Papers by Andreas Sprenger
Journal of Cognitive Neuroscience, 2009
When simultaneous series of stimuli are rapidly presented left and right, containing two target s... more When simultaneous series of stimuli are rapidly presented left and right, containing two target stimuli T1 and T2, T2 is much better identified when presented in the left than in the right hemifield. Here, this effect was replicated, even when shifts of gaze were controlled, and was only partially compensated when T1 side provided the cue where to expect T2. Electrophysiological measurement revealed earlier latencies of T1- and T2-evoked N2(pc) peaks at the right than at the left visual cortex, and larger right-hemisphere T2-evoked N2(pc) amplitudes when T2 closely followed T1. These findings suggest that the right hemisphere was better able to single out the targets in time. Further, sustained contralateral slow shifts remained active after T1 for longer time at the right than at the left visual cortex, and developed more consistently at the right visual cortex when expecting T2 on the contralateral side. These findings might reflect better capacity of right-hemisphere visual working memory. These findings about the neurophysiological underpinnings of the large right-hemisphere advantage in this complex visual task might help elucidating the mechanisms responsible for the severe disturbance of hemineglect following damage to the right hemisphere.
Experimental Brain Research, 2006
Non-consciously perceived arrow stimuli can speed up responses to similar stimuli that are shortl... more Non-consciously perceived arrow stimuli can speed up responses to similar stimuli that are shortly presented after a masked prime. Yet response facilitation may turn into a delay at particular intervals between masked primes and targets. In this case, the lateralized readiness potential, as a measure of the time course of differential activation between the primed and the unprimed motor cortices, consistently yielded two consecutive maxima of opposite polarity, at 250 and at 350 ms after prime onset. To further explore the mechanisms underlying inverse priming, we used single-pulse transcranial magnetic stimulation (TMS) of the left or right primary motor hand area (M1). Lateralized changes in corticomotor excitability induced by the masked prime were probed by assessing the effect of priming on the amplitude of the TMS-induced motor-evoked potentials (MEPs). In two experiments, MEPs increased and decreased, respectively, in the hand primed by the masked arrows when TMS was given at 250 and at 350 ms after prime onset, confirming the expectation that MEP changes may indicate the response tendencies induced by the masked primes. Both effects were more distinct with TMS of the left M1. However, there were also some differences between the patterns of results in the two experiments. We propose that the left M1 is activated for preparation of both right- and left-hand movements, and we relate the present results to current hypotheses about the nature of inverse priming.
Computers & Geosciences, 1990
Stratigraphic sections are the foundation of many regional stratigraphic analyses. The Pascal pro... more Stratigraphic sections are the foundation of many regional stratigraphic analyses. The Pascal program STRATCOLUMN is designed specifically as an aid to produce a graphical presentation oflithoand biostratigraphic data of a geologic section or a core. It is useful in a wide variety of geologic settings. The layout of the plot is highly flexible. In general it consists of a header, an explanation, a lithological column, and a series of adjacent columns filled with additional information. The stratigraphic layer. defined by a set of characteristics, is the fundamental element from which the lithological column is constructed. Text and data observed in the field or in the laboratory, are expressed in additional columns according to a variety of graphical layouts. Notations of lithotypes, icons of fossils, sedimentary and biogenic structures correspond as much as possible to conventional symbolism. Many are available by default in the program, but the system provides the user with ways to construct his own single or composite lithotype notations and icons. The present version of the program runs under NOS/BE operating system on a CDC CYBER mainframe. Only elementary graphic routines of CALCOMP are used, making the program adaptable to other computer environments. Free formatting throughout simplifies the structure of the input files, Large plots are produced economically, because all selected features are stored dynamically.
Neuropsychologia, 2009
Patients with homonymous visual field defects (HVFD) are often crucially disabled during self-gui... more Patients with homonymous visual field defects (HVFD) are often crucially disabled during self-guided visual exploration of their natural environment. Abnormal visual search may be related to the sensory deficit, deficient spatial orientation or compensatory eye movements. We tested the hypothesis that visual search in HVFD is purely determined by the visual-sensory deficit by comparing nine patients with HVFD due to occipital stroke in an acute stage to nine healthy subjects with technically simulated "virtual" homonymous visual field defects (vHVFD) and to nine controls with normal visual fields. The simulated gaze-contingent visual field defects in vHVFD subjects were individually matched to the patients' HVFD with respect to their size and side. Eye movements were recorded while subjects searched for targets among distractors and indicated target detection by clicks. All patients, in particular those with lesions involving the inferior occipito-temporal (fusiform) gyrus, but also those with small lesions restricted to the visual cortex, showed longer search durations than vHVFD subjects. This was tightly related to the higher number of fixations and particularly "re-fixations" (repeated scanning of fixated items). Working memory across saccades during the search was intact (no increased "re-clicks"). Scanpath strategies were similar in patients and vHVFD subjects. For both groups amplitude and frequency of saccades did not differ between the hemifields. In HVFD patients with acute occipital brain lesions, visual input failure does not fully account for abnormal visual search. It might either result from disconnections of the primary visual cortex to associated occipital and temporal brain areas or reflect an early stage of compensatory eye movements which differ from chronic HVFD patients.
Movement Disorders, 2006
Patients with essential tremor (ET) or with cerebellar lesions have in common oculomotor abnormal... more Patients with essential tremor (ET) or with cerebellar lesions have in common oculomotor abnormalities, with the exception of saccadic eye movements, which do not seem to be involved in ET. Since grasping is prolonged in ET and might be related to saccadic dysmetria, we tested whether simultaneous hand pointing could unmask it. Twelve ET patients and 14 controls performed saccades with and without simultaneous pointing movements to the same targets, and with and without a gap between the disappearance of the fixation point and the appearance of the target. Eye movements were recorded with the magnetic search-coil method, hand movements with an ultrasound-emitting probe. ET patients did not have saccadic dysmetria, and contrary to normal subjects their saccadic latency did not decrease during combined eye-hand movements compared with saccades performed in isolation. Hand movements had a longer duration in ET patients, with decreased peak acceleration, an increased latency of the peak velocity, and peak deceleration. In conclusion, this first study on eye-hand coordination in ET revealed abnormal kinematic changes in the early phase of pointing movements. These changes might be related to cerebellar disease but they are independent of the intention tremor component and saccade performance.
Neuroreport, 2002
Blinks are known to change the kinematic properties of fast eye movements, probably by changes in... more Blinks are known to change the kinematic properties of fast eye movements, probably by changes in the brain stem circuits. To determine whether slow disconjugate (slow vergence) eye movements are affected by blinks under natural viewing conditions, we elicited airpuff-evoked trigeminal blinks randomly during ongoing steady slow vergence eye movements. Lid and binocular eye movements were recorded by the scleral search coil method. Slow vergence eye movements showed a peak of vergence velocity during the final part of the blink, which depends on the stimulus direction. We propose that the direction-specific blink effect on slow vergence may be caused by changes in brain stem premotor circuits.
Neuroimage, 2007
Smooth pursuit eye movements (SPEM) are necessary to follow slowly moving targets while maintaini... more Smooth pursuit eye movements (SPEM) are necessary to follow slowly moving targets while maintaining foveal fixation. In about 50% of schizophrenic patients SPEM velocity is reduced. In this study we were interested in identifying the cortical mechanisms associated with extraretinal processing of SPEM in schizophrenic patients.
Neuroimage, 2008
Smooth pursuit eye movements (SPEM) are used to maintain focus upon moving targets. The generatio... more Smooth pursuit eye movements (SPEM) are used to maintain focus upon moving targets. The generation of SPEM velocity is controlled by retinal information and extraretinal signals. Although there is a wealth of studies investigating retinal and extraretinal SPEM control, the main questions regarding the cortical mechanisms involved in the processing of SPEM to different stimulus velocities are still unresolved. We applied an innovative event-related fMRI-design by presenting target ramps at different velocities (5, 10, 15, 20°/s) with both continuous target presentation and intervals of target blanking. The stimulus parameters were integrated into the statistical model and eye movements were registered to confirm SPEM performance. Our results clearly demonstrate that in humans the oculomotor network (V5, frontal and supplementary eye fields, lateral intraparietal area) is engaged in the processing of retinal and extraretinal SPEM velocity. Within this network neural activity increases with increasing target velocity. During extraretinal SPEM, additional engagement of the dorsolateral prefrontal cortex, angular gyrus, parahippocampal gyrus and superior temporal gyrus occurs. These regions encode cognitive functions such as memory, attention and monitoring. The activation of the inferior parietal cortex seems to be related to the interaction between velocity and blanking thereby underlining its relevance for task switching and sensorimotor transformation.
Journal of Neurology Neurosurgery and Psychiatry, 2008
To investigate substantia nigra (SN) echogenicity in members of a family with homozygous and hete... more To investigate substantia nigra (SN) echogenicity in members of a family with homozygous and heterozygous PTEN induced kinase (PINK1) mutations with or without signs of Parkinson's disease (PD). Transcranial sonography (TCS) was used to investigate 20 members of a family with PINK1 mutations, including four homozygous and 11 heterozygous mutation carriers and five individuals with no mutation. For comparison, a healthy control group of 18 subjects without a positive family history of PD (control group) and a healthy control group of 15 subjects with a positive family history of sporadic PD (relative group) were investigated. For statistical analysis, the larger area of the two SNs echogenicity (aSNmax) of each individual was selected. A significantly increased aSNmax was found for all subgroups compared with the control group. The group of homozygous carriers of a PINK1 mutation had a significantly increased aSNmax compared with all of the other subgroups, except the group of heterozygous mutation carriers. These findings in carriers of a PINK1 mutation are comparable with those in carriers of Parkin mutations and non-genetic PD. The increased aSNmax in family members without a mutation suggests an additional contributing factor independent of the PINK1 mutation that may also play a role in relatives of patients with sporadic PD.
Neuroimage, 2007
The posterior parietal cortex (PPC) is essential for the integration of visuomotor information du... more The posterior parietal cortex (PPC) is essential for the integration of visuomotor information during visually guided reaching. Studies in macaque monkeys have demonstrated a functional specialisation around the intraparietal sulcus (IPS) with a more medial representation of hand movements ("parietal reach region") and a more lateral representation of saccadic eye movements (lateral intraparietal area, LIP). Here we present evidence for the validity of this concept with respect to the human parietal cortex. We recorded isolated and combined goal-directed eye--hand movements in normal control subjects and in a patient with bilateral parieto-occipital lesions and incomplete Balint's syndrome including severe optic ataxia (misreaching to visual targets). Brain lesions in the patient were caused by acute posterior leucoencephalopathy in association with aortic surgery because of Takayasu's arteritis. MRI scans showed bilateral lineshaped hemorrhagic lesions, restricted to the cortex at the medial banks of the intraparietal sulcus, but leaving its lateral banks largely intact. In the patient visually guided reaching was significantly dysmetric, whereas the metrics of visually guided saccades were within normal limits. Dysmetria was more pronounced for the right visual field, with a gross hypermetria. Variability of the movement improved when a delay of 5 or 10 s was introduced between target presentation and movement execution. Lesion data support the concept of a functional specialisation around the human IPS: The cortex medial to the IPS predominantly controls rapid goal-directed reaching movements, comparable to the parietal reach region in monkeys, whereas saccadic eye movements appear to be controlled rather by the cortex lateral to the IPS.
Neuroreport, 2005
Recent studies have discussed the role of the cerebellum in not only motor but also cognitive fun... more Recent studies have discussed the role of the cerebellum in not only motor but also cognitive functions, and in particular, fronto-executive operations. Similar to a previous study on hemineglect patients, we recorded eye movements during a visual search task to investigate patients with isolated infarction of the cerebellum compared with controls. Patients showed longer search durations, associated with mild saccadic dysmetria, longer single fixation durations and a higher number of repeated fixations of items. Systematic search strategies were preserved, but less frequent in patients. In conclusion, though basic mechanisms of visual search including spatial memory were not affected by cerebellar lesions, patients' search behaviour was slower and less efficient, indicating a mild deficit of visual attention and motor planning.
Progress in Brain Research, 2002
In patients with hemi-spatial neglect eye movement patterns during visual search reflect not only... more In patients with hemi-spatial neglect eye movement patterns during visual search reflect not only inattention for the contralesional hemi-field, but interacting deficits of multiple visuo-spatial and cognitive functions, even in the ipsilesional hemi-field. Evidence for these deficits is presented from the literature and from saccadic scan-path analysis during feature and conjunction search in 10 healthy subjects and in 10 patients with manifest or recovered left visual neglect due to right-hemispheric stroke. Deficits include (1) a rightward shift of spatial representation, (2) deficient spatial working memory and failure of systematic search strategies, leading to multiple re-fixations, more after frontal lesions, and (3) a reduced spotlight of attention and a deficient pop-out effect of color, more after temporo-parietal lesions.
European Journal of Neuroscience, 2004
Smooth pursuit eye movements are evoked by retinal image motion of visible moving objects and can... more Smooth pursuit eye movements are evoked by retinal image motion of visible moving objects and can also be driven by the internal representation of a target due to extraretinal mechanisms (e.g. efference copy). To delineate the corresponding neuronal correlates, functional magnetic resonance imaging at 1.5 T was applied during smooth pursuit at 10 degrees /s with continuous target presentation and target blanking for 1 s to 16 right-handed healthy males. Eye movements were assessed during scanning sessions by infra-red reflection oculography. Smooth pursuit performance was optimal when the target was visible but decreased to a residual velocity of about 30% of the velocity observed during continuous target presentation. Random effects analysis of the imaging data yielded an activation pattern for smooth pursuit in the absence of a visual target (in contrast to continuous target presentation) which included a number of cortical areas in which extraretinal information is available such as the frontal eye field, the superior parietal lobe, the anterior and the posterior intraparietal sulcus and the premotor cortex, and also the supplementary and the presupplementary eye field, the supramarginal gyrus, the dorsolateral prefrontal cortex, cerebellar areas and the basal ganglia. We suggest that cortical mechanisms such as prediction, visuo-spatial attention and transformation, multimodal visuomotor control and working memory are of special importance for maintaining smooth pursuit eye movements in the absence of a visible target.
Psychiatry Research, 2006
In obsessive–compulsive disorder (OCD), a dysfunction of neuronal circuits involving prefrontal a... more In obsessive–compulsive disorder (OCD), a dysfunction of neuronal circuits involving prefrontal areas and the basal ganglia is discussed that implies specific oculomotor deficits. Performance during reflexive and predictive saccades, antisaccades and predictive smooth pursuit was compared between patients with OCD (n = 22), patients with schizophrenia (n = 21) and healthy subjects (n = 24). Eye movements were recorded by infrared reflection oculography. In both patient groups, higher frequencies of anticipatory saccades with reduced amplitudes in the predictive saccade task were observed. Additionally, reduced smooth pursuit eye velocity and increased frequencies of saccadic intrusions during smooth pursuit as well as increased error rates in the antisaccade task were demonstrated for patients suffering from schizophrenia. Patients with OCD and schizophrenia revealed different patterns of oculomotor impairment: whereas increased anticipation of predictive saccades provides evidence for a dysfunction of the circuit between the frontal eye field and the basal ganglia in both groups, results from the antisaccade task imply additional deficits involving the dorsolateral prefrontal cortex in schizophrenic patients. Furthermore, the cortical network for smooth pursuit (especially the frontal eye field) is also assumed to be disturbed in schizophrenia.
Brain, 2003
Experimental and clinical data indicate that the cerebellum is involved in the pathophysiology of... more Experimental and clinical data indicate that the cerebellum is involved in the pathophysiology of advanced stages of essential tremor (ET). The aim of this study was to determine whether a dysfunction also affects cerebellar structures involved in eye movement control. Eye movements of 14 patients with ET and 11 agematched control subjects were recorded using the scleral search-coil technique. Vestibular function was assessed by electro-oculography. Eight ET patients had clinical evidence of intention tremor (ET IT ); six had a predominantly postural tremor (ET PT ) without intention tremor. ET patients showed two major de®cits that may indicate cerebellar dysfunction: (i) an impaired smooth pursuit initiation; and (ii) pathological suppression of the vestibulo-ocular re¯ex (VOR) time constant by head tilts (`otolith dumping'). In the step ramp smooth pursuit paradigm, the initial eye acceleration in the ®rst 60 ms of pursuit generation was signi®cantly reduced in ET patients, particularly in ET IT patients, by~44% (mean 23.4°/s 2 ) compared with that of control subjects (mean 41.3°/s 2 ). Subsequent steady-state pursuit velocity and sinusoidal pursuit gain (e.g. 0.4 Hz: 0.90 versus 0.78) were also signi®cantly decreased in ET patients, whereas pursuit latency was unaffected. The intention tremor score correlated with the pursuit deficit, e.g. ET IT patients were signi®cantly more affected than ET PT patients. Gain and time constant (t) of horizontal VOR were normal, but suppression of the VOR time constant by head tilt (`otolith dumping') was pathological in 41% of ET patients, particularly in ET IT patients. Saccades and gaze-holding function were not impaired. The de®cit of pursuit initiation, its correlation with the intensity of intention tremor, and the pathological VOR dumping provide additional evidence of a cerebellar dysfunction in the advanced stage of ET, when intention tremor becomes part of the clinical symptoms, and point to a common pathomechanism. The oculomotor de®cits may indicate an impairment of the caudal vermis in ET.
Neuroimage, 2005
Smooth-pursuit eye movements are the essential tool for a clear and 14
Human Brain Mapping, 2008
In monkeys, areas in the intraparietal sulcus (IPS) play a crucial role in visuospatial informati... more In monkeys, areas in the intraparietal sulcus (IPS) play a crucial role in visuospatial information processing. Despite many human neuroimaging studies, the location of the human functional homologs of some IPS areas is still a matter of debate. The aim of the present functional magnetic resonance imaging (fMRI) study was to identify the distinct locations of specific human IPS areas based on their functional properties using stimuli adapted from nonhuman primate experiments, in particular, surface orientation discrimination and memory guided saccadic eye movements (SEM). Intersubject anatomical variability likely accounts for much of the debate. By applying subject by subject analysis, we can demonstrate that sufficient intersubject anatomical and functional commonalities exist. Both the lateral bank of the anterior part of IPS, the putative human homolog of the area AIP, and the caudal part of the IPS (putative CIP) showed activation related to spatial discrimination of surface orientation. Eye tracking conducted during fMRI data acquisition allowed us to show that both areas were separated by an area related to SEM. This area was located in the middle region of the IPS (most probably including LIP), i.e., similar to the location observed in nonhuman primates. In 10 of 11 subjects our putative CIP activation was located in a medial side branch of the posterior part of the IPS, on the opposite side as described in nonhuman primates, making this landmark a useful anatomical marker for the location of CIP. Hum Brain Mapp 2008. © 2007 Wiley-Liss, Inc.
Neuroimage, 2006
Smooth pursuit eye movements (SPEM) are performed to track slowly moving visual targets and are a... more Smooth pursuit eye movements (SPEM) are performed to track slowly moving visual targets and are accompanied by saccades whenever foveal representation is lost. In the present study, we correlated the cerebral activation as assessed by functional magnetic resonance imaging with parameters of eye movement performance in order to determine the cortical areas involved in the retinal and extraretinal processing of maintaining smooth pursuit velocity (SPV) and generating saccades in 16 healthy males. The stimulus consisted of a target moving at a constant velocity of 10-/s with and without target blanking.
Journal of Neurology, 2009
Neuropediatrics, 2006
We investigated a five-year-old girl suffering from genetically confirmed, action-induced myoclon... more We investigated a five-year-old girl suffering from genetically confirmed, action-induced myoclonus-dystonia (M-D) with functional magnetic resonance imaging (MRI). We compared the activation pattern by movements of her right hand as if drawing a picture, which elicited M-D, with simple snapping movements (without overt M-D). The drawing and snapping conditions resulted in activation of a motor network including the motor cortex, the putamen, and the cerebellar hemispheres. The direct comparison of the drawing condition with snapping as control revealed specific activations within the thalamus and the dentate nucleus. An age matched healthy control did not show significant activation within the thalamus or dentate nucleus.
Uploads
Papers by Andreas Sprenger