Conference Presentations by Andreas Otte
![Research paper thumbnail of Three Months Follow-Up of Mild Traumatic Brain Injury in Rats: A Combined [18F]FDG and [11C]PK11195 PET Study](https://attachments.academia-assets.com/39523348/thumbnails/1.jpg)
Annual Congress of the European Association of Nuclear Medicine (EANM'15)
Aim: Mild traumatic brain injury (mTBI) is the most common cause of head trauma and it is especia... more Aim: Mild traumatic brain injury (mTBI) is the most common cause of head trauma and it is especially relevant in adolescents and sport activities. However, the time course of its functional pathology is not well defined. In this study the consequences of mTBI were evaluated in a rat model over a period of 3 months. The presence of neuroinflammation ([11C]PK11195) and changes in brain metabolism([18F]FDG) were determined using small animal PET imaging.
Material and Methods: A weight-drop mTBI model was used to replicate the pathological features seen in humans. Male Sprague-Dawley rats were divided into sham (n=8) and trauma (n=8) groups. PET imaging and behavioral tests (i.e. open field, object recognition and Y-maze) were performed at different time points after induction of the trauma: acute stage (9-12 days), 1 and 3 months. Differences between groups in the bodyweight and behavioral scores were analyzed using the Generalized Estimating Equations model and p<0.05 were considered significant. Differences in tracer uptake were analyzed with a voxel-based analysis. T-maps were interrogated with uncorrected p<0.005 and 200 threshold voxels; only clusters with FDR-corrected p<0.05 were considered significant.
Results: Trauma induction did not result in death, skull fracture or neurological suppression of reflexes. A statistically significant decrease in gained body weight was observed in mTBI group (p=0.003). No statistical differences were found between groups in any of the behavioral tests. In the voxel-based analysis, a comparison between mTBI and sham groups was performed at each time point. A neuroinflammatory process was detected only in the acute phase, with significantly
higher [11C]PK11195 uptake located bilaterally in the pons, medulla, cerebellum, hypothalamus, caudate, putamen, and the right amygdala. Increased regional [18F]FDG uptake in mTBI rats was detected in all time points bilaterally in the medulla, in addition to an increased uptake at 3 months in the left motor, somatosensory, visual and parietal cortices. Moreover, decreased uptake was detected during the follow-up period in the thalamus, internal capsule, amygdala, caudate, putamen, globus pallidus, hippocampus, and somatosensory cortex.
Conclusion: Alterations in the regional glucose metabolism of the brain extend for a period of at least 3 months in regions that seem to present an acute neuroinflammatory response to the trauma. The presence of these long-lasting functional alterations must be considered carefully in the context of mTBI, especially in sports and recreational activities where patients may be exposed to a repeated head trauma.
Papers by Andreas Otte
Lupus, 1998
Time to change-let's end mental health discrimination: the challenges ahead October 2007 marked t... more Time to change-let's end mental health discrimination: the challenges ahead October 2007 marked the launch of another programme in England to tackle stigma and discrimination. 'Time to Change' models national initiatives from New Zealand and Scotland drawing on an expanding stigma evidence base 1 as well as lessons from past projects, including the Royal College of Psychiatrists' 'Defeat Depression' and 'Changing Minds' campaigns. How might this programme succeed where others have stalled? The programme is resource rich with £18 million from the Big Lottery Fund and Comic Relief to channel into 35 linked programmes. It has 4 years to prove change among targeted audiences within a 30 million adult reach. It is a four-party coalition with a desire to learn from organisations across health and disability fields. It is adopting an evidence-based approach 2-national social marketing, service user leadership and engagement, local direct action, multiple targets using 'stick and carrot' approaches-but this does not guarantee success. Key challenges are identifiable. Preparatory consultation during February 2008 using a pragmatic, non-systematic survey method through the membership networks of 18 organisations generated responses from 3038 service users and 661 family or friend carers. This consultation emphasised first, that stigma and discrimination are widespread and their impact far-reaching. (a) Seventy-one per cent reported to have stopped doing thingsaccessing employment, making friends, joining groups, engaging with health professionals. (b) Seventy-three per cent reported anticipated discrimination including one in two who fear disclosing their health problems because of the negative reactions they might receive. (c) Carers reported fewer personal effects but 85% felt that the person they supported was affected. (d) Time to Change will need to target its efforts to have a meaningful impact in any one area.
Vlaams Diergeneeskundig Tijdschrift
![Research paper thumbnail of Combined FDG and [F-18]fluoride whole-body PET: a feasible two-in-one approach to cancer imaging?](https://a.academia-assets.com/images/blank-paper.jpg)
Radiology, 1998
To evaluate the diagnostic usefulness of the combined application of 2-[fluorine-18]fluoro-2-deox... more To evaluate the diagnostic usefulness of the combined application of 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG; for the evaluation of soft tissue) and [F-18]fluoride (for the evaluation of the skeleton) in positron emission tomography (PET) of cancer. Sixty consecutive patients (23 women, 37 men; mean age +/- SD, 51 years +/- 14; age range, 13-76 years) were entered into this prospective study. Thirty patients underwent only FDG PET. Thirty patients underwent combined FDG and fluoride PET. The PET findings were correlated with the findings of other imaging modalities. Interobserver agreement for the anatomic lesion localization was calculated with the use of the kappa statistic. All 30 combined FDG and fluoride studies yielded high-quality whole-body images. PET findings correlated with other imaging findings in 54 (78%) of 69 lesions in the control group and with 64 (88%) of 73 lesions in the combined group. Interobserver agreement in the control group was 0.74; it was 0.95 in the combined group. Combined FDG and fluoride PET is an advanced metabolic imaging approach for the evaluation of cancer.
Unfallchirurgie, 1997
ABSTRACT
Hellenic journal of nuclear medicine
Nuclear Medicine in Psychiatry, 2004
Eating disorders have always been a rarity within the domain of psychiatry and its disorders. Eat... more Eating disorders have always been a rarity within the domain of psychiatry and its disorders. Eating is a basic behaviour in order to preserve and maintain one’s own physical and mental integrity. Therefore, disturbances of this life-saving habit and the often distressing clinical presentation that results have always drawn the specific attention of physicians. Within the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR, American Psychiatric Association 2000), anorexia nervosa and bulimia nervosa are the two major pathological entities that are outlined. Furthermore, all eating disturbances that do not meet criteria of the aforementioned pathologies are grouped separately into a single category: eating disorders not otherwise specified. Besides anorexia nervosa and bulimia nervosa, a section is addressed to the binge-eating disorder and another to the problem of obesity. Obesity is considered one of the principal pathologies that medicine will have to deal with in the near future. Many obese patients are probably suffering from a binge-eating disorder, but this is certainly not always objectified and is even overlooked. An overview of nuclear functional brain imaging and receptor studies, together with a discussion on the presented literature, is provided here.
The Lancet, 2002
... internal radiotherapy.. Am J Kidney Dis 2001; 37: 847-851. CrossRef | PubMed. 3 Cybulla M, We... more ... internal radiotherapy.. Am J Kidney Dis 2001; 37: 847-851. CrossRef | PubMed. 3 Cybulla M, Weiner SM, Otte A. End—stage renal disease after treatment with 90Y-DOTATOC.. Eur J Nucl Med 2001; 28: 1552-1554. CrossRef ...
3D Printing in Medicine, 2020
A new concept for robust non-invasive optical activation of motorized hand prostheses by simple a... more A new concept for robust non-invasive optical activation of motorized hand prostheses by simple and non-contact commands is presented. In addition, a novel approach for aiding hand amputees is shown, outlining significant progress in thinking worth testing. In this, personalized 3D-printed artificial flexible hands are combined with commercially available motorized exoskeletons, as they are used e.g. in tetraplegics.
Prosthesis
In this paper, a concept for an anthropomorphic replacement hand cast with silicone with an integ... more In this paper, a concept for an anthropomorphic replacement hand cast with silicone with an integrated sensory feedback system is presented. In order to construct the personalized replacement hand, a 3D scan of a healthy hand was used to create a 3D-printed mold using computer-aided design (CAD). To allow for movement of the index and middle fingers, a motorized orthosis was used. Information about the applied force for grasping and the degree of flexion of the fingers is registered using two pressure sensors and one bending sensor in each movable finger. To integrate the sensors and additional cavities for increased flexibility, the fingers were cast in three parts, separately from the rest of the hand. A silicone adhesive (Silpuran 4200) was examined to combine the individual parts afterwards. For this, tests with different geometries were carried out. Furthermore, different test series for the secure integration of the sensors were performed, including measurements of the registe...
EBioMedicine, 2019
a Laboratory of Computer Assisted Medicine, Division of Medical Engineering, Department of Electr... more a Laboratory of Computer Assisted Medicine, Division of Medical Engineering, Department of Electrical Engineering, Medical Engineering and Computer Science, Offenburg University, Badstr. 24, D-77652 Offenburg, Germany b Laboratory of NeuroScience, Division of Medical Engineering, Department of Electrical Engineering, Medical Engineering and Computer Science, Offenburg University, Badstr. 24, D-77652 Offenburg, Germany c Clinical Neurotechnology Laboratory, Neuroscience Research Center (NWFZ), University Hospital of Psychiatry and Psychotherapy (CCM), Charité University Medicine Berlin, Charitéplatz 1, D-10117 Berlin, Germany
PET and SPECT in Neurology, 2014
Dementia is a clinical diagnosis reflecting many possible underlying pathologies, including, for ... more Dementia is a clinical diagnosis reflecting many possible underlying pathologies, including, for example, vascular dementia and neurodegenerative disorders such as frontotemporal dementia, Lewy body-type disorder or Alzheimer’s disease (AD). The breakthrough of 99mtechnetium-labelled perfusion tracers in the 1990s resulted in many SPECT studies of flow changes in AD. In the first decade of 2000, the role of perfusion SPECT was shifted from diagnosis towards differential diagnosis, parallel to the growing attention for diagnosing early stages of dementia. This evolution is reflected in the upcoming guidelines, which are detailed in this chapter.
Nuclear Medicine Communications, 2009
Radiolabeled immunotherapy (RIT) is becoming a significant step forward in the treatment manageme... more Radiolabeled immunotherapy (RIT) is becoming a significant step forward in the treatment management of non-Hodgkin's lymphoma (NHL). In this state-of-the-art review article, general details, practical and health economic aspects, and next steps of RIT in NHL are reviewed from the existing literature and latest abstracts. As 90 Y-ibritumomab tiuxetan is the only marketed RIT in NHL in Europe, the special focus of this review is on 90 Y-ibritumomab tiuxetan, although the whole spectrum of available RIT concepts is highlighted. There is strong evidence to suggest that RIT is not only a safe and efficacious add-on treatment option in third or second line to chemotherapy, but is also a convincing asset as first-line therapy in various indications of lymphoma. Nucl Med Commun 30:5-15
The American Journal of Medicine, 1960
Current Opinion in Neurology, 1996
Neuroimaging techniques have had a dramatic impact on the evaluation and treatment of patients wi... more Neuroimaging techniques have had a dramatic impact on the evaluation and treatment of patients with epilepsy. In order to take full advantage of their potential, it is important to place them in clinical and electrophysiological context and to understand their technical limitations. Positron emission tomography with 18F-2-deoxyglucose and single photon emission computed tomography can provide valuable data for presurgical localization of epileptogenic zones. Interictal cerebral blood flow studies, however, using either positron emission tomography or simple photon emission computed tomography are unreliable. Positron emission tomography cerebral blood flow activation studies, on the other hand, are becoming very useful for presurgical cognitive mapping and may be able to replace the intracarotid amytal test for language and memory lateralization. There are a number of receptor ligands available for both positron emission tomography and simple photon emission computed tomography studies, including benzodiazepine, opiate, and cholinergic tracers. Increased mu opiate, decreased benzodiazepine, and increased monoamine oxidase B receptor binding have been reported.
Clinical Orthopaedics & Related Research
Prof. Otte and his team detail how they created a 3-D CAD reconstruction of the Roman Capua leg, ... more Prof. Otte and his team detail how they created a 3-D CAD reconstruction of the Roman Capua leg, one of the earliest known prosthetic limbs
Die Erfindung betrifft ein Verfahren zur Steuerung eines Geräts, insbesondere einer Handprothese ... more Die Erfindung betrifft ein Verfahren zur Steuerung eines Geräts, insbesondere einer Handprothese oder eines Roboterarms, wobei wenigstens ein an oder im Bezug zu dem Gerät positionierter Marker von einer an einer Bedienperson angeordneten Kamera erkannt wird, wobei ab dem Erkennen des wenigstens einen Markers eine vordefinierte Bewegung der Bedienperson zusammen mit der Kamera erkannt wird und zum Auslösen einer entsprechenden Aktion des Geräts verwendet wird, wobei die vordefinierte Bewegung einer Bedienperson in Form eines Sehstrahls mittels Kamera-Tracking erkannt wird. Weiterhin betrifft die Erfindung eine Anordnung aus einem Gerät, insbesondere einer Handprothese oder eines Roboterarms, und einer AR-Brille zur Durchführung eines derartigen Verfahrens
Restoring hand motion to people experiencing amputation, paralysis, and stroke is a critical area... more Restoring hand motion to people experiencing amputation, paralysis, and stroke is a critical area of research and development. While electrode-based systems that use input from the brain or muscle have proven successful, these systems tend to be expensive and di cult to learn. One group of researchers is exploring the use of augmented reality (AR) as a new way of controlling hand prostheses. A camera mounted on eyeglasses tracks LEDs on a prosthetic to execute opening and closing commands using one of two different AR systems. One system uses a rectangular command window to control motion: crossing horizontally signals "open" along one direction and "close" in the opposite direction. The second system uses a circular command window: once control is enabled, gripping strength can be controlled by the direction of head motion. While the visual system remains to be tested with patients, its low cost, ease of use, and lack of electrodes make the device a promising solution for restoring hand motion.
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Conference Presentations by Andreas Otte
Material and Methods: A weight-drop mTBI model was used to replicate the pathological features seen in humans. Male Sprague-Dawley rats were divided into sham (n=8) and trauma (n=8) groups. PET imaging and behavioral tests (i.e. open field, object recognition and Y-maze) were performed at different time points after induction of the trauma: acute stage (9-12 days), 1 and 3 months. Differences between groups in the bodyweight and behavioral scores were analyzed using the Generalized Estimating Equations model and p<0.05 were considered significant. Differences in tracer uptake were analyzed with a voxel-based analysis. T-maps were interrogated with uncorrected p<0.005 and 200 threshold voxels; only clusters with FDR-corrected p<0.05 were considered significant.
Results: Trauma induction did not result in death, skull fracture or neurological suppression of reflexes. A statistically significant decrease in gained body weight was observed in mTBI group (p=0.003). No statistical differences were found between groups in any of the behavioral tests. In the voxel-based analysis, a comparison between mTBI and sham groups was performed at each time point. A neuroinflammatory process was detected only in the acute phase, with significantly
higher [11C]PK11195 uptake located bilaterally in the pons, medulla, cerebellum, hypothalamus, caudate, putamen, and the right amygdala. Increased regional [18F]FDG uptake in mTBI rats was detected in all time points bilaterally in the medulla, in addition to an increased uptake at 3 months in the left motor, somatosensory, visual and parietal cortices. Moreover, decreased uptake was detected during the follow-up period in the thalamus, internal capsule, amygdala, caudate, putamen, globus pallidus, hippocampus, and somatosensory cortex.
Conclusion: Alterations in the regional glucose metabolism of the brain extend for a period of at least 3 months in regions that seem to present an acute neuroinflammatory response to the trauma. The presence of these long-lasting functional alterations must be considered carefully in the context of mTBI, especially in sports and recreational activities where patients may be exposed to a repeated head trauma.
Papers by Andreas Otte
Material and Methods: A weight-drop mTBI model was used to replicate the pathological features seen in humans. Male Sprague-Dawley rats were divided into sham (n=8) and trauma (n=8) groups. PET imaging and behavioral tests (i.e. open field, object recognition and Y-maze) were performed at different time points after induction of the trauma: acute stage (9-12 days), 1 and 3 months. Differences between groups in the bodyweight and behavioral scores were analyzed using the Generalized Estimating Equations model and p<0.05 were considered significant. Differences in tracer uptake were analyzed with a voxel-based analysis. T-maps were interrogated with uncorrected p<0.005 and 200 threshold voxels; only clusters with FDR-corrected p<0.05 were considered significant.
Results: Trauma induction did not result in death, skull fracture or neurological suppression of reflexes. A statistically significant decrease in gained body weight was observed in mTBI group (p=0.003). No statistical differences were found between groups in any of the behavioral tests. In the voxel-based analysis, a comparison between mTBI and sham groups was performed at each time point. A neuroinflammatory process was detected only in the acute phase, with significantly
higher [11C]PK11195 uptake located bilaterally in the pons, medulla, cerebellum, hypothalamus, caudate, putamen, and the right amygdala. Increased regional [18F]FDG uptake in mTBI rats was detected in all time points bilaterally in the medulla, in addition to an increased uptake at 3 months in the left motor, somatosensory, visual and parietal cortices. Moreover, decreased uptake was detected during the follow-up period in the thalamus, internal capsule, amygdala, caudate, putamen, globus pallidus, hippocampus, and somatosensory cortex.
Conclusion: Alterations in the regional glucose metabolism of the brain extend for a period of at least 3 months in regions that seem to present an acute neuroinflammatory response to the trauma. The presence of these long-lasting functional alterations must be considered carefully in the context of mTBI, especially in sports and recreational activities where patients may be exposed to a repeated head trauma.