Introduction: Study skills are vital for academic performance. This study aims to explore the stu... more Introduction: Study skills are vital for academic performance. This study aims to explore the study skills of the students in Riyadh Elm University (REU), Riyadh, Saudi Arabia and to identify possible correlations of students' study skills with gender, academic level, and/or study field. Materials and Methods: A total of 816 students participated in this study from April 25, 2015 to May 25, 2015. A modified study skills assessment questionnaire of Counseling Centre of Houston University was used in this study. The questionnaire consisted of 32 items distributed in eight domains. The students' responses were recorded on a 4-point Likert scale and the data were analyzed using descriptive statistics, and independent t-test. Results: The obtained responses were 816. The mean score of REU students' total study skills indicated moderate study skills. Good study skills were scored by 213 students (26.10%); moderate study skills by 574 students (70.34%); and poor study skills by 29 students (3.55%). Little variation in the mean study skills because of gender, study field or academic level was found. The highest scores were in domains II and IV (concentration/memory and test strategies/test anxiety) while the least scores were in domains and VII (reading and writing). Statistically significant differences were observed between male and female students in domain VI (motivation/attitude), between dental and nondental students in domains II and V (concentration/memory and organizing/processing information) and between junior and senior students in domains I, III, II, and VI (time management, concentration/memory, study aids/note taking, and motivation/attitude). Conclusion: The majority of REU students employed study skills at a moderate level. It is recommended to design and incorporate study skills educational courses for students in academic curricula.
Introduction: The present study was designed to investigate whether Ginkgo biloba (GB) might prot... more Introduction: The present study was designed to investigate whether Ginkgo biloba (GB) might protect the heart against myocardial injury induced by isoproterenol (ISO) on the basis of its effects on biochemical and histological parameters. Materials and Methods: Twenty four adult male albino rats (180–200 g) were used in this study. They were divided into 4 equal groups of six rats each. Group I was the control group and group II received ISO (85 mg/kg body weight (bw), subcutaneously (S.C.) for two consecutive days to induce myocardial injury. Group III received GB (200 mg/kg bw) orally by gastric gavage daily for 21 days while group IV received GB (200 mg/kg bw) orally daily for 21 days in addition to ISO (85 mg/kg bw), S.C. on the 20th and 21st day from starting GB. After 24 hours, rats were sacrificed and the levels of cardiac marker enzymes (creatine kinase [CK] and its myocardial isoenzyme [CK-MB]) were assessed in serum. Heart specimens were processed for light and electron m...
Background: The possible protective role ofCleome Viscosa (Cl V) administration in experimental c... more Background: The possible protective role ofCleome Viscosa (Cl V) administration in experimental chronic obstructive pulmonary disease(COPD) induced by porcine pancreatic elastase (PPE) was investigated. Material and Methods: Fifty adult male albino rats weredivided into four groups;control,sham control, an experimental group that receivedPPE and a protection group that received Cl V 4 weeks before PPE . Lung specimens were subjected to histological and iNOS immunostaining. Emphysematouschanges were quantified by destructive index (DI) and mean linear intercept measurement (Lm). Results: Administration of Cl V prior to PPE induced marked decrease in the emphysematous areas and in iNOS immune-reaction compared to the experimental COPD group. The DI,Lm and themean optical density (OD) of iNOS immune-reaction were also significantly reducedwith the administration of Cl V . Conclusion: Cl V administration minimized the histological manifestations of elastase induced COPD.
Aim: The aim of this research was to explore the relation between body mass index (BMI) and denta... more Aim: The aim of this research was to explore the relation between body mass index (BMI) and dental caries in adult patients. Materials and Method: The patients' data was collected through a questionnaire and oral examination after obtaining an informed consent. World Health Organization (WHO) and DMFT index were used for diagnosis of dental caries. An independent t test was applied to compare the mean decayed, missing, filled teeth and DMFT scores between genders and age groups. Post comparisons were performed with Tukey’s test to identify the significant differences between the groups. Results: A total of 476 subjects participated in this study. Higher percentage of males (62.4%), age group18-29 years (44.5%), with no medical problems (79.0%) were included. Dental Caries (55.9%) constituted the main reason for missing teeth. The BMI distribution of the participants in this study was normal (37.4%), overweight (33.8%), obese (22%) and underweight (6.8%). Conclusion: This study s...
Thirty adult male albino rats weighing ISO-170 grams were included. Divided into two groups: Grou... more Thirty adult male albino rats weighing ISO-170 grams were included. Divided into two groups: Group I : Consisted of 10 rats. They were given saline daily oralIy for 30 days. Group II: Consisted of 20 rats. TIley were given aspirin (acetylsalicylic acid) at a dose 50 mg / kg daily orally for 30 days. Aspirin was given in the dosage that had significant anti-inflammatory action and would significantly inhibit prostaglandin (PO) biosynthesis (Laneuville et al., 1994). All animals were fed ad libitum and alIowed for free water supply. One day after the last dose. they were sacrificed by decapitation. Each colon was immediately dissected, rinsed with ice-cold phosphate buffered saline (PBS, pH 7.4) and processed for paraffin blocks. They were sectioned at 5 urn and stained with hematoxylin and eosin, and periodic acid Schiff reaction.
Faculty development programs (FDPs) have proven to be successful for improving teaching skills in... more Faculty development programs (FDPs) have proven to be successful for improving teaching skills in higher education. This review article summarizes literature reviews and resource books on faculty development. It tackled why FDP is important, history of FDP in the past years, and questioned whether FDP produced any positive effect on students' academic achievement as well as the different methods to assess FDPs effectiveness. The review also discussed how to establish FDP, presented its ideal structure, features that make FDP effective, and outlined the barriers to its successful implementation as well as the future vision. This report also highlighted the situation of FDP in Saudi Arabia. Finally, the review concluded that professional FDPs produce promising outcomes in the learning and teaching practices and recommended that teachers in higher education should attend FDP training activities on regular basis and that the scope of planned FDPs should extend beyond the health professions discipline, to include social skills necessary for collaboration, professional growth as well as management, and leadership abilities.
Journal of International Society of Preventive & Community Dentistry, 2017
To assess the early effect of oral health education on oral health knowledge of primary and inter... more To assess the early effect of oral health education on oral health knowledge of primary and intermediate school students of private schools by utilizing pre/post questionnaires data from oral health educational projects in Riyadh city, Saudi Arabia. Second, to examine topic-specific knowledge differences between genders, nationalities, and educational levels of the students. Cross-sectional oral health educational data of private school students (n = 1279) in primary and intermediate levels were extracted from the King Salman Centre for Children's Health (KSCCH) projects undertaken by Riyadh Colleges of Dentistry and Pharmacy. Student's pre- and post-test data were analyzed for changes in oral health knowledge. Overall knowledge score and topic-specific knowledge scores were calculated and the differences between gender, nationality, and educational level were examined using Mann-Whitney U-test. Pre/post change in the oral health knowledge was evaluated by Wilcoxon's sig...
Background and study aims: The therapeutic effects of human umbilical cord-derived mesenchymal st... more Background and study aims: The therapeutic effects of human umbilical cord-derived mesenchymal stem cells (UC-MSCs) exposed to diode laser and/or hepatocyte growth factor (HGF) were compared in mice with experimental liver fibrosis induced by carbon tetra chloride (CCl 4). Material and methods: Animal model of liver cirrhosis was induced by intraperitoneal injection of CCl 4 in a dose of 0.4 ml/kg, twice a week for 6 weeks. UC-MSCs were obtained from normal full term placentas and were exposed to diode laser and/or HGF. Before treatment, UC-MSCs were labelled with red fluorescent PKH26. Fifty four male mice weighing 25-35 g were randomly divided into four groups control, stem cells, CCl 4 , and treated groups. After the experimental period, body and liver weights were recorded, and the liver specimens were processed for histological examination using haematoxylin and eosin, Periodic Acid-Schiff (PAS), and Masson's Trichrome staining (MT). Results: Results showed that administration of UC-MSCs stimulated by diode laser and/or HGF improved body and liver weights, reduced vascular dilatation and congestion, reduced mononuclear cellular infiltration, reduced hepatocyte vacuolation, eosinophilia, and pyknosis. Furthermore, periportal fibrosis was minimized and PAS reaction was increased. These effects were maximum when UC-MSCs were exposed to both diode laser and HGF. Conclusion: UC-MSCs stimulated by both diode laser and HGF proved to be an effective therapeutic option in experimental liver fibrosis induced by CCl 4 in mice.
Background: Free oxygen radicals play an important role in the pathogenesis of gentamicin (GEN) n... more Background: Free oxygen radicals play an important role in the pathogenesis of gentamicin (GEN) nephrotoxicity and curcumin (CMN) has a strong antioxidant activity. Aim of the Work: The possible protective role of CMN on GEN-induced nephrotoxicity was investigated in albino rats by histological and morphometric methods. Materials and Methods: Thirty-six adult male albino rats were randomly divided into six equal groups. Group I: Control group received intraperitoneal (i.p.) injection of 0.9% saline, Group II received 1 ml corn oil orally for 21 days, Group III received 200 mg/kg CMN dissolved in corn oil orally for 21 days. Group IV received 100 mg/kg GEN dissolved in 0.9% saline i.p. for seven days from day 14, Group V received corn oil for 21 days and GEN for seven days from day 14 and lastly Group VI received CMN for 21 days and GEN from day 14 for seven days. At the end of the experiment, animals were weighed, sacrificed and the kidneys were dissected out, then processed for light and electron microscopic studies. Morphometric and statistical analysis were also performed. Results: Treatment with GEN led to significant limitation of weight gain, hyaline degeneration and nuclear pyknosis in the renal proximal tubules, shrinking of glomeruli and weak PAS reaction. Ultrastructurally, the proximal tubules exhibited loss of microvilli, thickened tubular basement membrane, condensed nuclei, rarefied cytoplasm with dark bodies and reduced number of mitochondria. Podocytes displayed fusion of secondary foot processes and thickening of the glomerular basement membrane with focal loss of its trilamellar structure. Concomitant administration of CMN with GEN revealed an observable protection against these changes. Conclusion: CMN showed a protective effect against nephrotoxicity induced by GEN in albino rats.
Background: Clozapine is an efficacious antipsychotic drug particularly in schizophrenic patients... more Background: Clozapine is an efficacious antipsychotic drug particularly in schizophrenic patients refractory to other agents. Treatment with clozapine was reported to be associated with sudden death, myocarditis and hepatotoxicity in some patients. Aim of the Work: This study was conducted to investigate the toxic effect of clozapine on cardiac muscle and liver of adult male albino rats and to assess the potential protective role of selenium. Materials and Methods: This study employed fifty adult male albino rats randomly divided into five equal groups. Group I: Control group, Group II received daily 1 ml of 0.1 M HCl, balanced in phosphate buffered saline intraperitoneally (i.p.), Group III received oral selenium (1.5 mg/kg), Group IV received Clozapine (25 mg/kg) i.p. daily and Group V received both clozapine and selenium. After 14 days, the liver and ventricular myocardium of each animal were dissected and processed for light and electron microscopic studies. Results: After clozapine administration, the ventricular myocardium showed fragmentation and separation of cardiac muscles with diffuse mixed inflammatory cellular infiltrate. The Z-lines were irregularly oriented with rupture of mitochondrial membranes and cristae. The liver exhibited extensive inflammatory cellular infiltration around the portal areas and vacuolated hepatocyte cytoplasm with rupture of membranes and cristae of some mitochondria. Concomitant administration of selenium with clozapine displayed an observable protection against these changes. Conclusion: Selenium may have a protective role against cardiotoxicity and hepatotoxicity induced by clozapine therapy.
Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Eg... more Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Egyptian Journal of Histology. Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information ...
association was found between the presence of IHD and arteriogenic causes of ED, a poor response ... more association was found between the presence of IHD and arteriogenic causes of ED, a poor response to intracorporal injection, poor rigidity in the Digital Inflection Rigidometer, and low peak systolic velocity (PSV) in the cavernosal arteries (P < 0.05 for each). No statistically significant association was found between the presence of IHD and increasing end-diastolic velocity values or decreasing resistive index in the cavernosal arteries (P < 0.05 for each). A statistically significant association was found between a higher grade of IHD and a decreasing PSV value (P < 0.05). Conclusions: The results of this study established that a reduced PSV of the cavernous artery is associated with IHD. Determining the PSV could be a reliable screening tool for the detection of IHD in patients with ED.
Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Eg... more Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Egyptian Journal of Histology. Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information ...
Background and Objectives: The rapidly increasing number of diabetic patients across the world dr... more Background and Objectives: The rapidly increasing number of diabetic patients across the world drew the attention to develop more effective therapeutic approaches. Recent investigations on newly differentiated insulin producing cells (IPCs) revealed that they could be derived from embryonic, adult mesenchymal and hematopoietic stem cells. This work was planned to evaluate the role of StemEnhance (Aphanizomenon flos-aquae [AFA] plant extract) in mobilizing naturally occurring bone marrow stem cells as well as in improving streptozotocin-induced diabetic rats. Methods and Results: Twenty adult male albino rats were divided into four groups namely the control, the diabetic, the positive control-StemEnhance and the diabetic-StemEnhance groups. After diabetes induction by streptozotocin (STZ), rats received StemEnhance for four weeks. The mean number of blood CD34 immunopositive cells was measured by flowcytometry and random blood sugar was measured weekly. The pancreas was removed from the sacrificed rats and processed for staining with H&E and immunohistochemical staining for CD34+ve and insulin +ve cells. CD34+ve cells increased in the blood after introduction of StemEnhance. CD34+ve cells were observed in the pancreas and the insulin producing cells in the islets of Langerhans were increased from the second to the fourth week of treatment. Blood glucose level improved but it was still higher than the control level after four weeks of StemEnhance treatment. Conclusions: This work points to the significant role of StemEnhance in stem cell mobilization and the improvement of diabetes mellitus.
Introduction: Study skills are vital for academic performance. This study aims to explore the stu... more Introduction: Study skills are vital for academic performance. This study aims to explore the study skills of the students in Riyadh Elm University (REU), Riyadh, Saudi Arabia and to identify possible correlations of students' study skills with gender, academic level, and/or study field. Materials and Methods: A total of 816 students participated in this study from April 25, 2015 to May 25, 2015. A modified study skills assessment questionnaire of Counseling Centre of Houston University was used in this study. The questionnaire consisted of 32 items distributed in eight domains. The students' responses were recorded on a 4-point Likert scale and the data were analyzed using descriptive statistics, and independent t-test. Results: The obtained responses were 816. The mean score of REU students' total study skills indicated moderate study skills. Good study skills were scored by 213 students (26.10%); moderate study skills by 574 students (70.34%); and poor study skills by 29 students (3.55%). Little variation in the mean study skills because of gender, study field or academic level was found. The highest scores were in domains II and IV (concentration/memory and test strategies/test anxiety) while the least scores were in domains and VII (reading and writing). Statistically significant differences were observed between male and female students in domain VI (motivation/attitude), between dental and nondental students in domains II and V (concentration/memory and organizing/processing information) and between junior and senior students in domains I, III, II, and VI (time management, concentration/memory, study aids/note taking, and motivation/attitude). Conclusion: The majority of REU students employed study skills at a moderate level. It is recommended to design and incorporate study skills educational courses for students in academic curricula.
Introduction: The present study was designed to investigate whether Ginkgo biloba (GB) might prot... more Introduction: The present study was designed to investigate whether Ginkgo biloba (GB) might protect the heart against myocardial injury induced by isoproterenol (ISO) on the basis of its effects on biochemical and histological parameters. Materials and Methods: Twenty four adult male albino rats (180–200 g) were used in this study. They were divided into 4 equal groups of six rats each. Group I was the control group and group II received ISO (85 mg/kg body weight (bw), subcutaneously (S.C.) for two consecutive days to induce myocardial injury. Group III received GB (200 mg/kg bw) orally by gastric gavage daily for 21 days while group IV received GB (200 mg/kg bw) orally daily for 21 days in addition to ISO (85 mg/kg bw), S.C. on the 20th and 21st day from starting GB. After 24 hours, rats were sacrificed and the levels of cardiac marker enzymes (creatine kinase [CK] and its myocardial isoenzyme [CK-MB]) were assessed in serum. Heart specimens were processed for light and electron m...
Background: The possible protective role ofCleome Viscosa (Cl V) administration in experimental c... more Background: The possible protective role ofCleome Viscosa (Cl V) administration in experimental chronic obstructive pulmonary disease(COPD) induced by porcine pancreatic elastase (PPE) was investigated. Material and Methods: Fifty adult male albino rats weredivided into four groups;control,sham control, an experimental group that receivedPPE and a protection group that received Cl V 4 weeks before PPE . Lung specimens were subjected to histological and iNOS immunostaining. Emphysematouschanges were quantified by destructive index (DI) and mean linear intercept measurement (Lm). Results: Administration of Cl V prior to PPE induced marked decrease in the emphysematous areas and in iNOS immune-reaction compared to the experimental COPD group. The DI,Lm and themean optical density (OD) of iNOS immune-reaction were also significantly reducedwith the administration of Cl V . Conclusion: Cl V administration minimized the histological manifestations of elastase induced COPD.
Aim: The aim of this research was to explore the relation between body mass index (BMI) and denta... more Aim: The aim of this research was to explore the relation between body mass index (BMI) and dental caries in adult patients. Materials and Method: The patients' data was collected through a questionnaire and oral examination after obtaining an informed consent. World Health Organization (WHO) and DMFT index were used for diagnosis of dental caries. An independent t test was applied to compare the mean decayed, missing, filled teeth and DMFT scores between genders and age groups. Post comparisons were performed with Tukey’s test to identify the significant differences between the groups. Results: A total of 476 subjects participated in this study. Higher percentage of males (62.4%), age group18-29 years (44.5%), with no medical problems (79.0%) were included. Dental Caries (55.9%) constituted the main reason for missing teeth. The BMI distribution of the participants in this study was normal (37.4%), overweight (33.8%), obese (22%) and underweight (6.8%). Conclusion: This study s...
Thirty adult male albino rats weighing ISO-170 grams were included. Divided into two groups: Grou... more Thirty adult male albino rats weighing ISO-170 grams were included. Divided into two groups: Group I : Consisted of 10 rats. They were given saline daily oralIy for 30 days. Group II: Consisted of 20 rats. TIley were given aspirin (acetylsalicylic acid) at a dose 50 mg / kg daily orally for 30 days. Aspirin was given in the dosage that had significant anti-inflammatory action and would significantly inhibit prostaglandin (PO) biosynthesis (Laneuville et al., 1994). All animals were fed ad libitum and alIowed for free water supply. One day after the last dose. they were sacrificed by decapitation. Each colon was immediately dissected, rinsed with ice-cold phosphate buffered saline (PBS, pH 7.4) and processed for paraffin blocks. They were sectioned at 5 urn and stained with hematoxylin and eosin, and periodic acid Schiff reaction.
Faculty development programs (FDPs) have proven to be successful for improving teaching skills in... more Faculty development programs (FDPs) have proven to be successful for improving teaching skills in higher education. This review article summarizes literature reviews and resource books on faculty development. It tackled why FDP is important, history of FDP in the past years, and questioned whether FDP produced any positive effect on students' academic achievement as well as the different methods to assess FDPs effectiveness. The review also discussed how to establish FDP, presented its ideal structure, features that make FDP effective, and outlined the barriers to its successful implementation as well as the future vision. This report also highlighted the situation of FDP in Saudi Arabia. Finally, the review concluded that professional FDPs produce promising outcomes in the learning and teaching practices and recommended that teachers in higher education should attend FDP training activities on regular basis and that the scope of planned FDPs should extend beyond the health professions discipline, to include social skills necessary for collaboration, professional growth as well as management, and leadership abilities.
Journal of International Society of Preventive & Community Dentistry, 2017
To assess the early effect of oral health education on oral health knowledge of primary and inter... more To assess the early effect of oral health education on oral health knowledge of primary and intermediate school students of private schools by utilizing pre/post questionnaires data from oral health educational projects in Riyadh city, Saudi Arabia. Second, to examine topic-specific knowledge differences between genders, nationalities, and educational levels of the students. Cross-sectional oral health educational data of private school students (n = 1279) in primary and intermediate levels were extracted from the King Salman Centre for Children's Health (KSCCH) projects undertaken by Riyadh Colleges of Dentistry and Pharmacy. Student's pre- and post-test data were analyzed for changes in oral health knowledge. Overall knowledge score and topic-specific knowledge scores were calculated and the differences between gender, nationality, and educational level were examined using Mann-Whitney U-test. Pre/post change in the oral health knowledge was evaluated by Wilcoxon's sig...
Background and study aims: The therapeutic effects of human umbilical cord-derived mesenchymal st... more Background and study aims: The therapeutic effects of human umbilical cord-derived mesenchymal stem cells (UC-MSCs) exposed to diode laser and/or hepatocyte growth factor (HGF) were compared in mice with experimental liver fibrosis induced by carbon tetra chloride (CCl 4). Material and methods: Animal model of liver cirrhosis was induced by intraperitoneal injection of CCl 4 in a dose of 0.4 ml/kg, twice a week for 6 weeks. UC-MSCs were obtained from normal full term placentas and were exposed to diode laser and/or HGF. Before treatment, UC-MSCs were labelled with red fluorescent PKH26. Fifty four male mice weighing 25-35 g were randomly divided into four groups control, stem cells, CCl 4 , and treated groups. After the experimental period, body and liver weights were recorded, and the liver specimens were processed for histological examination using haematoxylin and eosin, Periodic Acid-Schiff (PAS), and Masson's Trichrome staining (MT). Results: Results showed that administration of UC-MSCs stimulated by diode laser and/or HGF improved body and liver weights, reduced vascular dilatation and congestion, reduced mononuclear cellular infiltration, reduced hepatocyte vacuolation, eosinophilia, and pyknosis. Furthermore, periportal fibrosis was minimized and PAS reaction was increased. These effects were maximum when UC-MSCs were exposed to both diode laser and HGF. Conclusion: UC-MSCs stimulated by both diode laser and HGF proved to be an effective therapeutic option in experimental liver fibrosis induced by CCl 4 in mice.
Background: Free oxygen radicals play an important role in the pathogenesis of gentamicin (GEN) n... more Background: Free oxygen radicals play an important role in the pathogenesis of gentamicin (GEN) nephrotoxicity and curcumin (CMN) has a strong antioxidant activity. Aim of the Work: The possible protective role of CMN on GEN-induced nephrotoxicity was investigated in albino rats by histological and morphometric methods. Materials and Methods: Thirty-six adult male albino rats were randomly divided into six equal groups. Group I: Control group received intraperitoneal (i.p.) injection of 0.9% saline, Group II received 1 ml corn oil orally for 21 days, Group III received 200 mg/kg CMN dissolved in corn oil orally for 21 days. Group IV received 100 mg/kg GEN dissolved in 0.9% saline i.p. for seven days from day 14, Group V received corn oil for 21 days and GEN for seven days from day 14 and lastly Group VI received CMN for 21 days and GEN from day 14 for seven days. At the end of the experiment, animals were weighed, sacrificed and the kidneys were dissected out, then processed for light and electron microscopic studies. Morphometric and statistical analysis were also performed. Results: Treatment with GEN led to significant limitation of weight gain, hyaline degeneration and nuclear pyknosis in the renal proximal tubules, shrinking of glomeruli and weak PAS reaction. Ultrastructurally, the proximal tubules exhibited loss of microvilli, thickened tubular basement membrane, condensed nuclei, rarefied cytoplasm with dark bodies and reduced number of mitochondria. Podocytes displayed fusion of secondary foot processes and thickening of the glomerular basement membrane with focal loss of its trilamellar structure. Concomitant administration of CMN with GEN revealed an observable protection against these changes. Conclusion: CMN showed a protective effect against nephrotoxicity induced by GEN in albino rats.
Background: Clozapine is an efficacious antipsychotic drug particularly in schizophrenic patients... more Background: Clozapine is an efficacious antipsychotic drug particularly in schizophrenic patients refractory to other agents. Treatment with clozapine was reported to be associated with sudden death, myocarditis and hepatotoxicity in some patients. Aim of the Work: This study was conducted to investigate the toxic effect of clozapine on cardiac muscle and liver of adult male albino rats and to assess the potential protective role of selenium. Materials and Methods: This study employed fifty adult male albino rats randomly divided into five equal groups. Group I: Control group, Group II received daily 1 ml of 0.1 M HCl, balanced in phosphate buffered saline intraperitoneally (i.p.), Group III received oral selenium (1.5 mg/kg), Group IV received Clozapine (25 mg/kg) i.p. daily and Group V received both clozapine and selenium. After 14 days, the liver and ventricular myocardium of each animal were dissected and processed for light and electron microscopic studies. Results: After clozapine administration, the ventricular myocardium showed fragmentation and separation of cardiac muscles with diffuse mixed inflammatory cellular infiltrate. The Z-lines were irregularly oriented with rupture of mitochondrial membranes and cristae. The liver exhibited extensive inflammatory cellular infiltration around the portal areas and vacuolated hepatocyte cytoplasm with rupture of membranes and cristae of some mitochondria. Concomitant administration of selenium with clozapine displayed an observable protection against these changes. Conclusion: Selenium may have a protective role against cardiotoxicity and hepatotoxicity induced by clozapine therapy.
Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Eg... more Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Egyptian Journal of Histology. Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information ...
association was found between the presence of IHD and arteriogenic causes of ED, a poor response ... more association was found between the presence of IHD and arteriogenic causes of ED, a poor response to intracorporal injection, poor rigidity in the Digital Inflection Rigidometer, and low peak systolic velocity (PSV) in the cavernosal arteries (P < 0.05 for each). No statistically significant association was found between the presence of IHD and increasing end-diastolic velocity values or decreasing resistive index in the cavernosal arteries (P < 0.05 for each). A statistically significant association was found between a higher grade of IHD and a decreasing PSV value (P < 0.05). Conclusions: The results of this study established that a reduced PSV of the cavernous artery is associated with IHD. Determining the PSV could be a reliable screening tool for the detection of IHD in patients with ED.
Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Eg... more Advertisement. Close Window. Close Window. Thank you for choosing to subscribe to the eTOC for Egyptian Journal of Histology. Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information ...
Background and Objectives: The rapidly increasing number of diabetic patients across the world dr... more Background and Objectives: The rapidly increasing number of diabetic patients across the world drew the attention to develop more effective therapeutic approaches. Recent investigations on newly differentiated insulin producing cells (IPCs) revealed that they could be derived from embryonic, adult mesenchymal and hematopoietic stem cells. This work was planned to evaluate the role of StemEnhance (Aphanizomenon flos-aquae [AFA] plant extract) in mobilizing naturally occurring bone marrow stem cells as well as in improving streptozotocin-induced diabetic rats. Methods and Results: Twenty adult male albino rats were divided into four groups namely the control, the diabetic, the positive control-StemEnhance and the diabetic-StemEnhance groups. After diabetes induction by streptozotocin (STZ), rats received StemEnhance for four weeks. The mean number of blood CD34 immunopositive cells was measured by flowcytometry and random blood sugar was measured weekly. The pancreas was removed from the sacrificed rats and processed for staining with H&E and immunohistochemical staining for CD34+ve and insulin +ve cells. CD34+ve cells increased in the blood after introduction of StemEnhance. CD34+ve cells were observed in the pancreas and the insulin producing cells in the islets of Langerhans were increased from the second to the fourth week of treatment. Blood glucose level improved but it was still higher than the control level after four weeks of StemEnhance treatment. Conclusions: This work points to the significant role of StemEnhance in stem cell mobilization and the improvement of diabetes mellitus.
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Papers by Ashraf Kamel