Papers by Churdchoo Ariyasriwatana
Age-specific prevalence of hepatitis A antibody in Thai children
The Southeast Asian journal of tropical medicine and public health, 1995
Age-specific prevalence of anti-HAV was determined for 3 groups of children whose mean ages were ... more Age-specific prevalence of anti-HAV was determined for 3 groups of children whose mean ages were 12.6, 20.7 and 52.5 months. There were 41, 43 and 99 children in the respective age groups. All children were healthy, from middle to low socioeconomic families in Bangkok and vicinity. None of the children in the two younger age groups had anti-HAV antibody while 2 of 99 children in the oldest age group did. One of them resided in central Bangkok (Amphoe Dusit) and the other in Nonthaburi Province. The overall prevalence of anti-HAV in children under 5 years old was 1.1%. This demonstrates that hepatitis A transmission rates in Bangkok are very low when compared to ten years ago when prevalence rates were as high as 50-65%. From this study hepatitis A vaccine is recommended for 4-5 years old children in Bangkok. We need more epidemiologic data concerning hepatitis A transmission in Thailand before we can consider hepatitis A immunization for the whole country.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2004
Thousands of measles cases are reported annually in Thailand even though measles vaccine has been... more Thousands of measles cases are reported annually in Thailand even though measles vaccine has been introduced in the expanded program of immunization for every 9-month-old infant for nearly 20 years. Severe cases are admitted to the hospital, usually with complications, some cases lead to death. To study the clinical presentations of severe cases of measles and its complications and find the correlations of severity of pneumonia with age, nutritional status and history of vaccination. The hospital charts of measles patients admitted to the Queen Sirikit National Institute of Child Health (QSNICH) during 1998-2002 were retrospectively reviewed. Demographic data, history including history of measles vaccination, physical examinations, laboratory investigations, treatment and hospital course which were relevant were recorded. Paired t-test and Pearson's correlation were used for data analysis. There were 156 cases of measles admitted to the QSNICH. There were 95 boys and 61 girls an...
Protective antibody after a 'one dollar' hepatitis B vaccine
The Southeast Asian journal of tropical medicine and public health, 1996
The seropositivity rate of anti-HBs after hepatitis B vaccines, "Hepavax B", a one-doll... more The seropositivity rate of anti-HBs after hepatitis B vaccines, "Hepavax B", a one-dollar per dose vaccine produced by Korean Green Cross Corporation, Korea which were widely distributed and used for the first few years in the National Expanded Program on Immunization in Thailand were assessed in children who regularly came for immunization at the Well Baby Clinic at the Children's Hospital between June to December 1994. The schedule for hepatitis B immunization is at birth, 2 and 6 months of age. The seropositivity rate of anti-HBs at 6 months after the last dose were 86.3% and 87.7% at 12 months which was comparable to the seropositivity rate after other more expensive hepatitis B vaccines at 2 years (88.1%). This result should convince people that a one-dollar hepatitis B vaccine, "Hepavax" is immunogenic and expected to be as effective as other expensive hepatitis B vaccines. The marked reduce in the cost of hepatitis B vaccines will enable us to prevent ...
Thai Journal of Obstetrics and Gynaecology, May 12, 2012
The Pediatric Infectious Disease Journal, 2008
We reviewed HIV-1 genotypes from 200 of 979 (20%) HIV-infected children in the U.K. Collaborative... more We reviewed HIV-1 genotypes from 200 of 979 (20%) HIV-infected children in the U.K. Collaborative HIV in Pediatric Study (CHIPS) cohort (343 resistance tests). Three of 44 samples had major primary resistance mutations before antiretroviral therapy. Three-class resistance was noted in 42 samples (14.1%). Our study also highlighted underutilization of testing and the need for prompt genotyping after drug discontinuation which may have lead to an underestimation of HIV-1 resistance.
A Three-Year Clinical Study On Immunogenicity, Safety, and Booster Response of Purified Chick Embryo Cell Rabies Vaccine Administered Intramuscularly or Intradermally to 12- to 18-Month-Old Thai Children, Concomitantly With Japanese Encephalitis Vaccine
The Pediatric Infectious Disease Journal, 2009
After concomitant administration of purified chick embryo cell rabies vaccine and Japanese enceph... more After concomitant administration of purified chick embryo cell rabies vaccine and Japanese encephalitis vaccine to toddlers, adequate rabies and Japanese encephalitis virus neutralizing antibodies concentrations were demonstrated by day 49, 7 days after a booster at 1 year, and in the majorly at 3 years postvaccination. The inclusion of rabies vaccine in the expanded program on immunization should be considered in rabies endemic countries.
Antibody response after measles immunization
Journal of the Medical Association of Thailand Chotmaihet Thangphaet, Aug 1, 2003
Measles is still an important public health problem in Thailand despite measles vaccination being... more Measles is still an important public health problem in Thailand despite measles vaccination being practiced since 1984. Vaccine failure is one of the suspected reasons for the high incidence of measles. To study the seroconversion rate of 9-month-old infants and to study the antibody level in 18 month-old and 4 year-old children who had measles vaccination at 9 months of age. Enrolled infants and children who attended the child health clinic for routine immunization at the Queen Sirikit National Institute of Child Health from March 1, 1994 to May 31, 1995. They were divided into 3 groups. Group A, 9 month-old infants who came for measles vaccination. Blood samples were drawn twice from these infants, before measles vaccination and 3 months later for measles antibody level. Group B and C were 18 month-old and 4-year-old children who came for their first and second DTP (Diphtheria, Tetanus, Pertussis vaccine) booster. One blood sample for measles antibody was drawn from the latter group of children. Measles antibody was determined by micro-neutralization technic at the National Institute of Health (NIH). The geometric mean antibody titer before and after measles vaccination was compared by using the paired t-test. There were 30, 31 and 34 infants/children in group A, B and C respectively. No significant measles antibody (NT antibody was less than 1:4) was detected in 93.5 per cent of 9-month-old infants. The seroconversion rate at 3 months after vaccination in group A children was 68.75 per cent while in group B, 9 months after vaccination it was 53.3 per cent. Ninety seven per cent of children in group C had NT antibody above 1:4. The geometric mean titer (GMT) of measles antibody in 9-month (before vaccination), 12-month, 18-month infants and 4 year old children was 1:2.5; 1:14.8, 1:8.2 and 1:73.8, respectively (p < 0.05). Almost 70 per cent of vaccinees at 9 months of age had seroconversion to measles vaccine with GMT of 1:14.8 while fifty three per cent of 18 month old children had an average GMT of 1:8.2. The GMT of the two groups was significantly different (p < 0.05). At 4 years of age almost all the children had NT antibody to measles with a GMT of 1:73.8 (p < 0.05) Vaccine failure is likely to be one factor responsible for the high incidence of measles after the introduction of measles vaccine into the Expanded Program of Immunization (EPI). The authors suggest giving a booster dose of measles at 15 months of age to boost the antibody level before waning of measles antibody at 18 months old, in order to protect this group of children from contracting measles.
Trend of measles morbidity in Thailand
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2003
Measles is still an important public health problem in Thailand despite the high coverage of meas... more Measles is still an important public health problem in Thailand despite the high coverage of measles vaccination since 1984, and the second dose of measles vaccination in primary school children in 1991. To study the trend of measles morbidity in Thai children. Review of the Annual Epidemiological Surveillance Report of the Epidemiology Section, Department of Communicable Disease Control, Ministry of Public Health (MOPH), and hospital records of measle cases at the Queen Sirikit National Institute of Child Health (QSNICH) (Bangkok Children's Hospital). Paired t-test and analysis of variance (ANOVA) were used for data analysis in the present study. Before 1984, measles morbidity was very high, at the level of 52.3 to 93.67 per 100,000 population. After measles vaccine was included in the EPI (Expanded Program on Immunization), the morbidity fluctuated for some years, and the group of children infected with measles changed from under 5 years to the age group of 5-9 years old. So a...
AGE-SPECIFIC PREVALENCE OF DENGUE ANTIBODIES IN BANGKOK INFANTS AND CHILDREN
The Pediatric Infectious Disease Journal, 2008
Seroprevalence of dengue antibodies were determined in healthy children in Bangkok. At 9, 12, and... more Seroprevalence of dengue antibodies were determined in healthy children in Bangkok. At 9, 12, and 18 months of age 23%, 9%, and 17% of children respectively had neutralizing antibodies against one or more serotypes. DEN1 was the most prevalent, followed by DEN3, DEN2, and DEN4. Twelve children had serologic evidence of dengue infection. The nadir of dengue antibodies in children was at 12 months of age. In highly endemic areas, dengue vaccination could be needed at an early age.
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Papers by Churdchoo Ariyasriwatana