Papers by Dianne Bautista
Scandinavian journal of trauma, resuscitation and emergency medicine, Jan 8, 2016
Anatomy-based injury severity scores are commonly used with physiological scores for reporting se... more Anatomy-based injury severity scores are commonly used with physiological scores for reporting severity of injury in a standardized manner. However, there is lack of consensus on choice of scoring system, with the commonly used injury severity score (ISS) performing poorly for certain sub-groups, eg head-injured patients. We hypothesized that adding a dichotomous variable for polytrauma (yes/no for Abbreviated Injury Scale (AIS) scores of 3 or more in at least two body regions) to the New Injury Severity Score (NISS) would improve the prediction of in-hospital mortality in injured patients, including head-injured patients-a subgroup that has a disproportionately high mortality. Our secondary hypothesis was that the ISS over-estimates the risk of death in polytrauma patients, while the NISS under-estimates it. Univariate and multivariable analysis was performed on retrospective cohort data of blunt injured patients aged 18 and over with an ISS over 9 from the Singapore National Traum...
Annals of the Academy of Medicine, Singapore
Introduction: Expectant mothers may appear anxious even during healthy pregnancies. Unfortunately... more Introduction: Expectant mothers may appear anxious even during healthy pregnancies. Unfortunately, little is known about antenatal anxiety, and affected women may remain undetected and untreated. This study aimed to examine the prevalence, incidence, course and associations of high state anxiety in routine obstetric care. Materials and Methods: This was an observational prospective cohort study at a large maternity unit. Obstetric outpatients with low-risk singleton pregnancies were recruited during first trimester consultations. Participants provided sociodemographic data and completed the State-Trait Anxiety Inventory (STAI) and Edinburgh Postnatal Depression Scale. The STAI was re-administered at each subsequent trimester. Results: Prevalence and incidence of high state anxiety among 634 completers were 29.5% (95% CI 25.6%-33.6%) and 13.9% (95% CI 9.9%-18.0%), respectively. Anxiety was persistent in 17.0% (95% CI 14.3%-20.2%) and transient in 26.3% (95% CI 23.1%-29.9%). Only per...
Table S1. Chronic Illnesses qualifying for patient recruitment. Figure S1 Flow chart describing t... more Table S1. Chronic Illnesses qualifying for patient recruitment. Figure S1 Flow chart describing the response rate. (DOCX 35 kb)
Additional file 5. Domain-specific item banks.
Value in Health, 2016
A829 higher than those from 3L in each dimension: "mobility" (0.31 vs. 0.22), "self-care" (0.14 v... more A829 higher than those from 3L in each dimension: "mobility" (0.31 vs. 0.22), "self-care" (0.14 vs. 0.10), "usual activities" (0.32 vs.0.19), "pain/discomfort" (1.07 vs. 0.75), and "anxiety/depression" (0.85 vs. 0.58), indicating better discriminatory power for 5L. Moreover, the findings of Shannon's indices in urban and rural samples were consistent to which of full sample. ConClusions: Compared with three-level version, EQ-5D-5L can reduce the ceiling effect and improve the discriminatory power when identifying different health status.
Health and Quality of Life Outcomes, 2020
Objectives To develop separate item banks for three health domains of health-related quality of l... more Objectives To develop separate item banks for three health domains of health-related quality of life (HRQOL) ranked as important by Singaporeans – physical functioning, social relationships, and positive mindset. Methods We adapted the Patient Reported Outcomes Measurement Information System Qualitative Item Review protocol, with input and endorsement from laymen and experts from various relevant fields. Items were generated from 3 sources: 1) thematic analysis of focus groups and in-depth interviews for framework (n = 134 participants) and item(n = 52 participants) development, 2) instruments identified from a literature search (PubMed) of studies that developed or validated a HRQOL instrument among adults in Singapore, 3) a priori identified instruments of particular relevance. Items from these three sources were “binned” and “winnowed” by two independent reviewers, blinded to the source of the items, who harmonized their selections to generate a list of candidate items (each item...
Additional file 3. Patient Reported Outcomes Measurement Instrument System (PROMIS) Domain Instru... more Additional file 3. Patient Reported Outcomes Measurement Instrument System (PROMIS) Domain Instruments included in the item library.
Additional file 1. In-depth interview probes.
Additional file 7 TableS2. Items for which instrument developer permission was sought.
Additional file 2. PubMed electronic search strategy for quality of life instruments validated in... more Additional file 2. PubMed electronic search strategy for quality of life instruments validated in a Singapore, adult population.
Additional file 4. Instruments excluded from the item library.
Studies have suggested that somatic events in tumors can depend on an individual’s constitutional... more Studies have suggested that somatic events in tumors can depend on an individual’s constitutional genotype. We used squamous cell carcinomas (SCC) of the skin, which arise in high multiplicity in organ transplant recipients, as a model to compare the pattern of somatic alterations within and across individuals. Specifically, we performed array comparative genomic hybridization on 104 tumors from 25 unrelated individuals who each had three or more independently arisen SCCs and compared the profiles occurring within patients to profiles of tumors across a larger set of 135 patients. In general, chromosomal aberrations in SCCs were more similar within than across individuals (two-sided exact-test p-value v1|10 {7), consistent with the notion that the genetic background was affecting the pattern of somatic changes. To
PsycTESTS Dataset, 2019
Öz: Canlı yaşamında önemli yeri olan yağların farklı etkenler ile oksidasyona uğraması besin ve k... more Öz: Canlı yaşamında önemli yeri olan yağların farklı etkenler ile oksidasyona uğraması besin ve kalite kaybına yol açmaktadır. Oksidatif reaksiyonlarla mücadele etmek için antioksidanlar kullanılmaktadır. Antioksidatif etki fenolik bileşiklerin en önemli biyolojik aktivitelerinden biri olarak bilinmektedir. Koruyucu ve tedavi edici etkileri bulunan ve çörekotu esansiyel yağının ana aktif bileşeni olan timokinon da sahip olduğu terapötik özelliklerden dolayı birçok çalışmada araştırma konusu olmuştur. Bu derlemede serbest radikaller, antioksidanlar, lipit oksidasyonu, lipit oksidasyonu ölçüm yöntemleri, fenolik bileşikler ve lipit oksidasyonunu önleme aktiviteleri ile timokinonun yapısı, koruyucu ve tedavi edici özellikleri, antioksidan, antifungal, antiviral ve antibakteriyel etkileri üzerine yapılan çalışmalar değerlendirilmiştir.
Health and Quality of Life Outcomes, 2019
Background: Social relationships (SR) is an important domain of health-related quality of life. W... more Background: Social relationships (SR) is an important domain of health-related quality of life. We developed and calibrated a novel item bank to measure SR in Singapore, a multi-ethnic city in Southeast Asia. We developed an initial candidate pool of 51 items from focus groups, individual in-depth interviews and existing instruments that had been developed and/or validated for use in Singapore. We administered all items in English to a multi-stage sample of subjects, stratified for age and gender, with and without medical conditions, recruited from community and hospital settings. We calibrated their responses using Samejima's Graded Response Model (SGRM). We evaluated a final 30-item bank with respect to Item Response Theory (IRT) model assumptions, model fit, differential item functioning (DIF), and concurrent and known-groups validity. Results: Among 503 participants (47.7% male, 41.4% above 50 years old, 34.0% Chinese, 33.6% Malay and 32.4% Indian), bi-factor model analyses supported essential unidimensionality: explained common variance of the general factor was 0.805 and omega hierarchical was 0.98. Local independence was deemed acceptable: the average absolute residual correlations were < 0.06 and 1.8% of the total item-pair residuals were flagged for local dependence. The overall SGRM model fit was adequate (p = 0.146). Five items exhibited DIF with respect to age, ethnicity and education, but were retained without modification of scores because they measured important aspects of SR. The SR scores correlated in the hypothesized direction with a self-reported measure of global health (Spearman's rho = -0.28, p < 0.001). The 30-item SR item bank has shown acceptable psychometric properties. Future studies to evaluate the validity of SR scores when items are administered adaptively are needed.
Value in Health, 2016
patients' intentions to adopt with the Theory of Planned Behavior as the theoretical framework. M... more patients' intentions to adopt with the Theory of Planned Behavior as the theoretical framework. Methods: A two phase mixed methodology involving first a qualitative exploration and the second a quantitative phase was conducted in public health facilities in Negeri Sembilan, Malaysia. A cross-sectional survey (N = 410) was conducted using the Pharmacy Value Added Services Questionnaire (PVASQ). Multiple regression and robust moderation analysis were performed. Results: Overall, perspectives were found to be significant predictors of intentions. In greater detail, subjective norms, perceived behavioural control, knowledge, expectations and ethnicity were found to be significant predictors of intentions to adopt PVAS. Perspectives and expectations are found to exert significant partial effects on intentions. We find that a significant self-reinforcing feedback loop exists between Expectations-Perspectives-Intentions. ConClusions: Overall, we suggest that patient perspectives and knowledge be enhanced through appropriate channels and expectations of service quality be met to increase intentions. Positive perspectives and meeting the high expectations of the public can greatly improve the uptake of the new service. Ethnicity plays a crucial role in determining uptake of the new service and should be given greater focus. Our results are robust and suggests that a bottom-up approach should be key to successful implementation of health policies and services.
The Patient: Patient-Centered Outcomes Research, 2010
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Papers by Dianne Bautista