Papers by Steluta Boroghina
International Journal of Molecular Sciences, 2021
Gestational diabetes mellitus (GDM) is defined as an impairment of glucose tolerance, manifested ... more Gestational diabetes mellitus (GDM) is defined as an impairment of glucose tolerance, manifested by hyperglycemia, which occurs at any stage of pregnancy. GDM is more common in the third trimester of pregnancy and usually disappears after birth. It was hypothesized that the glycemic status of the mother can modulate liver development and growth early during the pregnancy. The simplest modality to monitor the evolution of GDM employs noninvasive techniques. In this category, routinely obstetrical ultrasound (OUS) examinations (simple or 2D/3D) can be employed for specific fetal measurements, such as fetal liver length (FLL) or volume (FLV). FLL and FLV may emerge as possible predictors of GDM as they positively relate to the maternal glycated hemoglobin (HbA1c) levels and to the results of the oral glucose tolerance test. The aim of this review is to offer insight into the relationship between GDM and fetal nutritional status. Risk factors for GDM and the short- and long-term outcome...
Frontiers in Pharmacology
Monoamine oxidases are mitochondrial enzymes that catalyze the oxidative deamination of biogenic ... more Monoamine oxidases are mitochondrial enzymes that catalyze the oxidative deamination of biogenic amines (adrenaline, noradrenaline, serotonin, and dopamine), causing their inactivation and subsequently playing a fundamental role in the homeostasis of various neurotransmitters. As the regulation of these effects was deemed important in clinical practice, numerous modulators of these enzymes were tested for various clinical effects. The purpose of this paper is to present a few historical landmarks regarding monoaminoxidase inhibitors and their usefulness as psychopharmacological agents. We will be focusing on banisterine, iproniazid, selegiline, rasagiline, tranylcypromine, moclobemide, and their role in the history of psychopharmacology. An almost unknown fact is that harmine, an MAO-A alkaloid, was used as early as the latter half of the 1920s in Bucharest, to reduce catatonic symptoms in schizophrenia, thus ushering the dawn of psychopharmacology era which started with chlorpromaz...
The human microbiota consists of a variety of bacterial species which populate the mucosal surfac... more The human microbiota consists of a variety of bacterial species which populate the mucosal surfaces and contribute a great deal to the education of our immune system. In terms of metabolism, the microbiota plays an important role by decomposing nutrients that we consume in our food and degrading environmental toxicants and environmental chemicals and drugs. Changing the state of eubiosis to dysbiosis represents an area of extreme interest nowadays, as researchers try to understand the pathophysiology behind it fully. Blood pressure can be influenced by changes in ratios of gut microbiota categories, short-chain fatty acids, specific kidney and blood vessel receptors, gut metabolites trimethylamine (TMA), and trimethylamine N-oxide (TMAO). This minireview aims to reveal some of the major aspects that support the hypothesis that gut microbiota contributes to the regulation of blood pressure. The purpose of all research is to discover the possibility of future personalized microbiome t...
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Papers by Steluta Boroghina