[structure: see text] An indicator-displacement assay was used to study the kinetics of reactions... more [structure: see text] An indicator-displacement assay was used to study the kinetics of reactions that produce tartrate. The same assay was also found to be useful in developing tartrate test strips, by coating filter paper with the same receptor and indicator.
Global warming accelerates decomposition of soil organic carbon (SOC) pools with varying rates an... more Global warming accelerates decomposition of soil organic carbon (SOC) pools with varying rates and temperature sensitivities. Black carbon (BC) materials are among the slowest decomposing components of the SOC pool. Although BC is a large component of SOC in many systems, the influence of temperature on decomposition of BC bearing different chemical and physical structures remains poorly understood. Four BC materials, produced by carbonizing corn residue and oak wood at 350 and 600 degrees C (corn-350-BC, corn-600-BC, oak-350-BC, and oak-600-BC), were mixed with pure sand and incubated at 4, 10, 20, 30, 45, and 60 degrees C for 1 year. Corn-BC was more porous than oak-BC as determined by scanning electron microscopy (SEM). Increasing the charring temperature from 350 to 600 degrees C led to greater aromaticity with 5-15% more C in aromatic rings and a 39-57% increase in both nonprotonated aromatic C and aromatic bridgehead C quantified by nuclear magnetic resonance (NMR) spectroscopy and a greater degree of order and development of C layers as observed by transmission electron microscopy (TEM). With a temperature increase from 4 to 60 degrees C, C loss of corn-350-BC increased from 10 to 20%, corn-600-BC, from 4 to 20%, oak-350-BC, from 2.3 to 15%, and oak-600-BC from 1.5 to 14% of initial C content, respectively. Temperature sensitivity (Q(10)) decreased with increasing incubation temperature and was highest in oak-600-BC, followed by oak-350-BC, corn-600-BC, and corn-350-BC, indicating that decomposition of more stable BC was more sensitive to increased temperature than less stable materials. Carbon loss and potential cation exchange capacity (CECp) significantly (p < 0.05) correlated with O/C ratios and change in O/C ratios, suggesting that oxidative processes were the most important mechanism controlling BC decomposition in this study.
To evaluate the rheumatic manifestations associated with HIV infection in the highly active antir... more To evaluate the rheumatic manifestations associated with HIV infection in the highly active antiretroviral therapy (HAART) era. The overall prevalence of rheumatic manifestations in HIV population is approximately 9% with various clinical features. Anti-TNF agents do not appear to adversely affect the CD4 cell counts or viral load if the HIV infection is well controlled prior to initiation of therapy. In the HAART era, HIV-infected individuals can be affected by various rheumatic syndromes including arthritis, spondyloarthritis, DILS, vasculitides, connective tissue disease, myopathies, and musculoskeletal diseases. With the use of HAART, the prevalence of spondyloarthritis and Diffuse Infiltrative Lymphocytosis Syndrome has decreased, whereas the musculoskeletal complications of HIV and HAART, such as osteopenia, osteonecrosis, and infection continue to be a concern. With immune restoration, various inflammatory and autoimmune diseases, such as SLE, rheumatoid arthritis, and polymy...
OBJECTIVE-To examine the predictive role of HLA genetic markers for scleroderma renal crisis (SRC... more OBJECTIVE-To examine the predictive role of HLA genetic markers for scleroderma renal crisis (SRC) beyond the known clinical correlates in a large population of patients with systemic sclerosis (SSc).
Proceedings of the 4th workshop on All things cellular: operations, applications, & challenges - AllThingsCellular '14, 2014
The popularity of smartphones and smartphone applications means that data is the dominant traffic... more The popularity of smartphones and smartphone applications means that data is the dominant traffic type in current mobile networks. In this paper we present our work on a systematic investigation into facets of the LTE/EPC architecture that impact the performance of TCP as the predominant transport layer protocol used by applications on mobile networks. We found that (1) load increase in a cell causes dramatic bandwidth reduction on UEs and significantly degrades TCP performance, (2) seamless handover causes significant TCP losses while lossless handover increases TCP segments' delay.
There is significant interest in the potential use of telomerase-immortalized cells in transplant... more There is significant interest in the potential use of telomerase-immortalized cells in transplantation to replace neurons lost to neurodegenerative diseases and other central nervous system injuries. Neural progenitor cells (NPCs) transduced with human telomerase reverse transcriptase (hTERT), the catalytic component of telomerase, have the potential both to proliferate indefinitely in vitro and to respond to differentiation signals necessary for generating appropriate cells for transplantation. The purpose of this study was to evaluate the differentiation of neurons from NT2 cells, a model NPC cell line, following hTERT transduction. RT-PCR and telomerase activity data demonstrated that persistent exogenous hTERT expression significantly inhibited the differentiation of neurons from NT2 cells. Following retinoic acid induced differentiation, hTERT-NT2 cells produced only one fourth of the neurons generated by parental and vector-control cells. A differentiation-inhibiting effect of constitutive telomerase activity has not been reported previously in other hTERT-transduced progenitor cell lines, implying a unique role for telomerase in the proliferation and differentiation of NPCs that have tumorigenic potential. Elucidating the mechanism responsible for this effect may aid in understanding the potential role of telomerase activity in the tumorigenecity of NPCs, as well as in optimizing the production of safe, telomerase-engineered, transplantable neurons.
[structure: see text] An indicator-displacement assay was used to study the kinetics of reactions... more [structure: see text] An indicator-displacement assay was used to study the kinetics of reactions that produce tartrate. The same assay was also found to be useful in developing tartrate test strips, by coating filter paper with the same receptor and indicator.
Global warming accelerates decomposition of soil organic carbon (SOC) pools with varying rates an... more Global warming accelerates decomposition of soil organic carbon (SOC) pools with varying rates and temperature sensitivities. Black carbon (BC) materials are among the slowest decomposing components of the SOC pool. Although BC is a large component of SOC in many systems, the influence of temperature on decomposition of BC bearing different chemical and physical structures remains poorly understood. Four BC materials, produced by carbonizing corn residue and oak wood at 350 and 600 degrees C (corn-350-BC, corn-600-BC, oak-350-BC, and oak-600-BC), were mixed with pure sand and incubated at 4, 10, 20, 30, 45, and 60 degrees C for 1 year. Corn-BC was more porous than oak-BC as determined by scanning electron microscopy (SEM). Increasing the charring temperature from 350 to 600 degrees C led to greater aromaticity with 5-15% more C in aromatic rings and a 39-57% increase in both nonprotonated aromatic C and aromatic bridgehead C quantified by nuclear magnetic resonance (NMR) spectroscopy and a greater degree of order and development of C layers as observed by transmission electron microscopy (TEM). With a temperature increase from 4 to 60 degrees C, C loss of corn-350-BC increased from 10 to 20%, corn-600-BC, from 4 to 20%, oak-350-BC, from 2.3 to 15%, and oak-600-BC from 1.5 to 14% of initial C content, respectively. Temperature sensitivity (Q(10)) decreased with increasing incubation temperature and was highest in oak-600-BC, followed by oak-350-BC, corn-600-BC, and corn-350-BC, indicating that decomposition of more stable BC was more sensitive to increased temperature than less stable materials. Carbon loss and potential cation exchange capacity (CECp) significantly (p < 0.05) correlated with O/C ratios and change in O/C ratios, suggesting that oxidative processes were the most important mechanism controlling BC decomposition in this study.
To evaluate the rheumatic manifestations associated with HIV infection in the highly active antir... more To evaluate the rheumatic manifestations associated with HIV infection in the highly active antiretroviral therapy (HAART) era. The overall prevalence of rheumatic manifestations in HIV population is approximately 9% with various clinical features. Anti-TNF agents do not appear to adversely affect the CD4 cell counts or viral load if the HIV infection is well controlled prior to initiation of therapy. In the HAART era, HIV-infected individuals can be affected by various rheumatic syndromes including arthritis, spondyloarthritis, DILS, vasculitides, connective tissue disease, myopathies, and musculoskeletal diseases. With the use of HAART, the prevalence of spondyloarthritis and Diffuse Infiltrative Lymphocytosis Syndrome has decreased, whereas the musculoskeletal complications of HIV and HAART, such as osteopenia, osteonecrosis, and infection continue to be a concern. With immune restoration, various inflammatory and autoimmune diseases, such as SLE, rheumatoid arthritis, and polymy...
OBJECTIVE-To examine the predictive role of HLA genetic markers for scleroderma renal crisis (SRC... more OBJECTIVE-To examine the predictive role of HLA genetic markers for scleroderma renal crisis (SRC) beyond the known clinical correlates in a large population of patients with systemic sclerosis (SSc).
Proceedings of the 4th workshop on All things cellular: operations, applications, & challenges - AllThingsCellular '14, 2014
The popularity of smartphones and smartphone applications means that data is the dominant traffic... more The popularity of smartphones and smartphone applications means that data is the dominant traffic type in current mobile networks. In this paper we present our work on a systematic investigation into facets of the LTE/EPC architecture that impact the performance of TCP as the predominant transport layer protocol used by applications on mobile networks. We found that (1) load increase in a cell causes dramatic bandwidth reduction on UEs and significantly degrades TCP performance, (2) seamless handover causes significant TCP losses while lossless handover increases TCP segments' delay.
There is significant interest in the potential use of telomerase-immortalized cells in transplant... more There is significant interest in the potential use of telomerase-immortalized cells in transplantation to replace neurons lost to neurodegenerative diseases and other central nervous system injuries. Neural progenitor cells (NPCs) transduced with human telomerase reverse transcriptase (hTERT), the catalytic component of telomerase, have the potential both to proliferate indefinitely in vitro and to respond to differentiation signals necessary for generating appropriate cells for transplantation. The purpose of this study was to evaluate the differentiation of neurons from NT2 cells, a model NPC cell line, following hTERT transduction. RT-PCR and telomerase activity data demonstrated that persistent exogenous hTERT expression significantly inhibited the differentiation of neurons from NT2 cells. Following retinoic acid induced differentiation, hTERT-NT2 cells produced only one fourth of the neurons generated by parental and vector-control cells. A differentiation-inhibiting effect of constitutive telomerase activity has not been reported previously in other hTERT-transduced progenitor cell lines, implying a unique role for telomerase in the proliferation and differentiation of NPCs that have tumorigenic potential. Elucidating the mechanism responsible for this effect may aid in understanding the potential role of telomerase activity in the tumorigenecity of NPCs, as well as in optimizing the production of safe, telomerase-engineered, transplantable neurons.
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