e22061 Background: There is a great need to detect gastrointestinal cancers at an early stage, re... more e22061 Background: There is a great need to detect gastrointestinal cancers at an early stage, reduce morbidity and mortality. CEA and CA 19-9 are widely used serological markers for gastrointestinal cancers during follow-up. Their utility are limited because of their low sensitivity. In this study, a novel tumor marker DR-70 is evaluated for the sensitivity and specificity, relationship between clinical parameters and compared with CEA and CA 19-9. Methods: Blood sera of 101 histologically proven gastrointestinal cancer patients (38 female, 63 male; 42 colon, 25 rectum, 18 stomach, 9 pancreas, 4 esophagus and 3 cholangiocellular carcinomas) and 105 healthy blood donors were included. The TNM stage of the disease and histologic grade was shown. All patients and controls were also tested for CEA and CA 19-9 levels. In DR-70 immunoassay, the fibrin degradation products were quantitatively measured using ELISA DR-70 kits. Results: The median DR-70, CEA and CA19-9 levels were 1.6 µg/mL,...
e14646 Background: Colorectal cancer is the fourth most frequently diagnosed cancer, and the seco... more e14646 Background: Colorectal cancer is the fourth most frequently diagnosed cancer, and the second leading cause of cancer death in US. Most common localisation of metastasis are the lymph nodes a...
ABSTRACT Aim: Neoadjuvant chemotherapy (NAC) is used longer for both locally advanced breast canc... more ABSTRACT Aim: Neoadjuvant chemotherapy (NAC) is used longer for both locally advanced breast cancer and early stage to increase breast conservation. Discordance of the hormone receptor (HR) status was reported to be 8-33% of the breast cancer after NAC. The aim of this study was to compare the HR and HER2/neu status between core needle biopsy (CNB) and residual tumour after surgery of breast cancer treated with NAC and also to evaluate effect of discordance and other clinicopathological factors on survival. Methods: Oestrogen receptor (ER), progesterone receptor (PR) and HER2/neu status were evaluated by immunohistochemistry on 90 CNB of primary tumours and surgical specimens after NAC and 53 patients without NAC as a control group, and then discordance was compared between the two groups. The Chi-Square test was used to evaluate the relationship between discordance and other clinicopathological factors. The association between discordance of HR status after NAC and various other clinicopathological factors was also tested with Spearmen's test. Results: Pathological complete response (PCR) was achieved for 10 (11.1%) patients after NAC. ER and PR were changed significantly more than in the control group. ER and PR discordance were detected in 10 (12.5%) and 17 (21.2%) patients, respectively, in the NAC group, and in 1 (1.8%) and 2 (3.7%) patients in the control group, respectively (p = 0.04 and p = 0.005). ER discordance was related with HER2/neu alteration. Furthermore, PR discordance correlated with CNB, ER and treatment response while HER2/neu discordance was associated with treatment response (p = 0.05). ER discordance was found to be an important prognostic factor for PFS (p = 0.02). Table: 336P . Hormone receptor changes after NAC markers negative-negative positive-positive negative-positive poitive-negative change% ER control NAC 4 25 48 45 1 1 0 9 1.8 12.5 PR control NAC 5 22 46 41 2 7 0 10 3.7 21.2 Her2/NEU control NAC 41 42 4 18 0 2 1 6 1.8 10 Conclusions: NAC might cause alterations in ER, PR or HER2/neu status of tumours in breast cancer. It should be re-tested in the residual tumour after NAC to optimize adjuvant therapy. Disclosure: All authors have declared no conflicts of interest.
AIDS nephropathies, 12(0.32%) cases with medullary sponge kidney, 3(0.08%) persistent fetal lobul... more AIDS nephropathies, 12(0.32%) cases with medullary sponge kidney, 3(0.08%) persistent fetal lobulation, 2(0.05%) intrarenal post-biopsy arterio-venous fistulas, 3 (0.08%) renal hydatid cysts, 2 (0.05%) cases with bilateral angiomatosis-tuberous sclerosis, 35 (0.95%) renal unilateral artery stenosis-one partial, one case with bilateral fibrocystic dysplasia. Positive predictive value in all cases was 98%, with a 100% sensibility and 98% sensitivity of the positive diagnosis. CONCLUSIONS: Rare kidney diseases are considered very hard to diagnose because of the low incidence and lack of simptoms in many cases. Therefore we shoud think of them more often in order to detect them. Ultrasound is a very useful, accessible, costefective method for the diagnosis.
Peritoneal mesotheliomas are aggressive tumors arising from the peritoneal mesothelium. Tumor mar... more Peritoneal mesotheliomas are aggressive tumors arising from the peritoneal mesothelium. Tumor markers are biochemical substances produced by tumor cells due to the effect of malignant process. They can be used for screening, diagnosis, and predicting the prognosis. β-human chorionic β-human chorionic gonadotrophin (β-hCG), is a marker of germ cell tumors and trophoblastic diseases. In some reports, a relationship between β-hCG and other malignant diseases has been described. Hereby, we present a case of malignant peritoneal mesothelioma associated with elevated serum β-hCG levels. A 49-year-old man was admitted to the hospital with ascites. Peritoneal mesothelioma was diagnosed with peritoneal biopsy. During the treatment period, serum β-hCG levels were elevated together with disease progression and tissue samples stained positive for β-hCG. Rising levels of serum β-hCG due to disease progression can predict the response to treatment. If these levels were elevated at the beginning of the treatment, it may be a prognostic marker for peritoneal mesothelioma. Thus, β-hCG may be an important marker for prognosis or prediction of treatment for peritoneal mesothelioma patients.
Following metastasis resection, 5-year survival rate has been reported as approximately 40%. Ther... more Following metastasis resection, 5-year survival rate has been reported as approximately 40%. There is no consensus regarding prognostic factors related to progression-free survival after repeated metastasectomies. A total of 21 patients with metastatic colorectal cancer who underwent repeated metastasectomies were retrospectively analyzed. The periods between the first and second metastasectomies and that between the second metastasectomy and progression were defined as metastasis-free survival 1 (MFS1) and metastasis-free survival 2 (MFS2), respectively. Univariate analysis was used to analyze factors related to MFS1 and MFS2. Approximately two-thirds of the patients had synchronous metastasis, which were localized mostly in the liver (90%). During a 49-months follow-up, MFS1 was 15.7 (8.4-23) months and MFS2 was 26.3 (12.3-40.4) months. Systemic chemotherapy followed the first metastasectomy (p=0.01), and the recurrence site (p=0.03) was found to be related to MFS1. Furthermore, the number of metastases during the first metastasectomy (p=0.02), the type of the chemotherapy regimen administered following the first metastasectomy (p=0.04), and the number of metastases before the second metastasectomy (p=0.03) were significantly related to MFS2. Surgical resection is currently the most effective and curative form of therapy for colorectal metastasis, whenever possible. Repeated metastasectomies can be achieved safely in experienced centers; thus, the operability of the patients should be evaluated by a multidisciplinary approach during treatment.
Purpose In the literature, small number of study has addressed time of recurrence in breast cance... more Purpose In the literature, small number of study has addressed time of recurrence in breast cancer. We analyzed clinicopathological factors predicting early or late recurrence in breast cancer patients and also prognostic factors related with recurrence-free survival (RFS) in recurrent patients. Patients/methods We evaluated retrospectively 1980 breast cancer patients. Relapsed was defined as early if it was occured first 5 year of follow-up (Group 1) and late if it was occured after 5 years (Group 2). The clinicopathological factors were compared in respect of time of recurrence. The prognostic factors were evaluated using univariate and multivariate analyses. Results Recurrence wase detected in 141 patient during follow-up. Tumors recurred after 5 years more likely to have lower stage (p = 0.05), tumors without lymphovascular invasion (LVI) (p \ 0.001) and perineural invasion (PNI) (p = 0.01), and also HER2 negative (p \ 0.001). The median RFS time and 5 years RFS rates were 42.9 months and 31.9 %, respectively. LVI (p = 0.01), PNI (p = 0.03), HER2 (p = 0.003), progesterone receptor (PR) (p = 0.04), the presence of neoadjuvant chemotherapy (p = 0.003), adjuvant hormonotherapy (p = 0.05) were found to be related with RFS. Axillary lymph node metastasis (p = 0.05) and the presence of PNI (p = 0.009) were poor prognostic factors for early recurrent group. PRpositive tumors (p = 0.001) and luminal subtypes (p = 0.03) had instances of late recurrences significantly. Conclusions Clinicopathological factors predicting the recurrence time in breast cancer were important to modify adjuvant therapy.
Akciğer kanserinde cinsiyet, tümör tipi ve diğer klinik özelliklerin sıklık ve mortalitedeki artı... more Akciğer kanserinde cinsiyet, tümör tipi ve diğer klinik özelliklerin sıklık ve mortalitedeki artışa sebep olduğu belirtilmiştir. Çalışmamızda, akciğer kanserli hastalarda klinik ve patolojik özelliklerin sağkalım üzerine etkilerini araştırdık.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology
The aim of this study was to compare the hormone receptors' (HR) and HER2/neu status between ... more The aim of this study was to compare the hormone receptors' (HR) and HER2/neu status between core needle biopsy (CNB) and residual tumor after surgery of breast cancer treated with neoadjuvant chemotherapy (NAC), and also to evaluate the impact of discordance and other clinicopathological factors on survival. Oestrogen receptor (ER), progesterone receptor (PR) and HER2/neu status were evaluated by immunohistochemistry (IHC) on 90 CNBs of primary tumors and surgical specimens after NAC (study group); 53 patients without NAC served as control group, and discordance was compared between the two groups. The association between discordance of HR status after NAC and various other clinicopathological factors was tested with Spearman's test. Pathological complete response (PCR) was achieved in 10 (11.1%) patients after NAC. ER and PR changed significantly more in the study than in the control group. ER and PR discordance was detected in 10 (12.5%) and 17 (21.2%) patients in the NAC...
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2014
Figure 1. The neuroendocrine (arrow head), and the squamous (star) sides of tumor (chromogranine ... more Figure 1. The neuroendocrine (arrow head), and the squamous (star) sides of tumor (chromogranine staining, X4
e22061 Background: There is a great need to detect gastrointestinal cancers at an early stage, re... more e22061 Background: There is a great need to detect gastrointestinal cancers at an early stage, reduce morbidity and mortality. CEA and CA 19-9 are widely used serological markers for gastrointestinal cancers during follow-up. Their utility are limited because of their low sensitivity. In this study, a novel tumor marker DR-70 is evaluated for the sensitivity and specificity, relationship between clinical parameters and compared with CEA and CA 19-9. Methods: Blood sera of 101 histologically proven gastrointestinal cancer patients (38 female, 63 male; 42 colon, 25 rectum, 18 stomach, 9 pancreas, 4 esophagus and 3 cholangiocellular carcinomas) and 105 healthy blood donors were included. The TNM stage of the disease and histologic grade was shown. All patients and controls were also tested for CEA and CA 19-9 levels. In DR-70 immunoassay, the fibrin degradation products were quantitatively measured using ELISA DR-70 kits. Results: The median DR-70, CEA and CA19-9 levels were 1.6 µg/mL,...
e14646 Background: Colorectal cancer is the fourth most frequently diagnosed cancer, and the seco... more e14646 Background: Colorectal cancer is the fourth most frequently diagnosed cancer, and the second leading cause of cancer death in US. Most common localisation of metastasis are the lymph nodes a...
ABSTRACT Aim: Neoadjuvant chemotherapy (NAC) is used longer for both locally advanced breast canc... more ABSTRACT Aim: Neoadjuvant chemotherapy (NAC) is used longer for both locally advanced breast cancer and early stage to increase breast conservation. Discordance of the hormone receptor (HR) status was reported to be 8-33% of the breast cancer after NAC. The aim of this study was to compare the HR and HER2/neu status between core needle biopsy (CNB) and residual tumour after surgery of breast cancer treated with NAC and also to evaluate effect of discordance and other clinicopathological factors on survival. Methods: Oestrogen receptor (ER), progesterone receptor (PR) and HER2/neu status were evaluated by immunohistochemistry on 90 CNB of primary tumours and surgical specimens after NAC and 53 patients without NAC as a control group, and then discordance was compared between the two groups. The Chi-Square test was used to evaluate the relationship between discordance and other clinicopathological factors. The association between discordance of HR status after NAC and various other clinicopathological factors was also tested with Spearmen's test. Results: Pathological complete response (PCR) was achieved for 10 (11.1%) patients after NAC. ER and PR were changed significantly more than in the control group. ER and PR discordance were detected in 10 (12.5%) and 17 (21.2%) patients, respectively, in the NAC group, and in 1 (1.8%) and 2 (3.7%) patients in the control group, respectively (p = 0.04 and p = 0.005). ER discordance was related with HER2/neu alteration. Furthermore, PR discordance correlated with CNB, ER and treatment response while HER2/neu discordance was associated with treatment response (p = 0.05). ER discordance was found to be an important prognostic factor for PFS (p = 0.02). Table: 336P . Hormone receptor changes after NAC markers negative-negative positive-positive negative-positive poitive-negative change% ER control NAC 4 25 48 45 1 1 0 9 1.8 12.5 PR control NAC 5 22 46 41 2 7 0 10 3.7 21.2 Her2/NEU control NAC 41 42 4 18 0 2 1 6 1.8 10 Conclusions: NAC might cause alterations in ER, PR or HER2/neu status of tumours in breast cancer. It should be re-tested in the residual tumour after NAC to optimize adjuvant therapy. Disclosure: All authors have declared no conflicts of interest.
AIDS nephropathies, 12(0.32%) cases with medullary sponge kidney, 3(0.08%) persistent fetal lobul... more AIDS nephropathies, 12(0.32%) cases with medullary sponge kidney, 3(0.08%) persistent fetal lobulation, 2(0.05%) intrarenal post-biopsy arterio-venous fistulas, 3 (0.08%) renal hydatid cysts, 2 (0.05%) cases with bilateral angiomatosis-tuberous sclerosis, 35 (0.95%) renal unilateral artery stenosis-one partial, one case with bilateral fibrocystic dysplasia. Positive predictive value in all cases was 98%, with a 100% sensibility and 98% sensitivity of the positive diagnosis. CONCLUSIONS: Rare kidney diseases are considered very hard to diagnose because of the low incidence and lack of simptoms in many cases. Therefore we shoud think of them more often in order to detect them. Ultrasound is a very useful, accessible, costefective method for the diagnosis.
Peritoneal mesotheliomas are aggressive tumors arising from the peritoneal mesothelium. Tumor mar... more Peritoneal mesotheliomas are aggressive tumors arising from the peritoneal mesothelium. Tumor markers are biochemical substances produced by tumor cells due to the effect of malignant process. They can be used for screening, diagnosis, and predicting the prognosis. β-human chorionic β-human chorionic gonadotrophin (β-hCG), is a marker of germ cell tumors and trophoblastic diseases. In some reports, a relationship between β-hCG and other malignant diseases has been described. Hereby, we present a case of malignant peritoneal mesothelioma associated with elevated serum β-hCG levels. A 49-year-old man was admitted to the hospital with ascites. Peritoneal mesothelioma was diagnosed with peritoneal biopsy. During the treatment period, serum β-hCG levels were elevated together with disease progression and tissue samples stained positive for β-hCG. Rising levels of serum β-hCG due to disease progression can predict the response to treatment. If these levels were elevated at the beginning of the treatment, it may be a prognostic marker for peritoneal mesothelioma. Thus, β-hCG may be an important marker for prognosis or prediction of treatment for peritoneal mesothelioma patients.
Following metastasis resection, 5-year survival rate has been reported as approximately 40%. Ther... more Following metastasis resection, 5-year survival rate has been reported as approximately 40%. There is no consensus regarding prognostic factors related to progression-free survival after repeated metastasectomies. A total of 21 patients with metastatic colorectal cancer who underwent repeated metastasectomies were retrospectively analyzed. The periods between the first and second metastasectomies and that between the second metastasectomy and progression were defined as metastasis-free survival 1 (MFS1) and metastasis-free survival 2 (MFS2), respectively. Univariate analysis was used to analyze factors related to MFS1 and MFS2. Approximately two-thirds of the patients had synchronous metastasis, which were localized mostly in the liver (90%). During a 49-months follow-up, MFS1 was 15.7 (8.4-23) months and MFS2 was 26.3 (12.3-40.4) months. Systemic chemotherapy followed the first metastasectomy (p=0.01), and the recurrence site (p=0.03) was found to be related to MFS1. Furthermore, the number of metastases during the first metastasectomy (p=0.02), the type of the chemotherapy regimen administered following the first metastasectomy (p=0.04), and the number of metastases before the second metastasectomy (p=0.03) were significantly related to MFS2. Surgical resection is currently the most effective and curative form of therapy for colorectal metastasis, whenever possible. Repeated metastasectomies can be achieved safely in experienced centers; thus, the operability of the patients should be evaluated by a multidisciplinary approach during treatment.
Purpose In the literature, small number of study has addressed time of recurrence in breast cance... more Purpose In the literature, small number of study has addressed time of recurrence in breast cancer. We analyzed clinicopathological factors predicting early or late recurrence in breast cancer patients and also prognostic factors related with recurrence-free survival (RFS) in recurrent patients. Patients/methods We evaluated retrospectively 1980 breast cancer patients. Relapsed was defined as early if it was occured first 5 year of follow-up (Group 1) and late if it was occured after 5 years (Group 2). The clinicopathological factors were compared in respect of time of recurrence. The prognostic factors were evaluated using univariate and multivariate analyses. Results Recurrence wase detected in 141 patient during follow-up. Tumors recurred after 5 years more likely to have lower stage (p = 0.05), tumors without lymphovascular invasion (LVI) (p \ 0.001) and perineural invasion (PNI) (p = 0.01), and also HER2 negative (p \ 0.001). The median RFS time and 5 years RFS rates were 42.9 months and 31.9 %, respectively. LVI (p = 0.01), PNI (p = 0.03), HER2 (p = 0.003), progesterone receptor (PR) (p = 0.04), the presence of neoadjuvant chemotherapy (p = 0.003), adjuvant hormonotherapy (p = 0.05) were found to be related with RFS. Axillary lymph node metastasis (p = 0.05) and the presence of PNI (p = 0.009) were poor prognostic factors for early recurrent group. PRpositive tumors (p = 0.001) and luminal subtypes (p = 0.03) had instances of late recurrences significantly. Conclusions Clinicopathological factors predicting the recurrence time in breast cancer were important to modify adjuvant therapy.
Akciğer kanserinde cinsiyet, tümör tipi ve diğer klinik özelliklerin sıklık ve mortalitedeki artı... more Akciğer kanserinde cinsiyet, tümör tipi ve diğer klinik özelliklerin sıklık ve mortalitedeki artışa sebep olduğu belirtilmiştir. Çalışmamızda, akciğer kanserli hastalarda klinik ve patolojik özelliklerin sağkalım üzerine etkilerini araştırdık.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology
The aim of this study was to compare the hormone receptors' (HR) and HER2/neu status between ... more The aim of this study was to compare the hormone receptors' (HR) and HER2/neu status between core needle biopsy (CNB) and residual tumor after surgery of breast cancer treated with neoadjuvant chemotherapy (NAC), and also to evaluate the impact of discordance and other clinicopathological factors on survival. Oestrogen receptor (ER), progesterone receptor (PR) and HER2/neu status were evaluated by immunohistochemistry (IHC) on 90 CNBs of primary tumors and surgical specimens after NAC (study group); 53 patients without NAC served as control group, and discordance was compared between the two groups. The association between discordance of HR status after NAC and various other clinicopathological factors was tested with Spearman's test. Pathological complete response (PCR) was achieved in 10 (11.1%) patients after NAC. ER and PR changed significantly more in the study than in the control group. ER and PR discordance was detected in 10 (12.5%) and 17 (21.2%) patients in the NAC...
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2014
Figure 1. The neuroendocrine (arrow head), and the squamous (star) sides of tumor (chromogranine ... more Figure 1. The neuroendocrine (arrow head), and the squamous (star) sides of tumor (chromogranine staining, X4
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