Decio Barbosa

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Felipe J Hevia

CIESAS

Carlos Sanz

Universidad Complutense de Madrid

Jorge Marco

University of Bath

Camilo E Defelipe Villa

Pontificia Universidad Javeriana

Rubén Pallol

Universidad Complutense de Madrid

Luis Enrique OTERO CARVAJAL ORCID: 0000-0002-2492-238X

Universidad Complutense de Madrid

Gabriel Cid

Universidad San Sebastián

Roberto García Ferreira

Universidad de la República

Ángel Alcalde

University of Melbourne

Felipe Martínez Pinzón

Brown University

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Decreased Total Antioxidant Capacity and Increased Oxidative Stress and Serum Ferritin Levels in Untreated Chronic Hepatitis C Patients

The FASEB Journal, 2009

Menstruation distress is strongly associated with hormone-immune-metabolic biomarkers

Journal of Psychosomatic Research

OBJECTIVE To examine the associations between menstruation features and symptoms and hormone-immu... more OBJECTIVE To examine the associations between menstruation features and symptoms and hormone-immune-metabolic biomarkers. METHODS Forty-one women completed questionnaires assessing characteristic menstruation symptoms, duration of menstrual cycle and number of pads used/day and completed the Daily Record of Severity of Problems (DRSP) during the consecutive days of their menstrual cycle. Menses-related symptoms (MsRS) were computed from the sum of 10 pre- and post-menses symptoms and the menstruation blood and duration index (MBDI) was computed based on the daily number of pads and duration of menses. We assayed serum levels of various biomarkers at days 7, 14, 21, and 28 of the subjects' menstrual cycle. RESULTS MBDI was significantly associated with a) MsRS including low abdominal cramps, and gastro-intestinal (GI) and pain symptoms (positively); b) plasma levels of haptoglobin (Hp), CCL5, insulin growth factor (IGF)-1, and plasminogen activator inhibitor (PAI)1 (all positively); and c) estradiol and paraoxonase (PON)1 arylesterase activity (both inversely). MsRS were significantly predicted by CCL5 and IGF-1 (both positively) and progesterone (inversely). Low-abdominal cramps, and gastro-intestinal and pain symptoms were associated with lower progesterone levels. The MBDI+MsRS score was significantly predicted by the cumulative effects of (in descending order of importance): Hp, IGF-1, PON1 arylesterase, estradiol and PAI. CONCLUSION Menstruation-related features including estimated blood loss, duration of menses, cramps, pain, and gastro-intestinal symptoms are associated with hormone-immune-metabolic biomarkers, which mechanistically may explain those features. Future research should construct a cross-validated algorithm using MBDI+MsRS features in a larger study group to delineate a useful case-definition of menstruation-related distress.

Efeitos e Mecanismos De Ação Dos Ácidos Graxos Poliinsaturados N-3 Na Prevenção De Doenças Cardiovasculares

A ingestao de oleo de peixe tem demonstrado efeitos beneficos na prevencao das doencas cardiovasc... more A ingestao de oleo de peixe tem demonstrado efeitos beneficos na prevencao das doencas cardiovasculares (DCV) e este efeito esta relacionado a presenca de acidos graxos poliinsaturados n-3, em especial dos acidos eicosapentaenoico (EPA, C20:5n-3) e docosahexaenoico (DHA, C22:6n-3), encontrados nos oleos de peixes de aguas frias e profundas como salmao, arenque, atum e sardinhas. Estes compostos tem demonstrado importante acao antilipemica, antiinflamatoria, antitrombotica, antiarritimica, anti-hipertensiva, entre outras. A ingestao de oleo de peixe em pacientes com doenca cardiaca isquemica e hiperlipoproteinemia diminuiu os niveis sericos de fibrinogenio, a viscosidade plasmatica e a resistencia vascular periferica total. Eles tambem atuam ajudando a manter a elasticidade da parede das arterias, impedindo a coagulacao do sangue, reduzindo a pressao sanguinea e estabilizando a arritmia cardiaca. O seu principal efeito nas doencas coronarias e a reducao da producao de tromboxana A2, ...

Atividade física habitual e aptidão física relacionada à saúde em adolescentes

Decio Barbosa

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