Biochemical and Biophysical Research Communications, 1998
action of the natural products and/or at improving on PGYa and PGAa are synthetic, amphipathic, a... more action of the natural products and/or at improving on PGYa and PGAa are synthetic, amphipathic, a-helitheir antimicrobial activity, numerous artificial pepcal peptides that were designed using a novel ''setides have been synthesized, following various apquence template'' approach. Their antimicrobial activproaches (9, 12, 14-18). These are based principally on ity was tested against several pathogenic clinical isosynthesis of substitution analogs or on analogues with lates, most of which were multiply resistant to sequences dictated by physicochemical characteristics. conventional antibiotics. PGYa appeared to be more Some of the synthetic analogues have also been evaluactive towards Gram-positive species (MIC Å 0.5-4 ated as potential novel antibiotics, particularly for use
Biochemical and Biophysical Research Communications, 1998
action of the natural products and/or at improving on PGYa and PGAa are synthetic, amphipathic, a... more action of the natural products and/or at improving on PGYa and PGAa are synthetic, amphipathic, a-helitheir antimicrobial activity, numerous artificial pepcal peptides that were designed using a novel ''setides have been synthesized, following various apquence template'' approach. Their antimicrobial activproaches (9, 12, 14-18). These are based principally on ity was tested against several pathogenic clinical isosynthesis of substitution analogs or on analogues with lates, most of which were multiply resistant to sequences dictated by physicochemical characteristics. conventional antibiotics. PGYa appeared to be more Some of the synthetic analogues have also been evaluactive towards Gram-positive species (MIC Å 0.5-4 ated as potential novel antibiotics, particularly for use
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