lead to several Neurodegenerative Disorders. Albeit engineered medications are accessible for the treatment of Neurodegenerative Disorders, due to their numerous side effects, it becomes imperative to formulate and synthesize novel drug candidates. Objective: This study aims to investigate the potential of Bacopa monnieri phytochemicals as potent antineurodegenerative drugs by inspecting the interactions betw...

$Research paper thumbnail of Identification of phytocompounds from Paris polyphylla Smith as potential inhibitors against two breast cancer receptors (ER\a and EGFR tyrosine kinase) through chromatographic and In silico approaches$

Identification of phytocompounds from Paris polyphylla Smith as potential inhibitors against two breast cancer receptors (ER\a and EGFR tyrosine kinase) through chromatographic and In silico approaches

Journal of Applied Biology & Biotechnology

In the current decade, the potential side effects caused by synthetic kinase domain inhibitors ha... more In the current decade, the potential side effects caused by synthetic kinase domain inhibitors have paved the way for developing an alternative anti-breast cancer drug from botanical sources. Estrogen receptor-α (ERα) and epidermal growth factor receptor (EGFR) tyrosine kinase receptors play a key role in the activation of genomic and nongenomic related pathways of breast cancer progression. Paris polyphylla Smith (Melanthiaceae) is a rich source of steroidal saponins reported as an anti-breast cancer agent used among the local communities of Asian countries. In the present study, a total of 116 phytocompounds were characterized and identified from P. polyphylla rhizomes using gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry tools. They were subjected to virtual screening, molecular docking, and molecular simulation analysis with these two breast cancer receptors. Among them, only three steroidal saponins, namely, diosgenin, pennogenin, and 7-ketodiosgenin acetate binding affinity with target receptors were on the higher side when compared with natural ligands. The highest affinity for the receptors ERα and EGFR tyrosine kinase was shown by 7-ketodiosgenin acetate with docking scores of −10.4 Kcal/mol and −11.2 Kcal/mol, respectively, followed by diosgenin and pennogenin. LigPlot + analysis revealed that the selected three steroidal saponins utilized a combination of hydrogen bonding and hydrophobic interactions to align themselves more efficiently in the ligand-binding pocket of the target receptors. Molecular simulation analysis revealed a stable interaction between the phytocompounds and the target receptors. Lipinski's rule confirmed pennogenin as the best phytocompound that could be used as a potential inhibitor against the two target breast cancer receptors (ERα and EGFR tyrosine kinase).

On the introduction of paddy rice cultivation by swiddeners in Arunachal Pradesh, India

Tropics, 2015

The transformation of land from swidden based to permanent agriculture is an important issue rela... more The transformation of land from swidden based to permanent agriculture is an important issue related to the sustainable livelihood and land use system of people in mountain environments. This paper reports the introduction of paddy rice cultivation and its consequences in four swiddener communities in Arunachal Pradesh, India, by focusing on cultivation techniques. The Indian government introduced paddy rice cultivation to Arunachal Pradesh in the 1950 s by teaching the required techniques and supplying seed and agricultural tools. However, few swiddeners began rice cultivation because they disliked working in muddy paddies that could not produce non-rice crops. During the "green revolution" in the 1970 s, many people decided to create paddy fields after observing the remarkably high yield of new rice varieties. Over 60 years of trial and error, many swiddener communities have developed a unique cultivation system suited to their local environment, while often learning from their neighboring communities of Ahom and Apatani that already practiced paddy rice cultivation. The paddy field has become a symbol of wealth and social status because of the high and stable yield of paddy rice and escalating land prices. However, the communities usually continue some aspects of swidden cultivation, because only a limited amount of land is suitable for paddy rice, people need non-rice crops, or because older people prefer swidden cultivation work and the taste of upland rice. This case study shows the importance of local needs and knowledge of skilled farmers in swidden transformation.

Two new species of <i>Henckelia</i> (Gesneriaceae) from the Eastern Himalayan state Arunachal Pradesh, India

Feddes Repertorium, Aug 21, 2021

Two new species of Henckelia from the Eastern Himalayan state Arunachal Pradesh, India, are descr... more Two new species of Henckelia from the Eastern Himalayan state Arunachal Pradesh, India, are described and illustrated. The first, Henckelia dasii Taram, D.Borah, R.Kr.Singh &amp; Tag is allied to H. umbellata Kanthraj &amp; K.N.Nair, the second, H. lallanii Taram, D.Borah, Tag &amp; R.Kr.Singh is close to H. urticifolia (Buch.‐Ham. ex D.Don) A.Dietr. (type species of the former Chirita sect. Chirita). The differences are given in Table 1 and 2, respectively. A key is presented for the 21 Henckelia species presently known from N and NE India.

$Research paper thumbnail of F:\Pleione 12.1\PM_Final 12.1\1$

F:\Pleione 12.1\PM_Final 12.1\1

by Dr. Hui Tag and ABHAYA P Das