European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2018
In order to evaluate the usefulness of sonication of retrieved implants for the diagnosis of pros... more In order to evaluate the usefulness of sonication of retrieved implants for the diagnosis of prosthetic joint infection (PJI) in a large group of patients in a routine setting, we designed a 3-year retrospective study. Patients were classified into two groups: those meeting the clinical criteria of PJI and those that did not (control group). Two hundred patients and 276 samples were included. The types of infection were early (n = 44), delayed (n = 53), positive intraoperative cultures (n = 13) and late-acute (n = 8). The culture sensitivities of sonicate fluid, periprosthetic tissue, synovial fluid and combination of periprosthetic tissue and/or synovial fluid were 69.5, 52.8, 54.8 and 60.2%, respectively. The specificities were 97.6, 90.3, 93.0 and 89.9%, respectively. Sonicate fluid culture of implants was more sensitive than peri-implant tissue, synovial fluid and combination of periprosthetic tissue and/or synovial fluid for all infection types, though it was especially useful ...
... Titre du document / Document title. INVASIVE INFECTION OF THE GASTROINTESTINAL TRACT BY LEISH... more ... Titre du document / Document title. INVASIVE INFECTION OF THE GASTROINTESTINAL TRACT BY LEISHMANIA IN PATIENTSWITH AIDS. Auteur(s) / Author(s). DE GORGOLAS M. ; BELLO E. ; BLANCO A. ; RENEDO G. ; FERNANDEZ-GUERRERO ML ; Revue / Journal Title. ...
Enfermedades Infecciosas y Microbiología Clínica, 2016
Please cite this article in press as: Prieto-Borja L, et al. Evaluation of a commercial multiplex... more Please cite this article in press as: Prieto-Borja L, et al. Evaluation of a commercial multiplex PCR (Unyvero i60 ®) designed for the diagnosis of bone and joint infections using prosthetic-joint sonication. Enferm Infecc Microbiol Clin. 2016.
Introduction: Despite many advances, the management of prosthetic joint infection is still a comp... more Introduction: Despite many advances, the management of prosthetic joint infection is still a complex issue. Moreover, in recent years the problem of antimicrobial resistance has emerged as an important challenge. Areas covered: We analysed recent advances in different aspects of prosthetic joint infections. The importance of biofilms needs to be considered for antibiotic selection because, when embedded in these structures, bacteria acquire resistant behaviour. Moreover, the presence of resistance mechanisms in some species of organisms increases the difficulty of management. In this sense, the growing importance of methicillin-resistant staphylococci, multidrug-resistant Enterobacteriaceae or Pseudomonas aeruginosa is of increasing concern. Together with these organisms, others with consti-tutive resistance against most antibiotics (like Enterococcus sp., mycobacteria or fungi) represent a similar problem for selection of therapy. Research into new materials that can be used as drug carriers opens a new field for management of these infections and will likely come to the front line in the coming years. Expert opinion: Individualised therapies should carefully consider the aetiology, pathogenesis and antimicrobial susceptibility. Satisfactory clinical outcome could be further fostered by enhancing the multidisciplinary approach, with better collaboration in the antibiotic selection and the surgical management.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2018
In order to evaluate the usefulness of sonication of retrieved implants for the diagnosis of pros... more In order to evaluate the usefulness of sonication of retrieved implants for the diagnosis of prosthetic joint infection (PJI) in a large group of patients in a routine setting, we designed a 3-year retrospective study. Patients were classified into two groups: those meeting the clinical criteria of PJI and those that did not (control group). Two hundred patients and 276 samples were included. The types of infection were early (n = 44), delayed (n = 53), positive intraoperative cultures (n = 13) and late-acute (n = 8). The culture sensitivities of sonicate fluid, periprosthetic tissue, synovial fluid and combination of periprosthetic tissue and/or synovial fluid were 69.5, 52.8, 54.8 and 60.2%, respectively. The specificities were 97.6, 90.3, 93.0 and 89.9%, respectively. Sonicate fluid culture of implants was more sensitive than peri-implant tissue, synovial fluid and combination of periprosthetic tissue and/or synovial fluid for all infection types, though it was especially useful ...
... Titre du document / Document title. INVASIVE INFECTION OF THE GASTROINTESTINAL TRACT BY LEISH... more ... Titre du document / Document title. INVASIVE INFECTION OF THE GASTROINTESTINAL TRACT BY LEISHMANIA IN PATIENTSWITH AIDS. Auteur(s) / Author(s). DE GORGOLAS M. ; BELLO E. ; BLANCO A. ; RENEDO G. ; FERNANDEZ-GUERRERO ML ; Revue / Journal Title. ...
Enfermedades Infecciosas y Microbiología Clínica, 2016
Please cite this article in press as: Prieto-Borja L, et al. Evaluation of a commercial multiplex... more Please cite this article in press as: Prieto-Borja L, et al. Evaluation of a commercial multiplex PCR (Unyvero i60 ®) designed for the diagnosis of bone and joint infections using prosthetic-joint sonication. Enferm Infecc Microbiol Clin. 2016.
Introduction: Despite many advances, the management of prosthetic joint infection is still a comp... more Introduction: Despite many advances, the management of prosthetic joint infection is still a complex issue. Moreover, in recent years the problem of antimicrobial resistance has emerged as an important challenge. Areas covered: We analysed recent advances in different aspects of prosthetic joint infections. The importance of biofilms needs to be considered for antibiotic selection because, when embedded in these structures, bacteria acquire resistant behaviour. Moreover, the presence of resistance mechanisms in some species of organisms increases the difficulty of management. In this sense, the growing importance of methicillin-resistant staphylococci, multidrug-resistant Enterobacteriaceae or Pseudomonas aeruginosa is of increasing concern. Together with these organisms, others with consti-tutive resistance against most antibiotics (like Enterococcus sp., mycobacteria or fungi) represent a similar problem for selection of therapy. Research into new materials that can be used as drug carriers opens a new field for management of these infections and will likely come to the front line in the coming years. Expert opinion: Individualised therapies should carefully consider the aetiology, pathogenesis and antimicrobial susceptibility. Satisfactory clinical outcome could be further fostered by enhancing the multidisciplinary approach, with better collaboration in the antibiotic selection and the surgical management.
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