Ultrasound in Obstetrics & Gynecology, Sep 1, 2012
Objectives: Uterine Doppler is used in screening for placentaassociated diseases, such as pre-ecl... more Objectives: Uterine Doppler is used in screening for placentaassociated diseases, such as pre-eclampsia and intrauterine growth restriction of the fetus (IUGR). The aim of this study was to examine the predictive value of second trimester uterine Doppler in pregnancies complicated by systemic lupus eritematosus (SLE). Methods: Observational study on 55 pregnancies in women with SLE treated at our Unit from 2000 to 2008. The Doppler examination was performed between 23+0 and 25+6 weeks of gestation. The mean uterine artery pulsatility index (UtA PI) was calculated. Results: The median (interquartile range, IQR) UtA PI was 1.00 (0.90-1.20). Three patients had a mean uterine artery PI above the 95 th centile for gestational age. All these patients developed pre-eclampsia and IUGR. No cases of pre-eclampsia or IUGR were observed in patients with the mean uterine artery PI below the 95 th centile for gestational age. The sensitivity was 100% (95% CI 0.44-1.00), specificity was 100% (95% CI 0.93-1.00). Conclusions: In our series, the mean uterine artery PI was an excellent predictor for pre-eclampsia and IUGR in women with SLE.
American Journal of Obstetrics and Gynecology, 2014
OBJECTIVE: Preterm birth is a worldwide health problem. Risk of this perinatal complication follo... more OBJECTIVE: Preterm birth is a worldwide health problem. Risk of this perinatal complication follows a social gradient. The aim of this study was to examine the association between social inequalities and preterm birth using both psychosocial and material determinants. STUDY DESIGN: This study was a retrospective analysis of survey and linked hospital data from 16,886 women giving birth to singletons in the U.K. who were included in wave 1 (2000)(2001)(2002) of the Millennium Cohort Study. Preterm birth was the main outcome and defined as delivery between 24 weeks and 36 weeks, 6 days gestation. Social inequalities were measured with material (household income, housing tenure, perceived neighbourhood deprivation) and psychosocial (education, occupational class, employment, social support) indicators. Analysis used nested multivariate logistic regression to assess odds of preterm birth, adjusting for demographics, baseline health and health-related behaviours, pregnancy and delivery conditions, and pregnancy complications. RESULTS: Employment (OR¼0.70, 95%CI: 0.50-0.90, p¼0.039) and one indicator of social support (OR¼0.84, 95%CI: 0.72-0.97, p¼0.021) were protective against the risk of preterm birth and persisted following full adjustment. Effects of household income, housing tenure, perceived neighbourhood deprivation, and education were largely attenuated with adjustment for other social determinants. CONCLUSION: In this study, employment and one indicator of social support were associated with decreased odds of preterm birth, supporting the hypothesis that poor psychosocial and material circumstances place women at higher risk of preterm birth. Further research is needed to examine the causal pathways through which social inequalities affect this adverse health outcome.
Archives of Gynecology and Obstetrics, May 21, 2018
Objective To investigate the association between episiotomy and perineal damage in the subsequent... more Objective To investigate the association between episiotomy and perineal damage in the subsequent delivery. Study design A retrospective cohort study was conducted, comparing outcome of subsequent singleton deliveries of women with and without episiotomy in their first (index) delivery. Deliveries occurred between the years 1991-2015 in a tertiary medical center. Traumatic vaginal tears, multiple pregnancies, and cesarean deliveries (CD) in the index pregnancy were excluded from the analysis. Multiple logistic regression models were used to control for confounders. Results During the study period, 43,066 women met the inclusion criteria; of them, 50.4% (n = 21,711) had subsequent delivery after episiotomy and 49.6% (n = 21,355) had subsequent delivery without episiotomy in the index pregnancy. Patients with episiotomy in the index birth higher rates of subsequent episiotomy (17.5 vs. 3.1%; P < 0.001; OR 1.9; 95% CI). In addition, the rates of the first and second degree perineal tears as well as the third and fourth degree perineal tears were significantly higher in patients following episiotomy (33.6 vs. 17.8%; P < 0.001, and 0.2 vs. 0.1%; P = 0.002, respectively). Nevertheless, there was no significant difference at the rates of CD and instrumental deliveries, between the groups. While adjusting for maternal age, ethnicity, birth weight, and vacuum delivery-the previous episiotomy was noted as an independent risk factor for recurrent episiotomy in the subsequent delivery (adjusted OR 6.7; 95% CI 6.2-7.3, P < 0.001). The results remained significant for term (adjusted OR 6.8; 95% CI 6.2-7.4, P < 0.001) as well as preterm deliveries (adjusted OR 4.5; 95% CI 3.3-6.3, P < 0.001) in two different models. Conclusion Episiotomy is an independent risk factor for recurrent episiotomy in the subsequent delivery.
Objectives Cervical insufficiency (CI) is a condition consistent with painless cervical dilatatio... more Objectives Cervical insufficiency (CI) is a condition consistent with painless cervical dilatation that can lead to preterm delivery. Cervical cerclage is a procedure in which cervical suture is performed for preventing preterm labor in several indications. Late emergency cerclage is technically more challenging compared to elective cerclage, performed earlier during pregnancy, prior to cervical changes. Pregnancy outcomes with emergency cerclage were found to be improved in previous reports, but there is still inconclusive data. To assess the effectiveness and safety of emergency cerclage vs. conservative management with progesterone and/or bed resting, in preventing preterm birth and improving neonatal outcomes in women with clinically evident cervical insufficiency. Methods This is a retrospective cohort study conducted on all women diagnosed with cervical insufficiency between the 16th and 24th gestational week who met the inclusion criteria, from January 2012 to December 2018. Obstetric and neonatal outcomes: time from diagnosis to delivery, duration of pregnancy, birth weight and Apgar score, were compared between women who underwent cerclage and those who treated conservatively. Results Twenty eight women underwent emergency cerclage (cerclage group) and 194 managed with a conservative therapy, progesterone and/or bed rest (control group). Time from diagnosis to delivery 13 weeks vs. 8 weeks and birth weight 2,418 g vs. 1914 g were significantly higher in the first cohort. Average pregnancy duration was three weeks longer in the cerclage group, but that was not significant. No complications occurred in the cerclage group and no difference in mode of delivery were found. Conclusions Emergency cerclage is an effective and safe procedure in preventing preterm birth and prolongation of pregnancy, in women with cervical insufficiency in the late second trimester.
Objectives Cervical insufficiency (CI) is a condition consistent with painless cervical dilatatio... more Objectives Cervical insufficiency (CI) is a condition consistent with painless cervical dilatation that can lead to preterm delivery. Cervical cerclage is a procedure in which cervical suture is performed for preventing preterm labor in several indications. Late emergency cerclage is technically more challenging compared to elective cerclage, performed earlier during pregnancy, prior to cervical changes. Pregnancy outcomes with emergency cerclage were found to be improved in previous reports, but there is still inconclusive data. To assess the effectiveness and safety of emergency cerclage vs. conservative management with progesterone and/or bed resting, in preventing preterm birth and improving neonatal outcomes in women with clinically evident cervical insufficiency. Methods This is a retrospective cohort study conducted on all women diagnosed with cervical insufficiency between the 16th and 24th gestational week who met the inclusion criteria, from January 2012 to December 2018. ...
American Journal of Obstetrics and Gynecology, 2015
not change after controlling for gestational age at delivery in the linear or Poisson regression ... more not change after controlling for gestational age at delivery in the linear or Poisson regression models. CONCLUSION: In the presence of recurrent late decelerations, fetal oxygen saturation is not related to the presence of MS-AF. Decisions regarding labor management in patients with recurrent late decelerations should not be influenced by meconium staining.
American Journal of Obstetrics and Gynecology, 2016
BACKGROUND: Cerebral palsy (CP) is a late sequel of pregnancy, and the role of preeclampsia is de... more BACKGROUND: Cerebral palsy (CP) is a late sequel of pregnancy, and the role of preeclampsia is debatable. OBJECTIVE: The aims of this study were to determine the association between preeclampsia and cerebral palsy and to determine the risk factors for the development of cerebral palsy in these patients. STUDY DESIGN: A retrospective population-based cohort study was designed that included 229,192 singleton pregnancies. The study population was divided into 2 groups: (1) patients with preeclampsia (n ¼ 9749) and (2) normotensive gestations (n ¼ 219,443). Generalized Estimating Equation multiple logistic regression models were performed to study the associations among preeclampsia, small for gestational age, gestational age at delivery, and the risk factors for the development of cerebral palsy in neonates of women with preeclampsia. RESULTS: The rate of cerebral palsy was double in patients with preeclampsia than in the normotensive group (0.2% vs 0.1%; P ¼ .015); early onset preeclampsia and small for gestational age were independent risk factors for the subsequent development of cerebral palsy (odds ratio,
American Journal of Obstetrics and Gynecology, 2014
OBJECTIVE: To evaluate differential amniotic fluid cytokine profile in women with chorioamnioniti... more OBJECTIVE: To evaluate differential amniotic fluid cytokine profile in women with chorioamnionitis with and without funisitis. STUDY DESIGN: Thirty-nine women at high risk of chorioamnionitis between 24 and 32 weeks' gestation were studied (PPROM n ¼ 28,
is used in screening for placentaassociated diseases, such as pre-eclampsia and intrauterine grow... more is used in screening for placentaassociated diseases, such as pre-eclampsia and intrauterine growth restriction of the fetus (IUGR). The aim of this study was to examine the predictive value of second trimester uterine Doppler in pregnancies complicated by systemic lupus eritematosus (SLE). Methods: Observational study on 55 pregnancies in women with SLE treated at our Unit from 2000 to 2008. The Doppler examination was performed between 23+0 and 25+6 weeks of gestation. The mean uterine artery pulsatility index (UtA PI) was calculated. Results: The median (interquartile range, IQR) UtA PI was 1.00 (0.90-1.20). Three patients had a mean uterine artery PI above the 95 th centile for gestational age. All these patients developed pre-eclampsia and IUGR. No cases of pre-eclampsia or IUGR were observed in patients with the mean uterine artery PI below the 95 th centile for gestational age. The sensitivity was 100% (95% CI 0.44-1.00), specificity was 100% (95% CI 0.93-1.00). Conclusions: In our series, the mean uterine artery PI was an excellent predictor for pre-eclampsia and IUGR in women with SLE.
Objective: To determine whether the addition of polyphenols (gallic and caffeic acids) to infants... more Objective: To determine whether the addition of polyphenols (gallic and caffeic acids) to infants milk substitutes, prevents oxidation of unsaturated fatty acids, under conditions of oxidative stress. Materials and methods: In order to induce controlled oxidative stress we used ultraviolet radiation UV-C 254 nm with energy doses in the range of 0-14 J/ml. We followed lipid peroxidation by the thiobarbituric acid reactive substances (TBARS) assay in order to measure the amount of secondary oxidation products, malondialdehyde (MDA). Polyphenols were added to the type specified the range of 0-3 mM concentrations. To measure the change polyphenols amount, the method of Folin-Ciocalteu assay was used. Results: We have proved that UV-C radiation is able to oxidize PUFA. We found a direct relationship between radiation dose and the amount of oxidation products formed as a result of exposure to radiation. We showed that the polyphenols, gallic acid and acid coffee, are able to decrease oxidation by the observed decline in oxidation products of MDA. High concentrations of polyphenols can prevent oxidative damage radiation exposure: coffee acids are effective in about 20% more than gallic acid. Conclusion: We recommend adding acid coffee to newborns milk powder in order to protect PUFA fatty acids, as well as to allow additional nutritional benefit to the newborn.
Preeclampsia is a common pregnancy complication. Abnormal development of the placenta is the prev... more Preeclampsia is a common pregnancy complication. Abnormal development of the placenta is the prevailing cause theory of this complication. Women with preeclampsia suffer from acute oxidative stress and high lipid oxidation in plasma. The aim of this study was to compare levels of polyphenols and lipid peroxidation in colostrum of nursing mothers with and without preeclampsia. The study was conducted at the Department of Obstetrics and Gynecology at Soroka University Medical Center. The study group consisting of 18 women, who were diagnosed with preeclampsia, was compared to the control group: 22 healthy women. The total phenolic content in the colostrum was determined by using the Folin–Ciocalteu method. Lipid peroxidation was determined by measuring MDA, using the TBARS assay. Polyphenol concentrations were significantly higher (about 33%) in the colostrum of the study group compared with the control group (p=0.00042). Lipid peroxidation levels (MDA) were significantly lower (about...
To determine the correlation between the urine protein-creatinine ratio (UPCR)and the 24h-UPET;an... more To determine the correlation between the urine protein-creatinine ratio (UPCR)and the 24h-UPET;and to identify the optimal threshold values of UPCR for the diagnosis of preeclampsia and its severe form. This prospective cohort study included 81 hypertensive pregnant patients who had a 24h-UPET and a UPCR tests. Two groups were created using a UPCR cut-off of 23.2mg/mmol[negative UPCR(n=40);positive UPCR(n=41)]. 1)49 patients of were diagnosed with preeclampsia, and 23 of them had a severe disease; 2)there was a significant correlation between UPCR and 24h-UPET; 3)a cut-off PUCR value of 23.2 mg/mmol had an area under the curve=0.927, sensitivity of 89%, specificity 88%, positive predictive value 90%, a positive likelihood ratio (+LR) of 7.41 and a negative likelihood ratio (-LR) of 0.13 for the diagnosis of preeclampsia;4)UPCR value of 325mg/mmol had an area under the curve=0.841, and a sensitivity of 83%,specificity 81%, positive predictive value 81%,+LR of 4.4 and -LR of 0.2 for t...
Ultrasound in Obstetrics & Gynecology, Sep 1, 2012
Objectives: Uterine Doppler is used in screening for placentaassociated diseases, such as pre-ecl... more Objectives: Uterine Doppler is used in screening for placentaassociated diseases, such as pre-eclampsia and intrauterine growth restriction of the fetus (IUGR). The aim of this study was to examine the predictive value of second trimester uterine Doppler in pregnancies complicated by systemic lupus eritematosus (SLE). Methods: Observational study on 55 pregnancies in women with SLE treated at our Unit from 2000 to 2008. The Doppler examination was performed between 23+0 and 25+6 weeks of gestation. The mean uterine artery pulsatility index (UtA PI) was calculated. Results: The median (interquartile range, IQR) UtA PI was 1.00 (0.90-1.20). Three patients had a mean uterine artery PI above the 95 th centile for gestational age. All these patients developed pre-eclampsia and IUGR. No cases of pre-eclampsia or IUGR were observed in patients with the mean uterine artery PI below the 95 th centile for gestational age. The sensitivity was 100% (95% CI 0.44-1.00), specificity was 100% (95% CI 0.93-1.00). Conclusions: In our series, the mean uterine artery PI was an excellent predictor for pre-eclampsia and IUGR in women with SLE.
American Journal of Obstetrics and Gynecology, 2014
OBJECTIVE: Preterm birth is a worldwide health problem. Risk of this perinatal complication follo... more OBJECTIVE: Preterm birth is a worldwide health problem. Risk of this perinatal complication follows a social gradient. The aim of this study was to examine the association between social inequalities and preterm birth using both psychosocial and material determinants. STUDY DESIGN: This study was a retrospective analysis of survey and linked hospital data from 16,886 women giving birth to singletons in the U.K. who were included in wave 1 (2000)(2001)(2002) of the Millennium Cohort Study. Preterm birth was the main outcome and defined as delivery between 24 weeks and 36 weeks, 6 days gestation. Social inequalities were measured with material (household income, housing tenure, perceived neighbourhood deprivation) and psychosocial (education, occupational class, employment, social support) indicators. Analysis used nested multivariate logistic regression to assess odds of preterm birth, adjusting for demographics, baseline health and health-related behaviours, pregnancy and delivery conditions, and pregnancy complications. RESULTS: Employment (OR¼0.70, 95%CI: 0.50-0.90, p¼0.039) and one indicator of social support (OR¼0.84, 95%CI: 0.72-0.97, p¼0.021) were protective against the risk of preterm birth and persisted following full adjustment. Effects of household income, housing tenure, perceived neighbourhood deprivation, and education were largely attenuated with adjustment for other social determinants. CONCLUSION: In this study, employment and one indicator of social support were associated with decreased odds of preterm birth, supporting the hypothesis that poor psychosocial and material circumstances place women at higher risk of preterm birth. Further research is needed to examine the causal pathways through which social inequalities affect this adverse health outcome.
Archives of Gynecology and Obstetrics, May 21, 2018
Objective To investigate the association between episiotomy and perineal damage in the subsequent... more Objective To investigate the association between episiotomy and perineal damage in the subsequent delivery. Study design A retrospective cohort study was conducted, comparing outcome of subsequent singleton deliveries of women with and without episiotomy in their first (index) delivery. Deliveries occurred between the years 1991-2015 in a tertiary medical center. Traumatic vaginal tears, multiple pregnancies, and cesarean deliveries (CD) in the index pregnancy were excluded from the analysis. Multiple logistic regression models were used to control for confounders. Results During the study period, 43,066 women met the inclusion criteria; of them, 50.4% (n = 21,711) had subsequent delivery after episiotomy and 49.6% (n = 21,355) had subsequent delivery without episiotomy in the index pregnancy. Patients with episiotomy in the index birth higher rates of subsequent episiotomy (17.5 vs. 3.1%; P < 0.001; OR 1.9; 95% CI). In addition, the rates of the first and second degree perineal tears as well as the third and fourth degree perineal tears were significantly higher in patients following episiotomy (33.6 vs. 17.8%; P < 0.001, and 0.2 vs. 0.1%; P = 0.002, respectively). Nevertheless, there was no significant difference at the rates of CD and instrumental deliveries, between the groups. While adjusting for maternal age, ethnicity, birth weight, and vacuum delivery-the previous episiotomy was noted as an independent risk factor for recurrent episiotomy in the subsequent delivery (adjusted OR 6.7; 95% CI 6.2-7.3, P < 0.001). The results remained significant for term (adjusted OR 6.8; 95% CI 6.2-7.4, P < 0.001) as well as preterm deliveries (adjusted OR 4.5; 95% CI 3.3-6.3, P < 0.001) in two different models. Conclusion Episiotomy is an independent risk factor for recurrent episiotomy in the subsequent delivery.
Objectives Cervical insufficiency (CI) is a condition consistent with painless cervical dilatatio... more Objectives Cervical insufficiency (CI) is a condition consistent with painless cervical dilatation that can lead to preterm delivery. Cervical cerclage is a procedure in which cervical suture is performed for preventing preterm labor in several indications. Late emergency cerclage is technically more challenging compared to elective cerclage, performed earlier during pregnancy, prior to cervical changes. Pregnancy outcomes with emergency cerclage were found to be improved in previous reports, but there is still inconclusive data. To assess the effectiveness and safety of emergency cerclage vs. conservative management with progesterone and/or bed resting, in preventing preterm birth and improving neonatal outcomes in women with clinically evident cervical insufficiency. Methods This is a retrospective cohort study conducted on all women diagnosed with cervical insufficiency between the 16th and 24th gestational week who met the inclusion criteria, from January 2012 to December 2018. Obstetric and neonatal outcomes: time from diagnosis to delivery, duration of pregnancy, birth weight and Apgar score, were compared between women who underwent cerclage and those who treated conservatively. Results Twenty eight women underwent emergency cerclage (cerclage group) and 194 managed with a conservative therapy, progesterone and/or bed rest (control group). Time from diagnosis to delivery 13 weeks vs. 8 weeks and birth weight 2,418 g vs. 1914 g were significantly higher in the first cohort. Average pregnancy duration was three weeks longer in the cerclage group, but that was not significant. No complications occurred in the cerclage group and no difference in mode of delivery were found. Conclusions Emergency cerclage is an effective and safe procedure in preventing preterm birth and prolongation of pregnancy, in women with cervical insufficiency in the late second trimester.
Objectives Cervical insufficiency (CI) is a condition consistent with painless cervical dilatatio... more Objectives Cervical insufficiency (CI) is a condition consistent with painless cervical dilatation that can lead to preterm delivery. Cervical cerclage is a procedure in which cervical suture is performed for preventing preterm labor in several indications. Late emergency cerclage is technically more challenging compared to elective cerclage, performed earlier during pregnancy, prior to cervical changes. Pregnancy outcomes with emergency cerclage were found to be improved in previous reports, but there is still inconclusive data. To assess the effectiveness and safety of emergency cerclage vs. conservative management with progesterone and/or bed resting, in preventing preterm birth and improving neonatal outcomes in women with clinically evident cervical insufficiency. Methods This is a retrospective cohort study conducted on all women diagnosed with cervical insufficiency between the 16th and 24th gestational week who met the inclusion criteria, from January 2012 to December 2018. ...
American Journal of Obstetrics and Gynecology, 2015
not change after controlling for gestational age at delivery in the linear or Poisson regression ... more not change after controlling for gestational age at delivery in the linear or Poisson regression models. CONCLUSION: In the presence of recurrent late decelerations, fetal oxygen saturation is not related to the presence of MS-AF. Decisions regarding labor management in patients with recurrent late decelerations should not be influenced by meconium staining.
American Journal of Obstetrics and Gynecology, 2016
BACKGROUND: Cerebral palsy (CP) is a late sequel of pregnancy, and the role of preeclampsia is de... more BACKGROUND: Cerebral palsy (CP) is a late sequel of pregnancy, and the role of preeclampsia is debatable. OBJECTIVE: The aims of this study were to determine the association between preeclampsia and cerebral palsy and to determine the risk factors for the development of cerebral palsy in these patients. STUDY DESIGN: A retrospective population-based cohort study was designed that included 229,192 singleton pregnancies. The study population was divided into 2 groups: (1) patients with preeclampsia (n ¼ 9749) and (2) normotensive gestations (n ¼ 219,443). Generalized Estimating Equation multiple logistic regression models were performed to study the associations among preeclampsia, small for gestational age, gestational age at delivery, and the risk factors for the development of cerebral palsy in neonates of women with preeclampsia. RESULTS: The rate of cerebral palsy was double in patients with preeclampsia than in the normotensive group (0.2% vs 0.1%; P ¼ .015); early onset preeclampsia and small for gestational age were independent risk factors for the subsequent development of cerebral palsy (odds ratio,
American Journal of Obstetrics and Gynecology, 2014
OBJECTIVE: To evaluate differential amniotic fluid cytokine profile in women with chorioamnioniti... more OBJECTIVE: To evaluate differential amniotic fluid cytokine profile in women with chorioamnionitis with and without funisitis. STUDY DESIGN: Thirty-nine women at high risk of chorioamnionitis between 24 and 32 weeks' gestation were studied (PPROM n ¼ 28,
is used in screening for placentaassociated diseases, such as pre-eclampsia and intrauterine grow... more is used in screening for placentaassociated diseases, such as pre-eclampsia and intrauterine growth restriction of the fetus (IUGR). The aim of this study was to examine the predictive value of second trimester uterine Doppler in pregnancies complicated by systemic lupus eritematosus (SLE). Methods: Observational study on 55 pregnancies in women with SLE treated at our Unit from 2000 to 2008. The Doppler examination was performed between 23+0 and 25+6 weeks of gestation. The mean uterine artery pulsatility index (UtA PI) was calculated. Results: The median (interquartile range, IQR) UtA PI was 1.00 (0.90-1.20). Three patients had a mean uterine artery PI above the 95 th centile for gestational age. All these patients developed pre-eclampsia and IUGR. No cases of pre-eclampsia or IUGR were observed in patients with the mean uterine artery PI below the 95 th centile for gestational age. The sensitivity was 100% (95% CI 0.44-1.00), specificity was 100% (95% CI 0.93-1.00). Conclusions: In our series, the mean uterine artery PI was an excellent predictor for pre-eclampsia and IUGR in women with SLE.
Objective: To determine whether the addition of polyphenols (gallic and caffeic acids) to infants... more Objective: To determine whether the addition of polyphenols (gallic and caffeic acids) to infants milk substitutes, prevents oxidation of unsaturated fatty acids, under conditions of oxidative stress. Materials and methods: In order to induce controlled oxidative stress we used ultraviolet radiation UV-C 254 nm with energy doses in the range of 0-14 J/ml. We followed lipid peroxidation by the thiobarbituric acid reactive substances (TBARS) assay in order to measure the amount of secondary oxidation products, malondialdehyde (MDA). Polyphenols were added to the type specified the range of 0-3 mM concentrations. To measure the change polyphenols amount, the method of Folin-Ciocalteu assay was used. Results: We have proved that UV-C radiation is able to oxidize PUFA. We found a direct relationship between radiation dose and the amount of oxidation products formed as a result of exposure to radiation. We showed that the polyphenols, gallic acid and acid coffee, are able to decrease oxidation by the observed decline in oxidation products of MDA. High concentrations of polyphenols can prevent oxidative damage radiation exposure: coffee acids are effective in about 20% more than gallic acid. Conclusion: We recommend adding acid coffee to newborns milk powder in order to protect PUFA fatty acids, as well as to allow additional nutritional benefit to the newborn.
Preeclampsia is a common pregnancy complication. Abnormal development of the placenta is the prev... more Preeclampsia is a common pregnancy complication. Abnormal development of the placenta is the prevailing cause theory of this complication. Women with preeclampsia suffer from acute oxidative stress and high lipid oxidation in plasma. The aim of this study was to compare levels of polyphenols and lipid peroxidation in colostrum of nursing mothers with and without preeclampsia. The study was conducted at the Department of Obstetrics and Gynecology at Soroka University Medical Center. The study group consisting of 18 women, who were diagnosed with preeclampsia, was compared to the control group: 22 healthy women. The total phenolic content in the colostrum was determined by using the Folin–Ciocalteu method. Lipid peroxidation was determined by measuring MDA, using the TBARS assay. Polyphenol concentrations were significantly higher (about 33%) in the colostrum of the study group compared with the control group (p=0.00042). Lipid peroxidation levels (MDA) were significantly lower (about...
To determine the correlation between the urine protein-creatinine ratio (UPCR)and the 24h-UPET;an... more To determine the correlation between the urine protein-creatinine ratio (UPCR)and the 24h-UPET;and to identify the optimal threshold values of UPCR for the diagnosis of preeclampsia and its severe form. This prospective cohort study included 81 hypertensive pregnant patients who had a 24h-UPET and a UPCR tests. Two groups were created using a UPCR cut-off of 23.2mg/mmol[negative UPCR(n=40);positive UPCR(n=41)]. 1)49 patients of were diagnosed with preeclampsia, and 23 of them had a severe disease; 2)there was a significant correlation between UPCR and 24h-UPET; 3)a cut-off PUCR value of 23.2 mg/mmol had an area under the curve=0.927, sensitivity of 89%, specificity 88%, positive predictive value 90%, a positive likelihood ratio (+LR) of 7.41 and a negative likelihood ratio (-LR) of 0.13 for the diagnosis of preeclampsia;4)UPCR value of 325mg/mmol had an area under the curve=0.841, and a sensitivity of 83%,specificity 81%, positive predictive value 81%,+LR of 4.4 and -LR of 0.2 for t...
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