Papers by Claudio Pettinari
Chemistry - A European Journal, 2014
[RuCl(arene)(μ-Cl)]2 dimers were treated in a 1:2 molar ratio with sodium or thallium salts of bi... more [RuCl(arene)(μ-Cl)]2 dimers were treated in a 1:2 molar ratio with sodium or thallium salts of bis- and tris(pyrazolyl)borate ligands [Na(Bp(Br3))], [Tl(Tp(Br3))], and [Tl(Tp(iPr, 4Br))]. Mononuclear neutral complexes [RuCl(arene)(κ(2)-Bp(Br3))] (1: arene=p-cymene (cym); 2: arene=hexamethylbenzene (hmb); 3: arene=benzene (bz)), [RuCl(arene)(κ(2)-Tp(Br3))] (4: arene=cym; 6: arene=bz), and [RuCl(arene)(κ(2)-Tp(iPr, 4Br))] (7: arene=cym, 8: arene=hmb, 9: arene=bz) have been always obtained with the exception of the ionic [Ru2 (hmb)2-(μ-Cl)3][Tp(Br3)] (5'), which formed independently of the ratio of reactants and reaction conditions employed. The ionic [Ru-(CH3OH)(cym)(κ(2)-Bp(Br3))][X] (10: X=PF6, 12: X=O3SCF3) and the neutral [Ru(O2CCF3)(cym)(κ(2)-Bp(Br3))] (11) have been obtained by a metathesis reaction with corresponding silver salts. All complexes 1-12 have been characterized by analytical and spectroscopic data (IR, ESI-MS, (1)H and (13)C NMR spectroscopy). The structures of the thallium and calcium derivatives of ligand Tp(Br3), [Tl(Tp(Br3))] and [Ca(dmso)6][Tp(Br3)]2 ⋅2 DMSO, of the complexes 1, 4, 5', 6, 11, and of the decomposition product [RuCl(cym)(Hpz(iPr, 4Br))2][Cl] (7') have been confirmed by using single-crystal X-ray diffraction. Electrochemical studies showed that 1-9 and 11 undergo a single-electron Ru(II) →Ru(III) oxidation at a potential, measured by cyclic voltammetry, which allows comparison of the electron-donor characters of the bis- and tris(pyrazol-1-yl)borate and arene ligands, and to estimate, for the first time, the values of the Lever EL ligand parameter for Bp(Br3), Tp(Br3), and Tp(iPr, 4Br). Theoretical calculations at the DFT level indicated that both oxidation and reduction of the Ru complexes under study are mostly metal-centered with some involvement of the chloride ligand in the former case, and also demonstrated that the experimental isolation of the μ(3)-binuclear complex…
Polyhedron, 1996
... STRUCTURE OF [(4TRIFLUOROACETYL1 PHENYL3METHYLPYRAZOLON5ATO)BIS (TRIPHENYLPHOSPHINE)COPPER(I)... more ... STRUCTURE OF [(4TRIFLUOROACETYL1 PHENYL3METHYLPYRAZOLON5ATO)BIS (TRIPHENYLPHOSPHINE)COPPER(I)] FABIO MARCHETTI,* CLAUDIO PETTINARI, AUGUSTO CINGOLANI and DANTE LEONESI Dipartimento ... A green precipitate was formed immediately ...
The water-soluble copper(II) complex [Cu(H 2 R)(HL)]•H 2 O (1) was prepared by reaction of copper... more The water-soluble copper(II) complex [Cu(H 2 R)(HL)]•H 2 O (1) was prepared by reaction of copper(II) nitrate hydrate with (E)-2-(((1-hydroxynaphthalen-2-yl)methylene)amino) benzenesulfonic acid (H 2 L) and diethanolamine (H 3 R). It was characterized by IR and ESI-MS spectroscopies, elemental and X-ray crystal structural analyses. 1 shows a high catalytic activity for the solvent-free microwave (MW) assisted oxidation of 1-phenylethanol with tert-butylhydroperoxide, leading, in the presence of TEMPO, to yields up to 85% (TON = 850) in a remarkably short reaction time (15 min, with the corresponding TOF value of 3.40 × 10 3 h −1 ) under low power (25 W) MW irradiation.
![Research paper thumbnail of Tris(4-bromo-1H-pyrazol-1-yl)borato derivatives of first-row transition and group 12 and 14 metals. X-ray crystal structure of [HB(4-Brpz)3]2 Cd. 113Cd solution NMR study of bis[poly(pyrazolyl)borato]cadmium complexes](https://attachments.academia-assets.com/45965898/thumbnails/1.jpg)
Polyhedron, 1998
A series of metal complexes M[HB(4-Brpz)3]2 [HB(4-Brpz)3 = hydridotris(4-bromo-IH-pyrazol-1yl)bor... more A series of metal complexes M[HB(4-Brpz)3]2 [HB(4-Brpz)3 = hydridotris(4-bromo-IH-pyrazol-1yl)borate and M = Mn, Fe, Co, Ni, Cu, Zn, Cd, Pb] were obtained from reaction of K[HB(4-Brpz)3] and the appropriate metal salt in aqueous solution. These air-stable complexes are sparingly soluble in most common solvents ; they have been investigated through elemental analysis, conductivity measurements, IR, UV-vis and, in the case of diamagnetic compounds, ~H and 13C NMR spectroscopy. The X-ray crystal structure of cadmium(II)bis[hydridotris(4-bromo-lH-pyrazol-l-yl)borate] has been resolved. Six-coordinate cadmium is present in a slightly distorted octahedron with the axes not linear [angles 176.8(3), 177.2(3) and 178.7(3)°]. The 'bite' of the ligand, i.e. N--Cd--N angle, lies in the range 81.6(2)-84.1 (3) ° (weighted average 82.4(4)°). The Cd--N distances vary from 2.298(8) to 2.329(8) A (weighted average 2.317(5) A). The geometry around the B atom is tetrahedral. The N--B--N angles range from 105.8(8) to 110.5(7) ° (weighted average 108.5(7) °) ; the B--N bond distances vary from 1.53(2) to 1.62(1)/k (weighted average 1.58(1)/k). We report and discuss also the It3Cd NMR solution data of several cadmium poly(pyrazol-l-yl)borates).
Crystal Growth & Design, 2006
The structure of {p-C 6 H 4 [CH 2 OCH 2 C(pz) 3 ] 2 [Ru(p-cymene)] 2 }Cl 4 ‚14H 2 O (pz ) pyrazol... more The structure of {p-C 6 H 4 [CH 2 OCH 2 C(pz) 3 ] 2 [Ru(p-cymene)] 2 }Cl 4 ‚14H 2 O (pz ) pyrazolyl ring) contains a one-dimensional water chain associated into an inorganic (carbon-free) layer with chloride anions by hydrogen bonds. This layer acts as a "host" supporting the non-self-assembled metal-organic "guests".
Expert Opinion on Therapeutic Patents, 2001
Most antitumour Ti compounds act on tumours in the gastrointestinal tract. Some species with incr... more Most antitumour Ti compounds act on tumours in the gastrointestinal tract. Some species with increased water solubility also show activity towards breast, lung and melanoma cancers. These compounds are structurally and chemically diverse, ranging from complex salts to ...
Expert Opinion on Therapeutic Patents, 2001
Most antitumour Ti compounds act on tumours in the gastrointestinal tract. Some species with incr... more Most antitumour Ti compounds act on tumours in the gastrointestinal tract. Some species with increased water solubility also show activity towards breast, lung and melanoma cancers. These compounds are structurally and chemically diverse, ranging from complex salts to ...
Expert Opinion on Therapeutic Patents, 2001
Most antitumour Ti compounds act on tumours in the gastrointestinal tract. Some species with incr... more Most antitumour Ti compounds act on tumours in the gastrointestinal tract. Some species with increased water solubility also show activity towards breast, lung and melanoma cancers. These compounds are structurally and chemically diverse, ranging from complex salts to ...
Organometallics, 2001
... 9803026360 and grant no. MM03027791. We would like to thank Ms. Anna Rita Pierleoni for her t... more ... 9803026360 and grant no. MM03027791. We would like to thank Ms. Anna Rita Pierleoni for her technical assistance. This article references 14 other publications. (1) (a) Drent, E. Eur. Pat. Appl. 1986, 229, 408; Chem. Abstr. 1988, 108, 6617. ...
Journal of Organometallic Chemistry, 1995
A series of 1:1 adducts of the type [(L)RnSnX4−n]·zH2O (L ≡ bis(4-methylpyraazol-1-yl)ethane (L4)... more A series of 1:1 adducts of the type [(L)RnSnX4−n]·zH2O (L ≡ bis(4-methylpyraazol-1-yl)ethane (L4), bis(3,4,5-timethylpyrazol-1-yl)methane (LT), 1,2-bis(pyrazol-1-yl)ethane (LA) or 1,2-bis(3,5-dimethylpyrazol-1-yl)ethane (LB); R ≡ Me, Et, Bu or Ph; X ≡ I, Br or Cl; n = 0, 1 or 2; z = 1, 1.5 or 2), and the likely polynuclear [(LA)5(SnCl4)4]·(H2O)5 and [(LB)2(SnCl4)3]·12[Et2O] have been characterized in the solid state and in solution by analyses, spectral (IR, Mössbauer, and 1H, 13C and 119Sn NMR) data and conductivity measurements. When LT reacts with SnCl4, cleavage of a carbon (sp3)-nitrogen bond was observed and the adduct [(3,4,5-trimethyl-pyrazole)2SnCl4] was obtained. The diorganotin(IV) complexes generally dissociate in chloroform or in acetone solution, while the trichlorotin(IV) and tetrachlorotin(IV) adducts probably retain the hexacoordinate configuration. The crystal structures of L4 and of the adduct [(L4)(CH3)2SnCl2] have been determined by X-ray analysis. In the adduct the tin atom is coordinated to two halide atoms, two methyl groups and two N atoms, with trans-(CH3)2Sn in a slightly distorted octahedral configuration. The long SnN bond distance (2.436(6)Å) indicated weak donor ability of the N2 donor L4. Comparison is made with the X-ray crystal structures of several R2SnX2N2-type compounds.
Coordination Chemistry Reviews, 2005
Inorganica Chimica Acta, 2005
Single crystal X-ray structural characterizations are recorded for an array of adducts of the for... more Single crystal X-ray structural characterizations are recorded for an array of adducts of the form AgX:dppf (1:1) (n) , X = simple (pseudo-)halide or oxy-anion, ÔdppfÕ = bis(diphenyl phosphino)ferrocene, for adducts X = Cl (new phase), Br, I, SCN, OCN, CN, NO 3 (new phase), O 2 CCH 3 , n = 2, the form being dimeric [(dppf-P,P 0 )Ag(l-X) 2 Ag(P,P 0 -dppf)], for X = I, SCN, [Ag(l-X) 2 (P-dppf-P 0 ) 2 Ag 0 ]; for X = O 2 CCF 3 , n = 1, the form is an extended polymer: Á Á ÁAg(O AE CO AE CF 3 )(P-dppf-P 0 )Ag 0 (OÁ Á Á. A dichloromethane solvate phase of CuI:dppf (1:1) 2 (also centrosymmetric) is also recorded. Synthetic procedures for all adducts have been reported. All compounds have been characterized both in solution ( 1 H, 13 C, 31 P NMR, ESI MS) and in the solid state (IR). The topology of the structures in the solid state was found to depend on the nature of the counterion.
Biochemical Pharmacology, 2007
All other uses, reproduction and distribution, including without limitation commercial reprints, ... more All other uses, reproduction and distribution, including without limitation commercial reprints, selling or licensing copies or access, or posting on open internet sites, your personal or institution's website or repository, are prohibited. For exceptions, permission may be sought for such use through Elsevier's permissions site at: http://www.elsevier.com/locate/permissionusematerial A u t h o r ' s p e r s o n a l c o p y Mitochondria are primary targets in apoptosis induced by the mixed phosphine gold species chlorotriphenylphosphine-1, 3-bis(diphenylphosphino)propanegold(I) in melanoma cell lines b i o c h e m i c a l p h a r m a c o l o g y 7 3 ( 2 0 0 7 ) 7 7 3 -7 8 1 Apoptosis Mitochondria Gold Phosphine Caspase a b s t r a c t Based on previous evidence indicating a selective cytotoxic activity of the mixed phosphine gold complex chlorotriphenylphosphine-1,3-bis(diphenylphosphino)propanegold(I) for melanoma cells, we investigated the cellular bases of its antiproliferative effect in a panel of human melanoma cell lines (JR8, SK-Mel-5, Mel-501, 2/60, 2/21 and GRIG). The drug consistently induced a dose-dependent inhibition of cell growth, with IC 50 values ranging from 0.8 to 2.3 mM and, when tested under the same experimental conditions, its cytotoxic activity was higher than (from 2-to 5-fold) or comparable to that of cisplatin as a function of cell lines. The ability of the gold complex to activate programmed cell death was assessed in JR8 and 2/60 cells, and a dose-dependent increase in cells with an apoptotic nuclear morphology was observed in both cell lines (up to 40 and 66% of the overall cell population, for JR8 and 2/60 cell lines, respectively). Such an apoptotic response was mediated by a dosedependent loss of mitochondrial membrane potential, cytochrome c and Smac/DIABLO release from mitochondria into cytosol and enhanced caspase-9 and caspase-3 catalytic activity. A reduced or completely abrogated expression of the anti-apoptotic proteins c-IAP1, XIAP and survivin in drug-treated cells was also observed. Overall, results from the study indicate that chlorotriphenylphosphine-1,3-bis(diphenylphosphino)propanegold(I) markedly inhibits melanoma cell growth by inducing mitochondria-mediated apoptosis and suggest it as a good candidate for additional evaluation as an anticancer agent against melanoma. (F. Caruso). 1 These authors contributed equally to the work. Abbreviations: SRB, sulforhodamine B; LEHD-AFC, Leu-Glu-His-Asp-7-amino-4-trifluoromethylcoumarin; Ac-DEVD-AMC, N-acetyl-Asp-Glu-Val-Asp-aldehyde-7-amino-4-methylcoumarin; Dc mt , mitochondrial membrane potential a v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j o u r n a l h o m e p a g e : w w w . e l s e v i e r . c o m / l o c a t e / b i o c h e m p h a r m
Journal of The American Chemical Society, 2005
A new polycrystalline vapochromic polymorph of the one-dimensional copper bispyrazolate polymer r... more A new polycrystalline vapochromic polymorph of the one-dimensional copper bispyrazolate polymer reversibly and selectively absorbs a number of small molecules; the crystal structures of the anhydrous and fully hydrated species, determined by powder diffraction methods, are markedly different despite their simple, fast, and reversible interconversion.
Inorganic Chemistry, 2003
Cheminform, 2004
For Abstract see ChemInform Abstract in Full Text.
Inorganica Chimica Acta, 2007
Inorganic Chemistry, 2005
Complexes of composition [Cu(X-NO 2 bz) 2 (μ-3PM) 2 ] n [X-NO 2 bz = 2-nitrobenzoate (1), 3-nitro... more Complexes of composition [Cu(X-NO 2 bz) 2 (μ-3PM) 2 ] n [X-NO 2 bz = 2-nitrobenzoate (1), 3-nitrobenzoate (2) or 4-nitrobenzoate (3) and 3PM = 3-pyridylmethanol] were prepared and studied by elemental analysis, UV/Vis, IR and EPR spectroscopy. The molecular structures of two new complexes 1 and 3 were solved. The copper atoms of both complexes exhibit an elongated octahedral coordination environment with the equatorial positions occupied by two monoden-* Dr. J. Moncol Fax: +421-2524-93-198 E-Mail: [email protected] [a]
Journal of Medicinal Chemistry, 2000
Inorganic Chemistry, 2002
Adducts of triorganophosphine, triphenylarsine, and triphenylstibine with silver(I) nitrite have ... more Adducts of triorganophosphine, triphenylarsine, and triphenylstibine with silver(I) nitrite have been synthesized and characterized both in solution ((1)H, (31)P NMR) and in the solid state (IR, single-crystal X-ray structure analysis). In addition aggregates of AgNO(2) and ER(3) (E = P, As, Sb) have been identified in solution by electrospray ionization mass spectrometry (ESI-MS). The topology of the structures in the solid state was found to depend on the nature of ER(3) and on the stoichiometric ratio AgNO(2):ER(3). The adducts AgNO(2):EPh(3) (1:1) (E = P or Sb) are one-dimensional polymers, the role of NO(2)(-) being to bridge successive metal atoms by coordination of the two oxygens to one silver atom and the nitrogen lone pair to a successive Ag. The adduct AgNO(2):P(o-tolyl)(3) (1:1) is mononuclear, due to steric hindrance of the phosphine, the nitrite being O,O'-bidentate, a rare example of a quasi-linear P-Ag-X array. AgNO(2):P(p-F-C(6)H(4))(3) (1:1) is a dimer, the nitrite being coordinated through both oxygens, the first unidentate, the second bridging bidentate. P(o-tolyl)(3) and Pcy(3) form 1:2 adducts, also mononuclear, the nitrite still an O,O'-chelate. In contrast, the adduct AgNO(2):AsPh(3) (1:2) is a centrosymmetric dimer, essentially an aggregate of a pair of [Ag(O(2)N)(AsPh(3))(2)] arrays with one nitrite oxygen being the bridging atom. The adducts AgNO(2):EPh(3) (1:3) (E = As, Sb) are mononuclear, the nitrite behaving as a consistently strong O,O'-chelate. The E = As adduct is a triclinic solvated form, whereas the unsolvated E = Sb species is monoclinic. ESI-MS spectra of acetonitrile solutions of these complexes show the existence of [Ag(ER(3))](+), [Ag(CH(3)CN)](+), [Ag(CH(3)CN)(2)](+), [AgCl(2)](-), [Ag(NO(2))(2)](-), [Ag(ER(3))(CH(3)CN)](+), and [Ag(ER(3))(2)](+) as well as higher aggregates [Ag(2)(NO(2))(ER(3))(2)](+), [Ag(2)(NO(2))(3)](-) and [Ag(2)Cl(2)(NO(2))](-), which are less prevalent.
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Papers by Claudio Pettinari