Papers by Anjani Solankee
Advances in Applied Science Research, 2013
A series of Schiff bases (2a-f) have been prepared by the condensation of 5-bromofuran-2-carboxyh... more A series of Schiff bases (2a-f) have been prepared by the condensation of 5-bromofuran-2-carboxyhydrazide (1) with different aromatic and heterocyclic aldehydes. The synthesis of various 2-(substituted phenyl/quinolin 2-yl/6methoxy naphthalen 2-yl)-3-(5'-bromofuran-2'-carboxamido)-thiazolidine-4-ones (3a-f) by cyclocondensation reaction between schiff bases (2a-f) and thioglycolic acid. Cyclocondensation of Schiff bases (2a-f) with thiolactic acid resulted 2-(susbstituted phenyl)-3-(5'-bromofuran-2'-carboxamido)-5-methyl thiazolidine-4-ones (4a-f). The structures of all the synthesised compounds were confirmed by their elemental analysis and IR, 1 H NMR spectral data. All the synthesised compounds have been screened for their antimicrobial activity.
international journal of chemical sciences, 2008
Some novel 1-(6'-methylpyridine-3'-carboxamido)-2-phenyl-4-(benzylidine/substituted benzylidene)-... more Some novel 1-(6'-methylpyridine-3'-carboxamido)-2-phenyl-4-(benzylidine/substituted benzylidene)-imidazolin-5-ones (1a-e) have been prepared by refluxing the mixture of 5-oxazolones with 6-methylpyridine-3-carboxyhydrazide in pyridine. All the synthesized compounds were screened for their antibacterial activity. The structures of synthesized compounds have been characterized by elemental analysis and spectral data.
Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry, Mar 1, 2008
The title compounds 7a-d and 8a-d have been prepared starting from chalcones 6a-d having s-triazi... more The title compounds 7a-d and 8a-d have been prepared starting from chalcones 6a-d having s-triazine nucleus. These chalcones 6a-d on cyclisation with hydroxylamine hydrochloride in presence of alkali and 2-aminothiophenol in presence of a few drops of glacial acetic acid give isoxazoles 7a-d and 1,5benzothiazepines 8a-d respectively. All the products have been characterized by elemental analysis, IR, 1 H NMR and LCMS data.
Der Pharma Chemica, 2010
The title compounds (7a-e), (8a-e) and (9a-e) have been prepared from chalcones (6a-e) having s-t... more The title compounds (7a-e), (8a-e) and (9a-e) have been prepared from chalcones (6a-e) having s-triazine nucleus. These chalcones on cyclisation with hydroxyl amine hydrochloride in the presence of alkali give isoxazoles (7a-e). Chalcones (6a-e) on condensation with thiourea and urea in the presence of alkali give pyrimidinthiones (8a-e) and pyrimidin-2-ones (9a-e) respectively. Structures of newly synthesised compounds were established on the basis of their elemental analysis, IR and 1H NMR spectral data. All the synthesised compounds have been screened for their antibacterial activity.
Zenodo (CERN European Organization for Nuclear Research), Nov 30, 1992
ChemInform, Jul 22, 2008
The title compounds 7a-d and 8a-d have been prepared starting from chalcones 6a-d having s-triazi... more The title compounds 7a-d and 8a-d have been prepared starting from chalcones 6a-d having s-triazine nucleus. These chalcones 6a-d on cyclisation with hydroxylamine hydrochloride in presence of alkali and 2-aminothiophenol in presence of a few drops of glacial acetic acid give isoxazoles 7a-d and 1,5benzothiazepines 8a-d respectively. All the products have been characterized by elemental analysis, IR, 1 H NMR and LCMS data.
International journal of pharma and bio sciences, 2011
A series of 1-(5'-bromofuran-2'-carboxamido)-2-phenyl-4-(benzylidene / substituted benzylidene)-5... more A series of 1-(5'-bromofuran-2'-carboxamido)-2-phenyl-4-(benzylidene / substituted benzylidene)-5imidazolones (Ia-j) have been synthesized and evaluated for antibacterial activity. The structures of the newly synthesized compounds were confirmed on the basis of spectral data and physical data.
Chalcones 6a-e were achieved upon refluxing of ketone 5 and different substituted aromatic and he... more Chalcones 6a-e were achieved upon refluxing of ketone 5 and different substituted aromatic and heterocyclic aldehydes in suitable solvent. Chalcones 6a-e on cyclisation with malononitrile in presence of ammonium acetate and hydrazine hydrate in presence of acetic acid give cyanopyridines 7a-e and acetyl pyrazoline 8a-e respectively. All the synthesised compounds have been characterised by their physical data and spectral data.
Zenodo (CERN European Organization for Nuclear Research), Nov 30, 2011
6-Methylpyridine-3-carbohydrazide (2) on condensation wilh different aromatic aldehydes (1) resul... more 6-Methylpyridine-3-carbohydrazide (2) on condensation wilh different aromatic aldehydes (1) resulted In Schiff bases 3(a-l), which on cyclocondensation with thioglycolic acid resulted in 4-thiazolidinones 4(a-i). The newly synthesized compounds were characterized using IR, 1 H NMR, 13 C NMR arod elemental analysis. Synthesized compounds were evaluated for their in vitro antibacterial activity against Gram-posilive and Gram-negative strains.
A series of 2-(4'-chlorophenylamino)-4-(4'-fluorophenylamino)-6-[4'-{5''-(phenyl / substituted ph... more A series of 2-(4'-chlorophenylamino)-4-(4'-fluorophenylamino)-6-[4'-{5''-(phenyl / substituted phenyl)-isoxazole-3''-yl }phenyl amino]-s-triazine (7a-e) and 2-(4'-chlorophenylamino)-4-(4'fluorophenylamino)-6-[4'-{1''-phenyl-5''-(phenyl / substituted phenyl)-2''-pyrazolin-3''-yl}phenylamino]s triazine (8a-e) were prepared. The structures of isoxazole derivatives and pyrazoline derivatives were confirmed on the basis of spectral data. The compounds were screened for their in vitro antibacterial activity using Gram-positive and Gram-negative bacteria.
Oriental journal of chemistry, Sep 16, 2017
A new class of 3,5-disubstituted pyrazoles and isoxazoles were prepared from the Michael acceptor... more A new class of 3,5-disubstituted pyrazoles and isoxazoles were prepared from the Michael acceptors 1-furanyl / thiophenyl / pyridinyl-3-indole-prop-2-en-1-ones under ultrasonication and evaluated for antimicrobial activity. Amongst all the tested compounds fluoro substituted thiophene linked compounds 12b and 18b displayed promising antibacterial activity particularly against Bacillus subtilis and antifungal activity against Aspergillus niger. Furthermore, compounds with more number of electron withdrawing groups showed higher antimicrobial activity. This result indicates that compounds 12b and 18b can be used as lead compounds in the future studies.
Oriental journal of chemistry, Apr 22, 2004
ChemInform, Aug 19, 2010
Quinoline derivatives R 0410 Synthesis and Antituberculosis Activity of 2,4-Disubstituted Quinoli... more Quinoline derivatives R 0410 Synthesis and Antituberculosis Activity of 2,4-Disubstituted Quinolines.-A new series of 2,4-disubstituted quinolines (IX) (46 examples) is synthesized starting from inexpensive isatin. Derivatives (IXe) and (IXf) exhibit 99% inhibition against drug-sensitive and > 90% inhibition against isoniazid resistant M. tuberculosis H27Rs strains.-(NAYYAR, A.
ChemInform, Aug 4, 2010
Quinoline derivatives R 0410 Synthesis and Antituberculosis Activity of 2,4-Disubstituted Quinoli... more Quinoline derivatives R 0410 Synthesis and Antituberculosis Activity of 2,4-Disubstituted Quinolines.-A new series of 2,4-disubstituted quinolines (IX) (46 examples) is synthesized starting from inexpensive isatin. Derivatives (IXe) and (IXf) exhibit 99% inhibition against drug-sensitive and > 90% inhibition against isoniazid resistant M. tuberculosis H27Rs strains.-(NAYYAR, A.
Oriental journal of chemistry, Oct 18, 2017
Oriental journal of chemistry, Aug 25, 2017
A series of 5-(4-substituted phenyl)-1,3,4-thiadiazole-2-amines (4a-h) were prepared from dehydro... more A series of 5-(4-substituted phenyl)-1,3,4-thiadiazole-2-amines (4a-h) were prepared from dehydrocyclization of 4substituted benzoyl thiosemicarbazides (3a-h) using concentrated sulphuric acid. The chemical structures of compounds were elucidated by Infra-red, NMR, Mass spectral and elemental analyses. Antibacterial activities of these compounds against Staphylococcus aureus, Bacillus substilis, Eschereria coli and Pseudomonas aeruginosa using Ciprofloxacin while antifungal activities against Aspergillus niger and Candida albicans using Fluconazole as standard drugs were performed. Minimum inhibitory concentrations and anticancer activity of potent compounds was determined. The results indicate that compounds 4(a), 4(b) and 4(c) possess significant antibacterial activity whereas compounds 4(f) and 4(g) possess significant antifungal activity among the series of synthesized thiadiazoles comparing with standard drugs. Further, the results of anticancer studies on breast cancer cell line suggested that some potent antimicrobials i.e. 4(c), 4(f) and 4(g) associated with moderate to good anticancer activity. Thus, it may be found that synthesized compounds have good antibacterial activity and moderate antifungal activity. However, these compounds could be further screened for the antibacterial activities against a battery of bacteria to achieve their broad spectrum profile and also used to screen cytotoxic effect against other cancer cell lines.
Oriental journal of chemistry, Dec 22, 2003
Oriental journal of chemistry, Aug 22, 2002
Oriental journal of chemistry, Aug 22, 2001
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Papers by Anjani Solankee