Peak oxygen uptake (VO2peak ) is known as the gold standard measure of cardiopulmonary fitness. W... more Peak oxygen uptake (VO2peak ) is known as the gold standard measure of cardiopulmonary fitness. We therefore hypothesized that measures of physical health would predict long-term survival in heart transplant recipients (HTx). This retrospective study investigated survival in two HTx populations; the cardiopulmonary exercise test (CPET) cohort comprised 178 HTx patients who completed a VO2peak test during their annual follow-up (1990-2003), and the SF-36 cohort comprised 133 patients who completed a quality of life questionnaire, SF-36v1 (1998-2000). Mean (SD) age in the CPET cohort was 52 (12) yr and 54 (11) yr in the SF-36 cohort. Mean observation time was, respectively, 11 and 10 yr. Mean (SD) VO2peak was 19.6 (5.3) mL/kg/min, and median (IR) physical function (PF) score was 90 (30). VO2peak and PF scores were both significant predictors in univariate Cox regression. Multiple Cox regression analyses adjusted for other potential predictors showed that VO2peak , age, and cardiac allograft vasculopathy (CAV) were the most important predictors in the CPET cohort, whereas age, PF score, smoking, and CAV were the most important predictors in the SF-36 cohort. In Kaplan-Meier analysis, VO2peak and PF scores above the median value were related to significant longer survival time. Peak oxygen uptake and self-reported physical health are strong predictors for long-term survival in HTx recipients. VO2peak is a crucial measurement and should be more frequently used after HTx.
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række, Jan 13, 2007
The purpose of this study was to assess quality of life (QoL, self-reported health) and psycholog... more The purpose of this study was to assess quality of life (QoL, self-reported health) and psychological adjustment in a sample of heart transplanted patients. The sample comprised 147 (117 men) Norwegian heart transplanted patients (operated 1983 - 1999). Data on QoL and psychological adjustment were collected during annual routine follow-up controls between 1998 and 2000. The Short Form 36 (SF-36), the Symptom Checklist 90-Revised (SCL-90-R), and Beck Depression Inventory (BDI) were used. On average, heart transplant recipients reported significantly reduced QoL and increased levels of psychological symptoms compared to a normative population. Recently operated patients reported a generally good QoL compared to the norms, while there was a worsening after 3 years of both the patients' psychological symptoms and QoL, compared to patients who were transplanted less than 3 years ago. The clinical significance was underscored by the BDI; 30 % of the patients were classified as suffer...
Several studies indicate that heart transplantation (HTx) is associated with depression and reduc... more Several studies indicate that heart transplantation (HTx) is associated with depression and reduced quality of life. However, the impact of depression on the prognosis for HTx-patients has not yet been sufficiently established. The aim of the present study was to prospectively investigate the influence of depression on mortality in patients with HTx, adjusting for other known risk factors. Methods. In a prospective, cross-sectional study with minimum 5-year follow-up, symptoms of depression were assessed in 147 HTx-patients using the Beck Depression Inventory (BDI). Results. Mild to severe depressive symptoms (BDI Ն10) were observed in 36 patients (24.5%). Depressive symptoms on inclusion increased the risk of mortality during the follow-up period. The risk remained significant after adjusting for several somatic and lifestyle risk factors, and the adjusted relative risk associated with depression (risk ratio: 2.32; 95% CI: 1.13-4.79; Pϭ0.02) was comparable to the adjusted relative risk associated with time since HTx. Conclusions. Symptoms of depression predict mortality independently of somatic and lifestyle risk factors in HTx patients, and this group of patients should be screened for depressive symptoms.
The Journal of Heart and Lung Transplantation, 2010
The prognostic impact of pulmonary hypertension (PH) before and after heart transplantation (HTx)... more The prognostic impact of pulmonary hypertension (PH) before and after heart transplantation (HTx) is debated. We investigated: (i) the significance of pre-operative reversible PH on postoperative survival; (ii) the value of recatheterization while on the waiting list; (iii) the evolution of right heart hemodynamics (RHH) after HTx; and (iv) the prognostic impact of PH at 1 year after HTx. METHODS: We reviewed the records of 500 HTx recipients transplanted between 1983 and 2007. Preoperatively, a non-PH group (Group 1, n ϭ 365) fulfilled directly our RHH criteria for HTx, while a PH group (Group 2, n ϭ 135) was accepted after reversibility of PH by acute vasodilatory testing. Recatheterization was performed every third month while on the waiting list and repeatedly after transplantation. RESULTS: With a follow-up of 6.8 Ϯ 5.1 years and a 50% survival rate of 12.1 Ϯ 5.4 years, our main findings were as follows: (i) Patients with reversible PH on vasodilatory testing had a survival rate similar to that of patients without PH (11.7 Ϯ 0.8 vs 12.1 Ϯ 0.5 years, p ϭ 0.80). (ii) Pre-operative recatheterization was of limited value as RHH remained stable. Five percent of patients died while on the waiting list and 2 improved clinically and were removed. (iii) Mean pulmonary artery pressure (MAP) was reduced from 28 Ϯ 9 and 40 Ϯ 8 mm Hg pre-operatively to 21 Ϯ 7 and 24 Ϯ 6 mm Hg after 2 weeks and 16 Ϯ 7 and 18 Ϯ 8 mm Hg at 3 years in Groups 1 and 2, respectively. (iv) Recipients with MAP Ͼ20 mm Hg at 1 year post-HTx had significantly lower survival than those with MAP Յ20 mm Hg (11.5 Ϯ 0.7 vs 15.6 Ϯ 0.6 years, p Ͻ 0.001). CONCLUSIONS: Elevated pulmonary pressure 1 year after HTx provides significant prognostic information regarding long-term outcome, whereas pre-operative reversible PH in this group does not influence survival.
The Journal of Heart and Lung Transplantation, 2007
We prospectively investigated the tolerability and efficacy of daily treatment with 10mg ezetimib... more We prospectively investigated the tolerability and efficacy of daily treatment with 10mg ezetimibe in 28 heart allograft transplant patients already on stable statin therapy (mean equivalent dose of 49.3 Ϯ 4.3 mg pravastatin). Methods and Materials: Total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), triglycerides (TG), immunosuppressant drug levels, creatinine, liver enzymes, creatine kinase, full blood count, blood pressure and heart rate were measured before, 4 months after and 1 year after initiation of ezetimibe treatment. Results: Ezetimibe was generally well tolerated, nausea (nϭ 2) and dizziness (nϭ 2) resolved spontaneously; only two patients discontinued ezetimibe due to stomach pain or headache.
Peak oxygen uptake (VO2peak ) is known as the gold standard measure of cardiopulmonary fitness. W... more Peak oxygen uptake (VO2peak ) is known as the gold standard measure of cardiopulmonary fitness. We therefore hypothesized that measures of physical health would predict long-term survival in heart transplant recipients (HTx). This retrospective study investigated survival in two HTx populations; the cardiopulmonary exercise test (CPET) cohort comprised 178 HTx patients who completed a VO2peak test during their annual follow-up (1990-2003), and the SF-36 cohort comprised 133 patients who completed a quality of life questionnaire, SF-36v1 (1998-2000). Mean (SD) age in the CPET cohort was 52 (12) yr and 54 (11) yr in the SF-36 cohort. Mean observation time was, respectively, 11 and 10 yr. Mean (SD) VO2peak was 19.6 (5.3) mL/kg/min, and median (IR) physical function (PF) score was 90 (30). VO2peak and PF scores were both significant predictors in univariate Cox regression. Multiple Cox regression analyses adjusted for other potential predictors showed that VO2peak , age, and cardiac allograft vasculopathy (CAV) were the most important predictors in the CPET cohort, whereas age, PF score, smoking, and CAV were the most important predictors in the SF-36 cohort. In Kaplan-Meier analysis, VO2peak and PF scores above the median value were related to significant longer survival time. Peak oxygen uptake and self-reported physical health are strong predictors for long-term survival in HTx recipients. VO2peak is a crucial measurement and should be more frequently used after HTx.
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række, Jan 13, 2007
The purpose of this study was to assess quality of life (QoL, self-reported health) and psycholog... more The purpose of this study was to assess quality of life (QoL, self-reported health) and psychological adjustment in a sample of heart transplanted patients. The sample comprised 147 (117 men) Norwegian heart transplanted patients (operated 1983 - 1999). Data on QoL and psychological adjustment were collected during annual routine follow-up controls between 1998 and 2000. The Short Form 36 (SF-36), the Symptom Checklist 90-Revised (SCL-90-R), and Beck Depression Inventory (BDI) were used. On average, heart transplant recipients reported significantly reduced QoL and increased levels of psychological symptoms compared to a normative population. Recently operated patients reported a generally good QoL compared to the norms, while there was a worsening after 3 years of both the patients' psychological symptoms and QoL, compared to patients who were transplanted less than 3 years ago. The clinical significance was underscored by the BDI; 30 % of the patients were classified as suffer...
Several studies indicate that heart transplantation (HTx) is associated with depression and reduc... more Several studies indicate that heart transplantation (HTx) is associated with depression and reduced quality of life. However, the impact of depression on the prognosis for HTx-patients has not yet been sufficiently established. The aim of the present study was to prospectively investigate the influence of depression on mortality in patients with HTx, adjusting for other known risk factors. Methods. In a prospective, cross-sectional study with minimum 5-year follow-up, symptoms of depression were assessed in 147 HTx-patients using the Beck Depression Inventory (BDI). Results. Mild to severe depressive symptoms (BDI Ն10) were observed in 36 patients (24.5%). Depressive symptoms on inclusion increased the risk of mortality during the follow-up period. The risk remained significant after adjusting for several somatic and lifestyle risk factors, and the adjusted relative risk associated with depression (risk ratio: 2.32; 95% CI: 1.13-4.79; Pϭ0.02) was comparable to the adjusted relative risk associated with time since HTx. Conclusions. Symptoms of depression predict mortality independently of somatic and lifestyle risk factors in HTx patients, and this group of patients should be screened for depressive symptoms.
The Journal of Heart and Lung Transplantation, 2010
The prognostic impact of pulmonary hypertension (PH) before and after heart transplantation (HTx)... more The prognostic impact of pulmonary hypertension (PH) before and after heart transplantation (HTx) is debated. We investigated: (i) the significance of pre-operative reversible PH on postoperative survival; (ii) the value of recatheterization while on the waiting list; (iii) the evolution of right heart hemodynamics (RHH) after HTx; and (iv) the prognostic impact of PH at 1 year after HTx. METHODS: We reviewed the records of 500 HTx recipients transplanted between 1983 and 2007. Preoperatively, a non-PH group (Group 1, n ϭ 365) fulfilled directly our RHH criteria for HTx, while a PH group (Group 2, n ϭ 135) was accepted after reversibility of PH by acute vasodilatory testing. Recatheterization was performed every third month while on the waiting list and repeatedly after transplantation. RESULTS: With a follow-up of 6.8 Ϯ 5.1 years and a 50% survival rate of 12.1 Ϯ 5.4 years, our main findings were as follows: (i) Patients with reversible PH on vasodilatory testing had a survival rate similar to that of patients without PH (11.7 Ϯ 0.8 vs 12.1 Ϯ 0.5 years, p ϭ 0.80). (ii) Pre-operative recatheterization was of limited value as RHH remained stable. Five percent of patients died while on the waiting list and 2 improved clinically and were removed. (iii) Mean pulmonary artery pressure (MAP) was reduced from 28 Ϯ 9 and 40 Ϯ 8 mm Hg pre-operatively to 21 Ϯ 7 and 24 Ϯ 6 mm Hg after 2 weeks and 16 Ϯ 7 and 18 Ϯ 8 mm Hg at 3 years in Groups 1 and 2, respectively. (iv) Recipients with MAP Ͼ20 mm Hg at 1 year post-HTx had significantly lower survival than those with MAP Յ20 mm Hg (11.5 Ϯ 0.7 vs 15.6 Ϯ 0.6 years, p Ͻ 0.001). CONCLUSIONS: Elevated pulmonary pressure 1 year after HTx provides significant prognostic information regarding long-term outcome, whereas pre-operative reversible PH in this group does not influence survival.
The Journal of Heart and Lung Transplantation, 2007
We prospectively investigated the tolerability and efficacy of daily treatment with 10mg ezetimib... more We prospectively investigated the tolerability and efficacy of daily treatment with 10mg ezetimibe in 28 heart allograft transplant patients already on stable statin therapy (mean equivalent dose of 49.3 Ϯ 4.3 mg pravastatin). Methods and Materials: Total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), triglycerides (TG), immunosuppressant drug levels, creatinine, liver enzymes, creatine kinase, full blood count, blood pressure and heart rate were measured before, 4 months after and 1 year after initiation of ezetimibe treatment. Results: Ezetimibe was generally well tolerated, nausea (nϭ 2) and dizziness (nϭ 2) resolved spontaneously; only two patients discontinued ezetimibe due to stomach pain or headache.
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Papers by Anne Relbo