Papers by Berardinelli Pasqualino
This study applied multivariate statistical analysis (MSA) to the synthetic data simulated by the... more This study applied multivariate statistical analysis (MSA) to the synthetic data simulated by the river water quality model to investigate how two pollution sources with different characteristics and contributions affect the results of MSA. The results showed that when assessing the number and possible locations of pollution sources based on the results of cluster analysis (CA), hydrological information about surface water should be obtained to improve the accuracy of the results; when applying principal component analysis (PCA), the results of the second principal component (PC2) and the Pearson correlation coefficients among the pollutants should both be included, which can add more information about the characteristics of pollutant sources. In addition, this study found that the solid and liquid partition coefficients (Kd) of pollutants can affect the interpretation of the PCA results, so the Kd values should be determined before tracing the pollution sources to facilitate the ev...
Acta bio-medica : Atenei Parmensis, 2021
BACKGROUND AND AIM The urgency of having rapidly safe and efficient COVID-19 vaccines called for ... more BACKGROUND AND AIM The urgency of having rapidly safe and efficient COVID-19 vaccines called for the need to shorten trial phases, reduce sample sizes, and speed-up the approval process by the regulatory Agencies. In light of this, monitoring adverse effects (AEFI) (both immediate and at medium-long term) become of great importance. Aim of this cross-sectional study was to explore the associations between several factors and risk of immediate AEFI. METHODS Data come from the electronic dataset developed ad hoc to record demographic data, anamnesis and data related to immunization, set-up in the mass vaccination site in Novegro (Milan). Novegro mass vaccination site was one of the mass vaccinations sites with the highest flow in Lombardy Region, with a maximum capacity of 5,000 vaccinations/day. The center opened in April 2021 and closed the 1st of August 2021. A multivariable logistic regression model was used. Odds ratios adjusted (aOR) for age and sex are presented. Statistical si...
Giornale italiano di chemioterapia
SUMMARY Nineteen patients with chronic respiratory insufficiency, mean age 61-4 + 12-2, have been... more SUMMARY Nineteen patients with chronic respiratory insufficiency, mean age 61-4 + 12-2, have been investigated with pulmonary function tests, clinical neurological examination and neurophysiological methods including motor and sensory conduction studies and needle elec-tromyography. None of them had conditions known to affect the peripheral nervous system such as diabetes, alcoholism, or uraemia. The motor and sensory conduction studies showed only a reduced mean amplitude of the ulnar nerve SAP and of the compound muscle action potential of the APB and EDB muscles. The EMG was abnormal in 94-7 % of the cases and showed an increased percentage of polyphasic potentials and a reduced recruitment pattern of motor units firing at high frequency. The data seem to support the hypothesis of an involvement of motor neurons in this condition although the evidence for a neuropathy is lacking. While the effects of chronic respiratory insufficiency on the central nervous system are well known,&...
Objectives: Few and contrastingly data are available about use of osteopathic manipulative treatm... more Objectives: Few and contrastingly data are available about use of osteopathic manipulative treatment (OMT) in patients with chronic obstructive pulmonary disease (COPD). Design: Comparing the effects of the combination of pulmonary rehabilitation and OMT compared with pulmonary rehabilitation (PR) in patients with severely impaired COPD. Setting: Rehabilitative pulmonary department. Interventions: Patients underwent exercise training, OMT, educational support and nutritional and psychological counselling. Main outcomes measures: Exercise capacity through 6 min walk test (6MWT-primary outcome) and pulmonary function test (secondary outcomes) were evaluated at the beginning and at the end of the training. Patients were randomly assigned to receive PR + soft manipulation (G1) or OMT + PR (G2) for 5 days/week for 4 weeks. Results: 20 stable COPD patients (5 female-mean age, 63.8 ± 5.1 years; FEV1 26.9 ± 6.3% of predicted) referred for in-patient pulmonary rehabilitation were evaluated. Respect to the baseline, 6 MWT statistically improved in both group. In particular, G2 group gained 72.5 ± 7.5 m (p = 0.01) and G1 group 23.7 ± 9.7 m. Between group comparison showed a difference of 48.8 m (95% CI: 17 to 80.6 m, p = 0.04). Moreover, in G2 group we showed a decrease in residual volume (RV-from 4.4 ± 1.5 l to 3.9 ± 1.5 l, p = 0.05). Between group comparison showed an important difference (−0.44 l; 95% CI: −0.26 to −0.62 l, p = 0.001). Furthermore, only in G2 group we showed an increase in FEV1. Conclusions: This study suggests that OMT + PR may improve exercise capacity and reduce RV in severely impaired COPD patients with respect to PR alone.
methods including motorandsensoryconduction studies andneedle electromyography. Noneofthemhadcond... more methods including motorandsensoryconduction studies andneedle electromyography. Noneofthemhadconditions knowntoaffect theperipheral nervous systemsuch asdiabetes, alcoholism, or uraemia. Themotorandsensoryconduction studies showedonlya reduced mean amplitude oftheulnar nerveSAPandofthecompoundmuscle action potential of theAPB andEDB muscles. TheEMG was abnormal in94-7%ofthecases andshowedan increased percentage ofpolyphasic potentials anda reduced recruitment patternofmotorunits firing athighfrequency. Thedata seem tosupportthehypothesis ofan involvement ofmotor neuronsinthis condition although theevidence fora neuropathy islacking. While theeffects ofchronic respiratory insufficiency onthecentral nervous system arewell known,' -3the influence ofthis condition ontheperipheral nervous system hasbeenthesubject ofclinical investigation only inrecent years. Appenzeller etal4 reported the presence ofaperipheral neuropathy insevenoutof eight patients withchronic obstructive pulmonary ...
Electroencephalography and Clinical Neurophysiology, 1983
La Pediatria medica e chirurgica : Medical and surgical pediatrics
12 asthmatic children, suffering from frequent asthma (Ekwo-Weiberger classification), were studi... more 12 asthmatic children, suffering from frequent asthma (Ekwo-Weiberger classification), were studied; 3 groups were selected: A group: without therapy. B group: treated with plain theophylline. C group: treated with SR theophylline. Adequate serum theophylline levels were obtained in B and C group. Every child underwent then body plethysmography (Fenyves and Gutt's Pulmostar apparatus) before and after inhaling Albuterol through IPPB apparatus. We matched the different performances provided by the subjects of the various groups and compared them with the ones of a D group of healty subjects (pollinosics out of the exposure season). The indexes of pulmonary statics, and particularly TV and RV (as well as FRC) point out a better effect of plain theophylline vs. SR theophylline. Similar impression was done examining the conductances and the volume/flow curve, referring particularly to MMEF and V 0.50 TV. Further pharmacokinetic, clinical and spirometric studies are therefore necessa...
Respiratory Medicine, 2000
European journal of respiratory diseases. Supplement, 1986
Journal of Neurology, Neurosurgery & Psychiatry, 1984
Nineteen patients with chronic respiratory insufficiency, mean age 61-4 + 12-2, have been investi... more Nineteen patients with chronic respiratory insufficiency, mean age 61-4 + 12-2, have been investigated with pulmonary function tests, clinical neurological examination and neurophysiological methods including motor and sensory conduction studies and needle electromyography. None of them had conditions known to affect the peripheral nervous system such as diabetes, alcoholism, or uraemia. The motor and sensory conduction studies showed only a reduced mean amplitude of the ulnar nerve SAP and of the compound muscle action potential of the APB and EDB muscles. The EMG was abnormal in 94-7% of the cases and showed an increased percentage of polyphasic potentials and a reduced recruitment pattern of motor units firing at high frequency. The data seem to support the hypothesis of an involvement of motor neurons in this condition although the evidence for a neuropathy is lacking.
Complementary Therapies in Medicine, 2012
Objectives: Few and contrastingly data are available about use of osteopathic manipulative treatm... more Objectives: Few and contrastingly data are available about use of osteopathic manipulative treatment (OMT) in patients with chronic obstructive pulmonary disease (COPD). Design: Comparing the effects of the combination of pulmonary rehabilitation and OMT compared with pulmonary rehabilitation (PR) in patients with severely impaired COPD. Setting: Rehabilitative pulmonary department. Interventions: Patients underwent exercise training, OMT, educational support and nutritional and psychological counselling. Main outcomes measures: Exercise capacity through 6 min walk test (6MWT-primary outcome) and pulmonary function test (secondary outcomes) were evaluated at the beginning and at the end of the training. Patients were randomly assigned to receive PR + soft manipulation (G1) or OMT + PR (G2) for 5 days/week for 4 weeks. Results: 20 stable COPD patients (5 female-mean age, 63.8 ± 5.1 years; FEV1 26.9 ± 6.3% of predicted) referred for in-patient pulmonary rehabilitation were evaluated. Respect to the baseline, 6 MWT statistically improved in both group. In particular, G2 group gained 72.5 ± 7.5 m (p = 0.01) and G1 group 23.7 ± 9.7 m. Between group comparison showed a difference of 48.8 m (95% CI: 17 to 80.6 m, p = 0.04). Moreover, in G2 group we showed a decrease in residual volume (RV-from 4.4 ± 1.5 l to 3.9 ± 1.5 l, p = 0.05). Between group comparison showed an important difference (−0.44 l; 95% CI: −0.26 to −0.62 l, p = 0.001). Furthermore, only in G2 group we showed an increase in FEV1. Conclusions: This study suggests that OMT + PR may improve exercise capacity and reduce RV in severely impaired COPD patients with respect to PR alone.
Objectives: Few and contrastingly data are available about use of osteopathic manipulative treatm... more Objectives: Few and contrastingly data are available about use of osteopathic manipulative treatment (OMT) in patients with chronic obstructive pulmonary disease (COPD). Design: Comparing the effects of the combination of pulmonary rehabilitation and OMT compared with pulmonary rehabilitation (PR) in patients with severely impaired COPD. Setting: Rehabilitative pulmonary department. Interventions: Patients underwent exercise training, OMT, educational support and nutritional and psychological counselling. Main outcomes measures: Exercise capacity through 6 min walk test (6MWT-primary outcome) and pulmonary function test (secondary outcomes) were evaluated at the beginning and at the end of the training. Patients were randomly assigned to receive PR + soft manipulation (G1) or OMT + PR (G2) for 5 days/week for 4 weeks. Results: 20 stable COPD patients (5 female-mean age, 63.8 ± 5.1 years; FEV1 26.9 ± 6.3% of predicted) referred for in-patient pulmonary rehabilitation were evaluated. Respect to the baseline, 6 MWT statistically improved in both group. In particular, G2 group gained 72.5 ± 7.5 m (p = 0.01) and G1 group 23.7 ± 9.7 m. Between group comparison showed a difference of 48.8 m (95% CI: 17 to 80.6 m, p = 0.04). Moreover, in G2 group we showed a decrease in residual volume (RV-from 4.4 ± 1.5 l to 3.9 ± 1.5 l, p = 0.05). Between group comparison showed an important difference (−0.44 l; 95% CI: −0.26 to −0.62 l, p = 0.001). Furthermore, only in G2 group we showed an increase in FEV1. Conclusions: This study suggests that OMT + PR may improve exercise capacity and reduce RV in severely impaired COPD patients with respect to PR alone.
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Papers by Berardinelli Pasqualino