Papers by Angel Hernandez
e13031Background: The identification of patients with Breast Cancer (BC) and genetic risk has pro... more e13031Background: The identification of patients with Breast Cancer (BC) and genetic risk has proved a positive impact in reducing the mortality for BC and the prevention of second tumors. In 2010,...
Regulation of transcription requires mechanisms to both activate and terminate transcription fact... more Regulation of transcription requires mechanisms to both activate and terminate transcription factor activity. GATA‐1 is a key haemopoietic transcription factor whose activity is increased by acetylation. We show here that acetylated GATA‐1 is targeted for degradation via the ubiquitin/proteasome pathway. Acetylation positively signals ubiquitination, suggesting that activation by acetylation simultaneously marks GATA‐1 for degradation. Promoter‐specific MAPK phosphorylation then cooperates with acetylation to execute protein loss. The requirement for both modifications is novel and suggests a way by which degradation of the active protein can be specifically regulated in response to external phosphorylation‐mediated signalling. As many transcription factors are activated by acetylation, we suggest that this might be a general mechanism to control transcription factor activity.
I dedicate this dissertation to my mother, Clara, who is one of the strongest and most resilient ... more I dedicate this dissertation to my mother, Clara, who is one of the strongest and most resilient people I have ever met. She taught me to work hard, be humble, overcome adversity, and to never stop being grateful. My mother never attended college, and likely does fully comprehend what a dissertation is, but her love, guidance, and support helped make this dissertation (and defense) possible. Ma, I love you and hope this makes you proud. I dedicate this dissertation to my best friend, Sonia, who is my rock, my morale compass, and a true example of taking life's lemons and making something resembling lemonade. You remind me to make the most out of every day and to live life to its fullest. I dedicate this dissertation to my sister Kassandra, brother Andre, uncle Balmir, and grandma Clara. Your love, support, and encouragement helped me complete this journey. "I'm done with school." I never expected that seven years later, I would complete a doctoral degree. This would not have been possible without the love, support, and
Gazeta Médica
A global health emergency has been declared by the World Health Organization (WHO) as the SARS-Co... more A global health emergency has been declared by the World Health Organization (WHO) as the SARS-CoV-2 outbreak spread across the world. Patients infected with SARS-CoV-2 are at risk for developing respiratory failure and requiring admission to critical care units. While providing optimal treatment for these patients, careful execution of infection control measures is necessary to prevent nosocomial transmission to other patients and to health workers providing care.1 In the operating room, these preparations involve multiple stakeholders and can present a significant challenge. Here we described the measures for the outbreak adopted by the anesthesia department of a private tertiary care level hospital in Porto. These include engineering controls such as: identification and preparation of an isolation operating rooms, administrative measures such as: modification of workflow and processes, introduction of personal protective equipment, and formulation of clinical guidelines for anaes...
2019 Boston, Massachusetts July 7- July 10, 2019
Case reports in transplantation, 2017
After transplantation, the main concerns involve immunosuppression, the prevention and treatment ... more After transplantation, the main concerns involve immunosuppression, the prevention and treatment of infections and graft rejection, and tumor prevention. Sometimes the complications that may appear in the arteriovenous fistula are neglected following kidney transplantation. This is the reason why we are presenting the case of an angiosarcoma developing in an arteriovenous fistula after kidney transplantation. It is a very rare case and our goal is to create an alarm so that after kidney transplantation clinicians do not lose sight of the patients' previous history.
Revista Brasileira de Hematologia e Hemoterapia, 2016
Background: Treatment of sickle cell anemia is a challenging task and despite the well understood... more Background: Treatment of sickle cell anemia is a challenging task and despite the well understood genetic and biochemical pathway of sickle hemoglobin, current therapy continues to be limited to the symptomatic treatment of pain, supplemental oxygen, antibiotics, red blood cell transfusions and hydroxyurea. SANGUINATE is a carbon monoxide releasing molecule and oxygen transfer agent under clinical development for the treatment of sickle cell anemia and comorbidities. Methods: An open-label randomized Phase Ib study was performed in adult sickle cell anemia patients. Two dose levels of SANGUINATE were compared to hydroxyurea in 24 homozygotes for Hb SS. Twelve subjects received either a low dose (160 mg/kg) of SANGUINATE or 15 mg/kg hydroxyurea. Another 12 subjects received either a high dose (320 mg/kg) of SAN-GUINATE or 15 mg/kg hydroxyurea. The primary endpoint was the safety of SANGUINATE versus hydroxyurea in sickle cell anemia patients. Secondary endpoints included determination of the plasma pharmacokinetics and assessment of hematologic measurements. Results: Musculoskeletal related adverse events were the most common. Transient troponin I levels increased in three patients, one of whom had an increase in tricuspid regurgitant velocity; however, no clinical signs were noted. Following an assessment of vital signs, tricuspid regurgitant velocity, electrocardiogram, serum biochemistry, hematology, urinalysis, and analysis of reported adverse events, SANGUINATE was found to be safe in stable sickle cell anemia patients. Conclusions: The clinical trial met its primary objective of demonstrating an acceptable safety profile for SANGUINATE in patients with sickle cell anemia. This trial established the safety of SANGUINATE at both dose levels and permitted its advance to Phase II trials.
Butlleti Del Grup Catala D Anellament, 1994
Almacenarniento de alimento por el Alcaudón Dorsirrojo Lanius coVmb: observaciones sobre el papel... more Almacenarniento de alimento por el Alcaudón Dorsirrojo Lanius coVmb: observaciones sobre el papel de machos y hembras Food storing by the Red-backed Shrike Lanius collurio: observations on the role of males and fernales During breeding, f w d storing in shrikes is considered as a task performed by males. Data were obtained on the roles of male and female Red-backed Shrikes in prey storing by watching three pairs during their breeding in Northwestern Spain. During the care of nestlings and fledglings, both the male and the female stored important amounts of prey.
Rocky Mountain News, Dec 7, 1998
Medio Ambiente En Castilla Y Leon, 1997
Rocky Mountain News, Oct 18, 1997
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Papers by Angel Hernandez