... Hepatology 8 (1988), p. 385. 3. DT Hiyama, D. Von Allmen, L. Rosenblum, CK Ogle, PO Hasselgre... more ... Hepatology 8 (1988), p. 385. 3. DT Hiyama, D. Von Allmen, L. Rosenblum, CK Ogle, PO Hasselgren and JE Fischer, Synthesis of albumin and acute-phase proteins in perfused liver after burn injury in rats. J. Burn Care Rehab. ...
Exogenous insulin-like growth factor-I (IGF-I) is known to rhIGF-I protein. Body weights and woun... more Exogenous insulin-like growth factor-I (IGF-I) is known to rhIGF-I protein. Body weights and wound healing were improve the pathophysiology of a thermal injury, however, measured. Muscle and liver dry/wet weights and IGF-I condeleterious side-effects have limited its utility. Cholesterol-centrations in serum, skin and liver were measured by containing cationic liposomes that encapsulate comp-radioimmunoassay. Transfection was confirmed by histolementary DNA (cDNA) are nonviral carriers used for in chemical staining for -galactosidase. Rats receiving the vivo gene transfection. We propose that liposome IGF-I IGF-I cDNA constructs exhibited the most rapid wound regene transfer will accelerate wound healing in burned rats epithelialization and greatest increase in body weight and and attenuate deleterious side-effects associated with high gastrocnemius muscle protein content (P Ͻ 0.05). Local levels of IGF-I. To test this hypothesis IGF-I gene con-IGF-I protein concentrations in the skin were higher when structs, encapsulated in liposomes, were studied for their compared to liposomes containing only the lacZ gene efficacy in modulating the thermal injury response. Thirty (P Ͻ 0.05) Transfection was apparent in the cytoplasm of adult male Sprague-Dawley rats were given a 60% TBSA myofibroblasts, endothelial cells and macrophages of the scald burn and randomly divided into three groups to granulation tissue. Liposomes containing the IGF-I gene receive weekly subcutaneous injections of liposomes plus constructs proved effective in preventing muscle protein the lacZ gene coding for -galactosidase, liposomes plus wasting and preserving total body weight after a severe cDNA for IGF-I and -galactosidase or liposomes plus the thermal injury.
This review discusses the ways in which anesthetists can optimize anesthetic-analgesic drug admin... more This review discusses the ways in which anesthetists can optimize anesthetic-analgesic drug administration by utilizing pharmacokinetic and pharmacodynamic information. We therefore focus on the dose-response relationship and the interactions between i.v. hypnotics and opioids. For i.v. hypnotics and opioids, models that accurately predict the time course of drug disposition and effect can be applied. Various commercial or experimental drug effect measures have been developed and can be implemented to further fine-tune individual patient-drug titration. The development of advisory and closed-loop feedback systems, which combine and integrate all sources of pharmacological and effect monitoring, has taken the existing kinetic-based administration technology towards total coverage of the dose-response relationship.
This review discusses the ways in which anaesthetists can optimize anaesthetic-analgesic drug adm... more This review discusses the ways in which anaesthetists can optimize anaesthetic-analgesic drug administration by utilizing pharmacokinetic and pharmacodynamic information. We therefore focus on the dose-response relationship and interactions between intravenous hypnotics and opioids. For intravenous hypnotics and opioids, models that accurately predict the time course of drug disposition and effect can be applied. Various commercially or experimentally drug effect measures have been developed and can be implemented to further fine-tune patient individualized drug titration. The development of advisory and closed-loop feedback systems which combine and integrate all sources of pharmacological and effect monitoring, has taken the existing kinetic-based administration technology forwards towards a total coverage of the dose-response relationship.
Target controlled infusion (TCI) systems use population-based pharmacokinetic (PK) models that do... more Target controlled infusion (TCI) systems use population-based pharmacokinetic (PK) models that do not take into account inter-individual residual variation. This study compares the bias and inaccuracy of a population-based vs a personalized TCI propofol titration using Bayesian adaptation. Haemodynamic and hypnotic stability, and the prediction probability of alternative PK models, was studied. A double-blinded, prospective randomized controlled trial of 120 subjects undergoing cardiac surgery was conducted. Blood samples were obtained at 10, 35, 50, 65, 75 and 120 min and analysed using a point-of-care propofol blood analyser. Bayesian adaptation of the PK model was applied at 60 min in the intervention group. Median (Absolute) Performance Error (Md(A)PE) was used to evaluate the difference between bias and inaccuracy of the models. Haemodynamic (mean arterial pressure [MAP], heart rate) and hypnotic (bispectral index [BIS]) stability was studied. The predictive performance of four...
† Developments in pharmacokinetic modelling, effect-site monitors, and computer technology that a... more † Developments in pharmacokinetic modelling, effect-site monitors, and computer technology that are driving better optimization of anaesthetic drug administration are reviewed. † The authors emphasize that anaesthetists are now able to differentiate and measure hypnosis and analgesia, the two main facets of anaesthetic effect. † An important extension of this work is the development of advisory and closed-loop feedback systems combining effect-site monitoring and pharmacokinetic modelling. Summary. This review discusses the ways in which anaesthetists can optimize anaesthetic-analgesic drug administration by utilizing pharmacokinetic and pharmacodynamic information. We therefore focus on the dose-response relationship and the interactions between i.v. hypnotics and opioids. For i.v. hypnotics and opioids, models that accurately predict the time course of drug disposition and effect can be applied. Various commercial or experimental drug effect measures have been developed and can be implemented to further fine-tune individual patient-drug titration. The development of advisory and closed-loop feedback systems, which combine and integrate all sources of pharmacological and effect monitoring, has taken the existing kinetic-based administration technology forwards closer to total coverage of the dose-response relationship.
... Hepatology 8 (1988), p. 385. 3. DT Hiyama, D. Von Allmen, L. Rosenblum, CK Ogle, PO Hasselgre... more ... Hepatology 8 (1988), p. 385. 3. DT Hiyama, D. Von Allmen, L. Rosenblum, CK Ogle, PO Hasselgren and JE Fischer, Synthesis of albumin and acute-phase proteins in perfused liver after burn injury in rats. J. Burn Care Rehab. ...
Exogenous insulin-like growth factor-I (IGF-I) is known to rhIGF-I protein. Body weights and woun... more Exogenous insulin-like growth factor-I (IGF-I) is known to rhIGF-I protein. Body weights and wound healing were improve the pathophysiology of a thermal injury, however, measured. Muscle and liver dry/wet weights and IGF-I condeleterious side-effects have limited its utility. Cholesterol-centrations in serum, skin and liver were measured by containing cationic liposomes that encapsulate comp-radioimmunoassay. Transfection was confirmed by histolementary DNA (cDNA) are nonviral carriers used for in chemical staining for -galactosidase. Rats receiving the vivo gene transfection. We propose that liposome IGF-I IGF-I cDNA constructs exhibited the most rapid wound regene transfer will accelerate wound healing in burned rats epithelialization and greatest increase in body weight and and attenuate deleterious side-effects associated with high gastrocnemius muscle protein content (P Ͻ 0.05). Local levels of IGF-I. To test this hypothesis IGF-I gene con-IGF-I protein concentrations in the skin were higher when structs, encapsulated in liposomes, were studied for their compared to liposomes containing only the lacZ gene efficacy in modulating the thermal injury response. Thirty (P Ͻ 0.05) Transfection was apparent in the cytoplasm of adult male Sprague-Dawley rats were given a 60% TBSA myofibroblasts, endothelial cells and macrophages of the scald burn and randomly divided into three groups to granulation tissue. Liposomes containing the IGF-I gene receive weekly subcutaneous injections of liposomes plus constructs proved effective in preventing muscle protein the lacZ gene coding for -galactosidase, liposomes plus wasting and preserving total body weight after a severe cDNA for IGF-I and -galactosidase or liposomes plus the thermal injury.
This review discusses the ways in which anesthetists can optimize anesthetic-analgesic drug admin... more This review discusses the ways in which anesthetists can optimize anesthetic-analgesic drug administration by utilizing pharmacokinetic and pharmacodynamic information. We therefore focus on the dose-response relationship and the interactions between i.v. hypnotics and opioids. For i.v. hypnotics and opioids, models that accurately predict the time course of drug disposition and effect can be applied. Various commercial or experimental drug effect measures have been developed and can be implemented to further fine-tune individual patient-drug titration. The development of advisory and closed-loop feedback systems, which combine and integrate all sources of pharmacological and effect monitoring, has taken the existing kinetic-based administration technology towards total coverage of the dose-response relationship.
This review discusses the ways in which anaesthetists can optimize anaesthetic-analgesic drug adm... more This review discusses the ways in which anaesthetists can optimize anaesthetic-analgesic drug administration by utilizing pharmacokinetic and pharmacodynamic information. We therefore focus on the dose-response relationship and interactions between intravenous hypnotics and opioids. For intravenous hypnotics and opioids, models that accurately predict the time course of drug disposition and effect can be applied. Various commercially or experimentally drug effect measures have been developed and can be implemented to further fine-tune patient individualized drug titration. The development of advisory and closed-loop feedback systems which combine and integrate all sources of pharmacological and effect monitoring, has taken the existing kinetic-based administration technology forwards towards a total coverage of the dose-response relationship.
Target controlled infusion (TCI) systems use population-based pharmacokinetic (PK) models that do... more Target controlled infusion (TCI) systems use population-based pharmacokinetic (PK) models that do not take into account inter-individual residual variation. This study compares the bias and inaccuracy of a population-based vs a personalized TCI propofol titration using Bayesian adaptation. Haemodynamic and hypnotic stability, and the prediction probability of alternative PK models, was studied. A double-blinded, prospective randomized controlled trial of 120 subjects undergoing cardiac surgery was conducted. Blood samples were obtained at 10, 35, 50, 65, 75 and 120 min and analysed using a point-of-care propofol blood analyser. Bayesian adaptation of the PK model was applied at 60 min in the intervention group. Median (Absolute) Performance Error (Md(A)PE) was used to evaluate the difference between bias and inaccuracy of the models. Haemodynamic (mean arterial pressure [MAP], heart rate) and hypnotic (bispectral index [BIS]) stability was studied. The predictive performance of four...
† Developments in pharmacokinetic modelling, effect-site monitors, and computer technology that a... more † Developments in pharmacokinetic modelling, effect-site monitors, and computer technology that are driving better optimization of anaesthetic drug administration are reviewed. † The authors emphasize that anaesthetists are now able to differentiate and measure hypnosis and analgesia, the two main facets of anaesthetic effect. † An important extension of this work is the development of advisory and closed-loop feedback systems combining effect-site monitoring and pharmacokinetic modelling. Summary. This review discusses the ways in which anaesthetists can optimize anaesthetic-analgesic drug administration by utilizing pharmacokinetic and pharmacodynamic information. We therefore focus on the dose-response relationship and the interactions between i.v. hypnotics and opioids. For i.v. hypnotics and opioids, models that accurately predict the time course of drug disposition and effect can be applied. Various commercial or experimental drug effect measures have been developed and can be implemented to further fine-tune individual patient-drug titration. The development of advisory and closed-loop feedback systems, which combine and integrate all sources of pharmacological and effect monitoring, has taken the existing kinetic-based administration technology forwards closer to total coverage of the dose-response relationship.
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Papers by B. Lichtenbelt