Papers by Francisco Brandão
Palmar contact dermatitis due to (meth)acrylates
ABSTRACT
Contact Dermatitis, 1999
To test the screening value of the sesquiterpene lactone (SL) mix in Europe today and describe ep... more To test the screening value of the sesquiterpene lactone (SL) mix in Europe today and describe epidemiological and clinical features of Compositae-sensitive patients, the SL mix 0.1% pet. was included in the standard patch test series in 11 European clinics. 10,695 patients were tested, and 106 (1%) had positive reactions, 74% of which were of current or old relevance. The prevalence of positive reactions varied between 0.1 and 2.7% in different centres. The median age of the 66 females was 51.5 years, and 55.2 in the 40 males. The 20 occupationally sensitized had a higher % of males and a median age of 43 years, whereas 7 UV-sensitive patients had a median age of 72 years. Garden plants were the major suspected sensitizers and the clinical patterns were partly, in accordance with plant dermatoses in general, involving hands, forearms and face, and partly widespread eczema in a large proportion of the patients. More than 1/3 were positive to perfume and/ or colophony, possibly reflecting cross-reactivity. With only 1 case of active sensitization and no irritant reactions, the SL mix is a safe allergen and the overall prevalence of positive reactions supports its continued use in the standard patch test series.
Contact Dermatitis, 2003
Contact sensitivity to plants containing 1 or more sesquiterpene lactones (SLs) is difficult to d... more Contact sensitivity to plants containing 1 or more sesquiterpene lactones (SLs) is difficult to diagnose. The mixture of SLs (SL mix) has been shown to detect only about 60% of sensitized individuals. In order to improve the diagnosis of sensitization to plants containing SLs, we have tested a mixture of frullanolides contained in Frullania dilatata and Frullania tamarisci at 3 different concentrations (0Á01%, 0Á033% and 0Á1% in petrolatum). 8605 consecutive eczema patients in 1 North American and 15 European dermatology departments were tested with this mix, and 0Á35% of positive cases to the different concentrations were found. Routine use of this mix permitted detection of only a small percentage of extra cases and did not improve the SL mix score. The frullanolide mix should therefore be restricted to investigations in particular geographical zones and/ or in particular occupations.
A case of allergic contact dermatitis caused by propolis-enriched honey
Contact Dermatitis, 2014
Urticarial vasculitis due do infliximab
Journal of the European Academy of Dermatology and Venereology, 2008
Solitary fibrous tumour of the skin
Journal of the European Academy of Dermatology and Venereology, 2009
Journal of the European Academy of Dermatology and Venereology, 1998
We describe four cases of idiopathic plantar hidradenitis (IPH), a form of neutrophilic eccrine h... more We describe four cases of idiopathic plantar hidradenitis (IPH), a form of neutrophilic eccrine hidradenitis (NEH) localized on the feet of otherwise healthy young persons. Our patients were all males, 8-17 years old, in apparently good health, but presenting erythematous painful papules, plaques and nodules on the soles. They were afebrile and there were no constitutional symptoms. The differential diagnoses included erythema nodosum, vasculitis and traumatic plantar urticaria. The histological features of IPH are similar to those of NEH, except for the absence of syringosquamous metaplasia. The patients were treated with topical steroids and oral NSAID, with total resolution of the lesions in 1 or 2 weeks.
Journal of the American Academy of Dermatology, 2008
We have recently reported a patient with aspirininduced papuloerythroderma. 4 The patient describ... more We have recently reported a patient with aspirininduced papuloerythroderma. 4 The patient described here is the second case that was evoked by a drug. In both cases, the eruptions were different from the acute type of exanthema usually observed as drug eruption. Rather, they were chronically seen presumably in association with pre-existing eczematous dermatitis. It should be noted that widely used drugs are one of the important causative agents for papuloerythroderma.
Contact Dermatitis, 2005
A 5-year retrospective study of the frequency of sensitization to the 25 allergens of the Europea... more A 5-year retrospective study of the frequency of sensitization to the 25 allergens of the European standard series (ESS) was conducted in 10 centres in 8 European countries. Included were the results of 26 210 patients. The range in sensitivities differed moderately between the centres. Combining results of different centres and drawing conclusions on incidences can be done only with great care. The information on the ranking of the allergens and their sensitization incidence in the clinics are useful for decisions on the future composition of the standard series. The ESS is still a valid screening tool, and no substances should be deleted.
Contact Dermatitis, 2008
Background and Objectives: Hand eczema is a chronic disease with negative impact on quality of li... more Background and Objectives: Hand eczema is a chronic disease with negative impact on quality of life (QoL). In this study, QoL in hand eczema patients is assessed and related to age, sex, severity, and diagnostic subgroups.
Contact urticaria to chlorocresol
Contact Dermatitis, 1986
Contact Dermatitis, 2006
Departments of (Occupational) Dermatology, St. Thomas' Hospital, London, Departments of (Occupati... more Departments of (Occupational) Dermatology, St. Thomas' Hospital, London, Departments of (Occupational) Dermatology, Amersham Hospital, Bucks, UK Mercaptobenzothiazole (MBT) compounds are well known contact allergens. To detect rubber allergic patients we use both MBT (2% in petrolatum) and a mercapto-mix with 4 constituents of 0.5% each in our standard series. In this article the EECDRG presents data of in total 32 475 consecutive tested patients attending the respective contact dermatitis clinics from 11 centres in Europe to determine if the mix and MBT detected the same allergic patients. We found 327 patients positive to the mix or MBT, or to both. 261 were positive to the mix and 254 to MBT. MBT was negative in 73 patients who were positive to the mix. If the mix had not been in the standard series, on average 22% of patients allergic to a mercapto-compound would have been missed, for MBT this would have been on average 20%. All clinics would have missed a significant number of positive reactions if both compounds had not been tested. We conclude, that both the mercapto mix and MBT are required in the standard series.
Contact Dermatitis, 2000
This study investigated whether a corticosteroid mix containing tixocortol pivalate, budesonide, ... more This study investigated whether a corticosteroid mix containing tixocortol pivalate, budesonide, and hydrocortisone-17-butyrate could detect contact allergy to corticosteroids. 2 corticosteroid mixes, 1 with a high (mix I) and 1 with a low (mix II) concentration and the 3 individual constituents, each at 2 concentrations, were inserted into the standard series of 16 participating clinics. Tests were read on day (D) 3 or 4. 5432 patients were tested, and 110 (2.0%) had positive reactions to at least 1 of the 8 test preparations. Of the 8 preparations, mix I identified most allergic patients, followed by mix II, budesonide 0.10%, budesonide 0.002%, and tixocortol pivalate, both concentrations (1.0 and 0.10%) tracing the same number. With the mixes, 53.2-59.6% of tixocortol pivalate allergy was missed. 47 patients were allergic to either concentration of tixocortol pivalate, 25% of these only to 1.0% and another 25% only to 0.10%. Testing with mix I and tixocortol pivalate 0.10% picked up 98/110, testing with tixocortol pivalate 1.0% and 0.10% and budesonide 0.10% picked up 105/110. 3379 patients were read on both D3 or D4 as well as on D7. Without a late reading (D7), up to 30% of contact allergy to corticosteroid markers was missed.
FS01.2 Contact dermatitis to disperse blue 106 in Portugal
Contact Dermatitis, 2008
ABSTRACT
British Journal of Dermatology, 2009
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Papers by Francisco Brandão