Addiction is a complex, multi-factorial disease, and thus, analyzing genetic variants at multiple... more Addiction is a complex, multi-factorial disease, and thus, analyzing genetic variants at multiple loci and gene-gene interactions among them (epistasis) can provide crucial clues about causative factors of addiction which cannot be detected with single-nucleotide polymorphism (SNP) association studies. In this study, we discuss the interaction between the 1359 G/A polymorphism of the CNR1 gene and the DRD2 gene polymorphisms and the net effect of any possible epistasis on the cannabis addiction phenotype in a Turkish population. Using bivariate synergy and mutual information concepts as a means of capturing the magnitude of interaction between marker pairs, the present study not only confirms the A1 marker allele as a risk factor but also reveals a finer-grained association between A and B markers which manifests itself both as a preventive and a risk factor. Our results indicate that the increased phenotype of cases require an individual to be either heterozygous at both loci or homozygous at locus B with homozygous risk factor A1A1 present. We hypothesize that overlapping expressions of CB1 and D2R is the cause of CB1-D2R interactions in cases of substance abuse and the different polymorphisms of CNR1 and DRD2 genes may have decisive roles in the nature of these interactions in terms of promoting or alleviating the cannabis addiction risk factor of the individual.
The authors survey networking solutions that have been proposed for high-speed packet-switched ap... more The authors survey networking solutions that have been proposed for high-speed packet-switched applications. Using these solutions as examples, they identify the specific problems resulting from very high transmission rates and explain how these problems influence the design of high-speed networks and protocols. They conclude that the solutions based on deflection routing are the most promising ones and suggest a number
Collective Communication Algorithms for 2D torus networks have been investigated quite extensivel... more Collective Communication Algorithms for 2D torus networks have been investigated quite extensively in the literature and two broad approaches, namely direct methods and indirect (message combining) methods are recognized in the field. While direct methods minimize the volume of data, the indirect methods reduce the number of message start-ups. Consequently, either a suite of algorithms must be employed for efficiency over a wide range of message lengths and communication operations or algorithms should be able to adapt themselves to the current case, possibly by switching between direct and indirect routing modes as appropriate. In this paper, we propose adaptive routing algorithms for all-port, wormhole routed, synchronous, 2D torus networks optimized for one-to-all broadcast, gossiping and complete exchange collective communication operations. The proposed algorithms employ completely-connected subnetworks where complete exchange amongst the nodes in the subnetwork can be accomplished in one step only. Combined with suitable 2D plane tiling techniques, the proposed algorithms share the same set of primitive operations and yield superior performance compared to previously proposed methods, either pure or hybridized.
New matrix multiplication algorithms are proposed for massively parallel supercomputers with 2D/3... more New matrix multiplication algorithms are proposed for massively parallel supercomputers with 2D/3D, all-port torus interconnection networks. The proposed algorithms are based on the traditional row-by-column multiplication matrix product model and employ a special routing pattern for better scalability. They compare favorably to the variants of Cannon's and DNS algorithms since they allow matrices of the same size to be multiplied on a higher number of processors due to lower data communication overhead.
The authors survey networking solutions that have been proposed for high-speed packet-switched ap... more The authors survey networking solutions that have been proposed for high-speed packet-switched applications. Using these solutions as examples, they identify the specific problems resulting from very high transmission rates and explain how these problems influence the design of high-speed networks and protocols. They conclude that the solutions based on deflection routing are the most promising ones and suggest a number
IEEE Journal on Selected Areas in Communications, 1993
In this paper, a new MANWAN MAC-level protocol called CBRMA++/SR will be introduced. It is suitab... more In this paper, a new MANWAN MAC-level protocol called CBRMA++/SR will be introduced. It is suitable for folded bus topology with optical fiber used as the transmission medium.
In this paper, we discuss the general formulation and solution of linear mass balance equations f... more In this paper, we discuss the general formulation and solution of linear mass balance equations for mass-separators. One-input/two-output and two-input/two-output models with multi-component flows are discussed and a simple, yet efficient solution method is proposed. The proposed method does not require a separate gross error detection mechanism or any statistical knowledge derived from historical plant data. Numerical examples are presented with relevant MATLAB code fragments. Obtained results compare favorably to those provided by JKSimMet (Version 5.1) software.
Addiction is a complex, multi-factorial disease, and thus, analyzing genetic variants at multiple... more Addiction is a complex, multi-factorial disease, and thus, analyzing genetic variants at multiple loci and gene-gene interactions among them (epistasis) can provide crucial clues about causative factors of addiction which cannot be detected with single-nucleotide polymorphism (SNP) association studies. In this study, we discuss the interaction between the 1359 G/A polymorphism of the CNR1 gene and the DRD2 gene polymorphisms and the net effect of any possible epistasis on the cannabis addiction phenotype in a Turkish population. Using bivariate synergy and mutual information concepts as a means of capturing the magnitude of interaction between marker pairs, the present study not only confirms the A1 marker allele as a risk factor but also reveals a finer-grained association between A and B markers which manifests itself both as a preventive and a risk factor. Our results indicate that the increased phenotype of cases require an individual to be either heterozygous at both loci or homozygous at locus B with homozygous risk factor A1A1 present. We hypothesize that overlapping expressions of CB1 and D2R is the cause of CB1-D2R interactions in cases of substance abuse and the different polymorphisms of CNR1 and DRD2 genes may have decisive roles in the nature of these interactions in terms of promoting or alleviating the cannabis addiction risk factor of the individual.
The authors survey networking solutions that have been proposed for high-speed packet-switched ap... more The authors survey networking solutions that have been proposed for high-speed packet-switched applications. Using these solutions as examples, they identify the specific problems resulting from very high transmission rates and explain how these problems influence the design of high-speed networks and protocols. They conclude that the solutions based on deflection routing are the most promising ones and suggest a number
Collective Communication Algorithms for 2D torus networks have been investigated quite extensivel... more Collective Communication Algorithms for 2D torus networks have been investigated quite extensively in the literature and two broad approaches, namely direct methods and indirect (message combining) methods are recognized in the field. While direct methods minimize the volume of data, the indirect methods reduce the number of message start-ups. Consequently, either a suite of algorithms must be employed for efficiency over a wide range of message lengths and communication operations or algorithms should be able to adapt themselves to the current case, possibly by switching between direct and indirect routing modes as appropriate. In this paper, we propose adaptive routing algorithms for all-port, wormhole routed, synchronous, 2D torus networks optimized for one-to-all broadcast, gossiping and complete exchange collective communication operations. The proposed algorithms employ completely-connected subnetworks where complete exchange amongst the nodes in the subnetwork can be accomplished in one step only. Combined with suitable 2D plane tiling techniques, the proposed algorithms share the same set of primitive operations and yield superior performance compared to previously proposed methods, either pure or hybridized.
New matrix multiplication algorithms are proposed for massively parallel supercomputers with 2D/3... more New matrix multiplication algorithms are proposed for massively parallel supercomputers with 2D/3D, all-port torus interconnection networks. The proposed algorithms are based on the traditional row-by-column multiplication matrix product model and employ a special routing pattern for better scalability. They compare favorably to the variants of Cannon's and DNS algorithms since they allow matrices of the same size to be multiplied on a higher number of processors due to lower data communication overhead.
The authors survey networking solutions that have been proposed for high-speed packet-switched ap... more The authors survey networking solutions that have been proposed for high-speed packet-switched applications. Using these solutions as examples, they identify the specific problems resulting from very high transmission rates and explain how these problems influence the design of high-speed networks and protocols. They conclude that the solutions based on deflection routing are the most promising ones and suggest a number
IEEE Journal on Selected Areas in Communications, 1993
In this paper, a new MANWAN MAC-level protocol called CBRMA++/SR will be introduced. It is suitab... more In this paper, a new MANWAN MAC-level protocol called CBRMA++/SR will be introduced. It is suitable for folded bus topology with optical fiber used as the transmission medium.
In this paper, we discuss the general formulation and solution of linear mass balance equations f... more In this paper, we discuss the general formulation and solution of linear mass balance equations for mass-separators. One-input/two-output and two-input/two-output models with multi-component flows are discussed and a simple, yet efficient solution method is proposed. The proposed method does not require a separate gross error detection mechanism or any statistical knowledge derived from historical plant data. Numerical examples are presented with relevant MATLAB code fragments. Obtained results compare favorably to those provided by JKSimMet (Version 5.1) software.
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Papers by Cesur Baransel