Public procurement in Iraq plays an essential function in the development and recovery of the cou... more Public procurement in Iraq plays an essential function in the development and recovery of the country's economy as well as providing the essential infrastructure for the growth of the private sector. The Coalition Provisional Authority's Government Procurement Legislation No. 87 (2004) is the final procurement law in effect in Iraq. Preparations are underway for new procurement legislation as of Oct. 2021. The objective of the paper is to determine the effectiveness of the public procurement process used in a construction project in Iraq, there is also a lack of procurement methods and policy consistency between government agencies. procurement techniques, tender documentation information, Advertising deadlines, and document management procedures, for example, vary amongst federal contracting agencies. Furthermore, there is no mandatory process for the definition and disclosure of tender evaluation criteria, providing room for subjectivity in the tender award process. This p...
2015 12th IEEE International Conference on Electronic Measurement & Instruments (ICEMI)
In the seek of getting better sensibility, selectivity, times of response and recovery, interdigi... more In the seek of getting better sensibility, selectivity, times of response and recovery, interdigital electrode structures have been increasingly used in nano and microelectronic devices designed to the gas sensing, in the last decades, given their importance and performance characteristics presented for each new usage. In this sense, this work not only addresses on a review of performed researches along the years, but also discusses recent developments of gas sensors based on interdigital electrodes.
Debt relief is unlikely to stimulate investment and growth in the world's highly indebted poor co... more Debt relief is unlikely to stimulate investment and growth in the world's highly indebted poor countries (HIPCs). This is because the HIPCs do not suffer from debt overhang. The principal obstacle to investment and growth in the world's poorest countries is a lack of basic economic institutions that provide the foundation for profitable economic activity. If the goal is to help poor countries build the institutions that best suit their development needs, then the energy and resources currently devoted to the HIPC initiative could be more effectively employed as direct foreign aid.
Objective : to compare characteristics of the gram stain , culture, Real-time PCR to detection pa... more Objective : to compare characteristics of the gram stain , culture, Real-time PCR to detection pathogenic bacteria in CSF samples of patients were suspected of acute bacterial meningitis. Methods: 100 CSF sample were suspected of acute bacterial meningitidis Gram stain , bacterial culture, Real-time PCR based on SYBR Green I fluorescent dye for detection of Nisseria meningitidis in all samples. Results: Gram stain and bacteria culture for all samples were positive in 5 case (5%) including two bacterial genus Listeria monocytogenes in four case (80%) and Staphylococcus aureus in one case (20%) while in RT-PCR based on SYBR Green for detection of SodC gene which is specific gene to diagnosis of N. meningitidis were positive in 42 case (42%). Conclusion: RT-PCR method is rapid , sensitive and specific diagnostic test for acute meningitis. RT-PCR test was positive in 42 case (42%) and all these case was N. meningitidis .
International Journal of Computer Applications, 2017
In this paper, the semiconductor optical amplifier (SOA) is used with a Mach–Zehnder interferomet... more In this paper, the semiconductor optical amplifier (SOA) is used with a Mach–Zehnder interferometer (MZI) forming an SOA-MZI structure which is used to perform the logic gates OR, and NOT. It is simulated at 10 Gbps, 20 Gbps, and 40 Gbps to extract simple design rules. Two binary input data signals are simulated at several bitrate 10 Gbps, 20 Gbps, and 40 Gbps. It is demonstrated that high data rate can be achieved with a specific injection current in SOA. SOAs required low injection current, which leads to a low value on the total power consumption of the gate. In addition, this work includes the study of the effect of the bit rate on the received power, minimum bit error rate (BER), and maximum quality factor (Q-factor). The logical output of the gate has an extinction ratio of more than 10 dB with good eye opening. The output of the OR, NOT gates shows error-free operation at different bit rate with a clear eye opening. General Terms Optical amplifier, MZI, optical logic gates.
International Journal of Computer Applications, 2017
In this paper, the semiconductor optical amplifier (SOA) is used with a Mach–Zehnder interferomet... more In this paper, the semiconductor optical amplifier (SOA) is used with a Mach–Zehnder interferometer (MZI) forming an SOA-MZI structure which is used to perform the logic gates OR, and NOT. It is simulated at 10 Gbps, 20 Gbps, and 40 Gbps to extract simple design rules. Two binary input data signals are simulated at several bitrate 10 Gbps, 20 Gbps, and 40 Gbps. It is demonstrated that high data rate can be achieved with a specific injection current in SOA. SOAs required low injection current, which leads to a low value on the total power consumption of the gate. In addition, this work includes the study of the effect of the bit rate on the received power, minimum bit error rate (BER), and maximum quality factor (Q-factor). The logical output of the gate has an extinction ratio of more than 10 dB with good eye opening. The output of the OR, NOT gates shows error-free operation at different bit rate with a clear eye opening. General Terms Optical amplifier, MZI, optical logic gates.
A tuberculose é uma doença infectocontagiosa causada pelo Mycobacterium tuberculosis, comum em pa... more A tuberculose é uma doença infectocontagiosa causada pelo Mycobacterium tuberculosis, comum em países em desenvolvimento. Os acomentimentos pulmonares são as principais manifestações da doença, embora existam, também, manifestações extrapulmonares, as quais são mais comuns em pacientes imunocomprometidos, a exemplo dos pacientes coinfectados com o HIV. O abscesso hepático é a forma menos comum de lesão. Entretanto, quando analisadas as taxas de mortalidade e os resultados dos tratamentos, é uma das manifestações extrapulmonares com pior prognóstico. O caso relatado segue com o diagnóstico através dos sinais e sintomas clínicos, além da realização dos exames laboratoriais e de imagem, a fim de diagnosticar e indicar os tratamentos cirúrgico e medicamentoso para tratar a infecção e sua consequente manifestação.
We study properties of localized effective spins induced in gapped quantum spin chains by local i... more We study properties of localized effective spins induced in gapped quantum spin chains by local inhomogeneities of the lattice. As a prototype, we study effective spins induced in impunity sites doped AKLT model by constructing the exact ground state in a matrix product state (MPS) form. We characterize their responses to external fields by studying an extended Zeeman interaction. We also study the antiferromagnetic bond-alternating Heisenberg chain with defect structures. For this model, an MPS representation similar to that for the AKLT model, "a uniform MPS with windows," is constructed, and it gives a good approximation of the ground state. We discuss the trade-off relation between the window length and the precision of the MPS ansatz. The effective exchange interaction between the induced spins is also investigated by using this representation.
Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Zwecken und zum Privatgebrauch ge... more Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Zwecken und zum Privatgebrauch gespeichert und kopiert werden. Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich machen, vertreiben oder anderweitig nutzen. Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, gelten abweichend von diesen Nutzungsbedingungen die in der dort genannten Lizenz gewährten Nutzungsrechte. Terms of use: Documents in EconStor may be saved and copied for your personal and scholarly purposes. You are not to copy documents for public or commercial purposes, to exhibit the documents publicly, to make them publicly available on the internet, or to distribute or otherwise use the documents in public. If the documents have been made available under an Open Content Licence (especially Creative Commons Licences), you may exercise further usage rights as specified in the indicated licence.
Shofar: An Interdisciplinary Journal of Jewish Studies, 2010
The Much Too Promised Land: America's Elusive Search for Arab-Israeli Peace, by Aaron David M... more The Much Too Promised Land: America's Elusive Search for Arab-Israeli Peace, by Aaron David Miller. New York: Bantam, 2008. 398 pp. $26.00. For those of us teaching courses on U.S. policy in the Middle East, and on the Arab-Israeli conflict, The Much Too Promised Land by Aaron Miller is a very welcome addition to the literature. Miller, who served in a number of U.S. Government positions dealing with the Middle East, including as deputy to U.S. Middle East envoy Dennis Ross, presents an "insider's view" of what works - and what doesn't - in U.S. policy toward the Arab-Israeli conflict. Spicing up his narrative, Miller frequently cites the rather earthy language used by both U.S. officials and foreign leaders, as they discuss Middle Eastern personalities, such as the comments of the late King Hussein of Jordan who characterized Yasser Arafat in the following way: "That little shit. He hasn't a clue what he is doing" (p. 55). Similarly, Miller's portrayal of the eating habits of Israeli negotiators is absolutely hilarious (p. 50). Miller gives the reader a real feel for how Middle Eastern diplomacy actually works, including how divisions among U.S. policy-makers hampers U.S. policy in the region. The book is divided into three sections. The first is an introduction to the dynamics of Middle East peacemaking and the challenges which even a superpower like the United States faces in trying to enforce its will. This section also includes an entire chapter devoted to the impact of U.S. domestic politics and the strengths and weaknesses of the so-called "Israel Lobby." The second part of the book presents case studies of successful U.S. policymakers: Henry Kissinger in negotiating the Sinai I (1974) and Sinai II (1975) agreements between Israel and Egypt, and the Golan Heights Agreement (1974) between Israel and Syria; Jimmy Carter, who worked out a peace treaty between Israel and Egypt (1979); and James Baker, who successfully convened the Madrid Peace Conference in 1991 after the First Gulf War. The final section of the book deals with U.S. President Bill Clinton, who failed in his efforts to achieve peace between Israel and both Syria and the Palestinians, and President George W. Bush who, according to Miller, did not try very hard to achieve an Israeli-Palestinian peace agreement. In the first section of the book, Miller presents a number of lessons for U.S. policy-makers as they deal with the nations of the Middle East. Perhaps the most pithy are as follows: In negotiations, to be effective, you need to believe that things can change but have extraordinary patience if they don't, (p. 26) You need to be tough but empathetic, firm but practical. And above all, you need to be ready to endure the endless maneuvering and machinations of Arabs and Israelis for whom the conflict has sadly become a way of life. (pp. 26-27) Smaller nations will do just about anything to survive, and are not inclined to listen or even trust advice offered by a distant power whose political and physical survival is not at stake. The ghosts of the past, made real by history's fears and traumas, speak louder than the untested promise of a brighter future offered up by American diplomats, (p. 37) Americans who recognize the galactic gap between a secure and confident America and the insecure world of Israelis and Arabs fare best of all. (p. 41) This conviction (of Yitzhak Rabin), that however well intentioned, the Americans were naive and didn't understand the Arabs, was shared by almost every Israeli with whom we worked, (p. 42) In his chapter on the Israel Lobby, Miller shows how a combination of common values and common enemies has forged a close U.S.-Israeli alliance. He also cites the influence of pro-Israeli Jews in the Democratic Party, and pro-Israeli Evangelical Christians in the Republican Party to show the broad bipartisan support for Israel in the U.S. To those who deplore the power of lobbies, be it the NRA, the Drug Lobby, or the Israel Lobby, Miller gives a strong rejoinder - the U. …
Pleiotrophin (PTN) is a heparin binding growth factor known to have role in neuronal development.... more Pleiotrophin (PTN) is a heparin binding growth factor known to have role in neuronal development. It is highly expressed in embryo but has a very limited expression in adult tissues. PTN is considered a proto-oncogene and has been hypothesized to play role in oncogenesis as its expression is found to be increased in many different cancer subtypes. Its role in cell transformation, cell growth, survival, migration and angiogenesis has also been shown in various different types of cancers. The function of PTN is hypothesized to be carried out by its interaction with cell surface proteoglycans or binding to its selective cell surface receptor, protein tyrosine phosphatase receptor Z1 (PTPRZ1). The significance of role of PTN in pathogenesis of thyroid cancer has not been explored especially with the fact that papillary thyroid carcinoma (PTC) originating in this ethnic population is the second most common female malignancy, after breast. So in search for novel druggable molecular target we sought for PTN expression in a large cohort of Saudi PTC. We analysed PTN alteration in more than 1000 primary papillary thyroid carcinoma in a tissue microarray format with clinical follow up data. We found that PTN was overexpressed in 65.5% (658/1006) of PTC and was significantly associated with aggressive clinical parameters such as tall cell variant histological subtype (p = 0.0333), extrathyroidal extension (p = 0.0292), lymphovascular invasion (p = 0.0182) and large tumour size (p = 0.0160). Important significant molecular association was seen with PTPRZ-1 (p = 0.0316), Midkine (p = 0.0008) and pSTAT-3 (p Keywords: Papillary Thyroid Cancer; Pleiotrophin; Pleiotrophin Receptor Citation Format: Shaham Beg, Maqbool Ahmed, Azhar Hussein, Rong Bu, Zeeshan Qadri, Saif AlSobhi, Fouad Al Dayel, Abdul K. Siraj, Khawla S. Al-Kuraya. Pleiotrophin is a marker of poor prognosis in Middle Eastern papillary thyroid carcinoma. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3117.
Public procurement in Iraq plays an essential function in the development and recovery of the cou... more Public procurement in Iraq plays an essential function in the development and recovery of the country's economy as well as providing the essential infrastructure for the growth of the private sector. The Coalition Provisional Authority's Government Procurement Legislation No. 87 (2004) is the final procurement law in effect in Iraq. Preparations are underway for new procurement legislation as of Oct. 2021. The objective of the paper is to determine the effectiveness of the public procurement process used in a construction project in Iraq, there is also a lack of procurement methods and policy consistency between government agencies. procurement techniques, tender documentation information, Advertising deadlines, and document management procedures, for example, vary amongst federal contracting agencies. Furthermore, there is no mandatory process for the definition and disclosure of tender evaluation criteria, providing room for subjectivity in the tender award process. This p...
2015 12th IEEE International Conference on Electronic Measurement & Instruments (ICEMI)
In the seek of getting better sensibility, selectivity, times of response and recovery, interdigi... more In the seek of getting better sensibility, selectivity, times of response and recovery, interdigital electrode structures have been increasingly used in nano and microelectronic devices designed to the gas sensing, in the last decades, given their importance and performance characteristics presented for each new usage. In this sense, this work not only addresses on a review of performed researches along the years, but also discusses recent developments of gas sensors based on interdigital electrodes.
Debt relief is unlikely to stimulate investment and growth in the world's highly indebted poor co... more Debt relief is unlikely to stimulate investment and growth in the world's highly indebted poor countries (HIPCs). This is because the HIPCs do not suffer from debt overhang. The principal obstacle to investment and growth in the world's poorest countries is a lack of basic economic institutions that provide the foundation for profitable economic activity. If the goal is to help poor countries build the institutions that best suit their development needs, then the energy and resources currently devoted to the HIPC initiative could be more effectively employed as direct foreign aid.
Objective : to compare characteristics of the gram stain , culture, Real-time PCR to detection pa... more Objective : to compare characteristics of the gram stain , culture, Real-time PCR to detection pathogenic bacteria in CSF samples of patients were suspected of acute bacterial meningitis. Methods: 100 CSF sample were suspected of acute bacterial meningitidis Gram stain , bacterial culture, Real-time PCR based on SYBR Green I fluorescent dye for detection of Nisseria meningitidis in all samples. Results: Gram stain and bacteria culture for all samples were positive in 5 case (5%) including two bacterial genus Listeria monocytogenes in four case (80%) and Staphylococcus aureus in one case (20%) while in RT-PCR based on SYBR Green for detection of SodC gene which is specific gene to diagnosis of N. meningitidis were positive in 42 case (42%). Conclusion: RT-PCR method is rapid , sensitive and specific diagnostic test for acute meningitis. RT-PCR test was positive in 42 case (42%) and all these case was N. meningitidis .
International Journal of Computer Applications, 2017
In this paper, the semiconductor optical amplifier (SOA) is used with a Mach–Zehnder interferomet... more In this paper, the semiconductor optical amplifier (SOA) is used with a Mach–Zehnder interferometer (MZI) forming an SOA-MZI structure which is used to perform the logic gates OR, and NOT. It is simulated at 10 Gbps, 20 Gbps, and 40 Gbps to extract simple design rules. Two binary input data signals are simulated at several bitrate 10 Gbps, 20 Gbps, and 40 Gbps. It is demonstrated that high data rate can be achieved with a specific injection current in SOA. SOAs required low injection current, which leads to a low value on the total power consumption of the gate. In addition, this work includes the study of the effect of the bit rate on the received power, minimum bit error rate (BER), and maximum quality factor (Q-factor). The logical output of the gate has an extinction ratio of more than 10 dB with good eye opening. The output of the OR, NOT gates shows error-free operation at different bit rate with a clear eye opening. General Terms Optical amplifier, MZI, optical logic gates.
International Journal of Computer Applications, 2017
In this paper, the semiconductor optical amplifier (SOA) is used with a Mach–Zehnder interferomet... more In this paper, the semiconductor optical amplifier (SOA) is used with a Mach–Zehnder interferometer (MZI) forming an SOA-MZI structure which is used to perform the logic gates OR, and NOT. It is simulated at 10 Gbps, 20 Gbps, and 40 Gbps to extract simple design rules. Two binary input data signals are simulated at several bitrate 10 Gbps, 20 Gbps, and 40 Gbps. It is demonstrated that high data rate can be achieved with a specific injection current in SOA. SOAs required low injection current, which leads to a low value on the total power consumption of the gate. In addition, this work includes the study of the effect of the bit rate on the received power, minimum bit error rate (BER), and maximum quality factor (Q-factor). The logical output of the gate has an extinction ratio of more than 10 dB with good eye opening. The output of the OR, NOT gates shows error-free operation at different bit rate with a clear eye opening. General Terms Optical amplifier, MZI, optical logic gates.
A tuberculose é uma doença infectocontagiosa causada pelo Mycobacterium tuberculosis, comum em pa... more A tuberculose é uma doença infectocontagiosa causada pelo Mycobacterium tuberculosis, comum em países em desenvolvimento. Os acomentimentos pulmonares são as principais manifestações da doença, embora existam, também, manifestações extrapulmonares, as quais são mais comuns em pacientes imunocomprometidos, a exemplo dos pacientes coinfectados com o HIV. O abscesso hepático é a forma menos comum de lesão. Entretanto, quando analisadas as taxas de mortalidade e os resultados dos tratamentos, é uma das manifestações extrapulmonares com pior prognóstico. O caso relatado segue com o diagnóstico através dos sinais e sintomas clínicos, além da realização dos exames laboratoriais e de imagem, a fim de diagnosticar e indicar os tratamentos cirúrgico e medicamentoso para tratar a infecção e sua consequente manifestação.
We study properties of localized effective spins induced in gapped quantum spin chains by local i... more We study properties of localized effective spins induced in gapped quantum spin chains by local inhomogeneities of the lattice. As a prototype, we study effective spins induced in impunity sites doped AKLT model by constructing the exact ground state in a matrix product state (MPS) form. We characterize their responses to external fields by studying an extended Zeeman interaction. We also study the antiferromagnetic bond-alternating Heisenberg chain with defect structures. For this model, an MPS representation similar to that for the AKLT model, "a uniform MPS with windows," is constructed, and it gives a good approximation of the ground state. We discuss the trade-off relation between the window length and the precision of the MPS ansatz. The effective exchange interaction between the induced spins is also investigated by using this representation.
Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Zwecken und zum Privatgebrauch ge... more Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Zwecken und zum Privatgebrauch gespeichert und kopiert werden. Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich machen, vertreiben oder anderweitig nutzen. Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, gelten abweichend von diesen Nutzungsbedingungen die in der dort genannten Lizenz gewährten Nutzungsrechte. Terms of use: Documents in EconStor may be saved and copied for your personal and scholarly purposes. You are not to copy documents for public or commercial purposes, to exhibit the documents publicly, to make them publicly available on the internet, or to distribute or otherwise use the documents in public. If the documents have been made available under an Open Content Licence (especially Creative Commons Licences), you may exercise further usage rights as specified in the indicated licence.
Shofar: An Interdisciplinary Journal of Jewish Studies, 2010
The Much Too Promised Land: America's Elusive Search for Arab-Israeli Peace, by Aaron David M... more The Much Too Promised Land: America's Elusive Search for Arab-Israeli Peace, by Aaron David Miller. New York: Bantam, 2008. 398 pp. $26.00. For those of us teaching courses on U.S. policy in the Middle East, and on the Arab-Israeli conflict, The Much Too Promised Land by Aaron Miller is a very welcome addition to the literature. Miller, who served in a number of U.S. Government positions dealing with the Middle East, including as deputy to U.S. Middle East envoy Dennis Ross, presents an "insider's view" of what works - and what doesn't - in U.S. policy toward the Arab-Israeli conflict. Spicing up his narrative, Miller frequently cites the rather earthy language used by both U.S. officials and foreign leaders, as they discuss Middle Eastern personalities, such as the comments of the late King Hussein of Jordan who characterized Yasser Arafat in the following way: "That little shit. He hasn't a clue what he is doing" (p. 55). Similarly, Miller's portrayal of the eating habits of Israeli negotiators is absolutely hilarious (p. 50). Miller gives the reader a real feel for how Middle Eastern diplomacy actually works, including how divisions among U.S. policy-makers hampers U.S. policy in the region. The book is divided into three sections. The first is an introduction to the dynamics of Middle East peacemaking and the challenges which even a superpower like the United States faces in trying to enforce its will. This section also includes an entire chapter devoted to the impact of U.S. domestic politics and the strengths and weaknesses of the so-called "Israel Lobby." The second part of the book presents case studies of successful U.S. policymakers: Henry Kissinger in negotiating the Sinai I (1974) and Sinai II (1975) agreements between Israel and Egypt, and the Golan Heights Agreement (1974) between Israel and Syria; Jimmy Carter, who worked out a peace treaty between Israel and Egypt (1979); and James Baker, who successfully convened the Madrid Peace Conference in 1991 after the First Gulf War. The final section of the book deals with U.S. President Bill Clinton, who failed in his efforts to achieve peace between Israel and both Syria and the Palestinians, and President George W. Bush who, according to Miller, did not try very hard to achieve an Israeli-Palestinian peace agreement. In the first section of the book, Miller presents a number of lessons for U.S. policy-makers as they deal with the nations of the Middle East. Perhaps the most pithy are as follows: In negotiations, to be effective, you need to believe that things can change but have extraordinary patience if they don't, (p. 26) You need to be tough but empathetic, firm but practical. And above all, you need to be ready to endure the endless maneuvering and machinations of Arabs and Israelis for whom the conflict has sadly become a way of life. (pp. 26-27) Smaller nations will do just about anything to survive, and are not inclined to listen or even trust advice offered by a distant power whose political and physical survival is not at stake. The ghosts of the past, made real by history's fears and traumas, speak louder than the untested promise of a brighter future offered up by American diplomats, (p. 37) Americans who recognize the galactic gap between a secure and confident America and the insecure world of Israelis and Arabs fare best of all. (p. 41) This conviction (of Yitzhak Rabin), that however well intentioned, the Americans were naive and didn't understand the Arabs, was shared by almost every Israeli with whom we worked, (p. 42) In his chapter on the Israel Lobby, Miller shows how a combination of common values and common enemies has forged a close U.S.-Israeli alliance. He also cites the influence of pro-Israeli Jews in the Democratic Party, and pro-Israeli Evangelical Christians in the Republican Party to show the broad bipartisan support for Israel in the U.S. To those who deplore the power of lobbies, be it the NRA, the Drug Lobby, or the Israel Lobby, Miller gives a strong rejoinder - the U. …
Pleiotrophin (PTN) is a heparin binding growth factor known to have role in neuronal development.... more Pleiotrophin (PTN) is a heparin binding growth factor known to have role in neuronal development. It is highly expressed in embryo but has a very limited expression in adult tissues. PTN is considered a proto-oncogene and has been hypothesized to play role in oncogenesis as its expression is found to be increased in many different cancer subtypes. Its role in cell transformation, cell growth, survival, migration and angiogenesis has also been shown in various different types of cancers. The function of PTN is hypothesized to be carried out by its interaction with cell surface proteoglycans or binding to its selective cell surface receptor, protein tyrosine phosphatase receptor Z1 (PTPRZ1). The significance of role of PTN in pathogenesis of thyroid cancer has not been explored especially with the fact that papillary thyroid carcinoma (PTC) originating in this ethnic population is the second most common female malignancy, after breast. So in search for novel druggable molecular target we sought for PTN expression in a large cohort of Saudi PTC. We analysed PTN alteration in more than 1000 primary papillary thyroid carcinoma in a tissue microarray format with clinical follow up data. We found that PTN was overexpressed in 65.5% (658/1006) of PTC and was significantly associated with aggressive clinical parameters such as tall cell variant histological subtype (p = 0.0333), extrathyroidal extension (p = 0.0292), lymphovascular invasion (p = 0.0182) and large tumour size (p = 0.0160). Important significant molecular association was seen with PTPRZ-1 (p = 0.0316), Midkine (p = 0.0008) and pSTAT-3 (p Keywords: Papillary Thyroid Cancer; Pleiotrophin; Pleiotrophin Receptor Citation Format: Shaham Beg, Maqbool Ahmed, Azhar Hussein, Rong Bu, Zeeshan Qadri, Saif AlSobhi, Fouad Al Dayel, Abdul K. Siraj, Khawla S. Al-Kuraya. Pleiotrophin is a marker of poor prognosis in Middle Eastern papillary thyroid carcinoma. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3117.
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