David Wellisch

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Richard Zach

University of Calgary

Cody Paris

Middlesex University

Cristina Bicchieri

University of Pennsylvania

Giuseppe Primiero

Università degli Studi di Milano - State University of Milan (Italy)

ZIAD ALRAWADIEH

University of Jordan

Stephen Yablo

Massachusetts Institute of Technology (MIT)

Gizem Erdem, PhD, ILMFT

Koç University

Fabrizio Cariani

University of Maryland, College Park

Dennis Wendt

University of Washington School of Medicine

Dianne Dredge

Royal Roads University

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Papers by David Wellisch

Pilot study of modafinil for treatment of neurobehavioral dysfunction and fatigue in adult patients with brain tumors

Journal of Clinical Oncology, Jun 20, 2006

1503 Background: Patients with brain cancer develop neurobehavioral dysfunction and fatigue that ... more 1503 Background: Patients with brain cancer develop neurobehavioral dysfunction and fatigue that compromise their performance of daily activities. We report results from evaluating the efficacy and safety of modafinil treatment for tumor/therapy sequelae in this medically fragile patient population. Methods: Patients: 21–65 years old with primary malignant disease or nonmalignant cerebral tumors treated with neurosurgical resection, radiotherapy, and/or chemotherapy. Clinical Global Impression of Severity ratings of mild to severe attention/memory impairment and/or fatigue. Measures: Trail Making (TM) A and B, Symbol Digit Modalities (SDM), Verbal Fluency (VF), Hamilton Depression Scale (HAM-D), Fatigue Severity Scale (FSS), Visual Analogue Fatigue Scale (VAFS), Modified Fatigue Impact Scale (MFIS). Design: Double-blind dose-controlled randomization (200 or 400 mg/day modafinil in divided doses) 3 wks; Washout 1wk; Open label extension 8 wks. Statistical analyses: Changes from baseline at scheduled visits (1, 3, 4, 8, 12 wks) using paired t-tests or Wilcoxon Signed Rank tests as appropriate. Results: Thirty patients, 63% male, mean age (SD) = 45.3 (11.7) yrs were accrued from 6/03–10/05. Illness severity: moderate 3 (10%), marked 13 (43%), severe 14 (47%). Tumor histology: glioblastoma multiforme 8 (27%), anaplastic glioma 10 (33%), low grade glioma 10 (33%), meningioma 1 (3%), CNS lymphoma 1 (3%). Treatment: neurosurgical resection 93%, radiotherapy 87%, chemotherapy 70%. The table shows relationships of nine variables at baseline and 8 and 12 weeks after initiation of modafinil. Adverse events reported by ≥4 patients: headache 13 (42%); insomnia 8 (26%); dizziness 7 (23%); dry mouth 7 (23%); depressed consciousness 5 (16%); nausea 4 (13%). Conclusions: Results show improvement across cognitive, mood, and fatigue outcome measures. Modafinil was generally well tolerated, with a low incidence of adverse events. Greatest improvements in outcomes were observed 8 wks after baseline. [Table: see text] [Table: see text]

Psychological functioning of daughters of breast cancer patients. Part III: Experiences and perceptions of daughters related to mother's breast cancer

Psycho-oncology, Sep 1, 1996

Sixty daughters whose mothers had breast cancer were cross-sectionally studied. Daughters age 11-... more Sixty daughters whose mothers had breast cancer were cross-sectionally studied. Daughters age 11-20 reported feeling significantly more uncomfortable about involvement in their mothers&#39; illness than daughters age 20+. Daughters whose mothers died were more likely to report long-term life plan changes and role changes with their mothers during the mothers&#39; illness. The Global Symptom Index was predicted by the daughter&#39;s perceived degree of involvement with her mother (during her mother&#39;s illness), current emotional resolution (about her mother&#39;s illness), and sexual satisfaction. Sexual satisfaction was predicted by role changes during the mother&#39;s illness, frequency of sexual relations, and a depression scale.

A cross-cultural study of the prevalence and correlates of student drug use in the United States and Mexico

Bulletin on narcotics, 1974

UCLA Psychological Study of AIDS

Frontiers of Radiation Therapy and Oncology, Apr 20, 2015

Evaluation of Psychosocial Problems of the Homebound Cancer Patient: I. Methodology and Problem Frequencies

Psychosomatic Medicine, Mar 1, 1983

Psychological problem frequencies of very ill, homebound cancer patients were studied using an in... more Psychological problem frequencies of very ill, homebound cancer patients were studied using an instrument entitled &quot;Psychosocial Problem Categories for Homebound Cancer Patients.&quot; This instrument contains thirteen major categories of problems and fifty individual problems. A total of 570 patient records were obtained from two visiting nurse agencies in two different counties. Records were rated by a pair of trained raters, with level of interrater reliability being r = 0.96. Intervention frequencies by visiting health care professionals were also assessed. Percentages are based on at least one mention of problem or intervention. The five most frequent problem categories included: 1) Somatic side effects, 30% of total problems, of which pain involved 13% of total problems, 2) Patient mood disturbance, 15% of total problems, 3) Equipment problems, 8% of total problems, 4) Family relationship impairment, 7% of total problems, and 5) Cognitive impairment, 6% of total problems. The three most frequent interventions included: 1) Instructor/reinforcement to patient/family, 22% of total interventions, 2) No intervention for problem, 17% of total interventions, and 3) Counseling/emotional support, 17% of total interventions. Because the assessment instrument showed high interrater reliabilities for the two demographically dissimilar patient populations, it may be adaptable to heterogeneous populations.

Serum Gastrin and the Family Environment in Duodenal Ulcer Disease

Psychosomatic Medicine, Dec 1, 1981

The phys study investigated the relationships between specific demographic, psychosocial, and jjn... more The phys study investigated the relationships between specific demographic, psychosocial, and jjnysiological variables and the severity of duodenal ulcer disease in a population of patients with proved duodenal ulcer. Intercorrelations between psychosocial and physiological variables were also studied. The study design was cross sectional and retrospectively assessed life change units and DUD severity during the previous 6 months in 39 male ulcer clinic outpatients. Anxiety, depression, life change units, the family environment, ABO blood type, secretor status, serum pepsinogen, and serum fasting gastrin were evaluated. A DUD severity score was calculated from self-reported ulcer pain symptoms and ulcer complications. Gastrin levels correlated significantly with three Family Environment Scale (FES) subscales, including: (a) independence, (b) achievement orientation, and (c) expressiveness. Duodenal ulcer disease severity scores correlated with Zung SDS scores, but not with state or trait anxiety, life change units, or the FES. Duodenal ulcer disease (DUD) is defined as a defect in the duodenal mucosa that extends through the muscularis mucosae. Gastric secretion of hydrochloric acid and pepsin is necessary for duodenal ulcer formation. Factors associated with DUD risk include demographic, family history, genetic, behavioral, associated medical diseases, and abnormal gastric and duodenal physiological regulation (1). Gastrin is a peptide hormone that has been localized in the GI

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