Papers by Claudio Babiloni
Human Brain Mapping, Oct 30, 2003
High-resolution event-related potentials (ERPs) were used to model the hemispherical representati... more High-resolution event-related potentials (ERPs) were used to model the hemispherical representation of the transient cortical responses relating to the observation of movement during execution (right or left aimless finger extension). Subjects were seated in front of the observed person and looked at both their own and the observer's hand to receive similar visual feedback during the two conditions. In a visual control condition, a diode light moved at the observed person's hand. A first potential accompanying the movement execution peaked at about ϩ110 msec over the contralateral somatomotor areas. It was followed by a potential (P300) peaking at about ϩ350 msec over the central midline. In contrast, the potentials accompanying the movement observation peaked later over parietal-occipital other than somatomotor areas (N200 peak, ϩ200 msec; P300 peak, ϩ400 msec). Notably, the N200 was maximum in left parietal area whereas the P300 was maximum in right parietal area regardless the side of the movement. They markedly differed by the potentials following the displacement of the diode light. These results suggest a rapid time evolution (ϳ200 -400 msec) of the cortical responses characterizing the observation of aimless movements (as opposite to grasping or handling). The execution of these movements would mainly involve somatomotor cortical responses and would be scarcely founded on the visual feedback. In contrast, the observation of the same movements carried out by others would require dynamical responses of somatomotor and parietal-occipital areas (especially of the right hemisphere), possibly for a stringent visuospatial analysis of the motor event.
The Open Nuclear Medicine Journal, Nov 29, 2010
Physiological brain aging is characterized by a loss of synaptic contacts and neuronal apoptosis ... more Physiological brain aging is characterized by a loss of synaptic contacts and neuronal apoptosis that provoke age-dependent decline of cognitive functions. Neural/synaptic redundancy and plastic remodelling of brain networking, also secondary to mental and physical training, promotes maintenance of brain activity in healthy elderly for everyday life and fully productive affective and intellectual capabilities. However, age is the main risk factor for neurodegenerative disorders such as Alzheimer's disease (AD) that impact on cognition. Oscillatory electromagnetic brain activity is a hallmark of neuronal network function in various brain regions. Modern neurophysiological techniques including electroencephalography (EEG) can index normal and abnormal brain aging to facilitate non-invasive analysis of corticocortical connectivity and neuronal synchronization of firing, and coherence of rhythmic oscillations at various frequencies. The present review provides a perspective of these issues. It is concluded that discrimination between physiological and pathological brain aging clearly emerges at the group level, with applications at the individual level also suggested. Integrated approaches utilizing neurophysiological techniques together with biological markers and structural and functional imaging are promising for large-scale, low-cost and non-invasive evaluation of at-risk populations.
The Open Nuclear Medicine Journal, May 20, 2010
Journal of Alzheimer's Disease, Mar 4, 2013
Patients suffering from prodromal (i.e. amnesic mild cognitive impairment, aMCI) and overt Alzhei... more Patients suffering from prodromal (i.e. amnesic mild cognitive impairment, aMCI) and overt Alzheimer's disease (AD) show abnormal cortical sources of resting state electroencephalographic (EEG) rhythms. Here we tested the hypothesis that these sources show extensive abnormalities in liver cirrhosis (LC) patients with a cognitive impairment due to covert and diffuse hepatic encephalopathy (CHE). EEG activity was recorded in 64 LC (including 21 CHE), 21 aMCI, 21 AD, and 21 cognitively intact (Nold),subjects. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). EEG cortical sources were estimated by LORETA. Widespread sources of theta (all but frontal), alpha 1 (all but occipital), and alpha 2 (parietal, temporal) rhythms were higher in amplitude in all LC patients than in the Nold subjects. In these LC patients, the activity of central, parietal, and temporal theta sources correlated negatively, and parietal and temporal alpha 2 sources correlated positively with an index of global cognitive status. Finally, widespread theta (all but frontal) and alpha 1 (all but occipital) sources showed higher activity in the sub-group of LC patients with CHE than in the patients with aMCI or AD. These results unveiled the larger spatial-frequency abnormalities of the resting state EEG sources in the CHE compared to the AD condition.
Human Brain Mapping, Dec 1, 2008
International Journal of Alzheimer's Disease, 2011
Is directionality of electroencephalographic (EEG) synchronization abnormal in amnesic mild cogni... more Is directionality of electroencephalographic (EEG) synchronization abnormal in amnesic mild cognitive impairment (MCI) and Alzheimer's disease (AD)? And, do cerebrovascular and AD lesions represent additive factors in the development of MCI as a putative preclinical stage of AD? Here we reported two studies that tested these hypotheses. EEG data were recorded in normal elderly (Nold), amnesic MCI, and mild AD subjects at rest condition (closed eyes). Direction of information flow within EEG electrode pairs was performed by directed transfer function (DTF) at δ (2-4 Hz), θ (4-8 Hz), α1 (8-10 Hz), α2 (10-12 Hz), β1 (13-20 Hz), β2 (20-30 Hz), and γ (30-40 Hz). Parieto-to-frontal direction was stronger in Nold than in MCI and/or AD subjects for α and β rhythms. In contrast, the directional flow within interhemispheric EEG functional coupling did not discriminate among the groups. More interestingly, this coupling was higher at θ, α1, α2, and β1 in MCI with higher than in MCI with lower vascular load. These results suggest that directionality of parieto-to-frontal EEG synchronization is abnormal not only in AD but also in amnesic MCI, supporting the additive model according to which MCI state would result from the combination of cerebrovascular and neurodegenerative lesions.
Frontiers in Aging Neuroscience, Aug 5, 2022
Resting state electroencephalographic rhythms are affected by immediately preceding memory demand... more Resting state electroencephalographic rhythms are affected by immediately preceding memory demands in cognitively unimpaired elderly and patients with mild cognitive impairment.
Behavioural Brain Research, Dec 1, 2015
Objective: Previous findings have shown that alpha event-related desynchronization (-ERD) is ass... more Objective: Previous findings have shown that alpha event-related desynchronization (-ERD) is associated with reaction to visual stimuli in oddball paradigm, as a reflection of attention allocation and memory updating. This study tested the hypotheses that it reflects a modality and/or frequency specific mechanism. Methods: Electroencephalography (EEG) recordings (64 channels) were performed on 18 healthy subjects during visual, auditory, somatosensory, and pain oddball paradigms. Low-and high-frequency rhythms were analyzed on individual basis, and their sources were estimated by low resolution brain electromagnetic tomography (LORETA). -ERD, served as an index of cortical activation, was computed on the cortical voxel level and compared across the conditions (target vs. non-target), alpha sub-bands (lower vs. higher frequency), and modalities (visual, auditory, somatosensory, and pain). Results: In the visual modality, -ERD was mainly generated from occipital cortex for both target and non-target conditions. Its magnitude was enhanced across widespread cortical regions (e.g., bilateral occipital, parietal, and frontal areas) in the target condition and was greater in high-frequency band. Finally, -ERD difference between target and non-target conditions was not higher in visual than that in other control modalities. Conclusions: Human high-frequency -ERD reflects cognitive attention processes underlying reaction to oddball target stimuli regardless stimulus modality.
Clinical Neurophysiology, 2021
Artificial neural networks with stacked autoencoders detected Alzheimer's dementia patients based... more Artificial neural networks with stacked autoencoders detected Alzheimer's dementia patients based on EEG and structural MRI variables. Classification accuracies over control participants reached 80% (EEG), 85% (MRI), and 89% (both). These results motivate future multi-centric, harmonized prospective and longitudinal crossvalidation studies. Objective: This retrospective and exploratory study tested the accuracy of artificial neural networks (ANNs) at detecting Alzheimer's disease patients with dementia (ADD) based on input variables extracted from resting-state electroencephalogram (rsEEG), structural magnetic resonance imaging (sMRI) or both. Methods: For the classification exercise, the ANNs had two architectures that included stacked (autoencoding) hidden layers recreating input data in the output. The classification was based on LORETA source estimates from rsEEG activity recorded with 10-20 montage system (19 electrodes) and standard sMRI variables in 89 ADD and 45 healthy control participants taken from a national database. Results: The ANN with stacked autoencoders and a deep leaning model representing both ADD and control participants showed classification accuracies in discriminating them of 80%, 85%, and 89% using rsEEG, sMRI, and rsEEG + sMRI features, respectively. The two ANNs with stacked autoencoders and a deep leaning model specialized for either ADD or control participants showed classification accuracies of 77%, 83%, and 86% using the same input features.
Neurobiology of Aging, Jun 1, 2020
HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific r... more HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Clinical EEG and Neuroscience
Parkinson's disease (PD) is a movement disorder caused by degeneration in dopaminergic neuron... more Parkinson's disease (PD) is a movement disorder caused by degeneration in dopaminergic neurons. During the disease course, most of PD patients develop mild cognitive impairment (PDMCI) and dementia, especially affecting frontal executive functions. In this study, we tested the hypothesis that PDMCI patients may be characterized by abnormal neurophysiological oscillatory mechanisms coupling frontal and posterior cortical areas during cognitive information processing. To test this hypothesis, event-related EEG oscillations (EROs) during counting visual target (rare) stimuli in an oddball task were recorded in healthy controls (HC; N = 51), cognitively unimpaired PD patients (N = 48), and PDMCI patients (N = 53). Hilbert transform served to estimate instantaneous phase and amplitude of EROs from delta to gamma frequency bands, while modulation index computed ERO phase-amplitude coupling (PAC) at electrode pairs. As compared to the HC and PD groups, the PDMCI group was characterized...
Journal of Alzheimer's Disease
Background: In relaxed adults, staying in quiet wakefulness at eyes closed is related to the so-c... more Background: In relaxed adults, staying in quiet wakefulness at eyes closed is related to the so-called resting state electroencephalographic (rsEEG) rhythms, showing the highest amplitude in posterior areas at alpha frequencies (8–13 Hz). Objective: Here we tested the hypothesis that age may affect rsEEG alpha (8–12 Hz) rhythms recorded in normal elderly (Nold) seniors and patients with mild cognitive impairment due to Alzheimer’s disease (ADMCI). Methods: Clinical and rsEEG datasets in 63 ADMCI and 60 Nold individuals (matched for demography, education, and gender) were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands, as well as fixed beta (14–30 Hz) and gamma (30–40 Hz) bands. Each group was stratified into three subgroups based on age ranges (i.e., tertiles). Results: As compared to the younger Nold subgroups, the older one showed greater reductions in the rsEEG alpha rhythms with major topographical e...
International Journal of Psychophysiology
or visit the DOI to the publisher's website. • The final author version and the galley proof are ... more or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers. Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal. If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the "Taverne" license above, please follow below link for the End User
Frontiers in Neurology, 2020
Discussion: MCI status was relatively frequent in LOEU patients, involved multiple cognitive doma... more Discussion: MCI status was relatively frequent in LOEU patients, involved multiple cognitive domains, and might have been driven by amyloidosis according to CSF biomarkers. LOEU-MCI status was associated with abnormalities in cortical sources of EEG rhythms related to quiet vigilance. Future longitudinal studies should cross-validate our findings and test the predictive value of CSF and EEG variables.
Psychophysiology, 2021
Cerebrospinal and structural‐molecular neuroimaging in‐vivo biomarkers are recommended for diagno... more Cerebrospinal and structural‐molecular neuroimaging in‐vivo biomarkers are recommended for diagnostic purposes in Alzheimer’s disease (AD) and other dementias; however, they do not explain the effects of AD neuropathology on neurophysiological mechanisms underpinning cognitive processes. Here, an Expert Panel from the Electrophysiology Professional Interest Area of the Alzheimer’s Association reviewed the field literature and reached consensus on the event‐related electroencephalographic oscillations (EROs) that show consistent abnormalities in patients with significant cognitive deficits due to Alzheimer’s, Parkinson’s (PD), Lewy body (LBD), and cerebrovascular diseases. Converging evidence from oddball paradigms showed that, as compared to cognitively unimpaired (CU) older adults, AD patients had lower amplitude in widespread delta (>4 Hz) and theta (4–7 Hz) phase‐locked EROs as a function of disease severity. Similar effects were also observed in PD, LBD, and/or cerebrovascula...
Neurobiology of Aging, 2021
EEG/ERP measures are consistently abnormal in major VCI patients. Main EEG abnormalities affect d... more EEG/ERP measures are consistently abnormal in major VCI patients. Main EEG abnormalities affect delta, theta, and alpha rhythms. Main ERP abnormalities include delayed "oddball" N200/P300 peaks. Those EEG measures are not diagnostic but promising as predictors and endpoints.
Neurobiology of Aging, 2020
HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific r... more HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Brain Topography, 2018
Graph theory analysis on resting state electroencephalographic rhythms disclosed topological prop... more Graph theory analysis on resting state electroencephalographic rhythms disclosed topological properties of cerebral network. In Alzheimer's disease (AD) patients, this approach showed mixed results. Granger causality matrices were used as input to the graph theory allowing to estimate the strength and the direction of information transfer between electrode pairs. The number of edges (degree), the number of inward edges (in-degree), of outgoing edges (out-degree) were statistically compared among healthy controls, patients with mild cognitive impairment due to AD (AD-MCI) and AD patients with mild dementia (ADD) to evaluate if degree abnormality could involve low and/or high degree vertices, the so called hubs, in both prodromal and over dementia stage. Clustering coefficient and local efficiency were evaluated as measures of network segregation, path length and global efficiency as measures of integration, the assortativity coefficient as a measure of resilience. Degree, indegree and out-degree values were lower in AD-MCI and ADD than the control group for non-hubs and hubs vertices. The number of edges was preserved for frontal electrodes, where patients' groups showed an additional hub in F3. Clustering coefficient was lower in ADD compared with AD-MCI in the right occipital electrode, and it was positively correlated with mini mental state examination. Local and global efficiency values were lower in patients' than control groups. Our results show that the topology of the network is altered in AD patients also in its prodromal stage, begins with the reduction of the number of edges and the loss of the local and global efficiency.
Frontiers in aging neuroscience, 2017
Simultaneous resting state functional magnetic resonance imaging (rsfMRI)-resting state electroen... more Simultaneous resting state functional magnetic resonance imaging (rsfMRI)-resting state electroencephalography (rsEEG) studies in healthy adults showed robust positive associations of signal power in the alpha band with BOLD signal in the thalamus, and more heterogeneous associations in cortical default mode network (DMN) regions. Negative associations were found in occipital regions. In Alzheimer's disease (AD), rsfMRI studies revealed a disruption of the DMN, while rsEEG studies consistently reported a reduced power within the alpha band. The present study is the first to employ simultaneous rsfMRI-rsEEG in an AD sample, investigating the association of alpha band power and BOLD signal, compared to healthy controls (HC). We hypothesized to find reduced positive associations in DMN regions and reduced negative associations in occipital regions in the AD group. Simultaneous resting state fMRI-EEG was recorded in 14 patients with mild AD and 14 HC, matched for age and gender. Pow...
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Papers by Claudio Babiloni