Background: Pre-diabetes is a condition that occurs when blood glucose levels higher than normal ... more Background: Pre-diabetes is a condition that occurs when blood glucose levels higher than normal but not high enough to be diagnosed with diabetes. People with pre-diabetes in its development has three possibilities, about 1/3 will develop into type 2 diabetes, 1/3 will remain a pre-diabetic, while 1/3 the rest into normoglikemi. Based Riskesdas 2007, in Indonesia the prevalence of IGT gained almost twice the prevalence of DM is 5.7% of total DM and IGT 10.2%. The prevalence of DM and IGT in D.I. Yogyakarta is 5.4% and 8.4%. Base on the Integrated Disease Surveillance report (STP) Yogyakarta City Health Department, the prevalence of diabetes mellitus from 2008 until 2010 increased, in the year 2008 is 0.36%, in 2009 is 0.36% and in 2010 is 0.46% . Risk factors that can not be modified consists of race and ethnicity, family history of diabetes and age. The modifiable risk factors are overweight (BMI> 23 kg/m2), physical inactivity, hypertension, dyslipidemia and smoking. Objective: To determine the incidence of pre-diabetes risk factors in men aged � 45 years in Danurejan, the district of Yogyakarta. Research Methods: The study design was a cross-sectional to study the relationship between obesity, physical activity, smoking and family history of DM in the prediabetes. The sample in this study was as many as 141 people. Analysis of data is univariate anaysis, bivariate analysis and multivariate analysis. Result: There is significant association between obesity with prediabetes (p-value = 0,016), smoking with pre-diabetes (p-value = 0,038), physical activity with prediabetes (p-value = 0,000) dan family history of DM with pre-diabetes (pvalue = 0,000). Conclusions: Obesity, smoking, physical activity and family history of DM had a significant relationship and is a risk factor for the occurrence of pre-diabetes in men aged � 45 years in District Danurejan city of Yogyakarta.
Background and Objective: Emotional distress experienced by patients with diabetes (PWD) can affe... more Background and Objective: Emotional distress experienced by patients with diabetes (PWD) can affect glycemic control and quality of life. However, limited tools are available in Indonesia to detect emotional distress in PWD in clinical setting or research. This study aimed to evaluate the validity and reliability of the Indonesia version of the Problem Areas in Diabetes (PAID-5) scale. Methods: After the cross-cultural adaptation method was conducted, psychometric tests were done from August to November 2019 at affiliated hospitals in Yogyakarta by involving 100 adult PWD. All PWD with no medical records of mental health problems or cognitive disorders were voluntarily included. Content and construct validity and internal consistency measurements were used to evaluate the psychometric properties. Results: The mean age was 61.2 years of the men and women who equally participated in the study and mostly were non-working patients. The PAID-5 resulted in five question items to identify ...
To know the frequencies of insertion/deletion polymorphism in the angiotensin-converting enzyme (... more To know the frequencies of insertion/deletion polymorphism in the angiotensin-converting enzyme (ACE) gene among patients with type 2 diabetes and its relationship with metabolic syndrome at Sardjito Hospital Yogyakarta. We examined 69 patients with type 2 diabetes at Sardjito Hospital Yogyakarta, divided 2 groups based on ATP III criteria of metabolic syndrome. To determine the ACE genotype of the patients, a genomic DNA fragment on intron 16 of the ACE gene was amplified by polymerase chain reaction (PCR) using a forward primer 5'-CTG GAG ACC ACT CCC ATC CTT TCT-3' and reverse primer 5'-GAT GTG GCC ATC ACA RTC GTC AGA T-3'. II genotype 1 band on 490 bp (homozigot), DD genotype 1 band on 190 bp (homozigot) and ID genotype 2 band (heteroduplex) on 490 bp and 190 bp were separately detected on a 3% agarose gel containing ethidium bromide. Of 69 patients with type 2 diabetes, there were 51 females (73.91%) and 18 males (26.09%). Subjects with metabolic syndrome were 49...
Okra pods, commonly eaten at an immature stage, undergo quick postharvest deterioration due to hi... more Okra pods, commonly eaten at an immature stage, undergo quick postharvest deterioration due to high respiration, water loss, wilting, toughening and decay. As okra is a tropical crop, its pods are susceptible to chilling injury (CI) at low storage temperatures. The effects of low temperature storage on the physiobiochemical properties of okra pods were determined. Chilling injury symptoms were found only in pods stored at 4°C and were more apparent after transfer to 25°C. In seeds, the CI index was positively correlated with seed browning, H 2 O 2 , malondialdehyde (MDA) content, and catalase (CAT) activity. Chilling-injured seeds had lower total phenolic content (TPC), antioxidant activity (DPPH scavenging activity and FRAP assay), peroxidase (POD), and superoxide dismutase (SOD) activities than non-injured seeds. Additionally, the seed browning index was related to high polyphenol oxidase (PPO) activity. In the pericarp, the CI index was also positively correlated with the H 2 O 2 and MDA contents. The POD and SOD activities in chilling-injured pericarp were significantly lower than in non-injured pericarp. Chilling injury resulted in an initial increase in DPPH scavenging and CAT activities which later decreased as CI became severe. These results indicate that CI in okra is due to accumulation of H 2 O 2, and MDA, as well as its weak antioxidant defense mechanism. This resulted in development of CI symptoms, including seed browning.
To find out correlation between plasma adiponectin levels, insulin resistance and IDF criteria of... more To find out correlation between plasma adiponectin levels, insulin resistance and IDF criteria of Mets Patients. A case-control study was conducted on Native Javanese people from June 2006 to January 2007 in Outpatients Clinic of Dr Sardjito Hospital. The case group involved patients aged between 20 to 55 years old. The diagnosis of metabolic syndrome was confirmed according to IDF criteria. Patients without metabolic syndrome with matching age and sex,were taken as control group. there were significant differences between case and control group for BMI (body mass index) (30.2 +/- 4.1 vs 26.9 +/- 4.7 kg/m2), waist circumference (93.5 +/- 7.9 vs 84.4 +/- 11.5 cm), triglyceride (207.4 +/- 101.8 vs. 119.3 +/- 71.5 mg/dL) , HDL cholesterol (48.6 +/- 9.4 vs. 59.9 +/- 11.8m g/dL), systolic blood pressure (132.8 +/- 17.9 mmHg vs 120.6 +/- 13.5 mmHg) and diastolic blood pressure (83.8 +/- 8.5 mmHg vs. 79.4 +/- 10.7), fasting blood glucose (128.3 +/- 40.8 mg/dL vs. 100.7 +/- 29.4 mg/dL), HOM...
Journal of thee Medical Sciences (Berkala Ilmu Kedokteran), 2021
Insulin resistance is a major risk factor for patients with type 2 diabetes mellitus (T2DM). Telm... more Insulin resistance is a major risk factor for patients with type 2 diabetes mellitus (T2DM). Telmisartan and valsartan are angiotensin II type I receptor blockers (ARBs) that are often used in patients with metabolic syndrome and T2DM. This study aimed to compare the effect of valsartan and telmisartan in reducing insulin resistance on T2DM with hypertension. Patients of T2DM were open-label screened at the Endocrinology Policlinic, Department of Internal Medicine, Dr. Sardjito General Hospital, Yogyakarta, and then randomized into two groups. The first group received valsartan 80 mg per day up to 160 mg per day, the second group received telmisartan 40 mg per day up to 80 mg per day in addition with life-style modifying and diabetes therapy. Homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride and HDL cholesterol levels of patients were measured before and after receiving telmisartan and valsartan for 12 weeks. A total of forty-nine outpatients were involved i...
To evaluate the safety and effectiveness of biphasic insulin aspart 30 (BIAsp 30) in Indonesian p... more To evaluate the safety and effectiveness of biphasic insulin aspart 30 (BIAsp 30) in Indonesian patients with type 2 diabetes (T2D) as part of the 24-week, international, prospective, non-interventional A₁chieve study. Indonesian patients who started BIAsp 30 were included. Safety and efficacy was measured as part of routine clinical practice at baseline, Week 12 and Week 24. Overall, 1324 patients having a mean ± SD age, duration of diabetes and body mass index of 55.2 ± 9.9 yrs, 6.8 ± 5.2 yrs and 24.1 ± 3.6 kg/m(2), respectively, were enrolled. 67% of patients were insulin-naive and 33% were prior insulin users. Glycaemic control was poor at baseline. After 24 weeks, significant reductions from baseline were observed in the mean glycated haemoglobin A1c (HbA1c) (-2.6%), fasting plasma glucose (-93.8 mg/dL) and postprandial plasma glucose (-134.8 mg/dL) levels in the entire cohort (p < 0.001). Significant reductions were also seen in insulin-naive patients and prior insulin users. At Week 24, 29.9% of patients in the entire cohort achieved target HbA1c level of <7.0%, while 26.7% and 39.2% achieved this target among insulin-naive patients and prior insulin users, respectively. The proportion of patients reporting overall hypoglycaemia significantly decreased in the entire cohort after 24 weeks of BIAsp 30 therapy. A small significant increase in body weight was noted in the entire cohort, insulin-naive patients and prior insulin users. The current study suggests that BIAsp 30 can be considered as a safe and effective option for initiating as well as intensifying insulin therapy in Indonesian patients with T2D.
to determine the level of different concentration of leptin, adiponectin and resistin among obesi... more to determine the level of different concentration of leptin, adiponectin and resistin among obesity class I and class II population. cross sectional study was conducted from June 2006 until January 2007 on 57 patients with obese diabetic and non diabetic Native Javanese. They were divided into obese class I (body mass index [BMI] >25 kg/m2 to <30 kg/m2) and obese class II (BMI >30 kg/m2). Leptin, adiponectin and resistin level concentration were measured. leptin concentration in obese class I was 13.998 +/- 13.486 ng/ml; adiponectin was 3.98 +/- 1.78 microg/ml; resistin were 25.676 +/- 13.434 ng/ml. Leptin concentration in obese class II 31,074 +/- 26,158 ng/ml; adiponectin 4.75 +/- 1.88 microg/ml; resistin 25.46 +/- 12.26 ng/ml. Leptin concentration was significantly higher in obese class II than obese class I (p=0,002) and there was a positive weak correlation between BMI and leptin level, with Spearman correlation {coefficient correlation 0.363 (p=0.006)}. Adiponectin an...
To know the frequencies of insertion/deletion polymorphism in the angiotensin-converting enzyme (... more To know the frequencies of insertion/deletion polymorphism in the angiotensin-converting enzyme (ACE) gene among patients with type 2 diabetes and its relationship with metabolic syndrome at Sardjito Hospital Yogyakarta. We examined 69 patients with type 2 diabetes at Sardjito Hospital Yogyakarta, divided 2 groups based on ATP III criteria of metabolic syndrome. To determine the ACE genotype of the patients, a genomic DNA fragment on intron 16 of the ACE gene was amplified by polymerase chain reaction (PCR) using a forward primer 5'-CTG GAG ACC ACT CCC ATC CTT TCT-3' and reverse primer 5'-GAT GTG GCC ATC ACA RTC GTC AGA T-3'. II genotype 1 band on 490 bp (homozigot), DD genotype 1 band on 190 bp (homozigot) and ID genotype 2 band (heteroduplex) on 490 bp and 190 bp were separately detected on a 3% agarose gel containing ethidium bromide. Of 69 patients with type 2 diabetes, there were 51 females (73.91%) and 18 males (26.09%). Subjects with metabolic syndrome were 49...
To determine the differences in mean plasma values of von Willebrand factor and platelet aggregat... more To determine the differences in mean plasma values of von Willebrand factor and platelet aggregation in type 2 DM patient with or without peripheral arterial disease. This is a cross-sectional study, conducted from August to December 2006, in Dr. Sardjito General Hospital Yogyakarta, on type 2 DM patients, aged 50 years and above, and signed the informed consent. The exclusion criteria are cardiac failure, renal insufficiency (creatinine clearance <30 ml/minute), malignancy, acute disease, decrease hepatic function, having ulcer or DM gangrene, amputation, taking multivitamine and/or antiplatelet, and smoking. All samples that matched inclusion criteria were divided into 2 groups: with peripheral arterial disease and without peripheral arterial disease. The data of subjects are presented as mean and standard deviation and proportion. Variables with numeric data are analized with the student t-test for normal distribution and with Mann-Whitney U-test for abnormal distribution. Sig...
AIM to determine the level of different concentration of leptin, adiponectin and resistin among o... more AIM to determine the level of different concentration of leptin, adiponectin and resistin among obesity class I and class II population. METHODS cross sectional study was conducted from June 2006 until January 2007 on 57 patients with obese diabetic and non diabetic Native Javanese. They were divided into obese class I (body mass index [BMI] >25 kg/m2 to <30 kg/m2) and obese class II (BMI >30 kg/m2). Leptin, adiponectin and resistin level concentration were measured. RESULTS leptin concentration in obese class I was 13.998 +/- 13.486 ng/ml; adiponectin was 3.98 +/- 1.78 microg/ml; resistin were 25.676 +/- 13.434 ng/ml. Leptin concentration in obese class II 31,074 +/- 26,158 ng/ml; adiponectin 4.75 +/- 1.88 microg/ml; resistin 25.46 +/- 12.26 ng/ml. Leptin concentration was significantly higher in obese class II than obese class I (p=0,002) and there was a positive weak correlation between BMI and leptin level, with Spearman correlation {coefficient correlation 0.363 (p=0.0...
Background: Indonesian epidemiologic research result obtained 4.6% DM prevalence in an under 20 y... more Background: Indonesian epidemiologic research result obtained 4.6% DM prevalence in an under 20 year old population. It is estimated that in 2020 there will be 178 million people who are under 20 year old in the population
Background. Alteration of the endocrine system in the elderly people may be caused by changes in ... more Background. Alteration of the endocrine system in the elderly people may be caused by changes in secreted hormone levels or decreased sensitivity of target organs. These changes also apply to thyroid function, which can cause disability, cognitive impairment, cardiovascular risk, and decreased muscle mass and strength in the elderly. Physiologically, there are several changes in the concentration of thyroid hormone Concentrations due to aging process, such as reduced TSH (Thyroid Stimulating Hormone), total T3 (Triiodothyronine) and free T levels, and increased rT3 (Reverse triiodothyronine), which is an inactive T (Thyroxine) metabolite in the serum. Even so,the free T4 and the total T44 remain unchanged, except for the sick. As a result, proper diagnosis and management are expected to minimize the deprivation experienced by the subjects due to a decrease in functional mobility. Aims. The aim of the study was to assess the correlation between the levels of thyroid hormones and func...
Background: In Yogyakarta, the prevalence of type 2 diabetes mellitus according to the results Ri... more Background: In Yogyakarta, the prevalence of type 2 diabetes mellitus according to the results Riskesdas 2007 of 3.8%, and prevalence of Impaired Glucose Tolerance (IGT) of 8.2% with a diagnoswasaccording to WHO 1999 and ADA, 2007. Minimun level of knowledge about type 2 DM influenced the incidence of complications, and affected the quality of life of patients with type 2 diabetes. Objective: The objective of this study was to determine the relationship between knowledge of health information on quality of life in patients with type 2 diabetes in endocrinology department of DR. Sardjito hospital Yogyakarta. Method: Cross sectional study with population were patients of type 2 diabetes The sample size formula (Lemeshow et al., 1997), based on the previous research calculated P= 50%, I±= 5%, dan I²= 80% (Rahmat, 2009). The total samples were 126 people. Univariabel data analysis using frequency distributions, bivariabel using one way ANOVA test, independent t test and correlation test...
AIM This study aimed to test the validity and reliability of a four-item patient health questionn... more AIM This study aimed to test the validity and reliability of a four-item patient health questionnaire as a psychological distress screening tool for patients with type 2 diabetes in Indonesia. METHODS This cross-cultural adaptation study was applied in five public health-care centres in Indonesia in August-October 2018 using a four-item patient health questionnaire. The content, convergent and factorial validity were assessed, and Cronbach's alpha coefficient was the reliability indicator. RESULTS A total of 147 participants were involved. Content validity resulted in acceptable outcomes (item and scale content validity indexes were 0.95 and 0.75, respectively). Anxiety and depression were associated with total score and psychological distress status (P < 0.001), supporting the convergent validity outcomes. Principal component analysis using varimax rotation revealed two factors, explaining 76.14% of variance (P < 0.001). Cronbach's alpha coefficients for anxiety, depr...
Background: Pre-diabetes is a condition that occurs when blood glucose levels higher than normal ... more Background: Pre-diabetes is a condition that occurs when blood glucose levels higher than normal but not high enough to be diagnosed with diabetes. People with pre-diabetes in its development has three possibilities, about 1/3 will develop into type 2 diabetes, 1/3 will remain a pre-diabetic, while 1/3 the rest into normoglikemi. Based Riskesdas 2007, in Indonesia the prevalence of IGT gained almost twice the prevalence of DM is 5.7% of total DM and IGT 10.2%. The prevalence of DM and IGT in D.I. Yogyakarta is 5.4% and 8.4%. Base on the Integrated Disease Surveillance report (STP) Yogyakarta City Health Department, the prevalence of diabetes mellitus from 2008 until 2010 increased, in the year 2008 is 0.36%, in 2009 is 0.36% and in 2010 is 0.46% . Risk factors that can not be modified consists of race and ethnicity, family history of diabetes and age. The modifiable risk factors are overweight (BMI> 23 kg/m2), physical inactivity, hypertension, dyslipidemia and smoking. Objective: To determine the incidence of pre-diabetes risk factors in men aged � 45 years in Danurejan, the district of Yogyakarta. Research Methods: The study design was a cross-sectional to study the relationship between obesity, physical activity, smoking and family history of DM in the prediabetes. The sample in this study was as many as 141 people. Analysis of data is univariate anaysis, bivariate analysis and multivariate analysis. Result: There is significant association between obesity with prediabetes (p-value = 0,016), smoking with pre-diabetes (p-value = 0,038), physical activity with prediabetes (p-value = 0,000) dan family history of DM with pre-diabetes (pvalue = 0,000). Conclusions: Obesity, smoking, physical activity and family history of DM had a significant relationship and is a risk factor for the occurrence of pre-diabetes in men aged � 45 years in District Danurejan city of Yogyakarta.
Background and Objective: Emotional distress experienced by patients with diabetes (PWD) can affe... more Background and Objective: Emotional distress experienced by patients with diabetes (PWD) can affect glycemic control and quality of life. However, limited tools are available in Indonesia to detect emotional distress in PWD in clinical setting or research. This study aimed to evaluate the validity and reliability of the Indonesia version of the Problem Areas in Diabetes (PAID-5) scale. Methods: After the cross-cultural adaptation method was conducted, psychometric tests were done from August to November 2019 at affiliated hospitals in Yogyakarta by involving 100 adult PWD. All PWD with no medical records of mental health problems or cognitive disorders were voluntarily included. Content and construct validity and internal consistency measurements were used to evaluate the psychometric properties. Results: The mean age was 61.2 years of the men and women who equally participated in the study and mostly were non-working patients. The PAID-5 resulted in five question items to identify ...
To know the frequencies of insertion/deletion polymorphism in the angiotensin-converting enzyme (... more To know the frequencies of insertion/deletion polymorphism in the angiotensin-converting enzyme (ACE) gene among patients with type 2 diabetes and its relationship with metabolic syndrome at Sardjito Hospital Yogyakarta. We examined 69 patients with type 2 diabetes at Sardjito Hospital Yogyakarta, divided 2 groups based on ATP III criteria of metabolic syndrome. To determine the ACE genotype of the patients, a genomic DNA fragment on intron 16 of the ACE gene was amplified by polymerase chain reaction (PCR) using a forward primer 5'-CTG GAG ACC ACT CCC ATC CTT TCT-3' and reverse primer 5'-GAT GTG GCC ATC ACA RTC GTC AGA T-3'. II genotype 1 band on 490 bp (homozigot), DD genotype 1 band on 190 bp (homozigot) and ID genotype 2 band (heteroduplex) on 490 bp and 190 bp were separately detected on a 3% agarose gel containing ethidium bromide. Of 69 patients with type 2 diabetes, there were 51 females (73.91%) and 18 males (26.09%). Subjects with metabolic syndrome were 49...
Okra pods, commonly eaten at an immature stage, undergo quick postharvest deterioration due to hi... more Okra pods, commonly eaten at an immature stage, undergo quick postharvest deterioration due to high respiration, water loss, wilting, toughening and decay. As okra is a tropical crop, its pods are susceptible to chilling injury (CI) at low storage temperatures. The effects of low temperature storage on the physiobiochemical properties of okra pods were determined. Chilling injury symptoms were found only in pods stored at 4°C and were more apparent after transfer to 25°C. In seeds, the CI index was positively correlated with seed browning, H 2 O 2 , malondialdehyde (MDA) content, and catalase (CAT) activity. Chilling-injured seeds had lower total phenolic content (TPC), antioxidant activity (DPPH scavenging activity and FRAP assay), peroxidase (POD), and superoxide dismutase (SOD) activities than non-injured seeds. Additionally, the seed browning index was related to high polyphenol oxidase (PPO) activity. In the pericarp, the CI index was also positively correlated with the H 2 O 2 and MDA contents. The POD and SOD activities in chilling-injured pericarp were significantly lower than in non-injured pericarp. Chilling injury resulted in an initial increase in DPPH scavenging and CAT activities which later decreased as CI became severe. These results indicate that CI in okra is due to accumulation of H 2 O 2, and MDA, as well as its weak antioxidant defense mechanism. This resulted in development of CI symptoms, including seed browning.
To find out correlation between plasma adiponectin levels, insulin resistance and IDF criteria of... more To find out correlation between plasma adiponectin levels, insulin resistance and IDF criteria of Mets Patients. A case-control study was conducted on Native Javanese people from June 2006 to January 2007 in Outpatients Clinic of Dr Sardjito Hospital. The case group involved patients aged between 20 to 55 years old. The diagnosis of metabolic syndrome was confirmed according to IDF criteria. Patients without metabolic syndrome with matching age and sex,were taken as control group. there were significant differences between case and control group for BMI (body mass index) (30.2 +/- 4.1 vs 26.9 +/- 4.7 kg/m2), waist circumference (93.5 +/- 7.9 vs 84.4 +/- 11.5 cm), triglyceride (207.4 +/- 101.8 vs. 119.3 +/- 71.5 mg/dL) , HDL cholesterol (48.6 +/- 9.4 vs. 59.9 +/- 11.8m g/dL), systolic blood pressure (132.8 +/- 17.9 mmHg vs 120.6 +/- 13.5 mmHg) and diastolic blood pressure (83.8 +/- 8.5 mmHg vs. 79.4 +/- 10.7), fasting blood glucose (128.3 +/- 40.8 mg/dL vs. 100.7 +/- 29.4 mg/dL), HOM...
Journal of thee Medical Sciences (Berkala Ilmu Kedokteran), 2021
Insulin resistance is a major risk factor for patients with type 2 diabetes mellitus (T2DM). Telm... more Insulin resistance is a major risk factor for patients with type 2 diabetes mellitus (T2DM). Telmisartan and valsartan are angiotensin II type I receptor blockers (ARBs) that are often used in patients with metabolic syndrome and T2DM. This study aimed to compare the effect of valsartan and telmisartan in reducing insulin resistance on T2DM with hypertension. Patients of T2DM were open-label screened at the Endocrinology Policlinic, Department of Internal Medicine, Dr. Sardjito General Hospital, Yogyakarta, and then randomized into two groups. The first group received valsartan 80 mg per day up to 160 mg per day, the second group received telmisartan 40 mg per day up to 80 mg per day in addition with life-style modifying and diabetes therapy. Homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride and HDL cholesterol levels of patients were measured before and after receiving telmisartan and valsartan for 12 weeks. A total of forty-nine outpatients were involved i...
To evaluate the safety and effectiveness of biphasic insulin aspart 30 (BIAsp 30) in Indonesian p... more To evaluate the safety and effectiveness of biphasic insulin aspart 30 (BIAsp 30) in Indonesian patients with type 2 diabetes (T2D) as part of the 24-week, international, prospective, non-interventional A₁chieve study. Indonesian patients who started BIAsp 30 were included. Safety and efficacy was measured as part of routine clinical practice at baseline, Week 12 and Week 24. Overall, 1324 patients having a mean ± SD age, duration of diabetes and body mass index of 55.2 ± 9.9 yrs, 6.8 ± 5.2 yrs and 24.1 ± 3.6 kg/m(2), respectively, were enrolled. 67% of patients were insulin-naive and 33% were prior insulin users. Glycaemic control was poor at baseline. After 24 weeks, significant reductions from baseline were observed in the mean glycated haemoglobin A1c (HbA1c) (-2.6%), fasting plasma glucose (-93.8 mg/dL) and postprandial plasma glucose (-134.8 mg/dL) levels in the entire cohort (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001). Significant reductions were also seen in insulin-naive patients and prior insulin users. At Week 24, 29.9% of patients in the entire cohort achieved target HbA1c level of &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;7.0%, while 26.7% and 39.2% achieved this target among insulin-naive patients and prior insulin users, respectively. The proportion of patients reporting overall hypoglycaemia significantly decreased in the entire cohort after 24 weeks of BIAsp 30 therapy. A small significant increase in body weight was noted in the entire cohort, insulin-naive patients and prior insulin users. The current study suggests that BIAsp 30 can be considered as a safe and effective option for initiating as well as intensifying insulin therapy in Indonesian patients with T2D.
to determine the level of different concentration of leptin, adiponectin and resistin among obesi... more to determine the level of different concentration of leptin, adiponectin and resistin among obesity class I and class II population. cross sectional study was conducted from June 2006 until January 2007 on 57 patients with obese diabetic and non diabetic Native Javanese. They were divided into obese class I (body mass index [BMI] >25 kg/m2 to <30 kg/m2) and obese class II (BMI >30 kg/m2). Leptin, adiponectin and resistin level concentration were measured. leptin concentration in obese class I was 13.998 +/- 13.486 ng/ml; adiponectin was 3.98 +/- 1.78 microg/ml; resistin were 25.676 +/- 13.434 ng/ml. Leptin concentration in obese class II 31,074 +/- 26,158 ng/ml; adiponectin 4.75 +/- 1.88 microg/ml; resistin 25.46 +/- 12.26 ng/ml. Leptin concentration was significantly higher in obese class II than obese class I (p=0,002) and there was a positive weak correlation between BMI and leptin level, with Spearman correlation {coefficient correlation 0.363 (p=0.006)}. Adiponectin an...
To know the frequencies of insertion/deletion polymorphism in the angiotensin-converting enzyme (... more To know the frequencies of insertion/deletion polymorphism in the angiotensin-converting enzyme (ACE) gene among patients with type 2 diabetes and its relationship with metabolic syndrome at Sardjito Hospital Yogyakarta. We examined 69 patients with type 2 diabetes at Sardjito Hospital Yogyakarta, divided 2 groups based on ATP III criteria of metabolic syndrome. To determine the ACE genotype of the patients, a genomic DNA fragment on intron 16 of the ACE gene was amplified by polymerase chain reaction (PCR) using a forward primer 5'-CTG GAG ACC ACT CCC ATC CTT TCT-3' and reverse primer 5'-GAT GTG GCC ATC ACA RTC GTC AGA T-3'. II genotype 1 band on 490 bp (homozigot), DD genotype 1 band on 190 bp (homozigot) and ID genotype 2 band (heteroduplex) on 490 bp and 190 bp were separately detected on a 3% agarose gel containing ethidium bromide. Of 69 patients with type 2 diabetes, there were 51 females (73.91%) and 18 males (26.09%). Subjects with metabolic syndrome were 49...
To determine the differences in mean plasma values of von Willebrand factor and platelet aggregat... more To determine the differences in mean plasma values of von Willebrand factor and platelet aggregation in type 2 DM patient with or without peripheral arterial disease. This is a cross-sectional study, conducted from August to December 2006, in Dr. Sardjito General Hospital Yogyakarta, on type 2 DM patients, aged 50 years and above, and signed the informed consent. The exclusion criteria are cardiac failure, renal insufficiency (creatinine clearance <30 ml/minute), malignancy, acute disease, decrease hepatic function, having ulcer or DM gangrene, amputation, taking multivitamine and/or antiplatelet, and smoking. All samples that matched inclusion criteria were divided into 2 groups: with peripheral arterial disease and without peripheral arterial disease. The data of subjects are presented as mean and standard deviation and proportion. Variables with numeric data are analized with the student t-test for normal distribution and with Mann-Whitney U-test for abnormal distribution. Sig...
AIM to determine the level of different concentration of leptin, adiponectin and resistin among o... more AIM to determine the level of different concentration of leptin, adiponectin and resistin among obesity class I and class II population. METHODS cross sectional study was conducted from June 2006 until January 2007 on 57 patients with obese diabetic and non diabetic Native Javanese. They were divided into obese class I (body mass index [BMI] >25 kg/m2 to <30 kg/m2) and obese class II (BMI >30 kg/m2). Leptin, adiponectin and resistin level concentration were measured. RESULTS leptin concentration in obese class I was 13.998 +/- 13.486 ng/ml; adiponectin was 3.98 +/- 1.78 microg/ml; resistin were 25.676 +/- 13.434 ng/ml. Leptin concentration in obese class II 31,074 +/- 26,158 ng/ml; adiponectin 4.75 +/- 1.88 microg/ml; resistin 25.46 +/- 12.26 ng/ml. Leptin concentration was significantly higher in obese class II than obese class I (p=0,002) and there was a positive weak correlation between BMI and leptin level, with Spearman correlation {coefficient correlation 0.363 (p=0.0...
Background: Indonesian epidemiologic research result obtained 4.6% DM prevalence in an under 20 y... more Background: Indonesian epidemiologic research result obtained 4.6% DM prevalence in an under 20 year old population. It is estimated that in 2020 there will be 178 million people who are under 20 year old in the population
Background. Alteration of the endocrine system in the elderly people may be caused by changes in ... more Background. Alteration of the endocrine system in the elderly people may be caused by changes in secreted hormone levels or decreased sensitivity of target organs. These changes also apply to thyroid function, which can cause disability, cognitive impairment, cardiovascular risk, and decreased muscle mass and strength in the elderly. Physiologically, there are several changes in the concentration of thyroid hormone Concentrations due to aging process, such as reduced TSH (Thyroid Stimulating Hormone), total T3 (Triiodothyronine) and free T levels, and increased rT3 (Reverse triiodothyronine), which is an inactive T (Thyroxine) metabolite in the serum. Even so,the free T4 and the total T44 remain unchanged, except for the sick. As a result, proper diagnosis and management are expected to minimize the deprivation experienced by the subjects due to a decrease in functional mobility. Aims. The aim of the study was to assess the correlation between the levels of thyroid hormones and func...
Background: In Yogyakarta, the prevalence of type 2 diabetes mellitus according to the results Ri... more Background: In Yogyakarta, the prevalence of type 2 diabetes mellitus according to the results Riskesdas 2007 of 3.8%, and prevalence of Impaired Glucose Tolerance (IGT) of 8.2% with a diagnoswasaccording to WHO 1999 and ADA, 2007. Minimun level of knowledge about type 2 DM influenced the incidence of complications, and affected the quality of life of patients with type 2 diabetes. Objective: The objective of this study was to determine the relationship between knowledge of health information on quality of life in patients with type 2 diabetes in endocrinology department of DR. Sardjito hospital Yogyakarta. Method: Cross sectional study with population were patients of type 2 diabetes The sample size formula (Lemeshow et al., 1997), based on the previous research calculated P= 50%, I±= 5%, dan I²= 80% (Rahmat, 2009). The total samples were 126 people. Univariabel data analysis using frequency distributions, bivariabel using one way ANOVA test, independent t test and correlation test...
AIM This study aimed to test the validity and reliability of a four-item patient health questionn... more AIM This study aimed to test the validity and reliability of a four-item patient health questionnaire as a psychological distress screening tool for patients with type 2 diabetes in Indonesia. METHODS This cross-cultural adaptation study was applied in five public health-care centres in Indonesia in August-October 2018 using a four-item patient health questionnaire. The content, convergent and factorial validity were assessed, and Cronbach's alpha coefficient was the reliability indicator. RESULTS A total of 147 participants were involved. Content validity resulted in acceptable outcomes (item and scale content validity indexes were 0.95 and 0.75, respectively). Anxiety and depression were associated with total score and psychological distress status (P < 0.001), supporting the convergent validity outcomes. Principal component analysis using varimax rotation revealed two factors, explaining 76.14% of variance (P < 0.001). Cronbach's alpha coefficients for anxiety, depr...
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