Atil Yüksel

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Don Ross

University College Cork

John Stein

University of Oxford

Daniel Weiskopf

Georgia State University

FILIPPOS VLACHOS

UNIVERSITY OF THESSALY, GREECE

Mehmet Fatih Amasyali

Yildiz Technical University

Fabio Cuzzolin

Oxford Brookes University

Wolfgang Grodd

Max Planck Institute for Biological Cybernetics

Katherine Bryant

Aix-Marseille Université

Kun Hsien Chou

National Yang Ming Chiao Tung University

Jessica Richardson

University of New Mexico

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Papers by Atil Yüksel

Prenatal Sonographic Diagnosis and Evaluation of Isolated Macrodactyly

InTech eBooks, Jun 29, 2012

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Prenatal Evaluation of Fetuses Presenting with Short Femurs

InTech eBooks, Jun 29, 2012

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The role of umbilical artery Doppler analysis in estimating perinatal morbidity and mortality in hypertensive pregnancy

Journal of Controversies in Obstetrics & Gynecology and Pediatrics

Aims: Uteroplacental (uterine artery systolic/diastolic (S/D) ratio) and fetal circulation change... more Aims: Uteroplacental (uterine artery systolic/diastolic (S/D) ratio) and fetal circulation changes (umbilical artery pulsatility Index (PI) value) can be evaluated non-invasively by using Doppler ultrasonography spectral analysis. The present study aimed to demonstrate how Doppler ultrasonography should be combined with classical well-being tests to detect perinatal morbidity and mortality in hypertensive pregnancy. Methods: This prospective research was carried out with 88 pregnant women diagnosed with high-risk pregnancy and hypertension between April 1992 and May 1994. A non-stress test (NST) was performed in all cases, and fetal distress was evaluated by a biophysical profile (BP) and/or a contraction stress test (CST) subsequent to a non-reactive NST. Following the diagnosis of hypertension, longitudinal maternal (uterine artery) and fetal (umbilical artery) Doppler analyses were initiated at 7–10-day intervals. In the study, the Acuson 128 XP 10 device (Research project No. 51...

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İstanbul’Da 1989-2011 Yillari Arasinda İnvazi̇f Prenatal Taninin Kli̇ni̇k Ve Si̇togeneti̇k Bulgularindaki̇ Deği̇şi̇kli̇kler; Bi̇yoki̇myasal Tarama Testleri̇ni̇n Ve Fetal Ultrasonografi̇ni̇n Etki̇si̇

DergiPark (Istanbul University), Oct 19, 2020

İnvazif prenatal tanıda (IPT) maternal serum tarama testlerinin (MS-TT) ve fetal ultrasonografini... more İnvazif prenatal tanıda (IPT) maternal serum tarama testlerinin (MS-TT) ve fetal ultrasonografinin (USG) klinik ve sitogenetik bulgular üzerine olan etkisini belirlemek. Gereç ve Yöntem: 23 yıllık süreçte invazif girişimle elde edilen 23469 amniyosentez (AS) ve 2492 koryon villus aspirasyonu uygulama (KVA) sonuçları, 2000 yılı öncesi ve sonrası iki döneme ayrılarak karşılaştırıldı. Bulgular: İleri anne yaşı (İAY) ile başvuran olgu sayısı azalırken, MS-TT ve fetal USG endikasyonu ile başvuran olguların sayısında artma gözlendi. Kromozom anomali oranı KVA'da %10,1'den %17,6'ya ve AS'de %3,2'den %4,3'e yükseldi. Yaygın anöploidiler, KVA'da anomalilerin %69,6'sını (n=385) ve AS'de anomalilerin %65,1'ini (n=892) oluşturdu. Bilinen kromozom anomali taşıyıcıları hariç tutulduğunda, kromozomal yeniden düzenlemelerin oranı KVA'da %1,4 ve AS'de %1 idi. KVA'nun %1,7'sinde KVA ve AS arasında uyumsuz sitogenetik sonuçlar gözlendi. KVA'da gerçek/olası gerçek mozaiklik, yalancı pozitif plasentayla sınırlı mozaisizm (PSM) ve yalancı negatif PSM oranı sırasıyla %1,02, %0,57 ve %0,49 bulundu.

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Duchenne Kas Distrofisi İçin Riskli Ailelerde Taşıyıcılığın Belirlenmesi ve Prenatal Tanı Uygulamalarında Karşılaşılan Sorunlar

Neuroimaging of Fetal Infection

Journal of pediatric neurology, 2017

Infection during pregnancy is common and the developing fetal brain is vulnerable to vertical tra... more Infection during pregnancy is common and the developing fetal brain is vulnerable to vertical transmission due to immaturity of the fetal immune system. Infection is a major cause of multiple organ abnormalities, including the neuraxis, due to the neurotropism of the infectious agents. This review sets out to give an overview of fetal infection, review the general principles of the nature and timing of the infectious insult with respect to outcomes, review the neuroimaging of infection by ultrasound and magnetic resonance imaging (MRI), and review the various pathogens involved, including the two most common, cytomegalovirus (CMV) and Toxoplasma , and also other common viral and nonviral infections.

Prenatal diagnosis and conservative management of complex meconium peritonitis: a case report

Journal of Clinical and Investigative Surgery, 2019

Meconium peritonitis is a rare fetal disease due to the perforation of bowel in utero and sterile... more Meconium peritonitis is a rare fetal disease due to the perforation of bowel in utero and sterile inflammatory reaction related to the extravasation of the meconium. Various classification systems have been published in the literature, and better outcomes have been seen in recent years with a survival rate of more than 90%. The prognosis of meconium peritonitis is more favorable when detected in utero rather than when the neonatal diagnosis is made. Prenatal findings of meconium peritonitis in our case are meconium pseudocyst, polyhydramnios, and peritoneal calcifications. Although it was perceived as complex meconium peritonitis and was expected to require surgery in the postnatal period, it was managed conservatively. Probably, it did not need to undergo surgery because the perforation had occurred in mid-trimester and enough time has elapsed in the utero life to seal the perforation site and to decrease the size of the meconium pseudocyst. We cited a rare case of meconium peritonitis with a meconium pseudocyst in a fetus, which was managed conservatively and resolved spontaneously in the postnatal period.

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Prenatal Diagnosis of Isolated Split Hand/Foot Malformation: A Case Report

İstanbul Tıp Fakültesi Dergisi, 2018

Yarık el/ayak malformasyonu (split hand/foot malformation, SHFM) veya ektrodaktili; median apikal... more Yarık el/ayak malformasyonu (split hand/foot malformation, SHFM) veya ektrodaktili; median apikal ektodermal kabartı aktivitesindeki bozulma nedeniyle el ve ayaklarda oluşan santral ışın defekti ile karakterizedir. Etkilenen ekstremitede medial yarıklar, sindaktili ve falanks, metakarp ve metatarslarda hipoplazi ve/veya aplazi ile kendini gösterir. İzole bir anomali olabileceği gibi çeşitli anomalilerle birliktelik gösterek bir sendromun parçası olabilir. Bu makalede 27 haftada kliniğimizde tanısını koyduğumuz dört ekstremitede de ektrodaktili saptanan, ek anomali tespit edilmeyen ve kromozomal array analizinde patoloji saptanmayan ancak dört ekstremitede de ciddi derecede malformasyon saptanmış olması nedeniyle tıbbi genetik bilim dalı ile konsülte edilerek ailenin onayı ile gebelik terminasyonu uyguladığımız olgumuzu sunduk. Bu olgu nedeniyle fetüsün ultrasonografik muayenesinde ekstremitelerin değerlendirilmesinin önemini ve bir patoloji saptandığında ek anomaliler açısından fetüsün tüm sistemlerinin ayrıntılı muayenesinin yapılmasını ve ailelere danışmanlık verilirken multidispliner yaklaşımın öneminin vurgulanmasını amaçladık.

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P19.19: The visualisation of the fetal ureter in normal fetuses and fetuses with mild pyelectasis

Ultrasound in Obstetrics & Gynecology, 2012

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Sonographic depiction of fetal ureters

The Journal of Maternal-Fetal & Neonatal Medicine, 2015

ABSTRACT

How Does the Presence of Antenatally Detected Caliectasis Predict the Risk of Postnatal Surgical Intervention?

Urology, 2012

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Prenatal diagnosis of diastematomyelia: presentation of eight cases and review of the literature

Ultrasound in Obstetrics & Gynecology, 2007

ObjectivesDiastematomyelia is a rare form of spinal dysraphism. We present eight cases of diastem... more ObjectivesDiastematomyelia is a rare form of spinal dysraphism. We present eight cases of diastematomyelia diagnosed prenatally in our institution as well as a review of the literature in order to determine the prognosis of isolated cases of this very unusual condition.MethodsRecords of fetuses with diastematomyelia diagnosed in our institution between January 2000 and June 2005 were collected. All liveborn fetuses were examined by a pediatric neurologist. Pre‐ and postnatal data were analyzed. A search was then conducted using PubMed to review previously reported cases in the literature.ResultsEight cases of diastematomyelia were diagnosed during the study interval. The mean (range) gestational age at diagnosis was 21 (13–25) weeks. The main sonographic findings were widening of the spinal canal in the coronal view and an additional echogenic focus in the posterior part of the spinal column in the axial view. The diagnosis of associated open spina bifida was made in one fetus with ...

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Prenatal diagnosis of persistent left superior vena cava and its associated congenital anomalies

Ultrasound in Obstetrics & Gynecology, 2006

ObjectiveTo evaluate the associated conditions and the outcome of persistent left superior vena c... more ObjectiveTo evaluate the associated conditions and the outcome of persistent left superior vena cava (PLSVC) detected in fetal life.MethodsThis was a retrospective review of all cases of PLSVC detected prenatally between 1998 and 2004 in two tertiary referral centers in Germany. Patient charts, ultrasound video recordings and still frames of all cases were reviewed for associated conditions and outcome.ResultsEighty‐two cases of PLSVC were detected in the study period. Thirty‐seven cases (45%) were associated with heterotaxy syndromes, 19 (23%) with isolated cardiac malformations, seven (9%) with aneuploidy, six (7%) with complex malformation syndromes and six (7%) with isolated extracardiac malformations. Seven cases (9%) had no associated condition. Eighty‐three percent of the fetuses in this series had associated cardiac malformations; the most frequent cardiac malformations in those with heterotaxy syndromes were complete atrioventricular septal defect (75%) and right outflow tr...

Fetal cerebellar hemorrhage in a severely growth-restricted fetus: natural history and differential diagnosis from Dandy-Walker malformation

Ultrasound in Obstetrics and Gynecology, 2003

This is a report of an intracerebellar hemorrhage in a severely growth-restricted fetus with path... more This is a report of an intracerebellar hemorrhage in a severely growth-restricted fetus with pathological Doppler findings of the fetal and uteroplacental circulations. The diagnosis was made sonographically at 22 weeks of gestation and the natural course of the hemorrhage was followed. Interestingly, the final sonographic appearance of the posterior fossa was quite similar to that of the classic form of Dandy-Walker malformation: absence of the vermis and an enlarged fourth ventricle. However, careful sonographic examination showed that the enlargement of the fourth ventricle was actually caused by a porencephalic cystic lesion of the left cerebellar lobe. Pathological examination revealed complete absence of the vermis and cerebellar hypoplasia.

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P02.67: Hydrocolpos: an alerting finding for cloacal anomalies

Ultrasound in Obstetrics & Gynecology, 2006

Poster abstracts regression of the lesion. As it regards the other 9 cases, 4 cases with cyst dia... more Poster abstracts regression of the lesion. As it regards the other 9 cases, 4 cases with cyst diameter less than 5cm were aspirated in utero. Progressive decrease in size and subsequent prenatal or postnatal regression was observed. The remaining 5 cases were submitted to postnatal operative laparoscopy. 1 case among those treated in utero underwent premature rupture of membranes and 1 case showed preterm labor. Conclusion: Many complications associated with fetal and neonatal ovarian cysts have been reported, including gastrointestinal obstruction or perforation, ascites, polyhydramnios, cyst rupture, hemorrhage and torsion. Nevertheless, in utero procedures, make the patients at risk of rupture of membranes, bleeding, intrauterine infection and premature labor. Criteria for management are still debated. A controversial about conservative versus surgical therapy remains. Therapeutic approach should be personalized in order to considered gestational age, size of the cyst, the presence of complications. These considerations will be extensively discussed.

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P02.59: A case of crossed‐fused renal ectopy

Ultrasound in Obstetrics & Gynecology, 2006

Poster abstracts Conclusion: The ultrasonographic evaluation of the compensatory hyperplasia of t... more Poster abstracts Conclusion: The ultrasonographic evaluation of the compensatory hyperplasia of the contralateral kidney is useful in the differential diagnosis of the invisible single fetal kidney. Compensatory hyperplasia of contralateral kidney in a fetus with invisible single kidney may suggest the absence the other functioning kidney, such as agenesis and ectopic MCDK.

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P01.44: First‐trimester fetal heart rate and Down syndrome screening

Ultrasound in Obstetrics & Gynecology, 2006

Trisomy 9 in complete non-mosaic state is an uncommon chromosomal abnormality. Because of its hig... more Trisomy 9 in complete non-mosaic state is an uncommon chromosomal abnormality. Because of its high intrauterine lethality rate, mainly in the first trimester of pregnancy, only a few cases regarding sonographic findings have been reported. Ultrasound features leading to the diagnosis of this chromosomal abnormality include central nervous system, craniofacial, cardiovascular, genitourinary and musculoskeletal malformations as well as early intrauterine growth restriction and oligo-anhydramnios. We report two cases of complete trisomy 9 detected in the early second trimester. Both of them had a normal nuchal translucency (NT) at 11 week scan. In case 1, amniocentesis was performed because the risk for trisomy 18 at the combined test was greater than 1/50 (free BhCG: 0.09 MoMs; PaPP-A: 0.23 MoMs) and in case 2 because of advanced maternal age. Ultrasound examination before amniocentesis at 16 and 14 weeks of gestation, respectively, revealed similar findings (case 1: absent cerebellar vermis, ventriculomegaly, dysmorphic face and dysplastic kidneys; case 2: oligohydramnios, absent cerebellar vermis, hypotelorism, complete atrioventricular septal defect, echogenic bowel, echogenic kidneys, mild generalized subcutaneous edema and ductus venosus pulsatility index (DVPI) greater than 95th centile). Quantitative fluorescent polymerase chain reaction (QF-PCR) for chromosomes 21, 13, 18, X and Y was indicated with normal results in both of the cases but diagnosis of trisomy 9 was made by conventional cytogenetic analysis of amniotic fluid samples. An intrauterine fetal death was diagnosed in case 1; in case 2 parents opted for termination of pregnancy. Because the sonographic findings of trisomy 9 are similar to those of trisomy 18 and 13, in spite of its very rare incidence, diagnosis of trisomy 9 should be considered when QF-PCR studies are performed in these fetuses.

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P09.03: Evaluation of the complications of amniocentesis in pregnant women with uterine myomas

Ultrasound in Obstetrics & Gynecology, 2005

Results: Excellent visualization of the external fetal anatomy was obtained in 83% of cases (5/6)... more Results: Excellent visualization of the external fetal anatomy was obtained in 83% of cases (5/6) with the duration of procedures ranging 15 to 40 minutes. A diagnosis of Meckel-Gruber syndrome was made at 13 + 1 weeks of gestation by visualizing postaxial polydactyly and an occipital encephalocele. Subsequently the pregnancy was terminated. Three full-term infants were delivered with no gross limb or facial abnormalities. Amniotic fluid leakage after the procedure occurred in 2 cases resulting in termination of pregnancy. Conclusion: Our experiences confirm the efficacy of embryofetoscopy for early diagnosis in the first trimester of pregnancy. Procedure-related risks are to be established by multicenter studies.

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Prenatal ultrasound diagnosis of a large epignathus

Journal of Obstetrics and Gynaecology, 1999

(1999). Prenatal ultrasound diagnosis of a large epignathus. Journal of Obstetrics and Gynaecolog... more

The Results of Cytogenetic Analysis with Regard to Intracytoplasmic Sperm Injection in Males, Females and Fetuses

Fetal Diagnosis and Therapy, 2004

Objectives: To determine the incidence of chromosome abnormalities among couples for whom intracy... more Objectives: To determine the incidence of chromosome abnormalities among couples for whom intracytoplasmic sperm injection (ICSI) treatment was indicated and fetuses conceived through the ICSI procedure. Methods: All cytogenetic results were evaluated retrospectively. Patients undergoing ICSI (n = 508) were classified according to the referring indications as: (1) males with severe infertility (87 azoospermia and 34 oligoasthenoteratozoospermia, OAT), (2) prior to ICSI (56 males and 61 females), and (3) following an unsuccessful ICSI procedure (132 males and 138 females). Fetuses conceived through ICSI (n = 475) were also classified into 4 groups according to the additional risk factors for chromosome abnormalities: ICSI (n = 185), ICSI + advanced maternal age (AMA, n = 215), ICSI + positive triple test result (TT, n = 50), and ICSI + abnormal ultrasound findings (USG, n = 25). Results: An abnormal karyotype was found in 31.03% of males with azoospermia and 14.71% of males with OAT,...

Prenatal Sonographic Diagnosis and Evaluation of Isolated Macrodactyly

InTech eBooks, Jun 29, 2012

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Prenatal Evaluation of Fetuses Presenting with Short Femurs

InTech eBooks, Jun 29, 2012

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The role of umbilical artery Doppler analysis in estimating perinatal morbidity and mortality in hypertensive pregnancy

Journal of Controversies in Obstetrics & Gynecology and Pediatrics

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DergiPark (Istanbul University), Oct 19, 2020

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Duchenne Kas Distrofisi İçin Riskli Ailelerde Taşıyıcılığın Belirlenmesi ve Prenatal Tanı Uygulamalarında Karşılaşılan Sorunlar