Communications in Computer and Information Science, 2011
Proposing a strategy based on statistical value provided by each node of the network for detectin... more Proposing a strategy based on statistical value provided by each node of the network for detecting their malicious activity by comparing the node's present characteristic value with the old estimated value. If the difference between the two values is higher than expected ...
ABSTRACT The strong seasonal and inter-annual variability of the large Eastern Himalayan river ba... more ABSTRACT The strong seasonal and inter-annual variability of the large Eastern Himalayan river basins pose a great challenge to water users and managers on how to best manage the water resources of this highly populous region in an efficient and sustainable manner. While no official drought forecasting system currently exists, deterministic flood flow forecasts with short lead-times (2-6 days) are also insufficient for planning purposes in downstream regions. For the large remote watersheds such as that of the Brahmaputra and upstream parts of the Ganges, lack of coverage of rain gauges, snow stations, and radar observations pose a considerable challenge to accurate forecasting of downstream streamflow. In addition, there is a lack of cooperation among riparian countries in the region over the sharing of hydrological data. Therefore, in lieu of directly observable data, this project describes the development of multivariate regression models using freely available remote sensing and reanalysis datasets for estimating and forecasting discharge at monthly to seasonal lead periods for these rivers. The models show promising results and were able to estimate discharge in downstream Bangladesh with accuracies of 89%, 83%, and 72% for the Brahmaputra and 91%, 89% and 82% for the Ganges at lead times of 0, 1, and 2 months respectively. These results show that despite a lack of data sharing between riparian countries and the restrictions placed by inaccessible terrain, much progress can be made in flow forecasting and aiding water resources planning with the proliferation of satellite estimated data from remote regions.
Abstract A System Dynamics model is developed for South Florida to capture the complex interrelat... more Abstract A System Dynamics model is developed for South Florida to capture the complex interrelationships between water availability and competing water demands for municipal, agriculture, and environmental needs. The policies of introducing low flow appliances, xeriscaping, and pricing are tested for their effectiveness in reducing municipal water demand. The policies of area reduction, micro irrigation, and crop substitution are tested for their effectiveness in reducing agricultural water demand. Performance criteria of reliability ...
Bioorganic & Medicinal Chemistry Letters, 2011
This work reports the synthesis of a complex of a carboplatin analog having tethered adamantane t... more This work reports the synthesis of a complex of a carboplatin analog having tethered adamantane that is encapsulated in the hydrophobic cavity of β-cyclodextrin (βCD) and its cytotoxic activity towards human neuroblastoma cells (SK-N-SH). We found that this inclusion complex of βCD adamantane carboplatin analog exhibited higher cytotoxicity towards SK-N-SH cells than carboplatin itself, and the inclusion complex exhibited a higher binding to plasmid pBR322 deoxyribonucleic acid (DNA) than carboplatin. Confocal fluorescence images of SK-N-SH cells treated with βCD having an attached fluorescein isothiocyanate (FITC)-tag exhibited fluorescence in the vicinity of the nuclei of the neuroblastoma cells. Direct measurements of the platinum content in SK-N-SH cells using inductively coupled plasma mass spectrometry (ICP-MS) indicated that the uptake rate of carboplatin was about 4 times higher than βCD adamantane carboplatin analog inclusion complex. When compared to carboplatin, we believe that the higher cytotoxicity of inclusion complex towards SK-N-SH cells is due to its higher DNA binding ability as compared to carboplatin, and more efficient delivery to the nucleus of the cell. This work suggests that the advantage of deliberate noncovalent modification with βCD through host-guest chemistry may also be broadly applicable to other anticancer agents as well.
International Journal of Current Pharmaceutical Research, Mar 15, 2022
Objective: The new combination for Luliconazole and Clobetasol Propionate was approved for the tr... more Objective: The new combination for Luliconazole and Clobetasol Propionate was approved for the treatment of a variety of skin disease. The main objective of this research is development and validation of novel, simple, fast and responsive derivative spectroscopic process for simultaneous estimation of newly approved combination Luliconazole (LLZ) and Clobetasol Propionate (CLP). Methods: Here in this first derivative spectroscopic method, the absorbance of LLZ and CLP was taken at 312 nm (ZCP of CLP) and 249 nm (ZCP of LLZ), respectively. Establishment of linearity was in a concentration varies from 10-50 µg/ml for Luliconazole and 5-25µg/ml for Clobetasole Propionate. Results: From the method developed above the R 2 value observed for LLZ and CLP is 0.9961. Statistical validation of accuracy and reproducibility was done for planned procedure with the help of recovery studies. The mean % recovery of Luliconazole and Clobetasol Propionate was found to be 99.45 % and 99.43%, respectively. For LLZ the Limit of detection is 0.9988 µg/ml and limit of quantification is 0.0009µg/ml and for CLP the Limit of detection is0.0164µg/ml and limit of quantification 0.0027µg/ml. Conclusion: From research work the method development was done and shows fast, precise, exact and easy accessible laboratory procedure for routine evaluation of combination drugs.
ABSTRACT The world is heading towards new and advanced farming procedures, yet the cultivation of... more ABSTRACT The world is heading towards new and advanced farming procedures, yet the cultivation of spices under natural conditions commercially may prove much more fruitful. The spices were earlier confined to kitchen only, but their pharmacological and ...
International Journal of Current Pharmaceutical Research, Sep 15, 2021
The drugs with poor solubility results in delayed absorption which consequently affects the bioav... more The drugs with poor solubility results in delayed absorption which consequently affects the bioavailability. There are many drugs which are having good therapeutic value but not used commercially because of this reason. The permeation enhancers are therefore being utilized to counter this problem. There are many such synthetic and natural materials which have the ability to enhance the drug permeation rate. The essential oils, alcohols, terpenes, azoles and many other chemical derivatives have the capability to be used for permeation enhancer. The present review work suggested the role of permeation enhancer in the pharmaceutical world.
Journal of Clinical and Experimental Dentistry, 2011
Background: Treatment of temporomandibular joint (TMJ) ankylosis usually requires adequate excisi... more Background: Treatment of temporomandibular joint (TMJ) ankylosis usually requires adequate excision of the involved ankylotic block (arthroplasty) without interposing any material (gap arthroplasty) or interpositional arthroplasty using autogenous or alloplastic materials. The objective of this paper was to note the potential of the costochondral graft (CCGs) as an interpositional material and to see whether they induce normal growth potential in the reconstructed mandible. Materials and method: The ankylosed temporomandibular joint was reached by a preauricular incision with or without angulation and exposed. In the first 4 cases, arthroplasty was done using a bur. The bony mass was detached of its muscle attachments and removed. In the 5th case, condylectomy was performed. In all cases, this was followed by immediate costochondral grafting. Results: The maximal incisal opening in the pre-operative period ranged from 0-2mm and in the immediate postoperative period from 15-20mm. at the end of the follow up period it ranged from 20-35 mm. The increase in SNB angle, SND angle, ramus length and mandibular body length all showed linear growth of mandible on the side where costochondral grafting was done. Conclusion: The articular reconstruction with costochondral grafts for the treatment of TMJ ankylosis is efficient in relation to post-operative maximal incisal opening, recurrence and articular function.
Journal of Advances in Medicine and Medical Research
LNPs mix liposomes and inorganic/ organic nanoparticles. Liposomes and nanoparticles are therapeu... more LNPs mix liposomes and inorganic/ organic nanoparticles. Liposomes and nanoparticles are therapeutic. LNPs are a research tool (e.g., spatiotemporal control of drug release, hyperthermia, photothermal therapy, and biological imaging). Nanoparticles determine LNP characteristics. Nanoparticles enable liposomes overcome weak stability, few functions, and fast blood elimination. Structure, physicochemical properties, modification, and biological uses of nanoparticle materials and LNPs are reviewed.
OBJECTIVES We sought to determine whether American Indian tribe-based interventions that successf... more OBJECTIVES We sought to determine whether American Indian tribe-based interventions that successfully prevented toddler dental caries in a 2005 cohort study (the Toddler Overweight and Tooth Decay Prevention Study, or TOTS) influenced the prevalence of dental caries in children ages 11 to 13 in the same communities ten years later (the TOTS-to-Tweens study). METHODS We recruited original TOTS participants and conducted school- and community-based dental screenings at tribal communities that received family plus community-wide interventions (FÂ +Â CW), community interventions only (CW) or were control communities. We also enrolled children who did not participate in TOTS, but were exposed to CW interventions or to the control environment. Trained clinicians examined children's teeth and recorded whether each tooth was decayed, missing or filled (DMFT). We calculated DMFT scores for each child and evaluated differences in DMFT incidence rate ratios (IRR) and components of DMFT by in...
OBJECTIVES We sought to determine whether American Indian tribe-based interventions that successf... more OBJECTIVES We sought to determine whether American Indian tribe-based interventions that successfully prevented toddler dental caries in a 2005 cohort study (the Toddler Overweight and Tooth Decay Prevention Study, or TOTS) influenced the prevalence of dental caries in children ages 11 to 13 in the same communities ten years later (the TOTS-to-Tweens study). METHODS We recruited original TOTS participants and conducted school- and community-based dental screenings at tribal communities that received family plus community-wide interventions (FÂ +Â CW), community interventions only (CW) or were control communities. We also enrolled children who did not participate in TOTS, but were exposed to CW interventions or to the control environment. Trained clinicians examined children's teeth and recorded whether each tooth was decayed, missing or filled (DMFT). We calculated DMFT scores for each child and evaluated differences in DMFT incidence rate ratios (IRR) and components of DMFT by in...
International Journal of Current Pharmaceutical Research, 2022
Objective: The new combination for Luliconazole and Clobetasol Propionate was approved for the tr... more Objective: The new combination for Luliconazole and Clobetasol Propionate was approved for the treatment of a variety of skin disease. The main objective of this research is development and validation of novel, simple, fast and responsive derivative spectroscopic process for simultaneous estimation of newly approved combination Luliconazole (LLZ) and Clobetasol Propionate (CLP). Methods: Here in this first derivative spectroscopic method, the absorbance of LLZ and CLP was taken at 312 nm (ZCP of CLP) and 249 nm (ZCP of LLZ), respectively. Establishment of linearity was in a concentration varies from 10-50 µg/ml for Luliconazole and 5-25µg/ml for Clobetasole Propionate. Results: From the method developed above the R2 value observed for LLZ and CLP is 0.9961. Statistical validation of accuracy and reproducibility was done for planned procedure with the help of recovery studies. The mean % recovery of Luliconazole and Clobetasol Propionate was found to be 99.45 % and 99.43%, respective...
Psychology is the study of mentality and behaviour. Present study is an attempt to understand the... more Psychology is the study of mentality and behaviour. Present study is an attempt to understand the role of mental functions in individual. It tries to establish parameters which form the basis for the future research. Study of students’ psychology in the field of education is much more important in terms of career adoption behaviour of students. Present research was based on the survey in the college going students. The candidates were interviewed regarding their selection of the present non-professional course. The results of the study suggested that the conditions and background of the students effect the decision of their career adoption in present study area.
The present study deals with the growth trends in a rea, production and productivity of food grai... more The present study deals with the growth trends in a rea, production and productivity of food grains in Himachal Pradesh. In the process of development changes are occurring in these factors. The study presents nega tive trends towards area under all the food grains over the yea r. Production of all food grains has registered pos itive trend except barley and gram crops. To know about the tre nds in area, production and productivity of food gr ains, percentage method was utilized as a statistical mea sur . Key-Words: Himachal Pradesh, food grains, economics , changing growth trends Introduction Since long agriculture remains the main occupation of the people of Himachal Pradesh. It provides direct employment to about 71% of the total working population. Agriculture is beset with the disadvant age of small holdings. Only 65% of the total reported a rea is available for cultivation. Out of this area, net area sown and current fallows account for only 21% (Economics and Statistics Depar...
International Journal of Pharmaceutical Sciences Review and Research, 2021
The present review work tries to explore the present status of the nano carriers in the delivery ... more The present review work tries to explore the present status of the nano carriers in the delivery of anti cancer drugs. The shortcomings associated with the anticancer drugs like poor solubility, multiple resistance and less bioavailability is been investigating using different nano formulations. The recent advance work on nanoparticles for the delivery of anti tumor drugs is focused along with the different patents available. The different technologies available in the present scenario for the delivery of anti-cancers drugs are being highlightened.
Calcitriol is calcium channel agonist, antihypocalcaemic, antihypoparathyroid drug used to treat ... more Calcitriol is calcium channel agonist, antihypocalcaemic, antihypoparathyroid drug used to treat Vitamin D deficiency, refractory rickets, familial hypophosphatemia, hypoparathyroidism and used in the management of hypocalcemia & renal osteodystropy in patients with chronic renal failure undergoing dialysis. It is available in soft gelatin capsules form in market which accounts for its high cost. Calcitriol is heat, light and water sensitive so difficult to formulate in tablet dosage form. So present work is an attempt to stabilize calcitriol in tablet dosage form and formulate a calcitriol tablet of portable price. In the present work tablets of model drug was prepared by using medium chain triglycerides & combination of antioxidants. Starch was used to provide good powder flow. Forced degradation study was done to get know how of various degradation pathways of API & we found that oxidation is major degradative pathway of calcitriol. Drugexcipients compatibility studies are done a...
The Pharmaceutical aspects of the medications are very much essential for proper drug scheduling.... more The Pharmaceutical aspects of the medications are very much essential for proper drug scheduling. But the economical prospect is also essential for the proper patient compliance. These two parameters act in symbiotic relationship. Therefore, there is always the prerequisite for combining these parameters as Pharmaco-economical. This present work tries to present the Pharmaceutical medications of HIV/AIDS from economical view point/scenario.
Communications in Computer and Information Science, 2011
Proposing a strategy based on statistical value provided by each node of the network for detectin... more Proposing a strategy based on statistical value provided by each node of the network for detecting their malicious activity by comparing the node's present characteristic value with the old estimated value. If the difference between the two values is higher than expected ...
ABSTRACT The strong seasonal and inter-annual variability of the large Eastern Himalayan river ba... more ABSTRACT The strong seasonal and inter-annual variability of the large Eastern Himalayan river basins pose a great challenge to water users and managers on how to best manage the water resources of this highly populous region in an efficient and sustainable manner. While no official drought forecasting system currently exists, deterministic flood flow forecasts with short lead-times (2-6 days) are also insufficient for planning purposes in downstream regions. For the large remote watersheds such as that of the Brahmaputra and upstream parts of the Ganges, lack of coverage of rain gauges, snow stations, and radar observations pose a considerable challenge to accurate forecasting of downstream streamflow. In addition, there is a lack of cooperation among riparian countries in the region over the sharing of hydrological data. Therefore, in lieu of directly observable data, this project describes the development of multivariate regression models using freely available remote sensing and reanalysis datasets for estimating and forecasting discharge at monthly to seasonal lead periods for these rivers. The models show promising results and were able to estimate discharge in downstream Bangladesh with accuracies of 89%, 83%, and 72% for the Brahmaputra and 91%, 89% and 82% for the Ganges at lead times of 0, 1, and 2 months respectively. These results show that despite a lack of data sharing between riparian countries and the restrictions placed by inaccessible terrain, much progress can be made in flow forecasting and aiding water resources planning with the proliferation of satellite estimated data from remote regions.
Abstract A System Dynamics model is developed for South Florida to capture the complex interrelat... more Abstract A System Dynamics model is developed for South Florida to capture the complex interrelationships between water availability and competing water demands for municipal, agriculture, and environmental needs. The policies of introducing low flow appliances, xeriscaping, and pricing are tested for their effectiveness in reducing municipal water demand. The policies of area reduction, micro irrigation, and crop substitution are tested for their effectiveness in reducing agricultural water demand. Performance criteria of reliability ...
Bioorganic & Medicinal Chemistry Letters, 2011
This work reports the synthesis of a complex of a carboplatin analog having tethered adamantane t... more This work reports the synthesis of a complex of a carboplatin analog having tethered adamantane that is encapsulated in the hydrophobic cavity of β-cyclodextrin (βCD) and its cytotoxic activity towards human neuroblastoma cells (SK-N-SH). We found that this inclusion complex of βCD adamantane carboplatin analog exhibited higher cytotoxicity towards SK-N-SH cells than carboplatin itself, and the inclusion complex exhibited a higher binding to plasmid pBR322 deoxyribonucleic acid (DNA) than carboplatin. Confocal fluorescence images of SK-N-SH cells treated with βCD having an attached fluorescein isothiocyanate (FITC)-tag exhibited fluorescence in the vicinity of the nuclei of the neuroblastoma cells. Direct measurements of the platinum content in SK-N-SH cells using inductively coupled plasma mass spectrometry (ICP-MS) indicated that the uptake rate of carboplatin was about 4 times higher than βCD adamantane carboplatin analog inclusion complex. When compared to carboplatin, we believe that the higher cytotoxicity of inclusion complex towards SK-N-SH cells is due to its higher DNA binding ability as compared to carboplatin, and more efficient delivery to the nucleus of the cell. This work suggests that the advantage of deliberate noncovalent modification with βCD through host-guest chemistry may also be broadly applicable to other anticancer agents as well.
International Journal of Current Pharmaceutical Research, Mar 15, 2022
Objective: The new combination for Luliconazole and Clobetasol Propionate was approved for the tr... more Objective: The new combination for Luliconazole and Clobetasol Propionate was approved for the treatment of a variety of skin disease. The main objective of this research is development and validation of novel, simple, fast and responsive derivative spectroscopic process for simultaneous estimation of newly approved combination Luliconazole (LLZ) and Clobetasol Propionate (CLP). Methods: Here in this first derivative spectroscopic method, the absorbance of LLZ and CLP was taken at 312 nm (ZCP of CLP) and 249 nm (ZCP of LLZ), respectively. Establishment of linearity was in a concentration varies from 10-50 µg/ml for Luliconazole and 5-25µg/ml for Clobetasole Propionate. Results: From the method developed above the R 2 value observed for LLZ and CLP is 0.9961. Statistical validation of accuracy and reproducibility was done for planned procedure with the help of recovery studies. The mean % recovery of Luliconazole and Clobetasol Propionate was found to be 99.45 % and 99.43%, respectively. For LLZ the Limit of detection is 0.9988 µg/ml and limit of quantification is 0.0009µg/ml and for CLP the Limit of detection is0.0164µg/ml and limit of quantification 0.0027µg/ml. Conclusion: From research work the method development was done and shows fast, precise, exact and easy accessible laboratory procedure for routine evaluation of combination drugs.
ABSTRACT The world is heading towards new and advanced farming procedures, yet the cultivation of... more ABSTRACT The world is heading towards new and advanced farming procedures, yet the cultivation of spices under natural conditions commercially may prove much more fruitful. The spices were earlier confined to kitchen only, but their pharmacological and ...
International Journal of Current Pharmaceutical Research, Sep 15, 2021
The drugs with poor solubility results in delayed absorption which consequently affects the bioav... more The drugs with poor solubility results in delayed absorption which consequently affects the bioavailability. There are many drugs which are having good therapeutic value but not used commercially because of this reason. The permeation enhancers are therefore being utilized to counter this problem. There are many such synthetic and natural materials which have the ability to enhance the drug permeation rate. The essential oils, alcohols, terpenes, azoles and many other chemical derivatives have the capability to be used for permeation enhancer. The present review work suggested the role of permeation enhancer in the pharmaceutical world.
Journal of Clinical and Experimental Dentistry, 2011
Background: Treatment of temporomandibular joint (TMJ) ankylosis usually requires adequate excisi... more Background: Treatment of temporomandibular joint (TMJ) ankylosis usually requires adequate excision of the involved ankylotic block (arthroplasty) without interposing any material (gap arthroplasty) or interpositional arthroplasty using autogenous or alloplastic materials. The objective of this paper was to note the potential of the costochondral graft (CCGs) as an interpositional material and to see whether they induce normal growth potential in the reconstructed mandible. Materials and method: The ankylosed temporomandibular joint was reached by a preauricular incision with or without angulation and exposed. In the first 4 cases, arthroplasty was done using a bur. The bony mass was detached of its muscle attachments and removed. In the 5th case, condylectomy was performed. In all cases, this was followed by immediate costochondral grafting. Results: The maximal incisal opening in the pre-operative period ranged from 0-2mm and in the immediate postoperative period from 15-20mm. at the end of the follow up period it ranged from 20-35 mm. The increase in SNB angle, SND angle, ramus length and mandibular body length all showed linear growth of mandible on the side where costochondral grafting was done. Conclusion: The articular reconstruction with costochondral grafts for the treatment of TMJ ankylosis is efficient in relation to post-operative maximal incisal opening, recurrence and articular function.
Journal of Advances in Medicine and Medical Research
LNPs mix liposomes and inorganic/ organic nanoparticles. Liposomes and nanoparticles are therapeu... more LNPs mix liposomes and inorganic/ organic nanoparticles. Liposomes and nanoparticles are therapeutic. LNPs are a research tool (e.g., spatiotemporal control of drug release, hyperthermia, photothermal therapy, and biological imaging). Nanoparticles determine LNP characteristics. Nanoparticles enable liposomes overcome weak stability, few functions, and fast blood elimination. Structure, physicochemical properties, modification, and biological uses of nanoparticle materials and LNPs are reviewed.
OBJECTIVES We sought to determine whether American Indian tribe-based interventions that successf... more OBJECTIVES We sought to determine whether American Indian tribe-based interventions that successfully prevented toddler dental caries in a 2005 cohort study (the Toddler Overweight and Tooth Decay Prevention Study, or TOTS) influenced the prevalence of dental caries in children ages 11 to 13 in the same communities ten years later (the TOTS-to-Tweens study). METHODS We recruited original TOTS participants and conducted school- and community-based dental screenings at tribal communities that received family plus community-wide interventions (FÂ +Â CW), community interventions only (CW) or were control communities. We also enrolled children who did not participate in TOTS, but were exposed to CW interventions or to the control environment. Trained clinicians examined children's teeth and recorded whether each tooth was decayed, missing or filled (DMFT). We calculated DMFT scores for each child and evaluated differences in DMFT incidence rate ratios (IRR) and components of DMFT by in...
OBJECTIVES We sought to determine whether American Indian tribe-based interventions that successf... more OBJECTIVES We sought to determine whether American Indian tribe-based interventions that successfully prevented toddler dental caries in a 2005 cohort study (the Toddler Overweight and Tooth Decay Prevention Study, or TOTS) influenced the prevalence of dental caries in children ages 11 to 13 in the same communities ten years later (the TOTS-to-Tweens study). METHODS We recruited original TOTS participants and conducted school- and community-based dental screenings at tribal communities that received family plus community-wide interventions (FÂ +Â CW), community interventions only (CW) or were control communities. We also enrolled children who did not participate in TOTS, but were exposed to CW interventions or to the control environment. Trained clinicians examined children's teeth and recorded whether each tooth was decayed, missing or filled (DMFT). We calculated DMFT scores for each child and evaluated differences in DMFT incidence rate ratios (IRR) and components of DMFT by in...
International Journal of Current Pharmaceutical Research, 2022
Objective: The new combination for Luliconazole and Clobetasol Propionate was approved for the tr... more Objective: The new combination for Luliconazole and Clobetasol Propionate was approved for the treatment of a variety of skin disease. The main objective of this research is development and validation of novel, simple, fast and responsive derivative spectroscopic process for simultaneous estimation of newly approved combination Luliconazole (LLZ) and Clobetasol Propionate (CLP). Methods: Here in this first derivative spectroscopic method, the absorbance of LLZ and CLP was taken at 312 nm (ZCP of CLP) and 249 nm (ZCP of LLZ), respectively. Establishment of linearity was in a concentration varies from 10-50 µg/ml for Luliconazole and 5-25µg/ml for Clobetasole Propionate. Results: From the method developed above the R2 value observed for LLZ and CLP is 0.9961. Statistical validation of accuracy and reproducibility was done for planned procedure with the help of recovery studies. The mean % recovery of Luliconazole and Clobetasol Propionate was found to be 99.45 % and 99.43%, respective...
Psychology is the study of mentality and behaviour. Present study is an attempt to understand the... more Psychology is the study of mentality and behaviour. Present study is an attempt to understand the role of mental functions in individual. It tries to establish parameters which form the basis for the future research. Study of students’ psychology in the field of education is much more important in terms of career adoption behaviour of students. Present research was based on the survey in the college going students. The candidates were interviewed regarding their selection of the present non-professional course. The results of the study suggested that the conditions and background of the students effect the decision of their career adoption in present study area.
The present study deals with the growth trends in a rea, production and productivity of food grai... more The present study deals with the growth trends in a rea, production and productivity of food grains in Himachal Pradesh. In the process of development changes are occurring in these factors. The study presents nega tive trends towards area under all the food grains over the yea r. Production of all food grains has registered pos itive trend except barley and gram crops. To know about the tre nds in area, production and productivity of food gr ains, percentage method was utilized as a statistical mea sur . Key-Words: Himachal Pradesh, food grains, economics , changing growth trends Introduction Since long agriculture remains the main occupation of the people of Himachal Pradesh. It provides direct employment to about 71% of the total working population. Agriculture is beset with the disadvant age of small holdings. Only 65% of the total reported a rea is available for cultivation. Out of this area, net area sown and current fallows account for only 21% (Economics and Statistics Depar...
International Journal of Pharmaceutical Sciences Review and Research, 2021
The present review work tries to explore the present status of the nano carriers in the delivery ... more The present review work tries to explore the present status of the nano carriers in the delivery of anti cancer drugs. The shortcomings associated with the anticancer drugs like poor solubility, multiple resistance and less bioavailability is been investigating using different nano formulations. The recent advance work on nanoparticles for the delivery of anti tumor drugs is focused along with the different patents available. The different technologies available in the present scenario for the delivery of anti-cancers drugs are being highlightened.
Calcitriol is calcium channel agonist, antihypocalcaemic, antihypoparathyroid drug used to treat ... more Calcitriol is calcium channel agonist, antihypocalcaemic, antihypoparathyroid drug used to treat Vitamin D deficiency, refractory rickets, familial hypophosphatemia, hypoparathyroidism and used in the management of hypocalcemia & renal osteodystropy in patients with chronic renal failure undergoing dialysis. It is available in soft gelatin capsules form in market which accounts for its high cost. Calcitriol is heat, light and water sensitive so difficult to formulate in tablet dosage form. So present work is an attempt to stabilize calcitriol in tablet dosage form and formulate a calcitriol tablet of portable price. In the present work tablets of model drug was prepared by using medium chain triglycerides & combination of antioxidants. Starch was used to provide good powder flow. Forced degradation study was done to get know how of various degradation pathways of API & we found that oxidation is major degradative pathway of calcitriol. Drugexcipients compatibility studies are done a...
The Pharmaceutical aspects of the medications are very much essential for proper drug scheduling.... more The Pharmaceutical aspects of the medications are very much essential for proper drug scheduling. But the economical prospect is also essential for the proper patient compliance. These two parameters act in symbiotic relationship. Therefore, there is always the prerequisite for combining these parameters as Pharmaco-economical. This present work tries to present the Pharmaceutical medications of HIV/AIDS from economical view point/scenario.
Multiversatality and ease of acceptance has become a criterion for the acceptance and rejection o... more Multiversatality and ease of acceptance has become a criterion for the acceptance and rejection of any formulation. In case the formulation is not versatile then its chances of rejection or cementing its place in market remains doubtful. The only thing which could tackle this problem is the chance of modification. Hence the modification and ability to adapt the present position makes the formulation like FDT to cement its place in this uncertain pharmaceutical market.
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Papers by Deepak Prashar