Papers by Aurora Angelina Molinari Raggio
Heterocyclic Communications, 2003
Polymeric derivatives of 4-alkyldithiocarboxylate-5-hydroxypyrazoles have been prepared by bulk v... more Polymeric derivatives of 4-alkyldithiocarboxylate-5-hydroxypyrazoles have been prepared by bulk vinylic homo and copolymerization of 4-allyldithiocarboxylate-5-hydroxy-3-methyl-l-phenylpyrazol.
Scientific Reports, 2020
The cytotoxic mechanism of the saponin QS-21 and its aglycone quillaic acid (QA) was studied on h... more The cytotoxic mechanism of the saponin QS-21 and its aglycone quillaic acid (QA) was studied on human gastric cancer cells (SNU1 and KATO III). Both compounds showed in vitro cytotoxic activity with IC50values: 7.1 μM (QS-21) and 13.6 μM (QA) on SNU1 cells; 7.4 μM (QS-21) and 67 μM (QA) on KATO III cells. QS-21 and QA induce apoptosis on SNU1 and KATO III, as demonstrated by TUNEL, Annexin-V and Caspase Assays. Additionally, we performed in silico docking studies simulating the binding of both triterpenic compounds to key proteins involved in apoptotic pathways. The binding energies (∆Gbin) thus calculated, suggest that the pro-apoptotic protein Bid might be a plausible target involved in the apoptotic effect of both triterpenic compounds. Although QA shows some antiproliferative effects on SNU1 cells cultured in vitro, our results suggest that QS-21 is a more powerful antitumor agent,which merits further investigation regarding their properties as potential therapeutic agents for g...
Molecules
Quinones and nitrogen heterocyclic moieties have been recognized as important pharmacophores in t... more Quinones and nitrogen heterocyclic moieties have been recognized as important pharmacophores in the development of antitumor agents. This study aimed to establish whether there was any correlation between the in silico predicted parameters and the in vitro antiproliferative activity of a family of benzoindazolequinones (BIZQs), and to evaluate overexpressed proteins in human cancer cells as potential biomolecular targets of these compounds. For this purpose, this study was carried out using KATO-III and MCF-7 cell lines as in vitro models. Docking results showed that these BIZQs present better binding energies (ΔGbin) values for cyclooxygenase-2 (COX-2) than for other cancer-related proteins. The predicted ∆Gbin values of these BIZQs, classified in three series, positively correlated with IC50 measured in both cell lines (KATO-III: 0.72, 0.41, and 0.90; MCF-7: 0.79, 0.55, and 0.87 for Series I, II, and III, respectively). The results also indicated that compounds 2a, 2c, 6g, and 6k ...
Journal of heterocyclic chemistry, 1996
... Article. O-Alkylation of 3-hydroxy-1-phenyl-2-pyrazolin-5-one. Aurora Molinari,; Alfonso Oliv... more ... Article. O-Alkylation of 3-hydroxy-1-phenyl-2-pyrazolin-5-one. Aurora Molinari,; Alfonso Oliva. Article first published online: 6 MAY 2009. DOI: 10.1002/jhet.5570330242. Copyright © 1996 Journal of Heterocyclic Chemistry. Issue. Journal of Heterocyclic Chemistry. ...
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Papers by Aurora Angelina Molinari Raggio