Journal of Plastic Reconstructive and Aesthetic Surgery, Jun 1, 2018
The nervous system plays a key role in controlling the dynamic functions of multicellular complex... more The nervous system plays a key role in controlling the dynamic functions of multicellular complex organisms. Although peripheral nerves are supposed to play a pivotal role in tumor growth and dissemination, little experimental evidence exists to date. We assessed the effect of denervation on breast cancer growth by magnetic resonance imaging (MRI) in rats. Human breast cancer cells were implanted into adipofascial flaps with intact or surgically excised supplying nerve. Tumor volumes were measured 2 and 8 weeks after implantation by in vivo MRI. Results were validated by histology. Postoperative tumor volumes at 2 and 8 weeks were reduced by 76% (95% CI: 22-93%) in the denervated groups. Tumor area as determined histologically was reduced by 70% (95% CI: 60-78%). Thus, peripheral denervation may be an
Background: The radial forearm flap (RFF) and the anterolateral thigh flap (ALT) are commonly use... more Background: The radial forearm flap (RFF) and the anterolateral thigh flap (ALT) are commonly used for the reconstruction of head and neck soft-tissue defects. The aim of the study was to investigate and compare the surgical outcomes, complications and systemic condition of the patient after reconstruction of extensive head and neck defects with ALT or RFF following cancer extirpation. Patients and Methods: Between August 2011 and November 2013, a total of 36 patients affected by head and neck cancer (31 males and five females; mean age=64.7 years, range=40-86 years) underwent microsurgical reconstruction with 29 RFF and 10 ALT procedures. The surgical outcomes and complications among these two groups were retrospectively analyzed. Results: The success rate was 97% for the RFF group and 90% for the ALT group, with one total flap loss in each group. Donor-site complications occurred in 6% of the RFF group and in 7% of the ALT group. Seven RFF-treated patients (24%) and two treated with ALT (20%) experienced systemic complications. Statistical analysis confirmed no significant difference between the two groups regarding the variables investigated (p>0.05). Conclusion: In our experience, ALT and RFF demonstrated analogous practicability and reliability for the reconstruction of head and neck soft-tissue defects, with similar local and systemic complications and donor-site morbidity rates. Several sites for procurement of free flaps have been proposed for the reconstruction of soft-tissue defects after head and neck cancer extirpation. However, these defects have most commonly been reconstructed using radial forearm (RFF) and anterolateral thigh (ALT) flaps (1-4). Since its introduction, the RFF has become particularly popular and accepted worldwide for the reconstruction of tongue and intraoral defects (5-8). The advantages offered by RFF include a thin texture, which facilitates folding, and an easy harvesting procedure; however, the dissection of the RFF implies the sacrifice of a major blood vessel to the hand, and the wound at the donor site often requires to be closed with a skin graft (4). The clinical indications for using the ALT in soft-tissue head and neck reconstruction have recently increased (9). This flap indeed allows the transfer of different tissues with large amounts of skin and subcutaneous fat tissue of adjustable thickness, with a vascular pedicle of suitable length and relatively large-diameter vessels, and low donorsite morbidity (9). Several studies analyzed and compared the two flap sources (4, 8-11). However, to our knowledge, a systematic analysis considering all the variables related to the reconstruction has not been performed. This study investigated and compared the outcomes in terms of free-flap survival and complications in the reconstructed area, morbidity of the donor site, and systemic conditions of the patient after reconstruction of head and neck defects with ALT or RFF. Patients and Methods Between August 2011 and November 2013, 36 patients affected by early (stage I-II) or advanced (stage III-IV) head and neck cancer were treated at the Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel. Patients underwent composite resection, with excision of the primary tumor, including ipsilateral or bilateral neck dissection and microvascular flap reconstruction. Thirty-nine free-flap procedures (ALT or RFF) were performed to reconstruct the surgical defects. Patients were divided into two groups according to microsurgical reconstruction: ALT group (n=10) and RFF group (n=29). Analysis of the following demographic and clinical variables was conducted for each group: patient sex and age, underlying disease according to the American Society of Anesthesiologists score (ASA) (12), pathological diagnosis, recipient site, previous radiation therapy.
Online teilnehmen unter: www.springermedizin.de/cme Für diese Fortbildungseinheit werden 3 Punkte... more Online teilnehmen unter: www.springermedizin.de/cme Für diese Fortbildungseinheit werden 3 Punkte vergeben.
Background Stage III and IV pressure injuries (PIs) in patients with spinal cord injury (SCI) req... more Background Stage III and IV pressure injuries (PIs) in patients with spinal cord injury (SCI) require complex interdisciplinary and interprofessional treatment approaches that are difficult to implement. Practical aspects, such as information exchange and coordination, remain challenging. We investigated whether a computerized decision support system (CDSS) could increase treatment adherence and improve clinical outcomes and interprofessional collaboration. Method In this feasibility study, a core team developed the initial treatment process and adapted it based on several discussions with clinical experts and information technologists. The CDSS followed the Basel Decubitus Approach and was used in a clinic specializing in SCI. Thirty patients with SCI admitted for stage III/IV PI between July 2016 and May 2017 were randomly allocated to standard or CDSS-supported care. Between-group differences in treatment adherence, complication rates, length of stay, and costs were analyzed using descriptive statistics. The use of the CDSS and potential barriers and facilitators were evaluated through interprofessional focus groups, transcribed verbatim, and thematically analyzed (30 participants). Results No differences in SCI characteristics, comorbidities, or PI characteristics (localization: ischium [number (n) = 19 PI, 63%], sacrum [n = 10 PI, 33%], recurrent PI [n = 21, 70%]) were found between the two groups. Furthermore, no statistically significant differences were observed in treatment adherence, frequency of major (20% vs. 13% between CDSS and control group) and minor (33% vs 27%) complications, and length of stay (98 [±28] vs 81 [±23] days). Healthcare professionals found the CDSS to be helpful for visualizing the treatment process. However, the high workload and difficulties in the information technology processes, such as missing reminders, slow computer performance and data processing, and poor accessibility, hindered the effective implementation of the CDSS. Conclusion The implementation of the CDSS to support the treatment of stage III/IV PI in patients with SCI was feasible and included definitions of milestones, interventions, and outcomes. However, to assess the impact of the CDSS, a longer observation period is required. Further, the technical difficulties must be addressed, and solid integration of the CDSS into the clinical information system is necessary. † Anke Scheel-Sailer and Kamran Koligi contributed equally to the manuscript.
Vascular endothelial growth factor-A (VEGF) physiologically regulates both angiogenesis and osteo... more Vascular endothelial growth factor-A (VEGF) physiologically regulates both angiogenesis and osteogenesis, but its application in bone tissue engineering led to contradictory outcomes. A poorly understood aspect is how VEGF dose impacts the coordination between these two processes. Taking advantage of a unique and highly tunable platform, here we dissected the effects of VEGF dose over a 1,000-fold range in the context of tissue-engineered osteogenic grafts. We found that osteo-angiogenic coupling is exquisitely dependent on VEGF dose and that only a tightly defined dose range could stimulate both vascular invasion and osteogenic commitment of progenitors, with significant improvement in bone formation. Further, VEGF dose regulated Notch1 activation and the induction of a specific pro-osteogenic endothelial phenotype, independently of the promotion of vascular invasion. Therefore, in a therapeutic perspective, fine-tuning of VEGF dose in the signaling microenvironment is key to ensur...
Background The European Leadership Forum (ELF) of the European Society of Plastic, Reconstructive... more Background The European Leadership Forum (ELF) of the European Society of Plastic, Reconstructive and Aesthetic Surgery (ESPRAS) previously identified the need for harmonisation of breast reconstruction standards in Europe, in order to strengthen the role of plastic surgeons. This study aims to survey the status, current trends and potential regional differences in the practice of breast reconstruction in Europe, with emphasis on equity and access. Materials and Methods A largescale web-based questionnaire was sent to consultant plastic and reconstructive surgeons, who are experienced in breast reconstruction and with understanding of the national situation in their country. Suitable participants were identified via the Executive Committee (ExCo) of ESPRAS and national delegates of ESPRAS. The results were evaluated and related to evidence-based literature. Results A total of 33 participants from 29 European countries participated in this study. Overall, the incidence of breast reco...
Plastic and Reconstructive Surgery - Global Open, 2021
Background: In recent years, the demand for genital plastic procedures has increased. Of those, t... more Background: In recent years, the demand for genital plastic procedures has increased. Of those, the reduction of the labia minora has become very popular. Several techniques are described, with all its advantages and disadvantages. The aim of this study is to introduce a novel approach combining de-epithelialization with wedge resection. Methods: In this retrospective study, we included patients seen between September 2011 and April 2014 with hypertrophic labia minora. The surgical technique consisted in an integrated approach of de-epithelialization and wedge excision. Patients were examined for early and late postoperative complications. Furthermore, patient satisfaction was evaluated at the final follow-up. Results: A total of 17 labioplasties (Franco type II–IV) in 10 patients with a mean age of 29 ± 12 years (range 20–62 y) were performed. Three patients experienced wound-healing problems, requiring surgical revision. After a median follow-up of 39 ± 6 months (range 28–48 mo), ...
This case report highlights the importance of a wide differential diagnosis in transgender patien... more This case report highlights the importance of a wide differential diagnosis in transgender patients. A 77-year-old transgender (female-to-male) with recurrent urinary tract infections (UTI) and obstructive voiding difficulties presented with a perineal cyst. Further examinations, including computed tomography (CT) and puncture, revealed that the patient had a symptomatic Bartholin gland cyst, a phenomenon that normally only affects women. In his gender confirmation surgery (GCS) 30 years before, the patient's female labia minora and Bartholin glands were used to lengthen the urethra for the phalloplasty. This explains the unusual location and the prolonged time to the correct diagnose. We decided to perform an incision of the fluid collection from perineal. A follow-up sonography after one month revealed a remaining cyst size of 6 mL, which was assumed to be residual fluid or newly produced liquid; however, the patient has not had any UTIs since the incision of the cyst. Our case seems to be the first description of a symptomatic Bartholin gland cyst in a trans man. This stresses the importance of an expanded understanding of sex/ gender concepts, and underlines one of the many possible diagnostic pitfalls when treating trans people.
Zusammenfassung Hintergrund Das Exekutivkomitee (ExCo) der ESPRAS hat im Oktober 2020 das erste E... more Zusammenfassung Hintergrund Das Exekutivkomitee (ExCo) der ESPRAS hat im Oktober 2020 das erste ESPRAS European Leadership Forum (ELF) initiiert, um den internationalen Austausch zwischen den verschiedenen nationalen plastisch-chirurgischen Gesellschaften zu fördern und eine Plattform für die Bewältigung gemeinsamer Herausforderung bereitzustellen. Das vorgelegte Manuskript präsentiert die wichtigsten Ergebnisse und Schlussfolgerungen dieses Treffens. Materialien und Methoden Mitglieder des Vorstands (Präsidenten, Vize-Präsidenten, Generalsekretäre) und Delegierte der nationalen Gesellschaften für Plastische Chirurgie diskutierten aktuelle Themen der Plastischen Chirurgie über das virtuelle Konferenzsystem Zoom (Zoom Video Communications, Inc.). Über Zoom erfolgte zudem eine Umfrage zu verschiedenen international relevanten plastisch-chirurgischen Themen. Ergebnisse Die Durchführung ästhetischer Eingriffe durch Ärzte ohne Facharztweiterbildung in der Plastischen Chirurgie, sowie das...
The present article provides an overview of the current and expected effects of plastic surgery i... more The present article provides an overview of the current and expected effects of plastic surgery in Europe. It presents the experience of departments for plastic and reconstructive surgery, as evaluated by interviews with members of the Executive Committee (ExCo) of the European Society of Plastic, Reconstructive and Aesthetic Surgery (ESPRAS). The objective of this overview is to summmarise current information in our area of work and to make this accessible to a broad group of readers. As our knowledge is rapidly increasing during the current pandemic, it is evident that we can only provide a snapshot and this will inevitably be incomplete.
Therapeutic angiogenesis, that is, the generation of new vessels by delivery of specific factors,... more Therapeutic angiogenesis, that is, the generation of new vessels by delivery of specific factors, is required both for rapid vascularization of tissue-engineered constructs and to treat ischemic conditions. Vascular endothelial growth factor (VEGF) is the master regulator of angiogenesis. However, uncontrolled expression can lead to aberrant vascular growth and vascular tumors (angiomas). Major challenges to fully exploit VEGF potency for therapy include the need to precisely control in vivo distribution of growth factor dose and duration of expression. In fact, the therapeutic window of VEGF delivery depends on its amount in the microenvironment around each producing cell rather than on the total dose, since VEGF remains tightly bound to extracellular matrix (ECM). On the other hand, short-term expression of less than about 4 weeks leads to unstable vessels, which promptly regress following cessation of the angiogenic stimulus. Here, we will briefly overview some key aspects of the...
Background: Management of post-traumatic open fractures resulting from severe injuries of the low... more Background: Management of post-traumatic open fractures resulting from severe injuries of the lower extremity continues to challenge orthopedic and reconstructive surgeons. Moreover, post-traumatic osteoarticular infections due to Clostridium species are rare, with few reports in the literature. We describe possible pathomechanisms and propose treatment options for cases of delayed diagnosis of osteoarticular infections with Clostridium spp. Case Reports: Two patients sustained severe osteoarticular infection due to Clostridium spp. after open epi-and metaphyseal fractures of the lower extremity. In combination with radical debridement, ankle arthrodesis and long-term antibiotic treatment, satisfactory results were achieved after a followup of 18 months and 24 years. Conclusion: Clostridium species are difficult to identify, treatment is usually delayed and most patients have unfavourable outcomes. Although Clostridium species can be found regularly in posttraumatic wounds, post-traumatic osteoarticular infection due to Clostridium is rare. Approximately 20 cases have been reported in patients with open fractures, located mainly in the diaphyseal area (1-4). Clostridium species are found most often in fractures with severe environmental contamination of the wound during trauma (5). Clostridium species are anaerobic or occasionally aerotolerant gram-positive rods, found in soil, feces, sewage and marine sediments (6). They have the ability to form endospores, mainly under anaerobic conditions. These spores display high resistance to physical and chemical influences and are not sensitive to antibiotics. In addition, several Clostridium species have the ability to produce numerous protein toxins, causing necrotizing tissue destruction (7). Thus, bone marrow necrosis or necrotic bone fragments may occur (1, 8). The laboratory diagnosis of clostridial diseases depends on proper collection and handling of tissue samples (6). However, diagnosis is complicated by the fact that bone and joint infections due to Clostridium species are often polymicrobial (2). Although identification can be time-consuming, complete identification and testing of antimicrobial sensitivities have to be pursued. Species other than C. perfringens display a high variability in sensitivity testing, including to penicillin, cephalosporins, carbapenems and clindamycin (9). Once the strain has been identified, aggressive surgical treatment is mandatory (10). When in doubt, temporary or definitive external fixation should be preferred over internal fixation to allow repeated lavage if necessary (2). Wound excision and lavage without extensive bone tissue resection nearly always fails (2), probably due to persistence of spores in surrounding tissue. All the infected tissue must be excised and any internal fixation hardware removed (2). As a rule of thumb, Clostridium spp. complicating diaphyseal fractures cause extended bone loss due to necrosis. Reconstruction requires time-consuming segmental bone reconstruction, frequently combined with soft tissue restoration. In this report, we present two patients diagnosed with open malleolar dislocation fractures of the distal lower 291 This article is freely accessible online.
Aim: We investigated the role of induced endothelial cells (iECs) in mesenchymal stem cells (MSCs... more Aim: We investigated the role of induced endothelial cells (iECs) in mesenchymal stem cells (MSCs)/iECs co-culture and assessed their osteogenic ability on silk fibroin nanofiber scaffolds. Methods: The osteogenic differentiation was assessed by the ALP assay, calcium assay and gene expression studies. Results: The osteogenic differentiation of the iECs co-cultures was found to be higher than the MSCs group and proximal to endothelial cells (ECs) co-cultures. Furthermore, the usage of isogenic iECs for co-culture increased the osteogenic and endothelial gene expression. Conclusion: These findings suggest that iECs mimic endothelial cells when co-cultured with MSCs and that one MSCs source can be used to give rise to both MSCs and iECs. The isogenic MSCs/iECs co-culture provides a new option for bone tissue engineering applications.
Background: Fournier's gangrene (FG) is a life-threatening infection of the genital, perineal, an... more Background: Fournier's gangrene (FG) is a life-threatening infection of the genital, perineal, and perianal regions with a morbidity range between 3 and 67%. Our aim is to report our experience in treatment of FG and to assess whether three different scoring systems can accurately predict mortality and morbidity in FG patients. Methods: All patients that were treated for FG at the Department of Urology of the University Hospital Basel between June 2012 and March 2017 were included and assessed retrospectively by chart review. Furthermore, we calculated Fournier's Gangrene Severity Index (FGSI), the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC), and the neutrophil-lymphocyte ratio (NLR) in every patient and assessed whether those scores correlate with the patients' morbidity and mortality. Results: Twenty patients were included, with a median (IQR) age of 66 (46-73) years. Fifteen of twenty (75%) patients required treatment on an intensive care unit, and three died (mortality rate: 15%). The mean FGSI, LRINEC, and NLR scores were 13.0, 9.3, and 45.3 for non-survivors and 7.7, 6.5, and 26 for survivors, respectively. None of the risk scores correlated significantly with mortality; however, all three significantly correlated with infectionand surgically-induced morbidity. Conclusions: In our series, Fournier's gangrene was associated with a mortality rate of 15% despite maximum multidisciplinary therapy at a specialized center. All risk scores were able to predict the morbidity of the disease in terms of local extent and the required surgical measures.
ZusammenfassungDie Plastische Chirurgie ist stärker als viele andere Fachgebiete durch ein hohes ... more ZusammenfassungDie Plastische Chirurgie ist stärker als viele andere Fachgebiete durch ein hohes Maß an multidisziplinärer Vernetzung geprägt. Trotz des breiten fachlichen Spektrums der Plastischen Chirurgie ist das Fachgebiet nicht an jedem Universitätsklinikum oder Haus der Maximalversorgung als eigenständige Abteilung oder Klinik vertreten. Auch haben selbstständige Einrichtungen nicht selten mit einem niedrig angesetzten Stellenschlüssel zu kämpfen. Außer Frage steht, dass das Fachgebiet durch die stetige Entwicklung der rekonstruktiven Mikrochirurgie zu einer deutlich verbesserten und schnelleren Versorgung von Patienten mit komplexen Defektwunden beigetragen hat. Der Zustrom der Patienten erfolgt hierbei zum größten Teil über andere Fachabteilungen. Die Einbindung der zuführenden Abteilung in die Erstellung des rekonstruktiven Planes ist von entscheidender Bedeutung für den qualitativen Erfolg der Behandlung und die Funktionswiederherstellung. Der Schlüssel in der weiteren Ent...
Study design Retrospective chart analyses as part of a quality improvement project. Objectives To... more Study design Retrospective chart analyses as part of a quality improvement project. Objectives To demonstrate treatment of pressure injury (PI) in patients with spinal cord injuries (SCI) and analyse costs using the “modified Basel Decubitus Concept”. Setting Inpatient setting of a specialised acute care and rehabilitation clinic for SCI. Methods Complex treatment courses of four patients with chronic SCI and PI stage III or IV were described and costs were recorded. The total healthcare services’ costs per patient and different profession’s involvement were analysed in relation to patient characteristics, treatment phases and milestones demonstrated. Results The treatment of PI stage III and IV in patients with SCI included input from plastic surgery, rehabilitation medicine, nursing and other involved professions. Recommended interventions were chosen according to the “modified Basel Decubitus Concept”. The cost course of PI treatment in patients with SCI depicted the multimodal t...
ABSTRACTSutureless nerve repair has been regarded as a promising technique for nerve repair as th... more ABSTRACTSutureless nerve repair has been regarded as a promising technique for nerve repair as the suture materials often results in neuroma formation and scar tissue that impede nerve regeneration. The aim of this study was to analyze the mechanical stability and morphological outcome of sutureless repair using fibrin glue conduit and an alternative approach of modified suture placement. Using rat sciatic nerve, we tested the following experimental conditions: conventional suture repair; single suture combined with fibrin glue repair, and fibrin conduit reinforced with modified suture or fibrin glue. Nerve detachment anatomical measures such as axon density, myelin, and fiber caliber were analyzed for evaluation of nerve regeneration. Muscle atrophy were evaluated by muscle wet weight and H&E staining. All animals in sutureless repair group exhibited complete detachment or elongation by two or four weeks after repair. No detachment was found in any other groups. Animals treated wit...
Journal of Plastic Reconstructive and Aesthetic Surgery, Jun 1, 2018
The nervous system plays a key role in controlling the dynamic functions of multicellular complex... more The nervous system plays a key role in controlling the dynamic functions of multicellular complex organisms. Although peripheral nerves are supposed to play a pivotal role in tumor growth and dissemination, little experimental evidence exists to date. We assessed the effect of denervation on breast cancer growth by magnetic resonance imaging (MRI) in rats. Human breast cancer cells were implanted into adipofascial flaps with intact or surgically excised supplying nerve. Tumor volumes were measured 2 and 8 weeks after implantation by in vivo MRI. Results were validated by histology. Postoperative tumor volumes at 2 and 8 weeks were reduced by 76% (95% CI: 22-93%) in the denervated groups. Tumor area as determined histologically was reduced by 70% (95% CI: 60-78%). Thus, peripheral denervation may be an
Background: The radial forearm flap (RFF) and the anterolateral thigh flap (ALT) are commonly use... more Background: The radial forearm flap (RFF) and the anterolateral thigh flap (ALT) are commonly used for the reconstruction of head and neck soft-tissue defects. The aim of the study was to investigate and compare the surgical outcomes, complications and systemic condition of the patient after reconstruction of extensive head and neck defects with ALT or RFF following cancer extirpation. Patients and Methods: Between August 2011 and November 2013, a total of 36 patients affected by head and neck cancer (31 males and five females; mean age=64.7 years, range=40-86 years) underwent microsurgical reconstruction with 29 RFF and 10 ALT procedures. The surgical outcomes and complications among these two groups were retrospectively analyzed. Results: The success rate was 97% for the RFF group and 90% for the ALT group, with one total flap loss in each group. Donor-site complications occurred in 6% of the RFF group and in 7% of the ALT group. Seven RFF-treated patients (24%) and two treated with ALT (20%) experienced systemic complications. Statistical analysis confirmed no significant difference between the two groups regarding the variables investigated (p>0.05). Conclusion: In our experience, ALT and RFF demonstrated analogous practicability and reliability for the reconstruction of head and neck soft-tissue defects, with similar local and systemic complications and donor-site morbidity rates. Several sites for procurement of free flaps have been proposed for the reconstruction of soft-tissue defects after head and neck cancer extirpation. However, these defects have most commonly been reconstructed using radial forearm (RFF) and anterolateral thigh (ALT) flaps (1-4). Since its introduction, the RFF has become particularly popular and accepted worldwide for the reconstruction of tongue and intraoral defects (5-8). The advantages offered by RFF include a thin texture, which facilitates folding, and an easy harvesting procedure; however, the dissection of the RFF implies the sacrifice of a major blood vessel to the hand, and the wound at the donor site often requires to be closed with a skin graft (4). The clinical indications for using the ALT in soft-tissue head and neck reconstruction have recently increased (9). This flap indeed allows the transfer of different tissues with large amounts of skin and subcutaneous fat tissue of adjustable thickness, with a vascular pedicle of suitable length and relatively large-diameter vessels, and low donorsite morbidity (9). Several studies analyzed and compared the two flap sources (4, 8-11). However, to our knowledge, a systematic analysis considering all the variables related to the reconstruction has not been performed. This study investigated and compared the outcomes in terms of free-flap survival and complications in the reconstructed area, morbidity of the donor site, and systemic conditions of the patient after reconstruction of head and neck defects with ALT or RFF. Patients and Methods Between August 2011 and November 2013, 36 patients affected by early (stage I-II) or advanced (stage III-IV) head and neck cancer were treated at the Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel. Patients underwent composite resection, with excision of the primary tumor, including ipsilateral or bilateral neck dissection and microvascular flap reconstruction. Thirty-nine free-flap procedures (ALT or RFF) were performed to reconstruct the surgical defects. Patients were divided into two groups according to microsurgical reconstruction: ALT group (n=10) and RFF group (n=29). Analysis of the following demographic and clinical variables was conducted for each group: patient sex and age, underlying disease according to the American Society of Anesthesiologists score (ASA) (12), pathological diagnosis, recipient site, previous radiation therapy.
Online teilnehmen unter: www.springermedizin.de/cme Für diese Fortbildungseinheit werden 3 Punkte... more Online teilnehmen unter: www.springermedizin.de/cme Für diese Fortbildungseinheit werden 3 Punkte vergeben.
Background Stage III and IV pressure injuries (PIs) in patients with spinal cord injury (SCI) req... more Background Stage III and IV pressure injuries (PIs) in patients with spinal cord injury (SCI) require complex interdisciplinary and interprofessional treatment approaches that are difficult to implement. Practical aspects, such as information exchange and coordination, remain challenging. We investigated whether a computerized decision support system (CDSS) could increase treatment adherence and improve clinical outcomes and interprofessional collaboration. Method In this feasibility study, a core team developed the initial treatment process and adapted it based on several discussions with clinical experts and information technologists. The CDSS followed the Basel Decubitus Approach and was used in a clinic specializing in SCI. Thirty patients with SCI admitted for stage III/IV PI between July 2016 and May 2017 were randomly allocated to standard or CDSS-supported care. Between-group differences in treatment adherence, complication rates, length of stay, and costs were analyzed using descriptive statistics. The use of the CDSS and potential barriers and facilitators were evaluated through interprofessional focus groups, transcribed verbatim, and thematically analyzed (30 participants). Results No differences in SCI characteristics, comorbidities, or PI characteristics (localization: ischium [number (n) = 19 PI, 63%], sacrum [n = 10 PI, 33%], recurrent PI [n = 21, 70%]) were found between the two groups. Furthermore, no statistically significant differences were observed in treatment adherence, frequency of major (20% vs. 13% between CDSS and control group) and minor (33% vs 27%) complications, and length of stay (98 [±28] vs 81 [±23] days). Healthcare professionals found the CDSS to be helpful for visualizing the treatment process. However, the high workload and difficulties in the information technology processes, such as missing reminders, slow computer performance and data processing, and poor accessibility, hindered the effective implementation of the CDSS. Conclusion The implementation of the CDSS to support the treatment of stage III/IV PI in patients with SCI was feasible and included definitions of milestones, interventions, and outcomes. However, to assess the impact of the CDSS, a longer observation period is required. Further, the technical difficulties must be addressed, and solid integration of the CDSS into the clinical information system is necessary. † Anke Scheel-Sailer and Kamran Koligi contributed equally to the manuscript.
Vascular endothelial growth factor-A (VEGF) physiologically regulates both angiogenesis and osteo... more Vascular endothelial growth factor-A (VEGF) physiologically regulates both angiogenesis and osteogenesis, but its application in bone tissue engineering led to contradictory outcomes. A poorly understood aspect is how VEGF dose impacts the coordination between these two processes. Taking advantage of a unique and highly tunable platform, here we dissected the effects of VEGF dose over a 1,000-fold range in the context of tissue-engineered osteogenic grafts. We found that osteo-angiogenic coupling is exquisitely dependent on VEGF dose and that only a tightly defined dose range could stimulate both vascular invasion and osteogenic commitment of progenitors, with significant improvement in bone formation. Further, VEGF dose regulated Notch1 activation and the induction of a specific pro-osteogenic endothelial phenotype, independently of the promotion of vascular invasion. Therefore, in a therapeutic perspective, fine-tuning of VEGF dose in the signaling microenvironment is key to ensur...
Background The European Leadership Forum (ELF) of the European Society of Plastic, Reconstructive... more Background The European Leadership Forum (ELF) of the European Society of Plastic, Reconstructive and Aesthetic Surgery (ESPRAS) previously identified the need for harmonisation of breast reconstruction standards in Europe, in order to strengthen the role of plastic surgeons. This study aims to survey the status, current trends and potential regional differences in the practice of breast reconstruction in Europe, with emphasis on equity and access. Materials and Methods A largescale web-based questionnaire was sent to consultant plastic and reconstructive surgeons, who are experienced in breast reconstruction and with understanding of the national situation in their country. Suitable participants were identified via the Executive Committee (ExCo) of ESPRAS and national delegates of ESPRAS. The results were evaluated and related to evidence-based literature. Results A total of 33 participants from 29 European countries participated in this study. Overall, the incidence of breast reco...
Plastic and Reconstructive Surgery - Global Open, 2021
Background: In recent years, the demand for genital plastic procedures has increased. Of those, t... more Background: In recent years, the demand for genital plastic procedures has increased. Of those, the reduction of the labia minora has become very popular. Several techniques are described, with all its advantages and disadvantages. The aim of this study is to introduce a novel approach combining de-epithelialization with wedge resection. Methods: In this retrospective study, we included patients seen between September 2011 and April 2014 with hypertrophic labia minora. The surgical technique consisted in an integrated approach of de-epithelialization and wedge excision. Patients were examined for early and late postoperative complications. Furthermore, patient satisfaction was evaluated at the final follow-up. Results: A total of 17 labioplasties (Franco type II–IV) in 10 patients with a mean age of 29 ± 12 years (range 20–62 y) were performed. Three patients experienced wound-healing problems, requiring surgical revision. After a median follow-up of 39 ± 6 months (range 28–48 mo), ...
This case report highlights the importance of a wide differential diagnosis in transgender patien... more This case report highlights the importance of a wide differential diagnosis in transgender patients. A 77-year-old transgender (female-to-male) with recurrent urinary tract infections (UTI) and obstructive voiding difficulties presented with a perineal cyst. Further examinations, including computed tomography (CT) and puncture, revealed that the patient had a symptomatic Bartholin gland cyst, a phenomenon that normally only affects women. In his gender confirmation surgery (GCS) 30 years before, the patient's female labia minora and Bartholin glands were used to lengthen the urethra for the phalloplasty. This explains the unusual location and the prolonged time to the correct diagnose. We decided to perform an incision of the fluid collection from perineal. A follow-up sonography after one month revealed a remaining cyst size of 6 mL, which was assumed to be residual fluid or newly produced liquid; however, the patient has not had any UTIs since the incision of the cyst. Our case seems to be the first description of a symptomatic Bartholin gland cyst in a trans man. This stresses the importance of an expanded understanding of sex/ gender concepts, and underlines one of the many possible diagnostic pitfalls when treating trans people.
Zusammenfassung Hintergrund Das Exekutivkomitee (ExCo) der ESPRAS hat im Oktober 2020 das erste E... more Zusammenfassung Hintergrund Das Exekutivkomitee (ExCo) der ESPRAS hat im Oktober 2020 das erste ESPRAS European Leadership Forum (ELF) initiiert, um den internationalen Austausch zwischen den verschiedenen nationalen plastisch-chirurgischen Gesellschaften zu fördern und eine Plattform für die Bewältigung gemeinsamer Herausforderung bereitzustellen. Das vorgelegte Manuskript präsentiert die wichtigsten Ergebnisse und Schlussfolgerungen dieses Treffens. Materialien und Methoden Mitglieder des Vorstands (Präsidenten, Vize-Präsidenten, Generalsekretäre) und Delegierte der nationalen Gesellschaften für Plastische Chirurgie diskutierten aktuelle Themen der Plastischen Chirurgie über das virtuelle Konferenzsystem Zoom (Zoom Video Communications, Inc.). Über Zoom erfolgte zudem eine Umfrage zu verschiedenen international relevanten plastisch-chirurgischen Themen. Ergebnisse Die Durchführung ästhetischer Eingriffe durch Ärzte ohne Facharztweiterbildung in der Plastischen Chirurgie, sowie das...
The present article provides an overview of the current and expected effects of plastic surgery i... more The present article provides an overview of the current and expected effects of plastic surgery in Europe. It presents the experience of departments for plastic and reconstructive surgery, as evaluated by interviews with members of the Executive Committee (ExCo) of the European Society of Plastic, Reconstructive and Aesthetic Surgery (ESPRAS). The objective of this overview is to summmarise current information in our area of work and to make this accessible to a broad group of readers. As our knowledge is rapidly increasing during the current pandemic, it is evident that we can only provide a snapshot and this will inevitably be incomplete.
Therapeutic angiogenesis, that is, the generation of new vessels by delivery of specific factors,... more Therapeutic angiogenesis, that is, the generation of new vessels by delivery of specific factors, is required both for rapid vascularization of tissue-engineered constructs and to treat ischemic conditions. Vascular endothelial growth factor (VEGF) is the master regulator of angiogenesis. However, uncontrolled expression can lead to aberrant vascular growth and vascular tumors (angiomas). Major challenges to fully exploit VEGF potency for therapy include the need to precisely control in vivo distribution of growth factor dose and duration of expression. In fact, the therapeutic window of VEGF delivery depends on its amount in the microenvironment around each producing cell rather than on the total dose, since VEGF remains tightly bound to extracellular matrix (ECM). On the other hand, short-term expression of less than about 4 weeks leads to unstable vessels, which promptly regress following cessation of the angiogenic stimulus. Here, we will briefly overview some key aspects of the...
Background: Management of post-traumatic open fractures resulting from severe injuries of the low... more Background: Management of post-traumatic open fractures resulting from severe injuries of the lower extremity continues to challenge orthopedic and reconstructive surgeons. Moreover, post-traumatic osteoarticular infections due to Clostridium species are rare, with few reports in the literature. We describe possible pathomechanisms and propose treatment options for cases of delayed diagnosis of osteoarticular infections with Clostridium spp. Case Reports: Two patients sustained severe osteoarticular infection due to Clostridium spp. after open epi-and metaphyseal fractures of the lower extremity. In combination with radical debridement, ankle arthrodesis and long-term antibiotic treatment, satisfactory results were achieved after a followup of 18 months and 24 years. Conclusion: Clostridium species are difficult to identify, treatment is usually delayed and most patients have unfavourable outcomes. Although Clostridium species can be found regularly in posttraumatic wounds, post-traumatic osteoarticular infection due to Clostridium is rare. Approximately 20 cases have been reported in patients with open fractures, located mainly in the diaphyseal area (1-4). Clostridium species are found most often in fractures with severe environmental contamination of the wound during trauma (5). Clostridium species are anaerobic or occasionally aerotolerant gram-positive rods, found in soil, feces, sewage and marine sediments (6). They have the ability to form endospores, mainly under anaerobic conditions. These spores display high resistance to physical and chemical influences and are not sensitive to antibiotics. In addition, several Clostridium species have the ability to produce numerous protein toxins, causing necrotizing tissue destruction (7). Thus, bone marrow necrosis or necrotic bone fragments may occur (1, 8). The laboratory diagnosis of clostridial diseases depends on proper collection and handling of tissue samples (6). However, diagnosis is complicated by the fact that bone and joint infections due to Clostridium species are often polymicrobial (2). Although identification can be time-consuming, complete identification and testing of antimicrobial sensitivities have to be pursued. Species other than C. perfringens display a high variability in sensitivity testing, including to penicillin, cephalosporins, carbapenems and clindamycin (9). Once the strain has been identified, aggressive surgical treatment is mandatory (10). When in doubt, temporary or definitive external fixation should be preferred over internal fixation to allow repeated lavage if necessary (2). Wound excision and lavage without extensive bone tissue resection nearly always fails (2), probably due to persistence of spores in surrounding tissue. All the infected tissue must be excised and any internal fixation hardware removed (2). As a rule of thumb, Clostridium spp. complicating diaphyseal fractures cause extended bone loss due to necrosis. Reconstruction requires time-consuming segmental bone reconstruction, frequently combined with soft tissue restoration. In this report, we present two patients diagnosed with open malleolar dislocation fractures of the distal lower 291 This article is freely accessible online.
Aim: We investigated the role of induced endothelial cells (iECs) in mesenchymal stem cells (MSCs... more Aim: We investigated the role of induced endothelial cells (iECs) in mesenchymal stem cells (MSCs)/iECs co-culture and assessed their osteogenic ability on silk fibroin nanofiber scaffolds. Methods: The osteogenic differentiation was assessed by the ALP assay, calcium assay and gene expression studies. Results: The osteogenic differentiation of the iECs co-cultures was found to be higher than the MSCs group and proximal to endothelial cells (ECs) co-cultures. Furthermore, the usage of isogenic iECs for co-culture increased the osteogenic and endothelial gene expression. Conclusion: These findings suggest that iECs mimic endothelial cells when co-cultured with MSCs and that one MSCs source can be used to give rise to both MSCs and iECs. The isogenic MSCs/iECs co-culture provides a new option for bone tissue engineering applications.
Background: Fournier's gangrene (FG) is a life-threatening infection of the genital, perineal, an... more Background: Fournier's gangrene (FG) is a life-threatening infection of the genital, perineal, and perianal regions with a morbidity range between 3 and 67%. Our aim is to report our experience in treatment of FG and to assess whether three different scoring systems can accurately predict mortality and morbidity in FG patients. Methods: All patients that were treated for FG at the Department of Urology of the University Hospital Basel between June 2012 and March 2017 were included and assessed retrospectively by chart review. Furthermore, we calculated Fournier's Gangrene Severity Index (FGSI), the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC), and the neutrophil-lymphocyte ratio (NLR) in every patient and assessed whether those scores correlate with the patients' morbidity and mortality. Results: Twenty patients were included, with a median (IQR) age of 66 (46-73) years. Fifteen of twenty (75%) patients required treatment on an intensive care unit, and three died (mortality rate: 15%). The mean FGSI, LRINEC, and NLR scores were 13.0, 9.3, and 45.3 for non-survivors and 7.7, 6.5, and 26 for survivors, respectively. None of the risk scores correlated significantly with mortality; however, all three significantly correlated with infectionand surgically-induced morbidity. Conclusions: In our series, Fournier's gangrene was associated with a mortality rate of 15% despite maximum multidisciplinary therapy at a specialized center. All risk scores were able to predict the morbidity of the disease in terms of local extent and the required surgical measures.
ZusammenfassungDie Plastische Chirurgie ist stärker als viele andere Fachgebiete durch ein hohes ... more ZusammenfassungDie Plastische Chirurgie ist stärker als viele andere Fachgebiete durch ein hohes Maß an multidisziplinärer Vernetzung geprägt. Trotz des breiten fachlichen Spektrums der Plastischen Chirurgie ist das Fachgebiet nicht an jedem Universitätsklinikum oder Haus der Maximalversorgung als eigenständige Abteilung oder Klinik vertreten. Auch haben selbstständige Einrichtungen nicht selten mit einem niedrig angesetzten Stellenschlüssel zu kämpfen. Außer Frage steht, dass das Fachgebiet durch die stetige Entwicklung der rekonstruktiven Mikrochirurgie zu einer deutlich verbesserten und schnelleren Versorgung von Patienten mit komplexen Defektwunden beigetragen hat. Der Zustrom der Patienten erfolgt hierbei zum größten Teil über andere Fachabteilungen. Die Einbindung der zuführenden Abteilung in die Erstellung des rekonstruktiven Planes ist von entscheidender Bedeutung für den qualitativen Erfolg der Behandlung und die Funktionswiederherstellung. Der Schlüssel in der weiteren Ent...
Study design Retrospective chart analyses as part of a quality improvement project. Objectives To... more Study design Retrospective chart analyses as part of a quality improvement project. Objectives To demonstrate treatment of pressure injury (PI) in patients with spinal cord injuries (SCI) and analyse costs using the “modified Basel Decubitus Concept”. Setting Inpatient setting of a specialised acute care and rehabilitation clinic for SCI. Methods Complex treatment courses of four patients with chronic SCI and PI stage III or IV were described and costs were recorded. The total healthcare services’ costs per patient and different profession’s involvement were analysed in relation to patient characteristics, treatment phases and milestones demonstrated. Results The treatment of PI stage III and IV in patients with SCI included input from plastic surgery, rehabilitation medicine, nursing and other involved professions. Recommended interventions were chosen according to the “modified Basel Decubitus Concept”. The cost course of PI treatment in patients with SCI depicted the multimodal t...
ABSTRACTSutureless nerve repair has been regarded as a promising technique for nerve repair as th... more ABSTRACTSutureless nerve repair has been regarded as a promising technique for nerve repair as the suture materials often results in neuroma formation and scar tissue that impede nerve regeneration. The aim of this study was to analyze the mechanical stability and morphological outcome of sutureless repair using fibrin glue conduit and an alternative approach of modified suture placement. Using rat sciatic nerve, we tested the following experimental conditions: conventional suture repair; single suture combined with fibrin glue repair, and fibrin conduit reinforced with modified suture or fibrin glue. Nerve detachment anatomical measures such as axon density, myelin, and fiber caliber were analyzed for evaluation of nerve regeneration. Muscle atrophy were evaluated by muscle wet weight and H&E staining. All animals in sutureless repair group exhibited complete detachment or elongation by two or four weeks after repair. No detachment was found in any other groups. Animals treated wit...
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Papers by Dirk Schaefer