Abstract. We consider global attractors Af of dissipative parabolic equa-tions ut = uxx + f(x, u,... more Abstract. We consider global attractors Af of dissipative parabolic equa-tions ut = uxx + f(x, u, ux) on the unit interval 0 ≤ x ≤ 1 with Neumann boundary conditions. A permu-tation πf is defined by the two orderings of the set of (hyperbolic) equilibrium solutions ut ≡ 0 ...
... equations Bernold Fiedler Institut f ur Mathematik I Freie Universit at Berlin Arnimallee 2-6... more ... equations Bernold Fiedler Institut f ur Mathematik I Freie Universit at Berlin Arnimallee 2-6 D-14195 Berlin GERMANY Carlos Rocha Dept. de Matematica Instituto Superior Tecnico Avenida Rovisco Pais 1096 Lisboa Codex PORTUGAL version of December 6, 1995 Page 2. ...
We consider Neumann boundary value problems of the form u xx +f(x, u, u x )=0 on the unit interva... more We consider Neumann boundary value problems of the form u xx +f(x, u, u x )=0 on the unit interval 0 x 1 for a certain class of dissipative nonlinearities f. Associated to these problems we have (i) meanders in the phase space (u, u x ) 2 , which are connected oriented simple curves ...
One mechanism by which dengue (DEN) virus may cause cell death is apoptosis. In this study, we in... more One mechanism by which dengue (DEN) virus may cause cell death is apoptosis. In this study, we investigated whether the genetic determinants responsible for acquisition by DEN type 1 (DEN-1) virus of mouse neurovirulence interfere with the induction of apoptosis. Neurovirulent variant FGA/NA d1d was generated during the adaptation of the human isolate of DEN-1 virus strain FGA/89 to grow in newborn mouse brains and mosquito cells in vitro [Desprès, P. Frenkiel, M. -P. Ceccaldi, P.-E. Duarte Dos Santos, C. and Deubel, V. (1998) J. Virol., 72: 823-829]. Genetic determinants possibly responsible for mouse neurovirulence were studied by sequencing the entire genomes of both DEN-1 viruses. Three amino acid differences in the envelope E protein and one in the nonstructural NS3 protein were found. The cytotoxicity of the mouse-neurovirulent DEN-1 variant was studied in different target cells in vitro and compared with the parental strain. FGA/NA d1d was more pathogenic for mouse neuroblastoma cells and attenuated for human hepatoma cells. Changes in virus replicative functions and virus assembly may account, in a large part, for the differences in the induction of apoptosis. Our data suggest that identified amino acid substitutions in the envelope E protein and viral RNA helicase NS3 may influence DEN-1 virus pathogenicity by altering viral growth.
O presente artigo pretende investigar as raízes cínicas que se fazem presentes na eudemonologia s... more O presente artigo pretende investigar as raízes cínicas que se fazem presentes na eudemonologia schopenhaueriana, tendo em vista a possibilidade de melhor compreender tal orientação para uma "vida menos infeliz". Partindo da leitura que Schopenhauer desenvolve acerca da prática de vida dos cínicos, compreendida como matriz da elaboração teórica do estoicismo, pretende-se considerar quais elementos estariam significativamente presentes em sua proposta de uma "ética empírica" para enfrentar o "mal de viver".
Abstract. We consider global attractors Af of dissipative parabolic equa-tions ut = uxx + f(x, u,... more Abstract. We consider global attractors Af of dissipative parabolic equa-tions ut = uxx + f(x, u, ux) on the unit interval 0 ≤ x ≤ 1 with Neumann boundary conditions. A permu-tation πf is defined by the two orderings of the set of (hyperbolic) equilibrium solutions ut ≡ 0 ...
... equations Bernold Fiedler Institut f ur Mathematik I Freie Universit at Berlin Arnimallee 2-6... more ... equations Bernold Fiedler Institut f ur Mathematik I Freie Universit at Berlin Arnimallee 2-6 D-14195 Berlin GERMANY Carlos Rocha Dept. de Matematica Instituto Superior Tecnico Avenida Rovisco Pais 1096 Lisboa Codex PORTUGAL version of December 6, 1995 Page 2. ...
We consider Neumann boundary value problems of the form u xx +f(x, u, u x )=0 on the unit interva... more We consider Neumann boundary value problems of the form u xx +f(x, u, u x )=0 on the unit interval 0 x 1 for a certain class of dissipative nonlinearities f. Associated to these problems we have (i) meanders in the phase space (u, u x ) 2 , which are connected oriented simple curves ...
One mechanism by which dengue (DEN) virus may cause cell death is apoptosis. In this study, we in... more One mechanism by which dengue (DEN) virus may cause cell death is apoptosis. In this study, we investigated whether the genetic determinants responsible for acquisition by DEN type 1 (DEN-1) virus of mouse neurovirulence interfere with the induction of apoptosis. Neurovirulent variant FGA/NA d1d was generated during the adaptation of the human isolate of DEN-1 virus strain FGA/89 to grow in newborn mouse brains and mosquito cells in vitro [Desprès, P. Frenkiel, M. -P. Ceccaldi, P.-E. Duarte Dos Santos, C. and Deubel, V. (1998) J. Virol., 72: 823-829]. Genetic determinants possibly responsible for mouse neurovirulence were studied by sequencing the entire genomes of both DEN-1 viruses. Three amino acid differences in the envelope E protein and one in the nonstructural NS3 protein were found. The cytotoxicity of the mouse-neurovirulent DEN-1 variant was studied in different target cells in vitro and compared with the parental strain. FGA/NA d1d was more pathogenic for mouse neuroblastoma cells and attenuated for human hepatoma cells. Changes in virus replicative functions and virus assembly may account, in a large part, for the differences in the induction of apoptosis. Our data suggest that identified amino acid substitutions in the envelope E protein and viral RNA helicase NS3 may influence DEN-1 virus pathogenicity by altering viral growth.
O presente artigo pretende investigar as raízes cínicas que se fazem presentes na eudemonologia s... more O presente artigo pretende investigar as raízes cínicas que se fazem presentes na eudemonologia schopenhaueriana, tendo em vista a possibilidade de melhor compreender tal orientação para uma "vida menos infeliz". Partindo da leitura que Schopenhauer desenvolve acerca da prática de vida dos cínicos, compreendida como matriz da elaboração teórica do estoicismo, pretende-se considerar quais elementos estariam significativamente presentes em sua proposta de uma "ética empírica" para enfrentar o "mal de viver".
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