Atypical presentations of typical dermatological conditions are common in human immunodeficiency ... more Atypical presentations of typical dermatological conditions are common in human immunodeficiency virus (HIV). This article will focus on three specific topics: eosinophilic folliculitis, psoriasis, and cutaneous mycoses. Their unique presentations in HIV and treatments are discussed.
Page 128. CHAPTER 12 Life-Threatening Cutaneous Viral Diseases Aron J. Gewirtzman Brandon Christi... more Page 128. CHAPTER 12 Life-Threatening Cutaneous Viral Diseases Aron J. Gewirtzman Brandon Christianson Anne Marie Tremaine Brenda L. Pellicane Stephen Tyring VIRAL DISEASES frequently have cutaneous manifes ...
Many patients with rosacea cannot tolerate extended treatment periods with topical agents because... more Many patients with rosacea cannot tolerate extended treatment periods with topical agents because their skin sensitivity is often increased. To determine the long-term efficacy and tolerability of a new moisturizing lotion for improving the signs and symptoms of mild-to-moderate rosacea. In a 48-week, open-label study, a moisturizing lotion containing furfuryl tetrahydropyranyladenine as PRK-124 (0.125%, Pyratine-XR, Senetek PLC, Napa, CA) was applied twice daily by 18 subjects with mild-to-moderate rosacea. Clinical improvements were assessed by the treating physician. Skin barrier function was measured by transepidermal water loss after treatment. Tolerability and cosmetic outcome were evaluated by subjects. Subjects experienced a mean 44 percent reduction in erythema severity and a mean 89 percent reduction in inflammatory lesion count at week 48. Reductions were significant (P < 0.05) in both erythema and lesions at weeks 24, 36 and 48. Statistically significant (P < or = ...
It is essential for physicians to be fully informed regarding adverse events and malfunctions ass... more It is essential for physicians to be fully informed regarding adverse events and malfunctions associated with medical devices that occur in routine practice. There is limited information on this important issue in the medical literature, and it is mostly based on initial studies and case reports. More advanced knowledge regarding device adverse events is necessary to guide physicians towards providing safe treatments. The FDA requires that manufacturers and device users submit medical device reports (MDRs) for suspected injuries from device use or malfunction. The database of MDRs, entitled Manufacturer and User Facility Device Experience (MAUDE) enables the FDA to monitor device performance and identify potential safety issues. We employed the following search strategy to identify reported adverse events. We searched the MAUDE electronic database on the FDA website in December 2013: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfmaude/search.cfm We collected all reported cases...
Herpes simplex virus (HSV) infection is a highly prevalent condition responsible for significant ... more Herpes simplex virus (HSV) infection is a highly prevalent condition responsible for significant morbidity and occasional mortality each year. Approximately half of all patients infected by HSV will experience at least one recurrence in their lifetime. For these recurrences, traditional therapy has included both suppressive and episodic treatment with nucleoside analogs. In regards to episodic treatment, 2- to 5-day oral regimens are best studied and most commonly reported. As with any medical condition having a well-understood mechanism of action and targeted treatment, therapeutic intervention is only as effective as allowed by patient compliance. Based on these concerns, recent studies have focused on shorter, less complicated, and more affordable options. This review delineates the evidence for single-day treatments of orolabial and genital herpes. Randomized, double-blind studies of both valacyclovir and famciclovir as single-day episodic therapy for HSV have been reported in t...
Atypical presentations of typical dermatological conditions are common in human immunodeficiency ... more Atypical presentations of typical dermatological conditions are common in human immunodeficiency virus (HIV). This article will focus on three specific topics: eosinophilic folliculitis, psoriasis, and cutaneous mycoses. Their unique presentations in HIV and treatments are discussed.
Background-Pulsed dye laser is the gold standard for treatment of port wine stain birthmarks but ... more Background-Pulsed dye laser is the gold standard for treatment of port wine stain birthmarks but multiple treatments are required and complete resolution is often not achieved. Post-treatment vessel recurrence is thought to be a factor that limits efficacy of pulsed dye laser treatment of port wine stains. Imiquimod 5% cream is an immunomodulator with anti-angiogenic effects.
Laser hair removal has become an increasingly popular method to remove unwanted or excessive hair... more Laser hair removal has become an increasingly popular method to remove unwanted or excessive hair. We have assessed the relative efficacy and discomfort associated with competing hair removal techniques, namely a high average power 810 nm diode laser using an “in-motion” technique with a market-leading 810 nm device with a single-pass vacuum-assisted technique. This study has determined the long-term (6-12 months) hair reduction efficacy and the relative pain induction intensities of these devices. Prospective, randomized, side-by-side comparison of either the legs or axillae was performed comparing the Soprano XL 810 nm diode in super hair removal (SHR) mode (Alma Lasers, Buffalo Grove, IL) hereafter known as the “in-motion” device vs. the LightSheer Duet 810 nm diode laser (Lumenis) hereafter known as the “single pass” device. Five laser treatments were performed 6 to 8 weeks apart with 1, 6, and 12 months follow-ups for hair counts. Pain was assessed in a subjective manner by the patients on a 10-point grading scale. Hair count analysis was performed in a blinded fashion. There was a 33.5% (SD 46.8%) and 40.7% (SD 41.8%) reduction in hair counts at 6 months for the single pass and in-motion devices respectively (P = 0.2879). The average pain rating for the single pass treatment (mean 3.6, 95% CI: 2.8 to 4.5) was significantly (P = 0.0007) greater than the in-motion treatment (mean 2.7, 95% CI 1.8 to 3.5). This data supports the hypothesis that using diode lasers at low fluences and high average power with a multiple pass in-motion technique is an effective method for hair removal, with less pain and discomfort, while maintaining good efficacy. The 6 month results were maintained at 12 month for both devices.
Page 128. CHAPTER 12 Life-Threatening Cutaneous Viral Diseases Aron J. Gewirtzman Brandon Christi... more Page 128. CHAPTER 12 Life-Threatening Cutaneous Viral Diseases Aron J. Gewirtzman Brandon Christianson Anne Marie Tremaine Brenda L. Pellicane Stephen Tyring VIRAL DISEASES frequently have cutaneous manifes ...
Despite being the gold standard for lower extremity reticular vein treatment, few studies have ye... more Despite being the gold standard for lower extremity reticular vein treatment, few studies have yet evaluated foam sclerotherapy for hand veins. This retrospective study evaluates the safety and efficacy of foam sclerotherapy for reticular veins of the dorsal hands. A telephone-based questionnaire was used for patient self-assessment of overall improvement, satisfaction, prevalence of adverse events, and willingness for repeat treatment after foam sclerotherapy with sodium tetradecyl sulfate (STS). All patients had been treated with foam STS of 0.25% to 1.0% concentration using room air. Twenty-one of 45 patients were successfully contacted, with a total of 54 treatment sessions performed on 38 hands. Overall, patients reported scores of 2.55 ± 0.56 for overall improvement (0 = none, 1= mild, 2 = moderate, and 3 = complete resolution) and 1.79 ± 0.41 for satisfaction with results (0 = not satisfied at all, 1 = mildly satisfied, and 2 = very satisfied), with few significant treatment-related adverse events. Most patients stated they would undergo another treatment if needed. This single-center experience found that foam sclerotherapy with STS is a safe and effective treatment for reticular veins of the dorsal hands with excellent long-term patient satisfaction.
Atypical presentations of typical dermatological conditions are common in human immunodeficiency ... more Atypical presentations of typical dermatological conditions are common in human immunodeficiency virus (HIV). This article will focus on three specific topics: eosinophilic folliculitis, psoriasis, and cutaneous mycoses. Their unique presentations in HIV and treatments are discussed.
Page 128. CHAPTER 12 Life-Threatening Cutaneous Viral Diseases Aron J. Gewirtzman Brandon Christi... more Page 128. CHAPTER 12 Life-Threatening Cutaneous Viral Diseases Aron J. Gewirtzman Brandon Christianson Anne Marie Tremaine Brenda L. Pellicane Stephen Tyring VIRAL DISEASES frequently have cutaneous manifes ...
Many patients with rosacea cannot tolerate extended treatment periods with topical agents because... more Many patients with rosacea cannot tolerate extended treatment periods with topical agents because their skin sensitivity is often increased. To determine the long-term efficacy and tolerability of a new moisturizing lotion for improving the signs and symptoms of mild-to-moderate rosacea. In a 48-week, open-label study, a moisturizing lotion containing furfuryl tetrahydropyranyladenine as PRK-124 (0.125%, Pyratine-XR, Senetek PLC, Napa, CA) was applied twice daily by 18 subjects with mild-to-moderate rosacea. Clinical improvements were assessed by the treating physician. Skin barrier function was measured by transepidermal water loss after treatment. Tolerability and cosmetic outcome were evaluated by subjects. Subjects experienced a mean 44 percent reduction in erythema severity and a mean 89 percent reduction in inflammatory lesion count at week 48. Reductions were significant (P < 0.05) in both erythema and lesions at weeks 24, 36 and 48. Statistically significant (P < or = ...
It is essential for physicians to be fully informed regarding adverse events and malfunctions ass... more It is essential for physicians to be fully informed regarding adverse events and malfunctions associated with medical devices that occur in routine practice. There is limited information on this important issue in the medical literature, and it is mostly based on initial studies and case reports. More advanced knowledge regarding device adverse events is necessary to guide physicians towards providing safe treatments. The FDA requires that manufacturers and device users submit medical device reports (MDRs) for suspected injuries from device use or malfunction. The database of MDRs, entitled Manufacturer and User Facility Device Experience (MAUDE) enables the FDA to monitor device performance and identify potential safety issues. We employed the following search strategy to identify reported adverse events. We searched the MAUDE electronic database on the FDA website in December 2013: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfmaude/search.cfm We collected all reported cases...
Herpes simplex virus (HSV) infection is a highly prevalent condition responsible for significant ... more Herpes simplex virus (HSV) infection is a highly prevalent condition responsible for significant morbidity and occasional mortality each year. Approximately half of all patients infected by HSV will experience at least one recurrence in their lifetime. For these recurrences, traditional therapy has included both suppressive and episodic treatment with nucleoside analogs. In regards to episodic treatment, 2- to 5-day oral regimens are best studied and most commonly reported. As with any medical condition having a well-understood mechanism of action and targeted treatment, therapeutic intervention is only as effective as allowed by patient compliance. Based on these concerns, recent studies have focused on shorter, less complicated, and more affordable options. This review delineates the evidence for single-day treatments of orolabial and genital herpes. Randomized, double-blind studies of both valacyclovir and famciclovir as single-day episodic therapy for HSV have been reported in t...
Atypical presentations of typical dermatological conditions are common in human immunodeficiency ... more Atypical presentations of typical dermatological conditions are common in human immunodeficiency virus (HIV). This article will focus on three specific topics: eosinophilic folliculitis, psoriasis, and cutaneous mycoses. Their unique presentations in HIV and treatments are discussed.
Background-Pulsed dye laser is the gold standard for treatment of port wine stain birthmarks but ... more Background-Pulsed dye laser is the gold standard for treatment of port wine stain birthmarks but multiple treatments are required and complete resolution is often not achieved. Post-treatment vessel recurrence is thought to be a factor that limits efficacy of pulsed dye laser treatment of port wine stains. Imiquimod 5% cream is an immunomodulator with anti-angiogenic effects.
Laser hair removal has become an increasingly popular method to remove unwanted or excessive hair... more Laser hair removal has become an increasingly popular method to remove unwanted or excessive hair. We have assessed the relative efficacy and discomfort associated with competing hair removal techniques, namely a high average power 810 nm diode laser using an “in-motion” technique with a market-leading 810 nm device with a single-pass vacuum-assisted technique. This study has determined the long-term (6-12 months) hair reduction efficacy and the relative pain induction intensities of these devices. Prospective, randomized, side-by-side comparison of either the legs or axillae was performed comparing the Soprano XL 810 nm diode in super hair removal (SHR) mode (Alma Lasers, Buffalo Grove, IL) hereafter known as the “in-motion” device vs. the LightSheer Duet 810 nm diode laser (Lumenis) hereafter known as the “single pass” device. Five laser treatments were performed 6 to 8 weeks apart with 1, 6, and 12 months follow-ups for hair counts. Pain was assessed in a subjective manner by the patients on a 10-point grading scale. Hair count analysis was performed in a blinded fashion. There was a 33.5% (SD 46.8%) and 40.7% (SD 41.8%) reduction in hair counts at 6 months for the single pass and in-motion devices respectively (P = 0.2879). The average pain rating for the single pass treatment (mean 3.6, 95% CI: 2.8 to 4.5) was significantly (P = 0.0007) greater than the in-motion treatment (mean 2.7, 95% CI 1.8 to 3.5). This data supports the hypothesis that using diode lasers at low fluences and high average power with a multiple pass in-motion technique is an effective method for hair removal, with less pain and discomfort, while maintaining good efficacy. The 6 month results were maintained at 12 month for both devices.
Page 128. CHAPTER 12 Life-Threatening Cutaneous Viral Diseases Aron J. Gewirtzman Brandon Christi... more Page 128. CHAPTER 12 Life-Threatening Cutaneous Viral Diseases Aron J. Gewirtzman Brandon Christianson Anne Marie Tremaine Brenda L. Pellicane Stephen Tyring VIRAL DISEASES frequently have cutaneous manifes ...
Despite being the gold standard for lower extremity reticular vein treatment, few studies have ye... more Despite being the gold standard for lower extremity reticular vein treatment, few studies have yet evaluated foam sclerotherapy for hand veins. This retrospective study evaluates the safety and efficacy of foam sclerotherapy for reticular veins of the dorsal hands. A telephone-based questionnaire was used for patient self-assessment of overall improvement, satisfaction, prevalence of adverse events, and willingness for repeat treatment after foam sclerotherapy with sodium tetradecyl sulfate (STS). All patients had been treated with foam STS of 0.25% to 1.0% concentration using room air. Twenty-one of 45 patients were successfully contacted, with a total of 54 treatment sessions performed on 38 hands. Overall, patients reported scores of 2.55 ± 0.56 for overall improvement (0 = none, 1= mild, 2 = moderate, and 3 = complete resolution) and 1.79 ± 0.41 for satisfaction with results (0 = not satisfied at all, 1 = mildly satisfied, and 2 = very satisfied), with few significant treatment-related adverse events. Most patients stated they would undergo another treatment if needed. This single-center experience found that foam sclerotherapy with STS is a safe and effective treatment for reticular veins of the dorsal hands with excellent long-term patient satisfaction.
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