Papers by Atul Pratap Singh
APTI, 2022
Background: This study aimed to develop and describe a Cinnamon Oil-Salicylic Acid Blended Nanoem... more Background: This study aimed to develop and describe a Cinnamon Oil-Salicylic Acid Blended Nanoemulsion (CSN) for topical use. Different ratios of oil, surfactants, and water were used to create the base for the nanoemulsions. Methods: To determine the nanoemulsion (NE) base regions, pseudo ternary phase diagrams were created. In addition, nine formulations containing mixes of Tween 80 and ethanol were examined for their droplet size, zeta potential, viscosity, pH, microscopy and spectroscopic technique. Results: As a result of the experiments, it was discovered that the nanoemulsion comprising cinnamon oil and salicylic acid had an average size of 103.55 ± 1.83 and excellent rheological properties. Results revealed that the nanoemulsion bases, including ethanol as a co-surfactant, produced a larger emulsion area in the phase diagram than the other nanoemulsion bases. The formulation exhibited homogeneity, stability, and viscosity. Spherical NE was observed in transmission electron microscopy photos of CSN, and the size distribution was very narrow. The results of the in vitro release investigation showed that the medicine was released at a 95.87% effective rate in 24 hr. At a temperature of 25°C, the results of the short-term stability research, which was carried out for six months, revealed that CSN is stable. When applied to the skin of animals, CSN showed no signs of skin toxicity or irritation. Conclusion: As a result, CSN is an excellent natural-based preparation that may be utilized topically against different kinds of skin conditions.
Bentham Science Publishers, 2021
Background: Psoriasis is a challenging skin disorder due to its chronicity, high rate of prevalen... more Background: Psoriasis is a challenging skin disorder due to its chronicity, high rate of prevalence, disability, comorbidity and disfiguration. It is a multi-system disorder that includes joints and metabolic syndromes. Psoriasis is a condition of pathologic interaction among immune cells, biological signaling molecules and skin cells. Several contributing factors are responsible for the exacerbation and onset of psoriasis, i.e. genetic factors and environmental factors such as medications, infectious diseases and lifestyle. Objectives: To study the new insights in the treatment of psoriasis and future prospects. Methods: This review article gives an insight on the current concepts of psoriasis and deals with discussing the initiation and development of the diseases. We described the pathogenetic pathway for psoriasis. The article focuses on the treatment approaches for psoriasis that have arisen from the dissection of the inflammatory psoriatic pathways. Results: We aimed to highlight the novel therapies and drugs used in the treatment of psoriasis, including food and drug administration (FDA) approved drugs and drugs under clinical trials. The treatment can be initiated for mild to the moderate diseased condition employing vitamin D3 analogues, corticosteroids and a combination of products as first-line therapy. Conclusion: Psoriasis can be managed by a proper understanding of the immune function. We have also discussed medicinal herbs used for psoriasis based on their ethnopharmacological knowledge and reported work of researchers.
Uploads
Papers by Atul Pratap Singh