Se autoriza la reproducción total o parcial de este artículo, siempre y cuando se cite la fuente ... more Se autoriza la reproducción total o parcial de este artículo, siempre y cuando se cite la fuente completa y su dirección electrónica.
RNA interference (RNAi) is a relatively novel technology that is currently being exploited for th... more RNA interference (RNAi) is a relatively novel technology that is currently being exploited for therapeutic purposes for several indications. As of today, there is no approved therapy based on this technology but several compounds are in advanced phases of clinical development. The eye was one of the first settings in which proof of concept was achieved; but in the latest years successful development of delivery technologies to the liver have made this organ the preferred target of therapies based on RNAi. We have used the results obtained in preclinical and clinical development of several compounds for different ocular conditions to demonstrate that the eye represents an ideal organ for therapies based on RNAi.
Cyathea atrovirens occurs in a wide range of habitats in Brazil, Paraguay, Uruguay and Argentina.... more Cyathea atrovirens occurs in a wide range of habitats in Brazil, Paraguay, Uruguay and Argentina. In the Brazilian State of Rio Grande do Sul, this commonly found species is a target of intense exploitation, because of its ornamental characteristics. The in vitro culture is an important tool for propagation which may contribute toward the reduction of extractivism. However, exogenous contamination of spores is an obstacle for the success of aseptic long-term cultures. This study evaluated the influence of different sterilization methods combined with storage conditions on the contamination of the in vitro cultures and the gametophytic development of C. atrovirens, in order to establish an efficient propagation protocol. Spores were obtained from plants collected in Novo Hamburgo, State of Rio Grande do Sul, Brazil. In the first experiment, spores stored at 7 degrees C were surface sterilized with 0.5, 0.8 and 2% of sodium hypochlorite (NaClO) for 15 minutes and sown in Meyer's c...
Se autoriza la reproducción total o parcial de este artículo, siempre y cuando se cite la fuente ... more Se autoriza la reproducción total o parcial de este artículo, siempre y cuando se cite la fuente completa y su dirección electrónica.
RNA interference (RNAi) is a relatively novel technology that is currently being exploited for th... more RNA interference (RNAi) is a relatively novel technology that is currently being exploited for therapeutic purposes for several indications. As of today, there is no approved therapy based on this technology but several compounds are in advanced phases of clinical development. The eye was one of the first settings in which proof of concept was achieved; but in the latest years successful development of delivery technologies to the liver have made this organ the preferred target of therapies based on RNAi. We have used the results obtained in preclinical and clinical development of several compounds for different ocular conditions to demonstrate that the eye represents an ideal organ for therapies based on RNAi.
Cyathea atrovirens occurs in a wide range of habitats in Brazil, Paraguay, Uruguay and Argentina.... more Cyathea atrovirens occurs in a wide range of habitats in Brazil, Paraguay, Uruguay and Argentina. In the Brazilian State of Rio Grande do Sul, this commonly found species is a target of intense exploitation, because of its ornamental characteristics. The in vitro culture is an important tool for propagation which may contribute toward the reduction of extractivism. However, exogenous contamination of spores is an obstacle for the success of aseptic long-term cultures. This study evaluated the influence of different sterilization methods combined with storage conditions on the contamination of the in vitro cultures and the gametophytic development of C. atrovirens, in order to establish an efficient propagation protocol. Spores were obtained from plants collected in Novo Hamburgo, State of Rio Grande do Sul, Brazil. In the first experiment, spores stored at 7 degrees C were surface sterilized with 0.5, 0.8 and 2% of sodium hypochlorite (NaClO) for 15 minutes and sown in Meyer's c...
Uploads
Papers by Beatriz Vargas