Preserved Knowledge of Maps of Countries: Implications for the Organization of Semantic Memory
Neurocase, 2004
We describe two patients with selectively preserved knowledge of the category of countries. Follo... more We describe two patients with selectively preserved knowledge of the category of countries. Following a series of cerebral infarcts, patient DB presented with severe perceptual impairment, including dense apperceptive agnosia,prosopagnosia, and topographical agnosia. Despite these deficits, he could effortlessly name countries from their outline maps. Patient WH, who suffered from semantic dementia, had severe naming and comprehension difficulties, with extremely sparse residual semantic knowledge. Remarkably, the category of countries was preserved. First, we argue that, for both patients, this category preservation occurs at a semantic level. Second, we discuss our findings in the context of three current models of category-specific effects (perceptual, ontogenetic, and evolutionary models). We argue that the perceptual model (Humphreys and colleagues) cannot easily accommodate our findings. By contrast, the ontogenetic (Warrington and colleagues) and evolutionary models (Caramazza and colleagues) can explain our findings. However, some modifications to both models are required. The ontogenetic model needs to envisage a spatial channel for the development of map knowledge, which is anatomically separate from channels of other categories of knowledge. The evolutionary model needs to envisage the possibility that some categories of knowledge, such as countries, may not be prewired, but learned during ontogenetic development.
We report a single-case study of a patient who suddenly lost her ability to orient herself in her... more We report a single-case study of a patient who suddenly lost her ability to orient herself in her neighbourhood. On formal testing she demonstrated remarkably selective deficits in episodic and semantic memory of topographical items and routes. Her general intellectual abilities were unaffected as were basic perceptual processes and episodic and semantic memory other than topography. We interpret her deficit as a further example of category-specific processing impairment affecting knowledge acquired through selective channels -in this case visuo-locomotor information.
Aphasic individuals often inappropriately and unintentionally repeat recent responses, errors ter... more Aphasic individuals often inappropriately and unintentionally repeat recent responses, errors termed recurrent perseverations. In a series of picture naming experiments, we investigated the impact of manipulating stimulus factors on the number of perseverations produced by an aphasic patient (E.B.) with markedly impaired naming skills. E.B. produced significantly more perseverations to pictures with low frequency names and following stimulus repetition. In contrast, semantic relatedness and presentation rate failed to influence perseveration. Our results are considered in the context of theories that relate recurrent perseverations to intact priming mechanisms [Brain 121 (1998) 1641; Aphasiology 12 (1998) 319; J. Exp. Psychol. Learn. Mem. Cogn. 19 (1993) 243]. We conclude that these theories can correctly predict some but not all aspects of E.B.'s perseverations. In particular, they failed to predict that: (1) perseverations often appeared to reflect the earlier sequential proximity of stimuli and responses; and (2) perseverations became less likely as more experimental trials intervened, a trend that did not interact with presentation rate. We review evidence relating recurrent perseverations to neuromodulatory deficits and we conclude that a theory of the functional role of neuromodulation in the cerebral cortex proposed by Hasselmo [Neural Netw. 7 (1994) 13] is capable of accounting for all aspects of E.B.'s perseverative behavior.
Memory for Visuospatial Location Following Selective Hippocampal Sclerosis: The Use of Different Coordinate Systems
Neuropsychology, 2004
This study addressed the role of the medial temporal lobe regions and, more specifically, the con... more This study addressed the role of the medial temporal lobe regions and, more specifically, the contribution of the human hippocampus in memory for body-centered (egocentric) and environment-centered (allocentric) spatial location. Twenty-one patients with unilateral atrophy of the hippocampus secondary to long-standing epilepsy (left, n = 7; right, n = 14) and 15 normal control participants underwent 3 tasks measuring recall of egocentric or allocentric spatial location. Patients with left hippocampal sclerosis were consistently impaired in the allocentric conditions of all 3 tasks but not in the egocentric conditions. Patients with right hippocampal sclerosis were impaired to a lesser extent and in only 2 of the 3 tasks. It was concluded that hippocampal structures are crucial for allocentric, but not egocentric, spatial memory.
Recall of words from categorised lists was examined in 77 patients and 12 normal control subjects... more Recall of words from categorised lists was examined in 77 patients and 12 normal control subjects. In Experiment I, both left temporal-lobe excisions that included the hippocampus (LTH) and left frontal-lobe removals (LF) impaired free recall, but the LF group performed normally when encoding and retrieval strategies were supplied. In Experiment 2, experimentally induced interference during cued recall abnormally hampered performance for the LF, but not for the LTH group.
Preserved Knowledge of Maps of Countries: Implications for the Organization of Semantic Memory
Neurocase, 2004
We describe two patients with selectively preserved knowledge of the category of countries. Follo... more We describe two patients with selectively preserved knowledge of the category of countries. Following a series of cerebral infarcts, patient DB presented with severe perceptual impairment, including dense apperceptive agnosia,prosopagnosia, and topographical agnosia. Despite these deficits, he could effortlessly name countries from their outline maps. Patient WH, who suffered from semantic dementia, had severe naming and comprehension difficulties, with extremely sparse residual semantic knowledge. Remarkably, the category of countries was preserved. First, we argue that, for both patients, this category preservation occurs at a semantic level. Second, we discuss our findings in the context of three current models of category-specific effects (perceptual, ontogenetic, and evolutionary models). We argue that the perceptual model (Humphreys and colleagues) cannot easily accommodate our findings. By contrast, the ontogenetic (Warrington and colleagues) and evolutionary models (Caramazza and colleagues) can explain our findings. However, some modifications to both models are required. The ontogenetic model needs to envisage a spatial channel for the development of map knowledge, which is anatomically separate from channels of other categories of knowledge. The evolutionary model needs to envisage the possibility that some categories of knowledge, such as countries, may not be prewired, but learned during ontogenetic development.
We report a single-case study of a patient who suddenly lost her ability to orient herself in her... more We report a single-case study of a patient who suddenly lost her ability to orient herself in her neighbourhood. On formal testing she demonstrated remarkably selective deficits in episodic and semantic memory of topographical items and routes. Her general intellectual abilities were unaffected as were basic perceptual processes and episodic and semantic memory other than topography. We interpret her deficit as a further example of category-specific processing impairment affecting knowledge acquired through selective channels -in this case visuo-locomotor information.
Aphasic individuals often inappropriately and unintentionally repeat recent responses, errors ter... more Aphasic individuals often inappropriately and unintentionally repeat recent responses, errors termed recurrent perseverations. In a series of picture naming experiments, we investigated the impact of manipulating stimulus factors on the number of perseverations produced by an aphasic patient (E.B.) with markedly impaired naming skills. E.B. produced significantly more perseverations to pictures with low frequency names and following stimulus repetition. In contrast, semantic relatedness and presentation rate failed to influence perseveration. Our results are considered in the context of theories that relate recurrent perseverations to intact priming mechanisms [Brain 121 (1998) 1641; Aphasiology 12 (1998) 319; J. Exp. Psychol. Learn. Mem. Cogn. 19 (1993) 243]. We conclude that these theories can correctly predict some but not all aspects of E.B.'s perseverations. In particular, they failed to predict that: (1) perseverations often appeared to reflect the earlier sequential proximity of stimuli and responses; and (2) perseverations became less likely as more experimental trials intervened, a trend that did not interact with presentation rate. We review evidence relating recurrent perseverations to neuromodulatory deficits and we conclude that a theory of the functional role of neuromodulation in the cerebral cortex proposed by Hasselmo [Neural Netw. 7 (1994) 13] is capable of accounting for all aspects of E.B.'s perseverative behavior.
Memory for Visuospatial Location Following Selective Hippocampal Sclerosis: The Use of Different Coordinate Systems
Neuropsychology, 2004
This study addressed the role of the medial temporal lobe regions and, more specifically, the con... more This study addressed the role of the medial temporal lobe regions and, more specifically, the contribution of the human hippocampus in memory for body-centered (egocentric) and environment-centered (allocentric) spatial location. Twenty-one patients with unilateral atrophy of the hippocampus secondary to long-standing epilepsy (left, n = 7; right, n = 14) and 15 normal control participants underwent 3 tasks measuring recall of egocentric or allocentric spatial location. Patients with left hippocampal sclerosis were consistently impaired in the allocentric conditions of all 3 tasks but not in the egocentric conditions. Patients with right hippocampal sclerosis were impaired to a lesser extent and in only 2 of the 3 tasks. It was concluded that hippocampal structures are crucial for allocentric, but not egocentric, spatial memory.
Recall of words from categorised lists was examined in 77 patients and 12 normal control subjects... more Recall of words from categorised lists was examined in 77 patients and 12 normal control subjects. In Experiment I, both left temporal-lobe excisions that included the hippocampus (LTH) and left frontal-lobe removals (LF) impaired free recall, but the LF group performed normally when encoding and retrieval strategies were supplied. In Experiment 2, experimentally induced interference during cued recall abnormally hampered performance for the LF, but not for the LTH group.
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Papers by Antonio Incisa