Papers by Catherine Hosage Norman
Nature, 2004
Columns indicate total finished sequence deposited in public databases (including overlaps and al... more Columns indicate total finished sequence deposited in public databases (including overlaps and alternative alleles) and finished sequence incorporated into Build 35 (consisting of those clones chosen for inclusion in the tiling path by the individual chromosome coordinators). The total includes finished sequence completed at the time of the draft sequence 15,17,20 and subsequently. Some clones were sequenced to draft coverage by one centre, then finished by another. Abbreviations: SI,
This thesis is concerned with the application of genetic algorithms to solve the p-median problem... more This thesis is concerned with the application of genetic algorithms to solve the p-median problem. The problem finds a specified number of locations that are the most accessible among a fixed set of locations. Genetic algorithms are an adaptive search method based on models of mathematical population genetics. Basically, the algorithms simulate the evolution of a population in an environment, where selective pressure during evolution forces the population to improve. Modification to fit a particular environment is in a sense optimization. The extended analogy has the environment as the objective function of the p-median, the population as a set of solutions, and the optimal solution as creation after evolution.;This study describes the extant methodologies for solving the problem, and concludes that because they are either limited by computation time, or to small problems, methods with reliability and/or speed are needed.;The quantitative developments in population genetics are desc...
On Enumerating All Feasible Solutions to Polygon Aggregation Problems
ISA, Dec 1, 1983
Nature, 2005
Chromosome 13 is the largest acrocentric human chromosome. It carries genes involved in cancer in... more Chromosome 13 is the largest acrocentric human chromosome. It carries genes involved in cancer including the breast cancer type 2 (BRCA2) and retinoblastoma (RB1) genes, is frequently rearranged in B-cell chronic lymphocytic leukaemia, and contains the DAOA locus associated with bipolar disorder and schizophrenia. We describe completion and analysis of 95.5 megabases (Mb) of sequence from chromosome 13, which contains 633 genes and 296 pseudogenes. We estimate that more than 95.4% of the protein-coding genes of this chromosome have been identified, on the basis of comparison with other vertebrate genome sequences. Additionally, 105 putative non-coding RNA genes were found. Chromosome 13 has one of the lowest gene densities (6.5 genes per Mb) among human chromosomes, and contains a central region of 38 Mb where the gene density drops to only 3.1 genes per Mb.
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Papers by Catherine Hosage Norman