Seizures, arising from a variety of neurological conditions beyond epilepsy, pose significant hea... more Seizures, arising from a variety of neurological conditions beyond epilepsy, pose significant health risks, including injury, prolonged episodes, and status epilepticus, which can be fatal if untreated. The SeizureShield is a cutting-edge transdermal device designed to autonomously detect and respond to all types of seizures, regardless of their origin. Using continuous EEG monitoring, the device identifies abnormal brain activity and promptly delivers a pre-loaded dose of lorazepam, a fast-acting anticonvulsant, to halt the seizure. The SeizureShield employs a miniature EEG sensor near the mastoid area for optimal seizure detection and a micro-needle array for rapid lorazepam delivery. This technology offers real-time intervention, significantly reducing the risk of status epilepticus, neurological damage, and mortality. With a 94% success rate in terminating acute seizures when administered within 10 minutes, the SeizureShield provides a life-saving solution that empowers individuals with seizures, improving their autonomy and safety, particularly in regions with limited access to timely medical care.
The opioid overdose crisis continues to pose a significant public health challenge worldwide, wit... more The opioid overdose crisis continues to pose a significant public health challenge worldwide, with particularly severe consequences in countries like the U.S. and India, where timely intervention is often hindered by delays in emergency response. The Opioid Overdose Guardian is an innovative, wearable device designed to address this critical issue by autonomously detecting signs of opioid overdose and administering a life-saving dose of naloxone. This device integrates high-sensitivity sensors to monitor vital signs, including oxygen saturation (SpO₂), heart rate variability (HRV), and respiratory function (CO₂ levels). Upon detecting signs of overdose, the Guardian automatically delivers a calibrated dose of naloxone subcutaneously using a piezoelectric-actuated microfilament system, providing rapid, reliable intervention without the need for bystander assistance. By offering real-time overdose detection and intervention, the Opioid Overdose Guardian aims to reduce the number of overdose fatalities, particularly in areas with inadequate healthcare infrastructure or slow emergency response times. The device's affordability, supported by health insurance coverage and government healthcare initiatives, ensures accessibility for at-risk individuals, enhancing its potential to make a significant impact on public health. This paper outlines the design, functionality, and potential applications of the Opioid Overdose Guardian, emphasizing its role in both individual overdose prevention and broader public health efforts.
Seizures, arising from a variety of neurological conditions beyond epilepsy, pose significant hea... more Seizures, arising from a variety of neurological conditions beyond epilepsy, pose significant health risks, including injury, prolonged episodes, and status epilepticus, which can be fatal if untreated. The SeizureShield is a cutting-edge transdermal device designed to autonomously detect and respond to all types of seizures, regardless of their origin. Using continuous EEG monitoring, the device identifies abnormal brain activity and promptly delivers a pre-loaded dose of lorazepam, a fast-acting anticonvulsant, to halt the seizure. The SeizureShield employs a miniature EEG sensor near the mastoid area for optimal seizure detection and a micro-needle array for rapid lorazepam delivery. This technology offers real-time intervention, significantly reducing the risk of status epilepticus, neurological damage, and mortality. With a 94% success rate in terminating acute seizures when administered within 10 minutes, the SeizureShield provides a life-saving solution that empowers individuals with seizures, improving their autonomy and safety, particularly in regions with limited access to timely medical care.
The opioid overdose crisis continues to pose a significant public health challenge worldwide, wit... more The opioid overdose crisis continues to pose a significant public health challenge worldwide, with particularly severe consequences in countries like the U.S. and India, where timely intervention is often hindered by delays in emergency response. The Opioid Overdose Guardian is an innovative, wearable device designed to address this critical issue by autonomously detecting signs of opioid overdose and administering a life-saving dose of naloxone. This device integrates high-sensitivity sensors to monitor vital signs, including oxygen saturation (SpO₂), heart rate variability (HRV), and respiratory function (CO₂ levels). Upon detecting signs of overdose, the Guardian automatically delivers a calibrated dose of naloxone subcutaneously using a piezoelectric-actuated microfilament system, providing rapid, reliable intervention without the need for bystander assistance. By offering real-time overdose detection and intervention, the Opioid Overdose Guardian aims to reduce the number of overdose fatalities, particularly in areas with inadequate healthcare infrastructure or slow emergency response times. The device's affordability, supported by health insurance coverage and government healthcare initiatives, ensures accessibility for at-risk individuals, enhancing its potential to make a significant impact on public health. This paper outlines the design, functionality, and potential applications of the Opioid Overdose Guardian, emphasizing its role in both individual overdose prevention and broader public health efforts.
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Papers by Dhriti Vikram