Papers by Carlos V Garcia Cedeño
Frontiers in Oncology
BackgroundCIMAvax-EGF is an epidermal growth factor (EGF)-depleting immunotherapy which has shown... more BackgroundCIMAvax-EGF is an epidermal growth factor (EGF)-depleting immunotherapy which has shown survival benefit as a switch maintenance treatment after platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC). The primary objective of this trial is to establish the safety and recommended phase II dose (RP2D) of CIMAvax-EGF in combination with nivolumab as second-line therapy for NSCLC.MethodsPatients with immune checkpoint inhibitor-naive metastatic NSCLC were enrolled using a “3+3” dose-escalation design. Toxicities were graded according to CTCAE V4.03. Thirteen patients (one unevaluable), the majority with PD-L1 0%, were enrolled into two dose levels of CIMAvax-EGF.FindingsThe combination was determined to be safe and tolerable. The recommended phase 2 dose of CIMAvax-EGF was 2.4 mg. Humoral response to CIMAvax-EGF was achieved earlier and in a greater number of patients with the combination compared to historical control. Four out of 12 evaluable patients had...
PLOS Genetics
MDM2 and MDM4 are key regulators of p53 and function as oncogenes when aberrantly expressed. MDM2... more MDM2 and MDM4 are key regulators of p53 and function as oncogenes when aberrantly expressed. MDM2 and MDM4 partner to suppress p53 transcriptional transactivation and polyubiquitinate p53 for degradation. The importance of MDM2 E3-ligase-mediated p53 regulation remains controversial. To resolve this, we generated mice with an Mdm2 L466A mutation that specifically compromises E2 interaction, abolishing MDM2 E3 ligase activity while preserving its ability to bind MDM4 and suppress p53 transactivation. Mdm2L466A/L466A mice exhibit p53-dependent embryonic lethality, demonstrating MDM2 E3 ligase activity is essential for p53 regulation in vivo. Unexpectedly, cells expressing Mdm2L466A manifest cell cycle G2-M transition defects and increased aneuploidy even in the absence of p53, suggesting MDM2 E3 ligase plays a p53-independent role in cell cycle regulation and genome integrity. Furthermore, cells bearing the E3-dead MDM2 mutant show aberrant cell cycle regulation in response to DNA dam...
Neutrosophic sets and its application to decision support have become a topic of great importance... more Neutrosophic sets and its application to decision support have become a topic of great importance. In this paper, a new model for decision making for software quality appraisal is presented based on single valued neutrosophic number (SVN-numbers) and the fuzzy decision map method (FDM). The proposed framework is composed of four activities, framework, criteria weighting, gathering information and rating alternatives. Software alternatives are rated based on aggregation operator and the ranking of alternatives is based on scoring and accu-racy functions. The FDM method is included and allows a correct weighting of different criteria involved. Addi-tionally the common decision resolution scheme for helping decision maker to reach a reliable decision is used giving methodological support t. A case study is developed showing the applicability of the proposal for software quality appraisal. Further works will concentrate in extending the proposal for group decision making and developing ...
A framework for selecting cloud computing services based on consensus under single valued neutrosophic numbers
Many organizations are seeking to contract services from cloud computing with many cloud services... more Many organizations are seeking to contract services from cloud computing with many cloud services available and numerous criteria that should be counted in the selection process. Therefore, the selection process of cloud services can be considered as a type of multi-criteria decision analysis problems with multiples stakeholders.
Hygienic quality of the meat obtained at slaughterhouses in Manabí-Ecuador
RECUS. Revista Electrónica Cooperación Universidad Sociedad. ISSN 2528-8075, 2019
La harina de Zapallo posee la capacidad de esponjar la masa cárnica al incorporar agua, facilitan... more La harina de Zapallo posee la capacidad de esponjar la masa cárnica al incorporar agua, facilitando la capacidad de retención y mejorando la cohesión de las partículas de los diferentes ingredientes, la cerveza congelada mejora las características organolépticas de los productos cárnicos. El objetivo del presente trabajo fue evaluar el efecto de la adición de harina de Zapallo y cerveza congelada (tipo Pilsen) en las características bromatológicas y organolépticas de la mortadela Bologna. La elaboración de la harina de Zapallo se realizó a través del proceso de secado con circulación de aire, molienda y tamizado, para ser utilizada posteriormente como insumo en la elaboración de la mortadela Bologna, se utilizó cerveza congelada para bajar la temperatura de la masa cárnica y agregarle una innovación al producto. El producto cárnico se realizó por triplicado bajo las mismas condiciones, la unidad experimental formulada fue de 1 kilogramo por muestra. Se analizó la composición nutrici...
Proyecto: Manejo y Globalización de los Residuos Hospitalarios en el Distrito de Chitré
El ambiente es un factor determinante para la calidad de vida de una comunidad por ende es cuesti... more El ambiente es un factor determinante para la calidad de vida de una comunidad por ende es cuestion de todos velar por su preservacion. Debido a lo antes expuesto, surge el interes por realizar un estudio sobre el Manejo y Disposicion Final de los Residuos Hospitalarios en el Distrito de Chitre. Este estudio tiene como objetivos generales: 1 Analizar la situacion actual del manejo y disposicion final de los residuos hospitalarios en el Distrito de Chitre. 2. Recomendar alternativas de tratamiento de residuos hospitalarios.·
Sanitary quality in operators, utensils, and water at five municipality slaughterhouses in the province of Manabi, Ecuador
To know the sanitary situation of five slaughterhouses of the province of Manabí in Ecuador, swab... more To know the sanitary situation of five slaughterhouses of the province of Manabí in Ecuador, swab samples were taken form operators’ hands, forearms, chests, and knives. The counts of mesophilic aerobes, total coliforms and thermo-tolerant coliforms made in the samples were too high. The water used did not either meet the microbiological requisites for the drinkable water required for processing foods. It was concluded that these slaughterhouses did not have the necessary sanitary conditions to obtain bovine carcasses with low contaminations of the microorganisms examined.
Status of the neuromyelitis optica spectrum disorder in Latin America
Multiple Sclerosis and Related Disorders, 2021
BACKGROUND Neuromyelitis optica spectrum disorders (NMOSD) is an increasing diagnostic and therap... more BACKGROUND Neuromyelitis optica spectrum disorders (NMOSD) is an increasing diagnostic and therapeutic challenge in Latin America (LATAM). Despite the heterogeneity of this population, ethnic and socioeconomic commonalities exist, and epidemiologic studies from the region have had a limited geographic and population outreach. Identification of some aspects from the entire region are lacking. OBJECTIVES To determine ethnic, clinical characteristics, and utilization of diagnostic tools and types of therapy for patients with NMOSD in the entire Latin American region. METHODS The Latin American Committee for Treatment and Research in MS (LACTRIMS) created an exploratory investigational survey addressed by Invitation to NMOSD Latin American experts identified through diverse sources. Data input closed after 30 days from the initial invitation. The questionnaire allowed use of absolute numbers or percentages. Multiple option responses covering 25 themes included definition of type of practice; number of NMOSD cases; ethnicity; utilization of the 2015 International Panel criteria for the diagnosis of Neuromyelitis optica (IPDN); clinical phenotypes; methodology utilized for determination of anti-Aquaporin-4 (anti- AQP4) antibodies serological testing, and if this was performed locally or processed abroad; treatment of relapses, and long-term management were surveyed. RESULTS We identified 62 investigators from 21 countries reporting information from 2154 patients (utilizing the IPDN criteria in 93.9% of cases), which were categorized in two geographical regions: North-Central, including the Caribbean (NCC), and South America (SA). Ethnic identification disclosed Mestizos 61.4% as the main group. The most common presenting symptoms were concomitant presence of optic neuritis and transverse myelitis in 31.8% (p=0.95); only optic neuritis in 31.4% (more common in SA), p<0.001); involvement of the area postrema occurred in 21.5% and brain stem in 8.3%, both were more frequent in the South American cases (p<0.001). Anti-AQP4 antibodies were positive in 63.9% and anti-Myelin Oligodendrocyte Glycoprotein (MOG) antibodies in 4.8% of total cases. The specific laboratorial method employed was not known by 23.8% of the investigators. Acute relapses were identified in 81.6% of cases, and were treated in 93.9% of them with intravenous steroids (IVS); 62.1% with plasma exchange (PE), and 40.9% with intravenous immunoglobulin-G (IVIG). Therapy was escalated in some cases due to suboptimal initial response. Respondents favored Rituximab as long-term therapy (86.3%), whereas azathioprine was also utilized on 81.8% of the cases, either agent used indistinctly by the investigators according to treatment accessibility or clinical judgement. There were no differences among the geographic regions. CONCLUSIONS This is the first study including all countries of LATAM and the largest cohort reported from a multinational specific world area. Ethnic distributions and phenotypic features of the disease in the region, challenges in access to diagnostic tools and therapy were identified. The Latin American neurological community should play a determinant role encouraging and advising local institutions and health officials in the availability of more sensitive and modern diagnostic methodology, in facilitating the the access to licensed medications for NMOSD, and addressing concerns on education, diagnosis and management of the disease in the community.
Abstract CT130: Evidence for synergistic immune responses in the first-in-human (FIH) combination of B cell-activating immunotherapy (IO) with anti-PD1 immune checkpoint inhibitor nivolumab (N) as 2nd-line therapy in patients (pts) with advanced non-small cell lung cancer (aNSCLC)
Cancer Research, 2020
Introduction: While combined immunotherapeutic activation of B and T cells is predicted to synerg... more Introduction: While combined immunotherapeutic activation of B and T cells is predicted to synergistically enhance both humoral and cell-mediated immunity, this has not been previously tested in human cancer patients. To assess this, we conducted the FIH trial combining B cell-activating IO (CIMAvax-EGF (C)) with T cell-activating IO (PD-1 blockade with nivolumab (N)). C activates B cells to produce endogenous anti-epidermal growth factor (EGF) antibodies (Abs) that deplete EGF from circulation. As a single agent maintenance therapy in aNSCLC, C prolonged overall survival (OS) in a randomized phase III trial. We now present immune correlates of improved OS with this novel combination. Methods: We reported safety and preliminary efficacy data from 13 pts from the phase I study of C+N (AACR 2019). Serial blood samples were analyzed by Luminex for dynamic changes in circulating cytokines and proteins implicated in EGF signaling, and by flow cytometry for peripheral blood mononuclear ce...
A mis padres, Isaac y Sonia, por todo el esfuerzo entregado durante toda su vida para poder cumpl... more A mis padres, Isaac y Sonia, por todo el esfuerzo entregado durante toda su vida para poder cumplir esta meta y hacer cumplir mis sueños……Ser un profesional. A un ser muy especial, Mamá Dila, quien es mi guía para edificar mis principios y valores durante toda mi vida. VI AGRADECIMIENTO A mis padres, Isaac Paillacho y Sonia Cedeño, por brindarme su apoyo incondicionalmente cuando más lo necesitaba y ser los pilares principales para alcanzar esta meta. Al Ing. Salomón Gutt, Gerente de Palmeras de los Andes, por todo el apoyo brindado para que mis estudios continuaran durante mi carrera.
Revista Abra, 1990
En el trabajo que se nos asigna hoy, análisis del tema "Educación y Desarrollo: Elementos de la C... more En el trabajo que se nos asigna hoy, análisis del tema "Educación y Desarrollo: Elementos de la Crisis", generalmente se piensa, como se planteó al principio de este coloquio, que ambos términos se refieren a procesos diferentes. En efecto, cuando se consultan diferentes autores, algunos de ellos perciben la educación como una consecuencia y otros autores prefieren más bien considerar la educación. Como un requisito, entre otros indicadores, del desarrollo-La perspectiva con que hoy quiero referirme al problema, sugiere más bien una relación dialéctica entre educación y desarrollo. En ese sentido, y para los propósitos de este coloquio, considero educación y desarrollo un elemento de una misma problemática Educación es desarrollo, la educación como fundamento del proceso social, económico, cultural, tecnológico, etc., no se discute. En este sentido, dice Humberto Pérez "por ser el fundamento de cualquier renovación económico-social, poi ítica o estética, la educación es el factor principal y quizás el único medio suficiente para lograr el progreso y el desarrollo integral de Costa Rica y de toda nación. Por tanto, el sistema educativo del país si ha de llegar a ser una fuerza real y positiva para el desarrollo nacional, debe de tener una orientación filosófica clara y definida, formulada por educadores con el concurso de sociólogos, economistas, políticos, científicos, psicólogos y otros profesionales, porque debe estar estrechamente relacionada con los problemas y las oportunidades del país, y con el plan de desarrollo que éste se ha trazado?', Entonces, si la educación ha de contribuir a promover una nueva, una mejor unidad cultural,
Estudio espacial de la incidencia de parásitos helmintos en peces tiro (Goodea atripinnis) del lago de Pátzcuaro, Michoacán
Biologicas Revista De La Des Ciencias Biologico Agropecuarias Universidad Michoacana De San Nicolas De Hidalgo, Jun 22, 2013
En este trabajo se realizo un diagnostico de la parasitosis del tiro Goodea atripinnis en cuatros... more En este trabajo se realizo un diagnostico de la parasitosis del tiro Goodea atripinnis en cuatrositios especificos del lago de Patzcuaro Michoacan: Punta Santiago, Jaracuaro, Ucasanastacua ySanta Fe. La colecta de ejemplares se llevo a cabo en los meses de mayo a noviembre del 2007,mediante una red tipo chinchorro, de 30 m. por 2 m. y abertura de malla de 0.5 cm., con la que secolectaron un total de 68 peces. Se realizo una revision externa e interna de los organismos quepermitio cuantificar e identificar los helmintos presentes. Se encontraron un total de seis especiesde helmintos, pertenecientes a cuatro grupos: nematodos, trematodos, cestodos e hirudineos. Deacuerdo al total de hospederos estudiados, la abundancia de Posthodiplostomum minimum en suforma de metacercaria representa el parasito que ataca en mayor cantidad al tiro G. atripinnis, y enforma secundaria el adulto de Rhabdochona lichtenfelsi.
Los automóviles que utilizan turbos convencionales tienen el inconveniente que a bajas revoluci... more Los automóviles que utilizan turbos convencionales tienen el inconveniente que a bajas revoluciones del motor, el rodete de la turbina apenas es impulsada por los gases de escape, por lo que el motor se comporta como si fuera atmosférico. Para corregir este inconveniente se ha buscado la solución de dotar a una misma máquina soplante la capacidad de comprimir el aire con eficacia tanto a bajas como a altas revoluciones, para ello se han desarrollado los turbocompresores de geometría variable. Abrimos la carpeta y observamos las gráficas y el archivo de Excel con los datos, podemos hacer uso de éstos a conveniencia para realizar un análisis más profundo y también para realizar las guías de prácticas.
The effects of MPOA cGMP manipulation on dopamine levels and copulation in male rats
Estudio preliminar de una estrella de Bosones
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Papers by Carlos V Garcia Cedeño