Skip to main content

Diego Silva

Followers

0

Following

1

Public Views

Marcos Leandro Freitas Hübner

UNIRIO - Universidade Federal do Estado do Rio de Janeiro

Marina Valadares

Universidade Federal de Santa Catarina - UFSC (Federal University of Santa Catarina)

Natalia Gallo Cerrao

UFSCar - Federal University of São Carlos

Fabrício S Assumpção

Universidade Federal do Paraná

José Elias Soares

Universidade Federal De Sao Carlos

Zaira Regina Zafalon

UFSCar - Federal University of São Carlos

Luciana Candida

Cristina Dotta Ortega

Elisângela C . Aganette

UFMG - The Federal University of Minas Gerais

Interests

Uploads

Papers by Diego Silva

Controle de autoridades no campo das artes: relato de experiência na Pinacoteca de São Paulo

Para as bibliotecas e os arquivos, o catalogo se constitui como um meio importante para prover ac... more Para as bibliotecas e os arquivos, o catalogo se constitui como um meio importante para prover acesso a informacao. Nesse contexto, torna-se necessaria a elaboracao de catalogos com dados consistentes sobre os registros do conhecimento; caso contrario, o acesso pode ficar restrito e as informacoes dispersas. O presente relato descreve a reestruturacao do catalogo de autoridades de nomes da Biblioteca Walter Wey e do Centro de Documentacao e Memoria da Pinacoteca de Sao Paulo por meio da inclusao de campos MARC21, criados com base nas propostas da Resource Description Access (RDA) e nos principios dos Functional Requirements for Authority Data (FRAD). Tal medida possibilitou a organizacao dos registros de autoridade de forma a contextualizar as instituicoes especializadas (galerias de arte, museus, escolas, dentre outros) e os artistas atuantes no Brasil, no que diz respeito as alteracoes de nomes e localizacao. Considerando que muitos artistas e instituicoes existiram em uma epoca a...

Ciclos de la Nueva Granada. Guitare

Enabling Interactive Visualizations in Industrial Big Data

IFAC-PapersOnLine, 2020

Industries are considered data rich but information poor environments. Mainly due to systems desi... more Industries are considered data rich but information poor environments. Mainly due to systems design restrictions, to the lack of adequate processing power and to a sector culture notably focused on collecting, selecting, storing and preserving historical series in on-demand access repositories, massive data generated in industrial operations is traditionally neglected (or simply took aside). This huge amount of unprocessed data resting in these repositories is a latent and rich source of information that could be used to improve industrial processes. This work then proposes an approach in which an elastic processing engine is designed to be pluggedin to currently installed industrial information infrastructure to provide it with the ability of performing visual analytics on massive industrial data. A case study where an interactive visualization application is made possible in real-world industrial data scenario of over 100 million records is presented to attest the effectiveness and potential of the proposed approach in enabling interactive visualizations to Industrial Big Data.

Incidencia del factor de corrección por humedad relativa según zona geográfica en ensayos de alta tensión

2018 IEEE 9th Power, Instrumentation and Measurement Meeting (EPIM), 2018

Analyze the conditions in which the correction factor for relative humidity, according to IEC and... more Analyze the conditions in which the correction factor for relative humidity, according to IEC and IEEE standards, is applicable. The variation in the parameters of tests is important, being relevant to identify different places on the ground and meteorological conditions in which the corrections are applied. We will seek to see the difference in the results of certain results when considering the mentioned correction parameters.

Validação de método analítico por extração líquido-líquido e análise por cromatografia gasosa acoplada à espectrometria de massas para detecção de ácidos haloacéticos em amostras ambientais

Engenharia Sanitaria e Ambiental, 2021

RESUMO O estudo teve como objetivo o desenvolvimento e a validação de um método analítico para de... more RESUMO O estudo teve como objetivo o desenvolvimento e a validação de um método analítico para detecção e quantificação de ácidos haloacéticos por meio da extração líquido-líquido e da análise por cromatografia gasosa acoplada à espectrometria de massas. Para a validação, consideraram-se parâmetros como linearidade, precisão, limites de detecção e quantificação e seletividade. Adicionalmente, aplicou-se o método para avaliar a formação de ácidos haloacéticos em ensaios de cloração de células de Cylindrospermopsis raciborskii com o oxidante hipoclorito de cálcio, simulando situações em estações de tratamento de água. O método apresentou baixo tempo de análise, excelente seletividade, precisão, repetitividade e sensibilidade, com possibilidade de aplicação para análises de rotina em substituição à cromatografia a gás por captura de elétrons. Observou-se a formação de ácidos haloacéticos durante os ensaios com doses de 2,5 e 5,0 mg.L-1 do oxidante, com destaque para os ácidos dicloroac...

Coordenação de Veículos Aéreos não Tripulados Utilizando Inteligência de Enxames

Revista de Engenharia e Pesquisa Aplicada, 2016

Este artigo apresenta a análise de um modelo para a coordenação de veículos aéreos não tripulados... more Este artigo apresenta a análise de um modelo para a coordenação de veículos aéreos não tripulados (UAVs) utilizando uma abordagem de inteligência de enxames baseado no Particle Swarm Optimization. O modelo considera mecanismos de locomoção e anticolisão, comunicação ad hoc e informações do ambiente obtidas dos sensores do UAV. Foi analizada a performance em termos de rastreamento de alvos e escalabilidade. Um simulador foi desenvolvido com uma interface gráfica para permitir uma n´alise visual do enxame de UAVs.

Using LoRaWAN smart city infrastructure as backup network for Industry 4.0 enabled vehicles

Anais Estendidos do Simpósio Brasileiro de Engenharia de Sistemas Computacionais (SBESC), 2019

Intelligent vehicles are the very next future of the automotive sector, which is renewing itself ... more Intelligent vehicles are the very next future of the automotive sector, which is renewing itself following Industry 4.0 paradigms. Today, car manufacturers are rapidly increasing the number of vehicles that continuously transmit data to the Internet, in order to enable the virtuous feedback paths foreseen by Industry 4.0. Such data are used to improve production (and products) during the entire lifetime of plants (and cars, also). A data link between on board devices and Internet must be created. Currently, the OBD (On Board Diagnostic) interface is available in the majority of cars and trucks. Some Edge devices with OBD and 3G/4G modems have been created, enabling easy Internet connection. However, congestion situation, as well as temporary outages, may create significant holes in the 3G/4G coverage. Recently, the transformation of city into Smart City is begun. An impressive number of new sensors are deployed in urban area. New wireless technologies are on the rise and, among them...

Development of a discrete event simulation model for evaluating strategies of red blood cell provision following mass casualty events

European Journal of Operational Research, 2018

Development of a discrete event simulation model for evaluating strategies of red blood cell prov... more

Impact of fingolimod on clinical and magnetic resonance imaging outcomes in routine clinical practice: A retrospective analysis of the multiple sclerosis, clinical and MRI outcomes in the USA (MS-MRIUS) study

Multiple sclerosis and related disorders, Jan 3, 2018

The effectiveness of fingolimod on clinical and magnetic resonance imaging (MRI) outcomes in pati... more The effectiveness of fingolimod on clinical and magnetic resonance imaging (MRI) outcomes in patients with multiple sclerosis (MS) has been well established in trials and, to a lesser extent, in the real world. To evaluate clinical and MRI outcomes in patients with relapsing MS receiving fingolimod in US clinical practice. Clinical and MRI data from 590 patients initiating fingolimod treatment at 33 MS centers in the USA were retrospectively analyzed. Clinical data were obtained from medical records. MRI data were systematically quantified at a centralized imaging facility. Patients had an index (within 6 months before and 1 month after starting fingolimod) and post-index (9-24 months after starting fingolimod) MRI scan; 184 individuals had a pre-index scan (9-24 months before starting fingolimod). In the index to post-index period, mean annualized relapse rates decreased from 0.36 to 0.13 and disability progression occurred in 18.5% of patients. Median T2, T1 and gadolinium-enhanci...

Establishing pathological cut-offs for lateral ventricular volume expansion rates

NeuroImage. Clinical, 2018

A percent brain volume change (PBVC) cut-off of -0.4% per year has been proposed to distinguish b... more A percent brain volume change (PBVC) cut-off of -0.4% per year has been proposed to distinguish between pathological and physiological changes in multiple sclerosis (MS). Unfortunately, standardized PBVC measurement is not always feasible on scans acquired outside research studies or academic centers. Percent lateral ventricular volume change (PLVVC) is a strong surrogate measure of PBVC, and may be more feasible for atrophy assessment on real-world scans. However, the PLVVC rate corresponding to the established PBVC cut-off of -0.4% is unknown. To establish a pathological PLVVC expansion rate cut-off analogous to -0.4% PBVC. We used three complementary approaches. First, the original follow-up-length-weighted receiver operating characteristic (ROC) analysis method establishing whole brain atrophy rates was adapted to a longitudinal ventricular atrophy dataset of 177 relapsing-remitting MS (RRMS) patients and 48 healthy controls. Second, in the same dataset, SIENA PBVCs were used wi...

Neurological software tool for reliable atrophy measurement (NeuroSTREAM) of the lateral ventricles on clinical-quality T2-FLAIR MRI scans in multiple sclerosis

NeuroImage. Clinical, 2017

There is a need for a brain volume measure applicable to the clinical routine scans. Nearly every... more There is a need for a brain volume measure applicable to the clinical routine scans. Nearly every multiple sclerosis (MS) protocol includes low-resolution 2D T2-FLAIR imaging. To develop and validate cross-sectional and longitudinal brain atrophy measures on clinical-quality T2-FLAIR images in MS patients. A real-world dataset from 109 MS patients from 62 MRI scanners was used to develop a lateral ventricular volume (LVV) algorithm with a longitudinal Jacobian-based extension, called NeuroSTREAM. Gold-standard LVV was calculated on high-resolution T1 1 mm, while NeuroSTREAM LVV was obtained on low-resolution T2-FLAIR 3 mm thick images. Scan-rescan reliability was assessed in 5 subjects. The variability of LVV measurement at different field strengths was tested in 76 healthy controls and 125 MS patients who obtained both 1.5T and 3T scans in 72 hours. Clinical validation of algorithm was performed in 176 MS patients who obtained serial yearly MRI 1.5T scans for 10 years. Correlation ...

P1.01-047 Clinical Presentation and Outcome of Neuroendocrine Lung Tumors in a Brazilian Cohort from 2000 to 2016

Journal of Thoracic Oncology, 2017

An Observational Study to Assess Brain MRI Change and Disease Progression in Multiple Sclerosis Clinical Practice-The MS-MRIUS Study

Journal of neuroimaging : official journal of the American Society of Neuroimaging, May 5, 2016

To describe methodology, interim baseline, and longitudinal magnetic resonance imaging (MRI) acqu... more To describe methodology, interim baseline, and longitudinal magnetic resonance imaging (MRI) acquisition parameter characteristics of the multiple sclerosis clinical outcome and MRI in the United States (MS-MRIUS). The MS-MRIUS is an ongoing longitudinal and retrospective study of MS patients on fingolimod. Clinical and brain MRI image scan data were collected from 600 patients across 33 MS centers in the United States. MRI brain outcomes included change in whole-brain volume, lateral ventricle volume, T2- and T1-lesion volumes, and new/enlarging T2 and gadolinium-enhancing lesions. Interim baseline and longitudinal MRI acquisition parameters results are presented for 252 patients. Mean age was 44 years and 81% were female. Forty percent of scans had 3-dimensional (3D) T1 sequence in the preindex period, increasing to 50% in the postindex period. Use of 2-dimensional (2D) T1 sequence decreased over time from 85% in the preindex period to 65% in the postindex. About 95% of the scans ...

Integrating mobile devices and industrial automation through web services

2009 7th IEEE International Conference on Industrial Informatics, 2009

Page 1. Integrating Mobile Devices and Industrial Automation through Web Services Anderson Luiz d... more

Betwixt & Between: Peer Recruiter Proximity in Community-Based Research

The American Journal of Bioethics, 2010

Application of energy system models for designing a low-carbon society

Progress in Energy and Combustion Science, 2011

Rising concern about the effect of greenhouse gas (GHG) emissions on climate change is pushing na... more Rising concern about the effect of greenhouse gas (GHG) emissions on climate change is pushing national governments and the international community to achieve sustainable development in an economy that is less dependent on carbon emitting activities e a vision that is usually termed a "low-carbon society" (LCS). Since the utilization of energy resources is the main source of GHG emissions, restructuring current energy systems in order to incorporate low-carbon energy technologies is essential for the realization of the LCS vision. Energy policies promoting the penetration of these technologies must view the role of energy in society as a system, composed of several energy resources, conversion technologies and energy demand sectors. The feasibility of the LCS in the future can be better understood by means of energy models. Energy models are valuable mathematical tools based on the systems approach. They have been applied to aid decision-making in energy planning, to analyze energy policies and to analyze the implications arising from the introduction of technologies. The design of the LCS requires innovative energy systems considering a trans-disciplinary approach that integrates multi-dimensional elements, related to social, economic, and environmental aspects. This paper reviews the application of energy models considering scenarios towards an LCS under the energy systems approach. The models reviewed consider the utilization of waste for energy, the penetration of clean coal technologies, transportation sector models as a sample of sectoral approaches, and models related to energy-for-development issues in rural areas of developing countries.

Huachipato

Demyelination caused by the copper chelator cuprizone halts T cell mediated autoimmune neuroinflammation

Journal of Neuroimmunology, 2009

Myelin reactive T cells are central in the development of the autoimmune response leading to CNS ... more Myelin reactive T cells are central in the development of the autoimmune response leading to CNS destruction in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis (EAE). Investigations on the mechanisms underlying the activation and expansion of myelin reactive T have stressed the importance of non-autoimmune conditions impinging the autoimmune repertoire potentially involved in the disease. Here, we show that CNS injury caused by the toxic cuprizone results in the generation of immunoreactivity towards several myelin components. Paradoxically, exposure to CNS injury does not increase the susceptibility to develop EAE, but render mice protected to the pathogenic autoimmune response against myelin antigens.

LIBS spectra of polychromes with a low cost CCD camera based detector

Journal of Cultural Heritage, 2000

Two real samples of polychromes, from the Spanish Baroque period and from the XV century, were an... more Two real samples of polychromes, from the Spanish Baroque period and from the XV century, were analysed by time-integrated laser-induced breakdown spectroscopy (LIBS). The time-integrated spectra showed negligible contribution of continuum background emission. The spectra of the Baroque sample indicated the presence of vermilion; this was confirmed by near-infrared Fourier transform spectroscopy. LIBS spectra of the XV century sample showed Ca, Al, Mg, Na and Pb lines and the molecular emissions CN(B-X) and C 2 (d-a). Relative spectral intensities were measured as a function of the number of laser pulses delivered at the same position of the sample.

Elevation in interleukin 13 levels in patients diagnosed with systemic inflammatory response syndrome

Intensive Care Medicine, 2006

To examine plasma levels and circadian rhythm of interleukin 13 (IL-13), tumour necrosis factor (... more To examine plasma levels and circadian rhythm of interleukin 13 (IL-13), tumour necrosis factor (TNF) alpha and total serum cortisol in the systemic inflammatory response syndrome (SIRS). Prospective observational study in a 12-bed medical-surgical ICU of a 500-bed university hospital. Ten patients with SIRS and eight controls. Arterial blood was sampled hourly for 24 h for measurement of plasma IL-13, TNF- alpha, cortisol and white blood cell count (WCC) differential within 24 h of development of SIRS. There were significantly higher plasma IL-13 levels in SIRS patients than in controls (1282 vs. 713 pg/ml). IL-13 was significantly higher in patients with a diagnosis of sepsis than in those with non-infectious causes of SIRS (2080 vs. 515 pg/ml). In SIRS the elevation in IL-13 was associated with higher TNF-alpha and reduced WCC. A circadian rhythm was observed in plasma IL-13 secretion. No distinct circadian rhythm was noted for TNF- alpha, and the normal circadian rhythm of serum cortisol was lost. The anti-inflammatory cytokine IL-13 is elevated in early SIRS. Its plasma level exhibits a circadian rhythm and may be modulated in part by TNF-alpha. SIRS patients have disruption of the normal circadian rhythm of serum cortisol.

Controle de autoridades no campo das artes: relato de experiência na Pinacoteca de São Paulo

Para as bibliotecas e os arquivos, o catalogo se constitui como um meio importante para prover ac... more Para as bibliotecas e os arquivos, o catalogo se constitui como um meio importante para prover acesso a informacao. Nesse contexto, torna-se necessaria a elaboracao de catalogos com dados consistentes sobre os registros do conhecimento; caso contrario, o acesso pode ficar restrito e as informacoes dispersas. O presente relato descreve a reestruturacao do catalogo de autoridades de nomes da Biblioteca Walter Wey e do Centro de Documentacao e Memoria da Pinacoteca de Sao Paulo por meio da inclusao de campos MARC21, criados com base nas propostas da Resource Description Access (RDA) e nos principios dos Functional Requirements for Authority Data (FRAD). Tal medida possibilitou a organizacao dos registros de autoridade de forma a contextualizar as instituicoes especializadas (galerias de arte, museus, escolas, dentre outros) e os artistas atuantes no Brasil, no que diz respeito as alteracoes de nomes e localizacao. Considerando que muitos artistas e instituicoes existiram em uma epoca a...

Ciclos de la Nueva Granada. Guitare

Enabling Interactive Visualizations in Industrial Big Data

IFAC-PapersOnLine, 2020

Industries are considered data rich but information poor environments. Mainly due to systems desi... more Industries are considered data rich but information poor environments. Mainly due to systems design restrictions, to the lack of adequate processing power and to a sector culture notably focused on collecting, selecting, storing and preserving historical series in on-demand access repositories, massive data generated in industrial operations is traditionally neglected (or simply took aside). This huge amount of unprocessed data resting in these repositories is a latent and rich source of information that could be used to improve industrial processes. This work then proposes an approach in which an elastic processing engine is designed to be pluggedin to currently installed industrial information infrastructure to provide it with the ability of performing visual analytics on massive industrial data. A case study where an interactive visualization application is made possible in real-world industrial data scenario of over 100 million records is presented to attest the effectiveness and potential of the proposed approach in enabling interactive visualizations to Industrial Big Data.

Incidencia del factor de corrección por humedad relativa según zona geográfica en ensayos de alta tensión

2018 IEEE 9th Power, Instrumentation and Measurement Meeting (EPIM), 2018

Analyze the conditions in which the correction factor for relative humidity, according to IEC and... more Analyze the conditions in which the correction factor for relative humidity, according to IEC and IEEE standards, is applicable. The variation in the parameters of tests is important, being relevant to identify different places on the ground and meteorological conditions in which the corrections are applied. We will seek to see the difference in the results of certain results when considering the mentioned correction parameters.

Validação de método analítico por extração líquido-líquido e análise por cromatografia gasosa acoplada à espectrometria de massas para detecção de ácidos haloacéticos em amostras ambientais

Engenharia Sanitaria e Ambiental, 2021

RESUMO O estudo teve como objetivo o desenvolvimento e a validação de um método analítico para de... more RESUMO O estudo teve como objetivo o desenvolvimento e a validação de um método analítico para detecção e quantificação de ácidos haloacéticos por meio da extração líquido-líquido e da análise por cromatografia gasosa acoplada à espectrometria de massas. Para a validação, consideraram-se parâmetros como linearidade, precisão, limites de detecção e quantificação e seletividade. Adicionalmente, aplicou-se o método para avaliar a formação de ácidos haloacéticos em ensaios de cloração de células de Cylindrospermopsis raciborskii com o oxidante hipoclorito de cálcio, simulando situações em estações de tratamento de água. O método apresentou baixo tempo de análise, excelente seletividade, precisão, repetitividade e sensibilidade, com possibilidade de aplicação para análises de rotina em substituição à cromatografia a gás por captura de elétrons. Observou-se a formação de ácidos haloacéticos durante os ensaios com doses de 2,5 e 5,0 mg.L-1 do oxidante, com destaque para os ácidos dicloroac...

Coordenação de Veículos Aéreos não Tripulados Utilizando Inteligência de Enxames

Revista de Engenharia e Pesquisa Aplicada, 2016

Este artigo apresenta a análise de um modelo para a coordenação de veículos aéreos não tripulados... more Este artigo apresenta a análise de um modelo para a coordenação de veículos aéreos não tripulados (UAVs) utilizando uma abordagem de inteligência de enxames baseado no Particle Swarm Optimization. O modelo considera mecanismos de locomoção e anticolisão, comunicação ad hoc e informações do ambiente obtidas dos sensores do UAV. Foi analizada a performance em termos de rastreamento de alvos e escalabilidade. Um simulador foi desenvolvido com uma interface gráfica para permitir uma n´alise visual do enxame de UAVs.

Using LoRaWAN smart city infrastructure as backup network for Industry 4.0 enabled vehicles

Anais Estendidos do Simpósio Brasileiro de Engenharia de Sistemas Computacionais (SBESC), 2019

Intelligent vehicles are the very next future of the automotive sector, which is renewing itself ... more Intelligent vehicles are the very next future of the automotive sector, which is renewing itself following Industry 4.0 paradigms. Today, car manufacturers are rapidly increasing the number of vehicles that continuously transmit data to the Internet, in order to enable the virtuous feedback paths foreseen by Industry 4.0. Such data are used to improve production (and products) during the entire lifetime of plants (and cars, also). A data link between on board devices and Internet must be created. Currently, the OBD (On Board Diagnostic) interface is available in the majority of cars and trucks. Some Edge devices with OBD and 3G/4G modems have been created, enabling easy Internet connection. However, congestion situation, as well as temporary outages, may create significant holes in the 3G/4G coverage. Recently, the transformation of city into Smart City is begun. An impressive number of new sensors are deployed in urban area. New wireless technologies are on the rise and, among them...

Development of a discrete event simulation model for evaluating strategies of red blood cell provision following mass casualty events

European Journal of Operational Research, 2018

Development of a discrete event simulation model for evaluating strategies of red blood cell prov... more

Impact of fingolimod on clinical and magnetic resonance imaging outcomes in routine clinical practice: A retrospective analysis of the multiple sclerosis, clinical and MRI outcomes in the USA (MS-MRIUS) study

Multiple sclerosis and related disorders, Jan 3, 2018

The effectiveness of fingolimod on clinical and magnetic resonance imaging (MRI) outcomes in pati... more The effectiveness of fingolimod on clinical and magnetic resonance imaging (MRI) outcomes in patients with multiple sclerosis (MS) has been well established in trials and, to a lesser extent, in the real world. To evaluate clinical and MRI outcomes in patients with relapsing MS receiving fingolimod in US clinical practice. Clinical and MRI data from 590 patients initiating fingolimod treatment at 33 MS centers in the USA were retrospectively analyzed. Clinical data were obtained from medical records. MRI data were systematically quantified at a centralized imaging facility. Patients had an index (within 6 months before and 1 month after starting fingolimod) and post-index (9-24 months after starting fingolimod) MRI scan; 184 individuals had a pre-index scan (9-24 months before starting fingolimod). In the index to post-index period, mean annualized relapse rates decreased from 0.36 to 0.13 and disability progression occurred in 18.5% of patients. Median T2, T1 and gadolinium-enhanci...

Establishing pathological cut-offs for lateral ventricular volume expansion rates

NeuroImage. Clinical, 2018

A percent brain volume change (PBVC) cut-off of -0.4% per year has been proposed to distinguish b... more A percent brain volume change (PBVC) cut-off of -0.4% per year has been proposed to distinguish between pathological and physiological changes in multiple sclerosis (MS). Unfortunately, standardized PBVC measurement is not always feasible on scans acquired outside research studies or academic centers. Percent lateral ventricular volume change (PLVVC) is a strong surrogate measure of PBVC, and may be more feasible for atrophy assessment on real-world scans. However, the PLVVC rate corresponding to the established PBVC cut-off of -0.4% is unknown. To establish a pathological PLVVC expansion rate cut-off analogous to -0.4% PBVC. We used three complementary approaches. First, the original follow-up-length-weighted receiver operating characteristic (ROC) analysis method establishing whole brain atrophy rates was adapted to a longitudinal ventricular atrophy dataset of 177 relapsing-remitting MS (RRMS) patients and 48 healthy controls. Second, in the same dataset, SIENA PBVCs were used wi...

Neurological software tool for reliable atrophy measurement (NeuroSTREAM) of the lateral ventricles on clinical-quality T2-FLAIR MRI scans in multiple sclerosis

NeuroImage. Clinical, 2017

There is a need for a brain volume measure applicable to the clinical routine scans. Nearly every... more There is a need for a brain volume measure applicable to the clinical routine scans. Nearly every multiple sclerosis (MS) protocol includes low-resolution 2D T2-FLAIR imaging. To develop and validate cross-sectional and longitudinal brain atrophy measures on clinical-quality T2-FLAIR images in MS patients. A real-world dataset from 109 MS patients from 62 MRI scanners was used to develop a lateral ventricular volume (LVV) algorithm with a longitudinal Jacobian-based extension, called NeuroSTREAM. Gold-standard LVV was calculated on high-resolution T1 1 mm, while NeuroSTREAM LVV was obtained on low-resolution T2-FLAIR 3 mm thick images. Scan-rescan reliability was assessed in 5 subjects. The variability of LVV measurement at different field strengths was tested in 76 healthy controls and 125 MS patients who obtained both 1.5T and 3T scans in 72 hours. Clinical validation of algorithm was performed in 176 MS patients who obtained serial yearly MRI 1.5T scans for 10 years. Correlation ...

P1.01-047 Clinical Presentation and Outcome of Neuroendocrine Lung Tumors in a Brazilian Cohort from 2000 to 2016

Journal of Thoracic Oncology, 2017

An Observational Study to Assess Brain MRI Change and Disease Progression in Multiple Sclerosis Clinical Practice-The MS-MRIUS Study

Journal of neuroimaging : official journal of the American Society of Neuroimaging, May 5, 2016

To describe methodology, interim baseline, and longitudinal magnetic resonance imaging (MRI) acqu... more To describe methodology, interim baseline, and longitudinal magnetic resonance imaging (MRI) acquisition parameter characteristics of the multiple sclerosis clinical outcome and MRI in the United States (MS-MRIUS). The MS-MRIUS is an ongoing longitudinal and retrospective study of MS patients on fingolimod. Clinical and brain MRI image scan data were collected from 600 patients across 33 MS centers in the United States. MRI brain outcomes included change in whole-brain volume, lateral ventricle volume, T2- and T1-lesion volumes, and new/enlarging T2 and gadolinium-enhancing lesions. Interim baseline and longitudinal MRI acquisition parameters results are presented for 252 patients. Mean age was 44 years and 81% were female. Forty percent of scans had 3-dimensional (3D) T1 sequence in the preindex period, increasing to 50% in the postindex period. Use of 2-dimensional (2D) T1 sequence decreased over time from 85% in the preindex period to 65% in the postindex. About 95% of the scans ...

Integrating mobile devices and industrial automation through web services

2009 7th IEEE International Conference on Industrial Informatics, 2009

Page 1. Integrating Mobile Devices and Industrial Automation through Web Services Anderson Luiz d... more

Betwixt & Between: Peer Recruiter Proximity in Community-Based Research

The American Journal of Bioethics, 2010

Application of energy system models for designing a low-carbon society

Progress in Energy and Combustion Science, 2011

Rising concern about the effect of greenhouse gas (GHG) emissions on climate change is pushing na... more Rising concern about the effect of greenhouse gas (GHG) emissions on climate change is pushing national governments and the international community to achieve sustainable development in an economy that is less dependent on carbon emitting activities e a vision that is usually termed a "low-carbon society" (LCS). Since the utilization of energy resources is the main source of GHG emissions, restructuring current energy systems in order to incorporate low-carbon energy technologies is essential for the realization of the LCS vision. Energy policies promoting the penetration of these technologies must view the role of energy in society as a system, composed of several energy resources, conversion technologies and energy demand sectors. The feasibility of the LCS in the future can be better understood by means of energy models. Energy models are valuable mathematical tools based on the systems approach. They have been applied to aid decision-making in energy planning, to analyze energy policies and to analyze the implications arising from the introduction of technologies. The design of the LCS requires innovative energy systems considering a trans-disciplinary approach that integrates multi-dimensional elements, related to social, economic, and environmental aspects. This paper reviews the application of energy models considering scenarios towards an LCS under the energy systems approach. The models reviewed consider the utilization of waste for energy, the penetration of clean coal technologies, transportation sector models as a sample of sectoral approaches, and models related to energy-for-development issues in rural areas of developing countries.

Huachipato

Demyelination caused by the copper chelator cuprizone halts T cell mediated autoimmune neuroinflammation

Journal of Neuroimmunology, 2009

Myelin reactive T cells are central in the development of the autoimmune response leading to CNS ... more Myelin reactive T cells are central in the development of the autoimmune response leading to CNS destruction in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis (EAE). Investigations on the mechanisms underlying the activation and expansion of myelin reactive T have stressed the importance of non-autoimmune conditions impinging the autoimmune repertoire potentially involved in the disease. Here, we show that CNS injury caused by the toxic cuprizone results in the generation of immunoreactivity towards several myelin components. Paradoxically, exposure to CNS injury does not increase the susceptibility to develop EAE, but render mice protected to the pathogenic autoimmune response against myelin antigens.

LIBS spectra of polychromes with a low cost CCD camera based detector

Journal of Cultural Heritage, 2000

Two real samples of polychromes, from the Spanish Baroque period and from the XV century, were an... more Two real samples of polychromes, from the Spanish Baroque period and from the XV century, were analysed by time-integrated laser-induced breakdown spectroscopy (LIBS). The time-integrated spectra showed negligible contribution of continuum background emission. The spectra of the Baroque sample indicated the presence of vermilion; this was confirmed by near-infrared Fourier transform spectroscopy. LIBS spectra of the XV century sample showed Ca, Al, Mg, Na and Pb lines and the molecular emissions CN(B-X) and C 2 (d-a). Relative spectral intensities were measured as a function of the number of laser pulses delivered at the same position of the sample.

Elevation in interleukin 13 levels in patients diagnosed with systemic inflammatory response syndrome

Intensive Care Medicine, 2006

To examine plasma levels and circadian rhythm of interleukin 13 (IL-13), tumour necrosis factor (... more To examine plasma levels and circadian rhythm of interleukin 13 (IL-13), tumour necrosis factor (TNF) alpha and total serum cortisol in the systemic inflammatory response syndrome (SIRS). Prospective observational study in a 12-bed medical-surgical ICU of a 500-bed university hospital. Ten patients with SIRS and eight controls. Arterial blood was sampled hourly for 24 h for measurement of plasma IL-13, TNF- alpha, cortisol and white blood cell count (WCC) differential within 24 h of development of SIRS. There were significantly higher plasma IL-13 levels in SIRS patients than in controls (1282 vs. 713 pg/ml). IL-13 was significantly higher in patients with a diagnosis of sepsis than in those with non-infectious causes of SIRS (2080 vs. 515 pg/ml). In SIRS the elevation in IL-13 was associated with higher TNF-alpha and reduced WCC. A circadian rhythm was observed in plasma IL-13 secretion. No distinct circadian rhythm was noted for TNF- alpha, and the normal circadian rhythm of serum cortisol was lost. The anti-inflammatory cytokine IL-13 is elevated in early SIRS. Its plasma level exhibits a circadian rhythm and may be modulated in part by TNF-alpha. SIRS patients have disruption of the normal circadian rhythm of serum cortisol.