Papers by Patricia A Aronin
Pediatric infectious disease, Dec 1, 1991
Journal of Neurosurgery, Feb 1, 1981
Levamisole was evaluated as an immune stimulant in a randomized controlled study of patients with... more Levamisole was evaluated as an immune stimulant in a randomized controlled study of patients with anaplastic gliomas, who had undergone surgical resection and who were also treated with radiotherapy and BCNU chemotherapy. Of 102 patients placed into the study, 85 were determined to comprise the adequately treated group (ATG): a full course of radiotherapy and two cycles of BCNU chemotherapy. Within the ATG, those patients who received levamisole did not demonstrate significantly different serial delayed hypersensitivity reactions, peripheral blood lymphocyte and T-cell counts, or serum IgM levels, compared to those patients not receiving levamisole. There was no significant difference in survival times of the two groups. Studies utilizing the avian sarcoma virus-induced glioma in rats also showed no improvement in survival with levamisole stimulation as the only immune agent, but the combination of active immunization and adjuvant stimulation with bacillus Calmette-Guerin plus levamisole was found to be therapeutically effective in this model and will be used in future pilot studies of active immunization in patients. KEY WORDS 9 levamisole immunostimulation 9 malignant glioma therapy 9 glioma model 9 radiotherapy 9 BCNU chemotherapy *Phipps strain BCG from the Trudeau Institute Mycobacterial Culture Collection was kindly supplied by Dr. Herbert J. Rapp of the National Cancer Institute.
Pediatric Neurology, Jul 1, 1990
Lipomas of the cerebellopontine angle are very rare lesions. To date, 18 patients have been repor... more Lipomas of the cerebellopontine angle are very rare lesions. To date, 18 patients have been reported, 17 of whom were adults. A second child is described with cerebellopontine angle lipoma.
Pediatric Neurosurgery, 2010
Access to full text and tables of contents, including tentative ones for forthcoming issues: www.... more Access to full text and tables of contents, including tentative ones for forthcoming issues: www.karger.com/pne_issues
Pediatric Neurosurgery, 2010
Surg Neurol, 1983
Bacillus Calmette-Guerin cell-wall preparation was injected along with avian sarcoma virus in the... more Bacillus Calmette-Guerin cell-wall preparation was injected along with avian sarcoma virus in the brains of newborn Fischer 344 rats, and subsequent glioma induction was compared with rats injected with avian sarcoma virus alone. The percentage of glioma induction and survival were found to be directly related to avian sarcoma virus concentration (10(0), 10(-1), 10(-2), and 10(-3)). A significant reduction in glioma induction occurred when BCG cell-wall preparation was injected with 10(-2) ASV concentration. Above that concentration of ASV, the tumor induction was not significantly affected by bacillus Calmette-Guerin cell-wall preparation; below that concentration, the tumor induction was too low with avian sarcoma virus alone to evaluate an effect.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000
To evaluate prospectively the effects on survival, relapse-free survival, and patterns of relapse... more To evaluate prospectively the effects on survival, relapse-free survival, and patterns of relapse of reduced-dose (23.4 Gy in 13 fractions) compared with standard-dose (36 Gy in 20 fractions) neuraxis irradiation in patients 3 to 21 years of age with low-stage medulloblastoma, minimal postoperative residual disease, and no evidence of neuraxis disease. The Pediatric Oncology Group and Children's Cancer Group randomized 126 patients to the study. All patients received posterior fossa irradiation to a total dose of 54 Gy in addition to the neuraxis treatment. Patients were staged postoperatively with contrast-enhanced cranial computed tomography, myelography, and CSF cytology. Of the registered patients, 38 were ineligible. The planned interim analysis that resulted in closure of the protocol showed that patients randomized to the reduced neuraxis treatment had increased frequency of relapse. In the final analysis, eligible patients receiving standard-dose neuraxis irradiation had...
Pediatric radiology, 1995
AJNR. American journal of neuroradiology
Hemangiomas are the most common tumor of the head and neck in children, including intracranial ne... more Hemangiomas are the most common tumor of the head and neck in children, including intracranial neoplasms. Capillary hemangioma in turn is the commonest type of hemangioma. Our case establishes that its anatomic distribution may include the intracranial compartment. We were unable to distinguish capillary hemangioma from meningioma based on imaging findings alone.
The Journal of reproductive medicine, 1995
The objective of this study was to determine if an ultra-sound examination, when performed in the... more The objective of this study was to determine if an ultra-sound examination, when performed in the third trimester immediately preceding delivery, is useful in predicting outcome in infants with a myelomeningocele. A retrospective review was undertaken of prenatal ultrasound records and pediatric outcome data on fetuses with isolated myelomeningocele referred to our institution after 28 weeks' gestation during a three-year period. Macrocephaly proved to be the one antenatal ultrasound finding that most correlated with later poor outcomes in infants with myelomeningocele. Macrocephalic fetuses had a longer mean hospital stay after birth and were more likely to have significant respiratory and feeding difficulties. No fetus with macrocephaly had a normal mental score, and all had severe motor deficits on later follow-up testing. The ultrasound diagnosis of macrocephaly identified a group of fetuses with myelomeningocele, who were at highest risk of neonatal problems and development...
Pediatric neurology
Lipomas of the cerebellopontine angle are very rare lesions. To date, 18 patients have been repor... more Lipomas of the cerebellopontine angle are very rare lesions. To date, 18 patients have been reported, 17 of whom were adults. A second child is described with cerebellopontine angle lipoma.
Surgical Neurology, 1983
Bacillus Calmette-Guerin cell-wall preparation was injected along with avian sarcoma virus in the... more Bacillus Calmette-Guerin cell-wall preparation was injected along with avian sarcoma virus in the brains of newborn Fischer 344 rats, and subsequent glioma induction was compared with rats injected with avian sarcoma virus alone. The percentage of glioma induction and survival were found to be directly related to avian sarcoma virus concentration (10(0), 10(-1), 10(-2), and 10(-3)). A significant reduction in glioma induction occurred when BCG cell-wall preparation was injected with 10(-2) ASV concentration. Above that concentration of ASV, the tumor induction was not significantly affected by bacillus Calmette-Guerin cell-wall preparation; below that concentration, the tumor induction was too low with avian sarcoma virus alone to evaluate an effect.
Steroids, 1972
Abstract Tritiated progesterone androstenedione and testosterone were incubated with testicular h... more Abstract Tritiated progesterone androstenedione and testosterone were incubated with testicular homogenates of 4-and 32-week-old Stanley-Gumbreck pseudohermaphrodite (Ps) and normal (N1) male littermate rats. In 15 and 180 minute incubations, both 4-and 32-...
Steroids, 1974
ABSTRACT Testosterone formation from pregnenolone (3β-hydroxy-5-pregnen-20-one) and progesterone ... more ABSTRACT Testosterone formation from pregnenolone (3β-hydroxy-5-pregnen-20-one) and progesterone in testis of the Stanley-Gumbreck pseudohermaphrodite (Ps) adult rat is greatly reduced in comparison to the normal (Nl) adult rat testis. In an attempt to determine whether this defect is congenital or acquired postnatally with increasing age, minced testis of 1-month-old Ps and Nl rats were incubated with progesterone, and the labeled metabolites identified. Almost equal amounts of progesterone were metabolized by both Ps and Nl testis. In mince incubations without NADPH nearly as much testosterone and 4-androstene-3,17-dione accumulated in the Ps as in the Nl testis. Very little androsterone and 5α-androstane-3α,17β-diol were formed in these incubations. When minces were incubated with progesterone in the presence of NADPH, testosterone and 4-androstene-3,17-dione accumulation was greatly reduced, and instead 5α-androstane-3α,17β-diol was formed as the major product by Nl testis and androsterone by Ps testis. Neither heparin, a 5α-reductase inhibitor, nor glucose-6-phosphate dehydrogenase alone significantly influenced progesterone metabolism or the accumulation of testosterone or 4-androstene-3,17-dione in either Ps or Nl testis. These results indicated that the 5α-reductase activity in both the Ps and N1 testis is dependent only on NADPH. Although studies were not carried out in younger rats (2–5 days of age), our results are in agreement with previous studies of Goldstein and Wilson who demonstrated equal accumulation of testosterone in incubations of testis from normal and Tfm/y mice. However, it is apparent that differences between Nl and Ps testis may be revealed only under conditions which allow maximum rates of 17-oxo- and 5α-reductions.
Radiotherapy and Oncology, 1996
Pediatric Neurosurgery, 1996
... RM Thomas b , Jeffrey Krischer c , James M. Boyett d , Leland Albright c , Patricia Aronin f ... more ... RM Thomas b , Jeffrey Krischer c , James M. Boyett d , Leland Albright c , Patricia Aronin f , JamesLangston d , Jeffrey C. Allen g , Roger J. Packer p , Rita Linggood i , Raymond Mulhern d , Philip Stanley j , James A. Stehbens k , Patricia Duffner l , Larry Kun d , Lucy Rorke m ...
Pediatric Neurosurgery, 1995
Children with myelodysplasia frequently have abnormal hand function. Etiologies include brainstem... more Children with myelodysplasia frequently have abnormal hand function. Etiologies include brainstem and cervical cord compression due to the Chiari II malformation, syringomyelia, hydrocephalus, and cerebral dysmorphism. Determination of potentially correctable causes of hand dysfunction may be difficult. We describe the use of the Jaymar dynamometer for assessing grip strength as a means of detecting early changes in hand function.
Pediatric Neurosurgery, 2010
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Papers by Patricia A Aronin