The desiccation time of high-biomass pasture and nitrogen (N) fertilization of pasture and soybea... more The desiccation time of high-biomass pasture and nitrogen (N) fertilization of pasture and soybean can influence the soybean sowing, establishment and growth. The objective of this study was to evaluate how the time of desiccation of the preceding pasture of Urochloa brizantha cv. BRS Piatã, cultivated at three levels of N, and by the soybean N fertilization affect soybean growth and N accumulation. Three N rates (0; 150 and 300 kg ha-1), broadcast as urea on the U. brizantha pasture were evaluated separately in each N level, every one considered as one experiment. In each experiment, five times of pasture desiccation were evaluated (60; 45; 30; 15, and 1 day before soybean sowing) and two levels of soybean N fertilization: 30 kg ha-1 (urea) broadcast at sowing or without N fertilization. A randomized complete block design with five replications was used. Early desiccation of U. brizantha pasture favors the establishment of soybean and promotes an increase in biomass and N accumulat...
Revista Brasileira de Terapia Comportamental e Cognitiva
A corrupção tem sido objeto de estudo em diversas pesquisas, mas apenas recentemente tem sido inv... more A corrupção tem sido objeto de estudo em diversas pesquisas, mas apenas recentemente tem sido investigada experimentalmente. Uma maneira de estudar tal fenómeno é expor os participantes a um Jogo dos Bens Públicos (JBP) no qual eles precisam contribuir para produzir um bem público específico, e então precisam tomar decisões sobre como tal bem seria distribuído entre os demais participantes. Um participante que fizer distribuições desiguais beneficiando a si estaría se comportando de maneira análoga ao que é descrito pelo crime de peculato. O objetivo do presente estudo foi investigar como os participantes distribuiram recursos públicos no JBP. Seis participantes foram expostos ao procedimento. Cinco deles fizeram distribuições desiguais, isto é, alocaram a maior parte dos recursos para si mesmo. A partir destes resultados, sugerimos mudanças nas contingencias que controlam a ocorrência deste tipo de comportamento.
2009 Twenty-Fourth Annual IEEE Applied Power Electronics Conference and Exposition
Hybrid energy storage systems have been investigated with the objective of improving the storage ... more Hybrid energy storage systems have been investigated with the objective of improving the storage of electrical energy. In these systems, two (or more) energy sources work together to create a superior device in comparison with a single source. In particular, batteries and ultracapacitors have complementary characteristics that make them attractive for a hybrid energy storage system. But the result of
Introduction/Background Patients with low-risk gestational trophoblastic neoplasia (GTN) are almo... more Introduction/Background Patients with low-risk gestational trophoblastic neoplasia (GTN) are almost universally cured with chemotherapy, but second uterine curettage has been explored as an alternative to avoid chemotherapy-related toxicities. We systematically reviewed intervention studies to determine whether second curettage in patients with low-risk GTN affects: 1) the proportion of patients requiring chemotherapy; 2) the number of chemotherapy cycles; and 3) the need for multi-agent chemotherapy. Methodology A literature search was performed including the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and Web of Science. Two authors screened titles, abstracts, and full texts and abstracted data. Risk of bias was assessed for each outcome. Data were pooled using a randomeffects model and assessed for heterogeneity. Quality of evidence was assigned using GRADE. Results Six studies met inclusion criteria; 2 randomized studies (RCT) and 4 cohort studies with control arm (CS). Mean difference in number of chemotherapy cycles was 2.04 fewer in patients who underwent second curettage (95% CI-5.00 to 0.91) based on two pooled RCTs (N=138). Those who underwent second curettage had RR=0.60 (95% CI 0.31 to 1.18) for requiring chemotherapy based on 4 pooled CS (N=1105), and RR=1.17 (95% CI 0.76 to 1.80) for multi-agent chemotherapy based on two pooled CS (N=900). The certainty of evidence is very low due to risk of bias for potential confounding, selection bias, missing data, and inconsistency of the results.
Background Diabetes mellitus (DM) is a prognostic factor for some malignancies, but its clinical ... more Background Diabetes mellitus (DM) is a prognostic factor for some malignancies, but its clinical implications in metastatic colorectal cancer (mCRC) patients are less clear. Therefore, we conducted a retrospective study to evaluate the impact of pre-existing type 2 diabetes mellitus (T2DM) on the survival outcomes of patients with newly diagnosed mCRC. Methodology We retrospectively included patients with newly diagnosed mCRC between January 2017 and June 2021 and with pre-existing T2DM. Data on the characteristics of patients, clinicopathological features, and drug exposure were collected from the electronic medical records. The primary endpoint was overall survival (OS). Secondary endpoints were progression-free survival (PFS) and treatment-related adverse events (TRAEs). Results Among 187 mCRC patients, 54 (28.8%) had T2DM. The median follow-up was 25 months. We observed 150 OS events and 168 PFS events. Diabetes significantly and negatively impacted PFS and OS. The median for PFS (mPFS) was eight and 16 months for T2DM and no T2DM patients, respectively (p < 0.0001; log-rank test). The median overall survival (mOS) was 15 and 29 months for T2DM and no T2DM patients, respectively (p < 0.0001; log-rank test). Patients with diabetes were more often overweight or obese (59.3% vs. 24.8%; p < 0.01) and had a poorer performance status (53.7% vs. 21.1% with Eastern Cooperative Oncology Group Performance Status 1; p < 0.01). Additionally, T2DM patients had more high-risk pathological features, including G3 grading tumors (27.7% vs. 12.0%; p = 0.01), lymph node involvement (p < 0.01), BRAF-mutated (35.1% vs. 6.8%; p < 0.01), and right-sided CRC (63.0% vs. 30.1%; p < 0.01). We found no statistically significant differences in TRAEs. Nevertheless, a significantly higher rate of grade 2-4 peripheral neuropathy (22.2% vs. 5.3%; p < 0.01) was reported in T2DM patients. Conclusions T2DM is a negative prognostic factor for survival in mCRC. The paper provides empirical evidence in favor of the joint control of both pathologies. Further research is needed to establish the robustness of our results.
Purpose Amblyopia is a leading cause of preventable and treatable vision loss in the pediatric po... more Purpose Amblyopia is a leading cause of preventable and treatable vision loss in the pediatric population. Instrument-based screening of amblyopia-risk factors is being widely adopted but the audit of its results is still lacking. We sought to review the existing evidence regarding the outcomes of photoscreening applied to children under the age of three years. Methods A three-database search (Pubmed, ISI Web of Science, and Scopus) was performed from inception to March 2021. A meta-analysis of proportions was conducted to summarize the referral rate, untestable rate and positive predictive value (PPV). Results Thirteen studies were selected among 705 original abstracts. The quantitative analysis included twelve studies enrolling 64,041 children. Of these, 13% (95%CI: 7–19%) were referred for further confirmation of the screening result. Astigmatism was the most common diagnosis both after screening and after ophthalmologic assessment of referred children. The pooled untestable rate...
Melanoma is a malignancy of melanocytes, melanin-producing cells in the basal layer of the epider... more Melanoma is a malignancy of melanocytes, melanin-producing cells in the basal layer of the epidermis. Despite representing only 1% of skin cancers, melanoma is responsible for over 80% of skin cancer deaths. Treatment with immune checkpoint inhibitors (ICIs) that target the programmed death 1 (PD-1) protein and the cytotoxic T-lymphocyte antigen 4 (CTLA-4) pathways drastically transformed the management of patients with advanced melanoma. Before the introduction of ICIs, the average life expectancy for a patient with advanced melanoma ranged from six to 12 months, and now, this average survival has increased to over six years. However, despite this outstanding clinical success, most patients with advanced melanoma treated with ICIs will experience disease progression, immediately or after an initial response to treatment. Nowadays, some studies have looked at the mechanism behind the resistance to immunotherapy, with the aim of developing new treatments to overcome it. Emerging data suggest that gut microbiota (GM) influences response to immunotherapy. Importantly, unlike tumor genomics, the GM is changeable; thus, modulation of the GM is an attractive approach to overcome immunotherapy resistance. One of these approaches is the fecal microbiota transplant (FMT), which consists of the exchange of manipulated feces from a donor to a recipient who has a disorder related to intestinal dysbiosis to directly change the recipient's gut microbial composition and confer a health benefit. This review pretends to discuss the clinical benefit of FMT in the treatment of immunotherapy-resistant melanoma and potential adverse effects, including recent and ongoing clinical trials.
The objective of this work was to adjust the coefficients of six mathematical models and to ident... more The objective of this work was to adjust the coefficients of six mathematical models and to identify the one that best represents the drying of flint corn grains in a thin layer. For this purpose, a drying column was developed to obtain experimental data. Nine tests were performed for each model, using the velocities of 0.5, 1.0, and 1.5 m s-1 at 40, 50, and 60°C, respectively, for drying air. The thin-layer drying models of Lewis, Page, Thompson, Overhults, Brooker, and Midilli were tested. All adjusted models represent the phenomenon of flint corn drying at 5% probability (χ2 test). After adjusted, the models of Page, Midilli, and Overhults are the best ones for drying corn, with a coefficient of determination equal to 1.000 for all tests and errors lower than 1.0%. For the drying conditions of this work, the n parameter of the model of Page does not depend on the velocity and temperature of drying air, while the k parameter depends only on air temperature, which is confirmed by t...
This article presents the methodological proposal for Synthesis Cartography, considering the dime... more This article presents the methodological proposal for Synthesis Cartography, considering the dimensions (x, y, z, t) and the vertical (taxonomic scales) and horizontal (components and geographical attributes) dimensions for the spatial representation of the urban landscape dynamics, as well as the spatialization of flood susceptibles areas from two graphic scenarios (years 1989 and 2020), as support to municipal public policies. The study adopts the Census Sector Colônia do Marçal, located in the municipality of São João del-Rei, state of Minas Gerais, Brazil as a spatial clipping.The theoretical-methodological foundation was based on research with Multicriteria Decision Analysis for the application of modeling of areas susceptible to floods and inundations. The procedures consisted of preparing thematic algebra maps and elaboration of the graphic scenario of the Synthesis Cartography, considering the environment vertical and horizontal structures in the urban landscape. The two tim...
This study presents a microstructural model applicable to additively manufactured (AM) austenitic... more This study presents a microstructural model applicable to additively manufactured (AM) austenitic SS 316L components fabricated via a direct energy deposition (DED) process. The model is primarily intended to give an understanding of the effect of microscale and mesoscale features, such as grains and melt pool sizes, on the mechanical properties of manufactured components. Based on experimental observations, initial assumptions for the numerical model regarding grain size and melt pool dimensions were considered. Experimental observations based on miniature-sized 316L stainless steel DED-fabricated samples were carried out to shed light on the deformation mechanism of FCC materials at the grain scale. Furthermore, the dependency of latent strain hardening parameters based on the Bassani–Wu hardening model for a single crystal scale is investigated, where the Voronoi tessellation method and probability theory are utilized for the definition of the grain distribution. A hierarchical p...
Variação dos parâmetros hematopoiéticos e de toxicidade do ferro como biomarcadores de previsão c... more Variação dos parâmetros hematopoiéticos e de toxicidade do ferro como biomarcadores de previsão clínica da Hemocromatose Hereditária ligada ao HFE
Uma grande evolução tecnológica ao longo dos anos permitiu que o homem utilizasse de conhecimento... more Uma grande evolução tecnológica ao longo dos anos permitiu que o homem utilizasse de conhecimentos técnicos e empíricos a seu favor, com o intuito de moldar o meio a sua volta, melhorando sua vivência, conforto, comodidade e praticidade. No âmbito dos materiais, vem sendo recorrente a maior exigência de evolução, tendo em vista atender maiores necessidades, especificações e exigências a serem cumpridas. Define-se por um material ideal aquele que atenda às necessidades do usuário, no que diz respeito a aplicabilidade e custo benéfico e do meio ambiente, no que tange a poluição, e recursos naturais. De acordo com a SIAMIG (Associação das Indústrias Sucroenergéticas de Minas Gerais), em 2021 a produção de cana-de-açúcar chegou a 70.565.766 toneladas. Diante de todo este montante produzido parte do insumo final é descartado de forma incorreta. O presente trabalho tem por objetivo apresentar uma nova metodologia de uso e aplicabilidade ao dejeto da cana a partir do desenvolvimento de um ...
O motor a combustão interna é uma máquina térmica que evoluiu no decorrer dos anos, no qual o seu... more O motor a combustão interna é uma máquina térmica que evoluiu no decorrer dos anos, no qual o seu arrefecimento é realizado pelo radiador que executa a troca de calor deste sistema. Até a década de 70 os sistemas de arrefecimento eram abertos utilizando apenas a água como fluido de arrefecimento, após este período os sistemas passaram a ser fechados permitindo aos motores operarem em temperaturas mais altas melhorando assim a sua eficiência. Portanto, nos sistemas utilizados atualmente a água não é mais um fluido de arrefecimento viável, tornando-se necessário a adição de aditivos à mesma. O presente artigo tem por objetivo demonstrar os aditivos utilizados, comparar diferentes tipos de fluidos destacando os benefícios, além de trazer metodologias testadas em laboratório. As análises experimentais foram baseadas nos testes de viscosidade e calorimetria entre três fluidos, sendo eles um aditivo concentrado à base de etilenoglicol, um fluido de arrefecimento concentrado de base polimé...
Graefe's Archive for Clinical and Experimental Ophthalmology
To assess the outcomes of vitrectomy with or without cataract surgery for the treatment of idiopa... more To assess the outcomes of vitrectomy with or without cataract surgery for the treatment of idiopathic ERM in phakic eyes and evaluate predictors of functional and anatomical outcomes. Retrospective cohort of consecutive phakic ERM eyes distributed in three groups: a) combined (phacovitrectomy) group, b) PPV-only group, and c) consecutive group (PPV followed by cataract surgery). Main outcomes were final visual acuity (VA) and cystoid macular edema (CME) occurrence. Potential predictors of VA or CME included clinical variables and SD-OCT parameters. A total of 108 eyes were included in this study. There were no differences in the final VA between consecutive and combined groups (0.22 vs 0.10 logMAR, p = 0.851). Twelve eyes from the combined group (23%) and one eye from the PPV-only group presented CME (p = 0.001). There were no differences between postoperative CME occurrence in combined versus consecutive group (12 vs 7, p = 0.38). The presence of cotton-ball sign predicted the development of CME [OR 2.86 (95%CI 1.01–8.18), p = 0.049] while separated ERM–ILM complex was found to be protective [OR 0.25 (95%CI 0.08-0.77), p = 0.015]. Functional and anatomical results of PPV with ERM and ILM peeling combined with cataract surgery was equivalent to the consecutive procedure, with both strategies being effective. Separated ERM–ILM complex has prognostic value in these patients, as its presence at baseline was found to be protective for postoperative CME.
Revista Brasileira de Gestão e Desenvolvimento Regional, Feb 7, 2018
Esta pesquisa tem como objetivo avaliar os impactos econômicos provocados pela ampliação da Unive... more Esta pesquisa tem como objetivo avaliar os impactos econômicos provocados pela ampliação da Universidade Federal Fluminense em Volta Redonda (UFF-VR). Contando atualmente com dois campi na cidade de Volta Redonda, a UFF-VR foi diretamente beneficiada pelo REUNI que ampliou em todo o país o acesso ao ensino superior em universidades públicas. A revisão da bibliografia abordou estudos sobre impacto econômico da universidade na economia local, o REUNI, o perfil socioeconômico da cidade de Volta Redonda e a evolução dos dois campi da UFF-VR. Para realização da pesquisa foram utilizados como procedimentos metodológicos: (i) levantamento (survey) com 1409 alunos das UFF-VR, visando identificar os valores gastos por estes estudantes no município de Volta Redonda (UFF-VR); (ii) mapeamento da massa salarial dos docentes e servidores da UFF-VR; (iii) identificação dos gastos de custeio e investimento destas unidades. Os resultados mais relevantes do estudo indicam que os dois campi atraem mais de 1.270 alunos de outras cidades e empregam 305
Journal Biomedical and Biopharmaceutical Research, 2013
Caracterização psicológica dos pacientes com obesidade severa, antes e depois da cirurgia bariat ... more Caracterização psicológica dos pacientes com obesidade severa, antes e depois da cirurgia bariat rica 1 2,3 1 1 1
Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering, 2020
Technological evolution impacts several industries, including automotive. The combination of soft... more Technological evolution impacts several industries, including automotive. The combination of software with advancements in sensory capabilities results in new Advanced Driver Assistance System (ADAS). The pervasiveness of smartphones and their sensory capabilities makes them an solid platform for the development of ADAS. Our work is motivated by concerns on the reliability of data acquired from such devices for developing ADAS. We performed a number of controlled experiments to understand which factors impact the collection of accelerometer data with smartphones. We conclude that the quality of data acquired is not significantly affected by using different smartphones, car mounts, rates of sampling, or vehicles for the purpose of developing ADAS. Our results indicate that smartphone sensors can be used to develop ADAS.
The increase in D applications made necessary the research and development of standards for point... more The increase in D applications made necessary the research and development of standards for point cloud compression. Since point clouds represent a signi cant amount of data, compression standards are essential to e ciently transmit and store such data [ ], [ ]. For this reason, the Moving Pictures Expert Group (MPEG) started the standardization activities of point cloud compression algorithms resulting in two standards: the Geometry-based Point Cloud Compression (G-PCC) [ ] and the Video-based Point Cloud Compression (V-PCC) [ ]. G-PCC was designed to address static point clouds, those consisting of objects and scenes, and dynamically acquired point clouds, typically obtained by LiDAR technology. In contrast, V-PCC was addressed to dynamic point clouds, those consisting of several temporal frames similar to a video sequence. desenvolvida é de nida como fragment-based multiple decision e a segunda como level-based multiple decision. Ambos os esquemas são capazes de superar o uso apenas da predição intra-quadros ao lado da RAHT para compressão de nuvens de pontos dinâmicas. O algoritmo fragment-based tem um desempenho ligeiramente melhor se comparado ao uso apenas da predição intra-quadros com ganhos Bjontegaard delta (BD) [ ] PSNR-Y médios de , dB e economia média de taxa de bits de , %. O esquema level-based foi capaz de atingir ganhos mais substanciais sobre o uso apenas da predição intra-quadros com ganhos BD PSNR-Y médios de , dB e economia média de taxa de bits de , %.
The desiccation time of high-biomass pasture and nitrogen (N) fertilization of pasture and soybea... more The desiccation time of high-biomass pasture and nitrogen (N) fertilization of pasture and soybean can influence the soybean sowing, establishment and growth. The objective of this study was to evaluate how the time of desiccation of the preceding pasture of Urochloa brizantha cv. BRS Piatã, cultivated at three levels of N, and by the soybean N fertilization affect soybean growth and N accumulation. Three N rates (0; 150 and 300 kg ha-1), broadcast as urea on the U. brizantha pasture were evaluated separately in each N level, every one considered as one experiment. In each experiment, five times of pasture desiccation were evaluated (60; 45; 30; 15, and 1 day before soybean sowing) and two levels of soybean N fertilization: 30 kg ha-1 (urea) broadcast at sowing or without N fertilization. A randomized complete block design with five replications was used. Early desiccation of U. brizantha pasture favors the establishment of soybean and promotes an increase in biomass and N accumulat...
Revista Brasileira de Terapia Comportamental e Cognitiva
A corrupção tem sido objeto de estudo em diversas pesquisas, mas apenas recentemente tem sido inv... more A corrupção tem sido objeto de estudo em diversas pesquisas, mas apenas recentemente tem sido investigada experimentalmente. Uma maneira de estudar tal fenómeno é expor os participantes a um Jogo dos Bens Públicos (JBP) no qual eles precisam contribuir para produzir um bem público específico, e então precisam tomar decisões sobre como tal bem seria distribuído entre os demais participantes. Um participante que fizer distribuições desiguais beneficiando a si estaría se comportando de maneira análoga ao que é descrito pelo crime de peculato. O objetivo do presente estudo foi investigar como os participantes distribuiram recursos públicos no JBP. Seis participantes foram expostos ao procedimento. Cinco deles fizeram distribuições desiguais, isto é, alocaram a maior parte dos recursos para si mesmo. A partir destes resultados, sugerimos mudanças nas contingencias que controlam a ocorrência deste tipo de comportamento.
2009 Twenty-Fourth Annual IEEE Applied Power Electronics Conference and Exposition
Hybrid energy storage systems have been investigated with the objective of improving the storage ... more Hybrid energy storage systems have been investigated with the objective of improving the storage of electrical energy. In these systems, two (or more) energy sources work together to create a superior device in comparison with a single source. In particular, batteries and ultracapacitors have complementary characteristics that make them attractive for a hybrid energy storage system. But the result of
Introduction/Background Patients with low-risk gestational trophoblastic neoplasia (GTN) are almo... more Introduction/Background Patients with low-risk gestational trophoblastic neoplasia (GTN) are almost universally cured with chemotherapy, but second uterine curettage has been explored as an alternative to avoid chemotherapy-related toxicities. We systematically reviewed intervention studies to determine whether second curettage in patients with low-risk GTN affects: 1) the proportion of patients requiring chemotherapy; 2) the number of chemotherapy cycles; and 3) the need for multi-agent chemotherapy. Methodology A literature search was performed including the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and Web of Science. Two authors screened titles, abstracts, and full texts and abstracted data. Risk of bias was assessed for each outcome. Data were pooled using a randomeffects model and assessed for heterogeneity. Quality of evidence was assigned using GRADE. Results Six studies met inclusion criteria; 2 randomized studies (RCT) and 4 cohort studies with control arm (CS). Mean difference in number of chemotherapy cycles was 2.04 fewer in patients who underwent second curettage (95% CI-5.00 to 0.91) based on two pooled RCTs (N=138). Those who underwent second curettage had RR=0.60 (95% CI 0.31 to 1.18) for requiring chemotherapy based on 4 pooled CS (N=1105), and RR=1.17 (95% CI 0.76 to 1.80) for multi-agent chemotherapy based on two pooled CS (N=900). The certainty of evidence is very low due to risk of bias for potential confounding, selection bias, missing data, and inconsistency of the results.
Background Diabetes mellitus (DM) is a prognostic factor for some malignancies, but its clinical ... more Background Diabetes mellitus (DM) is a prognostic factor for some malignancies, but its clinical implications in metastatic colorectal cancer (mCRC) patients are less clear. Therefore, we conducted a retrospective study to evaluate the impact of pre-existing type 2 diabetes mellitus (T2DM) on the survival outcomes of patients with newly diagnosed mCRC. Methodology We retrospectively included patients with newly diagnosed mCRC between January 2017 and June 2021 and with pre-existing T2DM. Data on the characteristics of patients, clinicopathological features, and drug exposure were collected from the electronic medical records. The primary endpoint was overall survival (OS). Secondary endpoints were progression-free survival (PFS) and treatment-related adverse events (TRAEs). Results Among 187 mCRC patients, 54 (28.8%) had T2DM. The median follow-up was 25 months. We observed 150 OS events and 168 PFS events. Diabetes significantly and negatively impacted PFS and OS. The median for PFS (mPFS) was eight and 16 months for T2DM and no T2DM patients, respectively (p < 0.0001; log-rank test). The median overall survival (mOS) was 15 and 29 months for T2DM and no T2DM patients, respectively (p < 0.0001; log-rank test). Patients with diabetes were more often overweight or obese (59.3% vs. 24.8%; p < 0.01) and had a poorer performance status (53.7% vs. 21.1% with Eastern Cooperative Oncology Group Performance Status 1; p < 0.01). Additionally, T2DM patients had more high-risk pathological features, including G3 grading tumors (27.7% vs. 12.0%; p = 0.01), lymph node involvement (p < 0.01), BRAF-mutated (35.1% vs. 6.8%; p < 0.01), and right-sided CRC (63.0% vs. 30.1%; p < 0.01). We found no statistically significant differences in TRAEs. Nevertheless, a significantly higher rate of grade 2-4 peripheral neuropathy (22.2% vs. 5.3%; p < 0.01) was reported in T2DM patients. Conclusions T2DM is a negative prognostic factor for survival in mCRC. The paper provides empirical evidence in favor of the joint control of both pathologies. Further research is needed to establish the robustness of our results.
Purpose Amblyopia is a leading cause of preventable and treatable vision loss in the pediatric po... more Purpose Amblyopia is a leading cause of preventable and treatable vision loss in the pediatric population. Instrument-based screening of amblyopia-risk factors is being widely adopted but the audit of its results is still lacking. We sought to review the existing evidence regarding the outcomes of photoscreening applied to children under the age of three years. Methods A three-database search (Pubmed, ISI Web of Science, and Scopus) was performed from inception to March 2021. A meta-analysis of proportions was conducted to summarize the referral rate, untestable rate and positive predictive value (PPV). Results Thirteen studies were selected among 705 original abstracts. The quantitative analysis included twelve studies enrolling 64,041 children. Of these, 13% (95%CI: 7–19%) were referred for further confirmation of the screening result. Astigmatism was the most common diagnosis both after screening and after ophthalmologic assessment of referred children. The pooled untestable rate...
Melanoma is a malignancy of melanocytes, melanin-producing cells in the basal layer of the epider... more Melanoma is a malignancy of melanocytes, melanin-producing cells in the basal layer of the epidermis. Despite representing only 1% of skin cancers, melanoma is responsible for over 80% of skin cancer deaths. Treatment with immune checkpoint inhibitors (ICIs) that target the programmed death 1 (PD-1) protein and the cytotoxic T-lymphocyte antigen 4 (CTLA-4) pathways drastically transformed the management of patients with advanced melanoma. Before the introduction of ICIs, the average life expectancy for a patient with advanced melanoma ranged from six to 12 months, and now, this average survival has increased to over six years. However, despite this outstanding clinical success, most patients with advanced melanoma treated with ICIs will experience disease progression, immediately or after an initial response to treatment. Nowadays, some studies have looked at the mechanism behind the resistance to immunotherapy, with the aim of developing new treatments to overcome it. Emerging data suggest that gut microbiota (GM) influences response to immunotherapy. Importantly, unlike tumor genomics, the GM is changeable; thus, modulation of the GM is an attractive approach to overcome immunotherapy resistance. One of these approaches is the fecal microbiota transplant (FMT), which consists of the exchange of manipulated feces from a donor to a recipient who has a disorder related to intestinal dysbiosis to directly change the recipient's gut microbial composition and confer a health benefit. This review pretends to discuss the clinical benefit of FMT in the treatment of immunotherapy-resistant melanoma and potential adverse effects, including recent and ongoing clinical trials.
The objective of this work was to adjust the coefficients of six mathematical models and to ident... more The objective of this work was to adjust the coefficients of six mathematical models and to identify the one that best represents the drying of flint corn grains in a thin layer. For this purpose, a drying column was developed to obtain experimental data. Nine tests were performed for each model, using the velocities of 0.5, 1.0, and 1.5 m s-1 at 40, 50, and 60°C, respectively, for drying air. The thin-layer drying models of Lewis, Page, Thompson, Overhults, Brooker, and Midilli were tested. All adjusted models represent the phenomenon of flint corn drying at 5% probability (χ2 test). After adjusted, the models of Page, Midilli, and Overhults are the best ones for drying corn, with a coefficient of determination equal to 1.000 for all tests and errors lower than 1.0%. For the drying conditions of this work, the n parameter of the model of Page does not depend on the velocity and temperature of drying air, while the k parameter depends only on air temperature, which is confirmed by t...
This article presents the methodological proposal for Synthesis Cartography, considering the dime... more This article presents the methodological proposal for Synthesis Cartography, considering the dimensions (x, y, z, t) and the vertical (taxonomic scales) and horizontal (components and geographical attributes) dimensions for the spatial representation of the urban landscape dynamics, as well as the spatialization of flood susceptibles areas from two graphic scenarios (years 1989 and 2020), as support to municipal public policies. The study adopts the Census Sector Colônia do Marçal, located in the municipality of São João del-Rei, state of Minas Gerais, Brazil as a spatial clipping.The theoretical-methodological foundation was based on research with Multicriteria Decision Analysis for the application of modeling of areas susceptible to floods and inundations. The procedures consisted of preparing thematic algebra maps and elaboration of the graphic scenario of the Synthesis Cartography, considering the environment vertical and horizontal structures in the urban landscape. The two tim...
This study presents a microstructural model applicable to additively manufactured (AM) austenitic... more This study presents a microstructural model applicable to additively manufactured (AM) austenitic SS 316L components fabricated via a direct energy deposition (DED) process. The model is primarily intended to give an understanding of the effect of microscale and mesoscale features, such as grains and melt pool sizes, on the mechanical properties of manufactured components. Based on experimental observations, initial assumptions for the numerical model regarding grain size and melt pool dimensions were considered. Experimental observations based on miniature-sized 316L stainless steel DED-fabricated samples were carried out to shed light on the deformation mechanism of FCC materials at the grain scale. Furthermore, the dependency of latent strain hardening parameters based on the Bassani–Wu hardening model for a single crystal scale is investigated, where the Voronoi tessellation method and probability theory are utilized for the definition of the grain distribution. A hierarchical p...
Variação dos parâmetros hematopoiéticos e de toxicidade do ferro como biomarcadores de previsão c... more Variação dos parâmetros hematopoiéticos e de toxicidade do ferro como biomarcadores de previsão clínica da Hemocromatose Hereditária ligada ao HFE
Uma grande evolução tecnológica ao longo dos anos permitiu que o homem utilizasse de conhecimento... more Uma grande evolução tecnológica ao longo dos anos permitiu que o homem utilizasse de conhecimentos técnicos e empíricos a seu favor, com o intuito de moldar o meio a sua volta, melhorando sua vivência, conforto, comodidade e praticidade. No âmbito dos materiais, vem sendo recorrente a maior exigência de evolução, tendo em vista atender maiores necessidades, especificações e exigências a serem cumpridas. Define-se por um material ideal aquele que atenda às necessidades do usuário, no que diz respeito a aplicabilidade e custo benéfico e do meio ambiente, no que tange a poluição, e recursos naturais. De acordo com a SIAMIG (Associação das Indústrias Sucroenergéticas de Minas Gerais), em 2021 a produção de cana-de-açúcar chegou a 70.565.766 toneladas. Diante de todo este montante produzido parte do insumo final é descartado de forma incorreta. O presente trabalho tem por objetivo apresentar uma nova metodologia de uso e aplicabilidade ao dejeto da cana a partir do desenvolvimento de um ...
O motor a combustão interna é uma máquina térmica que evoluiu no decorrer dos anos, no qual o seu... more O motor a combustão interna é uma máquina térmica que evoluiu no decorrer dos anos, no qual o seu arrefecimento é realizado pelo radiador que executa a troca de calor deste sistema. Até a década de 70 os sistemas de arrefecimento eram abertos utilizando apenas a água como fluido de arrefecimento, após este período os sistemas passaram a ser fechados permitindo aos motores operarem em temperaturas mais altas melhorando assim a sua eficiência. Portanto, nos sistemas utilizados atualmente a água não é mais um fluido de arrefecimento viável, tornando-se necessário a adição de aditivos à mesma. O presente artigo tem por objetivo demonstrar os aditivos utilizados, comparar diferentes tipos de fluidos destacando os benefícios, além de trazer metodologias testadas em laboratório. As análises experimentais foram baseadas nos testes de viscosidade e calorimetria entre três fluidos, sendo eles um aditivo concentrado à base de etilenoglicol, um fluido de arrefecimento concentrado de base polimé...
Graefe's Archive for Clinical and Experimental Ophthalmology
To assess the outcomes of vitrectomy with or without cataract surgery for the treatment of idiopa... more To assess the outcomes of vitrectomy with or without cataract surgery for the treatment of idiopathic ERM in phakic eyes and evaluate predictors of functional and anatomical outcomes. Retrospective cohort of consecutive phakic ERM eyes distributed in three groups: a) combined (phacovitrectomy) group, b) PPV-only group, and c) consecutive group (PPV followed by cataract surgery). Main outcomes were final visual acuity (VA) and cystoid macular edema (CME) occurrence. Potential predictors of VA or CME included clinical variables and SD-OCT parameters. A total of 108 eyes were included in this study. There were no differences in the final VA between consecutive and combined groups (0.22 vs 0.10 logMAR, p = 0.851). Twelve eyes from the combined group (23%) and one eye from the PPV-only group presented CME (p = 0.001). There were no differences between postoperative CME occurrence in combined versus consecutive group (12 vs 7, p = 0.38). The presence of cotton-ball sign predicted the development of CME [OR 2.86 (95%CI 1.01–8.18), p = 0.049] while separated ERM–ILM complex was found to be protective [OR 0.25 (95%CI 0.08-0.77), p = 0.015]. Functional and anatomical results of PPV with ERM and ILM peeling combined with cataract surgery was equivalent to the consecutive procedure, with both strategies being effective. Separated ERM–ILM complex has prognostic value in these patients, as its presence at baseline was found to be protective for postoperative CME.
Revista Brasileira de Gestão e Desenvolvimento Regional, Feb 7, 2018
Esta pesquisa tem como objetivo avaliar os impactos econômicos provocados pela ampliação da Unive... more Esta pesquisa tem como objetivo avaliar os impactos econômicos provocados pela ampliação da Universidade Federal Fluminense em Volta Redonda (UFF-VR). Contando atualmente com dois campi na cidade de Volta Redonda, a UFF-VR foi diretamente beneficiada pelo REUNI que ampliou em todo o país o acesso ao ensino superior em universidades públicas. A revisão da bibliografia abordou estudos sobre impacto econômico da universidade na economia local, o REUNI, o perfil socioeconômico da cidade de Volta Redonda e a evolução dos dois campi da UFF-VR. Para realização da pesquisa foram utilizados como procedimentos metodológicos: (i) levantamento (survey) com 1409 alunos das UFF-VR, visando identificar os valores gastos por estes estudantes no município de Volta Redonda (UFF-VR); (ii) mapeamento da massa salarial dos docentes e servidores da UFF-VR; (iii) identificação dos gastos de custeio e investimento destas unidades. Os resultados mais relevantes do estudo indicam que os dois campi atraem mais de 1.270 alunos de outras cidades e empregam 305
Journal Biomedical and Biopharmaceutical Research, 2013
Caracterização psicológica dos pacientes com obesidade severa, antes e depois da cirurgia bariat ... more Caracterização psicológica dos pacientes com obesidade severa, antes e depois da cirurgia bariat rica 1 2,3 1 1 1
Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering, 2020
Technological evolution impacts several industries, including automotive. The combination of soft... more Technological evolution impacts several industries, including automotive. The combination of software with advancements in sensory capabilities results in new Advanced Driver Assistance System (ADAS). The pervasiveness of smartphones and their sensory capabilities makes them an solid platform for the development of ADAS. Our work is motivated by concerns on the reliability of data acquired from such devices for developing ADAS. We performed a number of controlled experiments to understand which factors impact the collection of accelerometer data with smartphones. We conclude that the quality of data acquired is not significantly affected by using different smartphones, car mounts, rates of sampling, or vehicles for the purpose of developing ADAS. Our results indicate that smartphone sensors can be used to develop ADAS.
The increase in D applications made necessary the research and development of standards for point... more The increase in D applications made necessary the research and development of standards for point cloud compression. Since point clouds represent a signi cant amount of data, compression standards are essential to e ciently transmit and store such data [ ], [ ]. For this reason, the Moving Pictures Expert Group (MPEG) started the standardization activities of point cloud compression algorithms resulting in two standards: the Geometry-based Point Cloud Compression (G-PCC) [ ] and the Video-based Point Cloud Compression (V-PCC) [ ]. G-PCC was designed to address static point clouds, those consisting of objects and scenes, and dynamically acquired point clouds, typically obtained by LiDAR technology. In contrast, V-PCC was addressed to dynamic point clouds, those consisting of several temporal frames similar to a video sequence. desenvolvida é de nida como fragment-based multiple decision e a segunda como level-based multiple decision. Ambos os esquemas são capazes de superar o uso apenas da predição intra-quadros ao lado da RAHT para compressão de nuvens de pontos dinâmicas. O algoritmo fragment-based tem um desempenho ligeiramente melhor se comparado ao uso apenas da predição intra-quadros com ganhos Bjontegaard delta (BD) [ ] PSNR-Y médios de , dB e economia média de taxa de bits de , %. O esquema level-based foi capaz de atingir ganhos mais substanciais sobre o uso apenas da predição intra-quadros com ganhos BD PSNR-Y médios de , dB e economia média de taxa de bits de , %.
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