known, the mechanism of activation remains controver-1 Division of Developmental Biology sial. In... more known, the mechanism of activation remains controver-1 Division of Developmental Biology sial. In Xenopus, sperm entry activates oriented micro-Cincinnati Children's Research Foundation tubule polymerization that causes dorsally directed cy-3333 Burnet Avenue toplasmic and organelle movements within a thin layer Cincinnati, Ohio 45229 of cortical cytoplasm during the first cell cycle (Elinson 2 Department of Life Sciences and Rowning, 1988; Houliston and Elinson, 1991; Lara-The University of Tokyo bell et al., 1996; Vincent et al., 1986). One hypothesis 3-8-1 Komaba, Meguro-ku suggests that this movement concentrates β-catenin Tokyo 153-8902 (Rowning et al., 1997) or dishevelled protein (Miller et Japan al., 1999) on the dorsal side during the cleavage stages and that this activates the Wnt pathway intracellularly. Another model suggests that the downregulation on the Summary dorsal side of the inhibitor, GSK-3β, establishes an asymmetry of β-catenin function (Dominguez and Wnt signaling pathways play essential roles in pat-Green, 2000
known, the mechanism of activation remains controver-1 Division of Developmental Biology sial. In... more known, the mechanism of activation remains controver-1 Division of Developmental Biology sial. In Xenopus, sperm entry activates oriented micro-Cincinnati Children's Research Foundation tubule polymerization that causes dorsally directed cy-3333 Burnet Avenue toplasmic and organelle movements within a thin layer Cincinnati, Ohio 45229 of cortical cytoplasm during the first cell cycle (Elinson 2 Department of Life Sciences and Rowning, 1988; Houliston and Elinson, 1991; Lara-The University of Tokyo bell et al., 1996; Vincent et al., 1986). One hypothesis 3-8-1 Komaba, Meguro-ku suggests that this movement concentrates β-catenin Tokyo 153-8902 (Rowning et al., 1997) or dishevelled protein (Miller et Japan al., 1999) on the dorsal side during the cleavage stages and that this activates the Wnt pathway intracellularly. Another model suggests that the downregulation on the Summary dorsal side of the inhibitor, GSK-3β, establishes an asymmetry of β-catenin function (Dominguez and Wnt signaling pathways play essential roles in pat-Green, 2000
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