Papers by Atsushi Sengoku
PubMed, Jul 1, 1992
Two cases of renal oncocytoma are reviewed. A 67-year-old man and a 21-year-old man with a right ... more Two cases of renal oncocytoma are reviewed. A 67-year-old man and a 21-year-old man with a right renal mass were incidentally revealed by echography. Selective renal angiogram showed no spoke-wheel configuration of vessels in either case. Both cases were pathologically diagnosed as oncocytomas, constructed of large eosinophilic cells with granular cytoplasm and small regular nuclei. The electron micrograph showed cytoplasm packed abundantly with mitochondria. The two patients are in good condition 2.5 and 1.5 years after diagnosis.
Glutamate-induced currents in acutely dissociated guinea pig locus coeruleus neurons
PubMed, Apr 1, 1999
To investigate the properties of L-glutamate (Glu) receptors in single locus coeruleus (LC) neuro... more To investigate the properties of L-glutamate (Glu) receptors in single locus coeruleus (LC) neurons at mature stage, we recorded the Glu-induced currents in the LC neurons acutely dissociated from adult guinea pigs, using the whole-cell patch-clamp technique. The concentration-current relationships show that Glu-induced currents in LC neurons might be predominantly mediated by non-NMDA receptors rather than NMDA receptors. The current-voltage relationship of NMDA or non-NMDA receptor-mediated currents indicated that both subtypes of the Glu-receptors operate non-selective cation channels, and that the NMDA receptor-operated channels but not the non-NMDA receptor-operated channels are permeable to Ca2+. These results suggest that in LC neurons, the normal excitatory neurotransmission may be mediated through non-NMDA receptors, and that NMDA receptors may be involved in intracellular signal transduction by their Ca2+ permeability.
The impact of the coronavirus disease 2019 pandemic on changes in antimicrobial prophylaxis and development of genito‐urinary tract infections after urodynamic study: A retrospective comparative study of a single rehabilitation hospital in Japan
Neurourology and Urodynamics, Jun 8, 2022
AimsTo investigate the changes in the proportion of antimicrobial prophylaxis (AP) during the uro... more AimsTo investigate the changes in the proportion of antimicrobial prophylaxis (AP) during the urodynamic study (UDS) and the frequency of posttest genito‐urinary tract infections (GUTI) before and after coronavirus disease 2019 (COVID‐19) pandemic, and evaluate this associations.Patients and MethodsPatients who underwent UDS between 2015 and 2021 were targeted, and they were allocated to pre‐2020 as before the appearance of COVID‐19 and post‐2020 as after that, and propensity score matching was performed. The impact on AP was assessed by the administration rate, and that on the development of febrile GUTI after UDS was assessed for an equivalence by the GUTI‐free rate at 7 days after testing.ResultsAfter matching, 384 cases of 192 cases each were included. The frequency of AP was 58.3% in pre‐2020 and 77.1% in post‐2020, an increase of about 19%, and the rate increased significantly in post‐2020 (p < 0.001). However, the incidence of GUTI after UDS was 4.2% and 4.7%, respectively, with no significant difference. The ratio of GUTI‐free rates was within the equivalence margin, confirming an equivalence before and after the appearance of COVID‐19.ConclusionsUnder the influence of COVID‐19 pandemic, even though AP rate during UDS was increased by 19% from that brought by following the guideline‐based administration methods, the frequency of GUTI after UDS was similar, so it is thought to be important to use AP during UDS appropriately for high‐risk cases as recommended in the guidelines.
PubMed, Apr 1, 1990
We report a case of a traumatic dislocation of the testis in a 17-year-old male. He noticed lack ... more We report a case of a traumatic dislocation of the testis in a 17-year-old male. He noticed lack of right scrotal contents three months after a motorcycle accident. The right testis, located at the inguinal subcutaneous region, was surgically replaced into the scrotum. The biopsy specimen of the dislocated testis showed partial atrophy of the seminiferous tubules that resulted in impaired spermatogenesis. Our case represents the 57th case of traumatic dislocation of the testis reported in Japan.
International Journal of Urology, Sep 20, 2017
Nippon Daicho Komonbyo Gakkai Zasshi, 2018
To evaluate the efficacy and safety of transanal irrigation (TAI) for the management of refractor... more To evaluate the efficacy and safety of transanal irrigation (TAI) for the management of refractory disordered defecation. Method: This was a prospective multicenter clinical study. Patients with fecal incontinence and/or constipation who had not responded to standard conservative therapies were treated with TAI for 10 weeks. Its efficacy was evaluated with Visual Analogue Scale (VAS, 0: unsatisfied -10: satisfied) regarding their satisfaction about current bowel management as well as with the proportion of patients who wished to continue TAI after the study (success rate). Results: TAI was performed in 32 patients (median age: 55.5 yo; male: 19). Out of the 25 patients (78％) who completed the 10-week TAI therapy, 23 patients (success rate: 72％) wished to continue TAI after the study. The VAS of the satisfaction in the 23 success patients significantly improved from a median of 2.2 before TAI to 7.5 at the 10th week after its commencement (P<0.0001). Colonic perforation occurred in 3 patients (9.4％). Conclusion: TAI is effective in a majority of patients with refractory disordered defecation, although colonic perforation could occur. Sufficient education and supervision should be provided so that patients can properly and safely perform TAI.
The Japanese Journal of Urology, 1989
The clinical significance of serum basic fetoprotein (BFP) in renal cell carcinoma was investigat... more The clinical significance of serum basic fetoprotein (BFP) in renal cell carcinoma was investigated in comparison with serum immunosuppressive acid protein (IAP). Investigated in this study were 46 patients with renal cell carcinoma, 31 males and 15 females ranging in age from 40 to 85 years (mean age: 56 years). According to Robson's system of staging, 10 cases (22%) had a stage I disease, 14 cases (30%) a stage II disease, and 18(39%) a stage N disease. The positivity rate for and levels of serum BFP were found higher as disease stage avanced, with 54% of the entire cases and 72% of stage N cases being positive for serum BFP. On the other hand, 76% of 34 cases for whom assay of serum IAP was feasible and 79% of stage IV cases were positive for serum IAP, thus here again the positivity rate for and serum levels of the marker became increasingly higher with avancing disease stage. Simultaneous assay of serum BFP and TAP demonstrated that 85% of stage N renal cell carcinoma cases were positive for at least one of the two marders. A study of changes in these tumor markers before and after curative resection of the tumor showed that BFP decreased below the preoperative level within 1 week postoperatively in 92% and even returned to nomal in 75% of cases who were positive for the tumor markers preoperatively, while serum IAP reduced below the preoperative level in 82% and returned to nomal in 27% of the cases preoperatively.
The 1‐year continuation rate and discontinuation factors of vibegron and mirabegron: A retrospective comparative study in a rehabilitation hospital in Japan
Luts: Lower Urinary Tract Symptoms, May 24, 2021
To compare the 1‐year continuation rate and discontinuation factors between vibegron and mirabegr... more To compare the 1‐year continuation rate and discontinuation factors between vibegron and mirabegron in patients with neurogenic and nonneurogenic overactive bladder.
Neurogenic Bladder Associated With Pure Cervical Spondylotic Myelopathy
Spine, 2013
Retrospective study. To examine the prevalence of lower urinary tract symptoms (LUTS) and neuroge... more Retrospective study. To examine the prevalence of lower urinary tract symptoms (LUTS) and neurogenic bladder (NB), and surgical outcomes in pure cervical spondylotic myelopathy. The inclusion of various types of cervical diseases, NB, and no obvious definition of NB provided the wide range of NB prevalence frequency among previous reports. Of the 220 operated patients with cervical myelopathy, 54 were selected by excluding other cervical and/or concomitant diseases contributing to LUTS. All patients with LUTS were referred to urologists and recommended to undergo urodynamic study (UDS). The presence of NB was judged by abnormal findings of UDS according to the most recent criteria and a congruity between LUTS and the course of cervical myelopathy. Patients were divided into 4 groups: no symptoms, positive symptoms without UDS examination, positive symptoms with positive NB, and positive symptoms with negative NB. Evaluation scores were compared among the groups before and after surgery. There were no particular LUTS in NB patients. Prevalence of LUTS was 53.7% and that of NB was at least 20.4% in the patients with pure cervical spondylotic myelopathy. The scores of all 4 groups improved after surgery (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.05); however, the recovery rate of NB group (47.1%) was the worst among the groups (no-symptoms group, 69.3%; negative-NB group, 53.5%; and positive symptoms without UDS group, 57.1%). Preoperative part scores showed no difference among the groups, whereas NB group demonstrated lower scores in finger and lower extremity postoperatively. A post hoc analysis confirmed a significantly poorer recovery rate related to the NB group only in the lower extremities. This study is the first to describe the prevalence of LUTS and NB according to the most recent criteria in patients with pure cervical spondylotic myelopathy, which demonstrated that neurological functions in NB patients may recover; however, the extent will be limited to two-thirds of those in patients with no-NB; moreover, the remaining symptoms derive from poor lower limb function.
A Therapeutic Experience of Rapid Progressive HTLV-1 Associated Myelopathy in a Convalescent Rehabilitation Ward：A Case Report
The Japanese journal of rehabilitation medicine, Feb 16, 2022
Journal of Clinical Medicine, Mar 1, 2021
Study design: Prospective observational study. Objective: To validate the Monitoring Efficacy of ... more Study design: Prospective observational study. Objective: To validate the Monitoring Efficacy of NBD Treatment On Response (MENTOR) tool in individuals with a spinal cord injury (SCI) or spina bifida, suffering from neurogenic bowel dysfunction (NBD) in a rehabilitation center in Japan. Methods: First, the MENTOR tool was translated from English to Japanese using a validated translation process. Second, the MENTOR tool was validated in a rehabilitation clinic in Japan. Participants completed the MENTOR tool prior to a consultation with an expert physician. According to the results of the tool, each participant was allocated to one of three categories regarding change in treatment: "adequately treated," "further discussion," and "recommended change." The results of the MENTOR tool were compared with the treatment decision made by an expert physician, who was blinded to the results of the MENTOR tool. Results: A total of 60 participants completed the MENTOR tool. There was an acceptable concordance between individuals allocated as respectively, being adequately treated (100%) and recommended change in treatment (61%) and the physicians' decision on treatment. The concordance was lower for individuals allocated as requiring further discussion (48%). Conclusions: In this study the MENTOR tool was successfully validated in a Japanese rehab setting. The tool will help identify individuals with SCI that need further treatment of their NBD symptoms.
International Journal of Urology, Mar 18, 2019
to Urodynamic analysis of the impact of diabetes mellitus on bladder function The retrospective s... more to Urodynamic analysis of the impact of diabetes mellitus on bladder function The retrospective study by Majima et al. shows the relationships between diabetes mellitus (DM) courses and the findings of urodynamic study in a single center. 1 This is thought to be a clinically valuable study, because it is one of very few reports regarding this topic; however, this study had some limitations, as mentioned by the authors. In cases of typical diabetic cystopathy due to peripheral nerve disorders, it is known that afferent nerves from the bladder tend to be damaged in the first stage, followed by efferent nerve disorders for the long term. 2,3 In contrast, even in the cases without neuronal disorders, detrusor overactivity could often be caused by bladder ischemia due to damage to the vascular endothelium, coexisting central vascular diseases, such as lacunar infarction, 4 and so on. In this study, sequential changes of DM cystopathy are beautifully shown in Figure 1, especially for detrusor contractility and overactivity. However, significant differences are not shown in first desire to void and maximum cystometric capacity with the DM stages, which could be in disagreement with well-known relationships between progress of the bladder sensory disturbance and the DM stages. As a possible reason for that, it could be enumerated as follows: the small number of cases, lack of evaluation for the DM neuropathy (as mentioned by the authors) and an inaccurate method of evaluation for the bladder sensory disturbance merely using urodynamic bladder volumes. For studies in the future, therefore, it is expected that relationships between DM cystopathy and the stages would be analyzed using quantitative evaluations for patients with DM neuropathy and bladder sensory disturbance. Regarding relationships with urodynamic bladder capacities (first desire to void and maximum cystometric capacity) and post-void residual urine volume, it would also be necessary to consider a possible participation of urethral sensory disturbance and the urethrovesical reflex; that is, the former could reduce the latter reflex to facilitate detrusor contraction continuity, resulting in an increase in post-void residual urine volume. 5
Journal of Pharmacy and Pharmacology, Dec 1, 2002
We examined the effect of a kappa agonist, U-50488H, upon the bladder motility of anaesthetized r... more We examined the effect of a kappa agonist, U-50488H, upon the bladder motility of anaesthetized rats. The frequency of distension-induced rhythmic bladder contractions was reduced by the intravenous (10 mg kg 1) or intrathecal (10-100 g) administration of U-50488H. The effect of intravenous U-50488H was inhibited by pre-treatment with nor-binaltorphimine (10 mg kg 1 , s.c.). The inhibition of bladder contractions by intrathecal U-50488H (30 g) was eliminated with the concomitant use of nor-binaltorphimine (10 mg kg 1 , s.c.), and diminished by reserpine (4 mg kg 1 , i.p.), yohimbine (10 g, i.t.) or methysergide (20 g, i.t.). The amplitude of bladder contractions induced by an electrical stimulation of the pontine micturition centre was not inhibited by intrathecal U-50488H (30 and 100 g). These results suggested that a kappa agonist could inhibit micturition re ex as well as other opioids, and at least part of the inhibition was due to the diminishment of bladder sensation based on the activation of the descending monoaminergic systems through the spinal kappa-opioid receptors.
International Journal of Urology, Apr 1, 2020
The present article is an abridged English translation of the Japanese clinical guidelines for th... more The present article is an abridged English translation of the Japanese clinical guidelines for the diagnosis and treatment of lower urinary tract dysfunction in patients with spinal cord injury updated as of July 2019. The patients are adult spinal cord injured patients with lower urinary tract dysfunction; special consideration of pediatric and elderly populations is presented separately. The target audience is healthcare providers who are engaged in the medical care of patients with spinal cord injury. The mandatory assessment includes medical history, physical examination, frequency-volume chart, urinalysis, blood chemistry, transabdominal ultrasonography, measurement of postvoid residual urine, uroflowmetry and video-urodynamic study. Optional assessments include questionnaires on the quality of life, renal scintigraphy and cystourethroscopy. The presence or absence of risk factors for renal damage and symptomatic urinary tract infection affects urinary management, as well as pharmacological treatments. Further treatment is recommended if the maximum conservative treatment fails to improve or prevent renal damage and symptomatic urinary tract infection. In addition, management of urinary incontinence should be considered individually in patients with risk factors for urinary incontinence and decreased quality of life.
Journal of Pharmacological Sciences, 2004
We investigated the actions of Gosha-jinki-gan, a traditional Japanese medicine containing proces... more We investigated the actions of Gosha-jinki-gan, a traditional Japanese medicine containing processed Aconiti tubers, on urinary bladder function in anesthetized rats. In cystometrical investigations, Gosha-jinki-gan (1.0 g / kg, i.d.) increased bladder capacity as well as micturition threshold pressure. In addition, it decreased the frequency of distension-induced rhythmic bladder contractions. However, it did not influence the amplitude of bladder contractions induced by electrical stimulation of the pontine micturition center. The inhibitory effect of Gosha-jinki-gan on bladder motility was abolished by pretreatment with nor-binaltorphimine (10 mg / kg, s.c.), and was diminished by the concomitant use of anti-dynorphin A antiserum (10 m g, i.t.), yohimbine (10 mg, i.t.), or methysergide (20 m g, i.t.). Processed Aconiti tuber extract (27 mg / kg, i.d.) also suppressed bladder motility, and the effect was abolished by nor-binaltorphimine. These results suggest that Gosha-jinki-gan attenuates bladder sensation via the kappaopioid receptor-stimulating action of processed Aconiti tuber. Gosha-jinki-gan may be a useful anti-pollakiuria agent that does not influence bladder contractility at micturition.
PD8-08 Risk Factors for Febrile Uti in Spinal Cord Injury Patients with Routine Concomitant Intermittent Catheterization (Cic)
The Journal of Urology, Apr 1, 2015
ABSTRACT
World Journal of Urology, Apr 4, 2019
Introduction To investigate the risk factors for febrile genito-urinary tract infection (GUTI) in... more Introduction To investigate the risk factors for febrile genito-urinary tract infection (GUTI) in spinal cord injury-associated neurogenic lower urinary tract dysfunction (NLUTD) patients who perform routine clean intermittent catheterization (CIC) evaluated by urodynamic study (UDS) and cystography. Patients and methods Over a 3-year period, we retrospectively assessed risk factors for febrile UTI in 141 spinal cord injury patients diagnosed as NLUTD and performing routine CIC, regarding gender, UDS findings such as bladder compliance, maximum cystometric capacity, and cystography. Results A total of 41 patients had febrile GUTI in the follow-up period as along with 32 cases of pyelonephritis, 10 cases of epididymitis, and 1 case of prostatitis, including patients with multiple infectious diseases. The causative bacteria were Escherichia coli (14 cases) followed by Pseudomonas aeruginosa (n = 5), Klebsiella pneumoniae (n = 4), and Klebsiella oxytoca (n = 4). Antibiotic-resistant E. coli were seen, with 36.4% instances of extended-spectrum beta-lactamase production in whole of E. coli. Male gender (p = 0.018), ASIA Impairment Scale (AIS) C or more severe (p = 0.031), the number of CIC (p = 0.034), use of quinolones (p < 0.001) and severe bladder deformity (DG 2 or more, p = 0.004) were significantly associated with febrile GUTI occurrence. Conclusions Our data demonstrated that male gender, severe bladder deformity (DG 2 or more), AIS C or more, the number of CIC, and use of quinolones were significantly associated with febrile GUTI occurrence in NLUTD patients employing routine CIC. Further prospective studies are necessary to define the full spectrum of possible risk factors for febrile GUTI in these patients.
Hygiene management of intermittent self‐catheterization using reusable silicone catheters in people with spinal cord lesions: A cross‐sectional Internet survey in Japan
LUTS: Lower Urinary Tract Symptoms
ObjectivesTo investigate hygiene management and catheter maintenance of reusable silicone cathete... more ObjectivesTo investigate hygiene management and catheter maintenance of reusable silicone catheters for intermittent self‐catheterization (ISC) in Japan and examine their relationship with symptomatic urinary tract infection (sUTI).MethodsWe conducted a cross‐sectional Internet survey of people performing ISC using reusable silicone catheters owing to spinal cord lesions in Japan. Hygiene management and catheter maintenance of reusable silicone catheters and the incidence and frequency of sUTI were evaluated. We also examined the significant risk factors for sUTI.ResultsOf 136 respondents, 62 (46%), 41 (30%), and 58 (43%) washed hands with water, washed hands with soap, and cleaned or disinfected the urethral meatus every time or most of the time before ISC, respectively. No significant difference was observed in the incidence and frequency of sUTI between respondents who adhered to these procedures and those who did not. There were no significant differences in the incidence and fr...
Cross-sectional internet survey exploring symptomatic urinary tract infection by type of urinary catheter in persons with spinal cord lesion in Japan
Spinal Cord Series and Cases
Uploads
Papers by Atsushi Sengoku