El descubrimiento de los números irracionales introduce una ruptura en la visión de mundo del hom... more El descubrimiento de los números irracionales introduce una ruptura en la visión de mundo del hombre de la Grecia antigua. En este trabajo se analiza brevemente la época posterior a ese descubrimiento, tal como incidentalmente aparece en el Menón, en especial donde Sócrates interroga a un joven esclavo. De manera más extensa se describe la época anterior, pero no directamente, sino por medio de la descripción de un instrumento de múltiples funciones: el gnomón.
Proyecto académico sin fines de lucro, desarrollado bajo la iniciativa de acceso abierto 1 Como É... more Proyecto académico sin fines de lucro, desarrollado bajo la iniciativa de acceso abierto 1 Como Étienne de La Boëtie lo pone de manifiesto en el Discurso sobre la servidumbre voluntaria [Estudio preliminar, traducción y notas de J. M. Hernández Rubio], Madrid, Tecnos, 1986. Variaciones semióticas del acorde.
The Pioglitazone In Prevention Of Diabetes (PIPOD) study was conducted to evaluate β-cell functio... more The Pioglitazone In Prevention Of Diabetes (PIPOD) study was conducted to evaluate β-cell function, insulin resistance, and the incidence of diabetes during treatment with pioglitazone in Hispanic women with prior gestational diabetes who had completed participation in the Troglitazone In Prevention Of Diabetes (TRIPOD) study. Women who completed the TRIPOD study were offered participation in the PIPOD study for a planned 3 years of drug treatment and 6 months of postdrug washout. Oral glucose tolerance tests were performed annually on pioglitazone and at the end of the postdrug washout. Intravenous glucose tolerance tests (IVGTTs) for assessment of insulin sensitivity and β-cell function were conducted at baseline, after 1 year on pioglitazone, and at the end of the postdrug washout. Of 95 women who were not diabetic at the end of the TRIPOD study, 89 enrolled in the PIPOD study, 86 completed at least one follow-up visit, and 65 completed all study visits, including the postdrug te...
Background and aims: The prevalence of the metabolic syndrome increases with age, although only f... more Background and aims: The prevalence of the metabolic syndrome increases with age, although only few data are available about its prevalence in the general elderly population. This study describes the prevalence of the metabolic syndrome in an elderly population, and its ...
El objetivo general de esta investigación es analizar el acoso laboral desde una perspectiva doct... more El objetivo general de esta investigación es analizar el acoso laboral desde una perspectiva doctrinal y jurídica. Se pretende enfatizar en la importancia que tiene eliminar este tipo de acciones que afectan los derechos de los trabajadores y en general el entorno de trabajo. Se trata de una investigación bibliográfica doctrinal y jurídica cuyo resultado ha determinado que el acoso laboral no solamente se presenta como un factor palpable desde la perspectiva de la realidad laboral en el mundo del trabajo, sino que requiere una reformulación jurídica mediante la elaboración de anteproyectos, leyes o reformas a leyes vigentes cuya efectividad en este tema no es la más conveniente.
Recent Patents on Anti-Infective Drug Discovery, 2016
According to the World Health Organization, as of 2014 9% of the world&am... more According to the World Health Organization, as of 2014 9% of the world's adult population is affected by diabetes. Uncontrolled diabetes is a pro-inflammatory process that increases generation of reactive oxygen species (ROS). The production of ROS leads to a chronic increase in oxidative stress which results in an increased susceptibility to infections. Individuals with type 2 diabetes mellitus (T2DM) are highly susceptible to Mycobacterium tuberculosis (M. tb) infection. Previous research has demonstrated that glutathione (GSH) plays an important role in the control of M. tb infection. Recent studies have demonstrated that phagocytosis of M. tb is diminished in patients with T2DM. Phagocytosis in macrophages is thought to be mediated in part by complement protein 3b (C3b)-complement protein receptor 3b (C3R) interactions. Since C3b production is not diminished in patients with T2DM we propose that C3R production is reduced and is the cause for impaired macrophage phagocytosis as well as IL-12 and IFN-γ signaling. This study utilizes a quantitative PCR (qPCR), demonstrating decreased transcription of C3R mRNA in patients with T2DM as compared to non-diabetics.
OBJECTIVE—We have tested whether the Pro12Ala variant of the peroxisome proliferator–activated re... more OBJECTIVE—We have tested whether the Pro12Ala variant of the peroxisome proliferator–activated receptor (PPAR)-γ nuclear receptor involved in thiazolidinedione (TZD) action accounted for the failure of troglitazone to increase insulin sensitivity in nondiabetic Hispanic women with previous gestational diabetes treated in the Troglitazone in Prevention of Diabetes (TRIPOD) study. RESEARCH DESIGN AND METHODS—Ninety-three women assigned to troglitazone had intravenous glucose tolerance tests at randomization and after 3 months of treatment with troglitazone, 400 mg/day, and were genotyped for the Pro12Ala variant of the PPAR-γ gene. Subjects were divided into tertiles based on their change in minimal model insulin sensitivity (Si) during the first 3 months of troglitazone treatment. RESULTS—The mean changes in Si in the bottom, middle, and top tertiles of Si response were −0.21 ± 0.57, 0.91 ± 0.26, and 2.58 ± 1.32 min−1 per μU/ml · 10−4, respectively. Frequencies of the Ala/− genotype ...
Uno de los teóricos literarios latinoamericanos más lúcidos, Cornejo Polar, usó en sus últimos es... more Uno de los teóricos literarios latinoamericanos más lúcidos, Cornejo Polar, usó en sus últimos escritos las nociones de sistema literario y de heterogeneidad. La historia de esas nociones se remonta a la obra de los formalistas rusos y, posteriormente, a Bajtín, pero también se relacionan con la noción
We tested the effects of treatment with a thiazolidinedione drug on rates of progression of carot... more We tested the effects of treatment with a thiazolidinedione drug on rates of progression of carotid intima-media thickness (CIMT) and some putative determinants of CIMT in young women at high risk for type 2 diabetes. A total of 266 nondiabetic, Hispanic women with recent ...
RESULTSThe mean changes in S i in the bottom, middle, and top tertiles of S i response were −0.2... more RESULTSThe mean changes in S i in the bottom, middle, and top tertiles of S i response were −0.21 ± 0.57, 0.91 ± 0.26, and 2.58 ± 1.32 min −1 per μU/ml · 10 −4 , respectively. Frequencies of the Ala/− genotype were 30, 22, and 26% in the same three tertiles (P = 0.77). Analysis ...
El descubrimiento de los números irracionales introduce una ruptura en la visión de mundo del hom... more El descubrimiento de los números irracionales introduce una ruptura en la visión de mundo del hombre de la Grecia antigua. En este trabajo se analiza brevemente la época posterior a ese descubrimiento, tal como incidentalmente aparece en el Menón, en especial donde Sócrates interroga a un joven esclavo. De manera más extensa se describe la época anterior, pero no directamente, sino por medio de la descripción de un instrumento de múltiples funciones: el gnomón.
Proyecto académico sin fines de lucro, desarrollado bajo la iniciativa de acceso abierto 1 Como É... more Proyecto académico sin fines de lucro, desarrollado bajo la iniciativa de acceso abierto 1 Como Étienne de La Boëtie lo pone de manifiesto en el Discurso sobre la servidumbre voluntaria [Estudio preliminar, traducción y notas de J. M. Hernández Rubio], Madrid, Tecnos, 1986. Variaciones semióticas del acorde.
The Pioglitazone In Prevention Of Diabetes (PIPOD) study was conducted to evaluate β-cell functio... more The Pioglitazone In Prevention Of Diabetes (PIPOD) study was conducted to evaluate β-cell function, insulin resistance, and the incidence of diabetes during treatment with pioglitazone in Hispanic women with prior gestational diabetes who had completed participation in the Troglitazone In Prevention Of Diabetes (TRIPOD) study. Women who completed the TRIPOD study were offered participation in the PIPOD study for a planned 3 years of drug treatment and 6 months of postdrug washout. Oral glucose tolerance tests were performed annually on pioglitazone and at the end of the postdrug washout. Intravenous glucose tolerance tests (IVGTTs) for assessment of insulin sensitivity and β-cell function were conducted at baseline, after 1 year on pioglitazone, and at the end of the postdrug washout. Of 95 women who were not diabetic at the end of the TRIPOD study, 89 enrolled in the PIPOD study, 86 completed at least one follow-up visit, and 65 completed all study visits, including the postdrug te...
Background and aims: The prevalence of the metabolic syndrome increases with age, although only f... more Background and aims: The prevalence of the metabolic syndrome increases with age, although only few data are available about its prevalence in the general elderly population. This study describes the prevalence of the metabolic syndrome in an elderly population, and its ...
El objetivo general de esta investigación es analizar el acoso laboral desde una perspectiva doct... more El objetivo general de esta investigación es analizar el acoso laboral desde una perspectiva doctrinal y jurídica. Se pretende enfatizar en la importancia que tiene eliminar este tipo de acciones que afectan los derechos de los trabajadores y en general el entorno de trabajo. Se trata de una investigación bibliográfica doctrinal y jurídica cuyo resultado ha determinado que el acoso laboral no solamente se presenta como un factor palpable desde la perspectiva de la realidad laboral en el mundo del trabajo, sino que requiere una reformulación jurídica mediante la elaboración de anteproyectos, leyes o reformas a leyes vigentes cuya efectividad en este tema no es la más conveniente.
Recent Patents on Anti-Infective Drug Discovery, 2016
According to the World Health Organization, as of 2014 9% of the world&am... more According to the World Health Organization, as of 2014 9% of the world's adult population is affected by diabetes. Uncontrolled diabetes is a pro-inflammatory process that increases generation of reactive oxygen species (ROS). The production of ROS leads to a chronic increase in oxidative stress which results in an increased susceptibility to infections. Individuals with type 2 diabetes mellitus (T2DM) are highly susceptible to Mycobacterium tuberculosis (M. tb) infection. Previous research has demonstrated that glutathione (GSH) plays an important role in the control of M. tb infection. Recent studies have demonstrated that phagocytosis of M. tb is diminished in patients with T2DM. Phagocytosis in macrophages is thought to be mediated in part by complement protein 3b (C3b)-complement protein receptor 3b (C3R) interactions. Since C3b production is not diminished in patients with T2DM we propose that C3R production is reduced and is the cause for impaired macrophage phagocytosis as well as IL-12 and IFN-γ signaling. This study utilizes a quantitative PCR (qPCR), demonstrating decreased transcription of C3R mRNA in patients with T2DM as compared to non-diabetics.
OBJECTIVE—We have tested whether the Pro12Ala variant of the peroxisome proliferator–activated re... more OBJECTIVE—We have tested whether the Pro12Ala variant of the peroxisome proliferator–activated receptor (PPAR)-γ nuclear receptor involved in thiazolidinedione (TZD) action accounted for the failure of troglitazone to increase insulin sensitivity in nondiabetic Hispanic women with previous gestational diabetes treated in the Troglitazone in Prevention of Diabetes (TRIPOD) study. RESEARCH DESIGN AND METHODS—Ninety-three women assigned to troglitazone had intravenous glucose tolerance tests at randomization and after 3 months of treatment with troglitazone, 400 mg/day, and were genotyped for the Pro12Ala variant of the PPAR-γ gene. Subjects were divided into tertiles based on their change in minimal model insulin sensitivity (Si) during the first 3 months of troglitazone treatment. RESULTS—The mean changes in Si in the bottom, middle, and top tertiles of Si response were −0.21 ± 0.57, 0.91 ± 0.26, and 2.58 ± 1.32 min−1 per μU/ml · 10−4, respectively. Frequencies of the Ala/− genotype ...
Uno de los teóricos literarios latinoamericanos más lúcidos, Cornejo Polar, usó en sus últimos es... more Uno de los teóricos literarios latinoamericanos más lúcidos, Cornejo Polar, usó en sus últimos escritos las nociones de sistema literario y de heterogeneidad. La historia de esas nociones se remonta a la obra de los formalistas rusos y, posteriormente, a Bajtín, pero también se relacionan con la noción
We tested the effects of treatment with a thiazolidinedione drug on rates of progression of carot... more We tested the effects of treatment with a thiazolidinedione drug on rates of progression of carotid intima-media thickness (CIMT) and some putative determinants of CIMT in young women at high risk for type 2 diabetes. A total of 266 nondiabetic, Hispanic women with recent ...
RESULTSThe mean changes in S i in the bottom, middle, and top tertiles of S i response were −0.2... more RESULTSThe mean changes in S i in the bottom, middle, and top tertiles of S i response were −0.21 ± 0.57, 0.91 ± 0.26, and 2.58 ± 1.32 min −1 per μU/ml · 10 −4 , respectively. Frequencies of the Ala/− genotype were 30, 22, and 26% in the same three tertiles (P = 0.77). Analysis ...
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