perceived by each group. The purpose of this study is to compare doctor and patient perceptions o... more perceived by each group. The purpose of this study is to compare doctor and patient perceptions of the same after hours telephone conversations. Methods: Patient-initiated, after hours telephone calls to a university based fellowship program during a 4-month period were included. Each month was covered by one of four 2nd year fellows. Information was recorded about the call. Immediately after the call, the fellow answered a 6 question survey. Within one week, the patient was called and a similar survey was administered. Only calls that had both doctor and patient surveys completed were included in this study. The surveys used a 5-point Likert scale (1-not at all, to 5-very). Ratings for points 1, 2 and 3 were combined and compared to the sum of ratings for points 4 and 5, using McNemars test. The surveys addressed the 1) Seriousness of the problem 2) Disability of the patient 3) Reasonableness of the request 4) Helpfulness of the doctor 5) Satisfaction with the recommendations and 5) Likeability of the doctor/patient. Results: There were 104 patient telephone calls assessed. Mean age of patients was 42 (range 17-85). Patients were 69% female, 83% European American, 11% African American and 6% other.
VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy, 2018
These articles are available on the VideoGIE website by clicking on the "Articles in Press" tab. ... more These articles are available on the VideoGIE website by clicking on the "Articles in Press" tab. Articles in Press represent the final edited text of articles that are accepted for publication but not yet scheduled to appear in a specific issue. They are considered officially published as of the date of Web publication, which means readers can access the information and authors can cite the research months prior to its availability in an issue. To cite Articles in Press, include the journal title, year, and the article's Digital Object Identifier (DOI), located in the article footnote. Visit the website today to stay current on the latest research in the field of gastrointestinal endoscopy.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, Jan 15, 2018
There have been few studies of abdominal imaging screening of individuals at high risk for pancre... more There have been few studies of abdominal imaging screening of individuals at high risk for pancreatic cancer (based on family history or genetic variants). We performed a meta-analysis of prospective cohort studies to determine the diagnostic yield and outcomes of abdominal imaging screening for asymptomatic individuals at high risk. Through a systematic review of multiple electronic databases and conference proceedings through July 2017, we identified prospective cohort studies (>20 patients) of asymptomatic adults determined to be at high-risk of pancreatic cancer (lifetime risk >5%, including specific genetic-associated conditions) who were screened by endoscopic ultrasound (EUS) and/or magnetic resonance imaging (MRI) to detect pancreatic lesions. Our primary outcome was identification of high-risk pancreatic lesions (high-grade pancreatic intraepithelial neoplasia, high-grade dysplasia, or adenocarcinoma) at initial screening, and overall incidence during follow up. Summa...
Unresectable malignant biliary strictures are generally managed by palliative stent placement for... more Unresectable malignant biliary strictures are generally managed by palliative stent placement for drainage of biliary tree. Recently, radiofrequency ablation (RFA) has been used to improve the patency of biliary stents in these patients. Several studies have evaluated the effectiveness of biliary stent placement with RFA on stent patency and patient survival with variable results. We performed this meta-analysis to evaluate the efficacy and safety of biliary stent placement with RFA compared with stent placement alone in patients with malignant biliary strictures. We performed a comprehensive search of electronic databases for all the studies comparing RFA with biliary stent placement versus stent placement-only. Measured outcomes included patient survival, stent patency and procedure-related adverse events. Inverse variance method was used to pool data on stent patency into random-effects model. Cox-regression analysis was used to calculate Hazard ratio (HR) for survival analysis. ...
Conflicting data exist with regard to recurrence rates of intestinal metaplasia (IM) and dysplas... more Conflicting data exist with regard to recurrence rates of intestinal metaplasia (IM) and dysplasia after achieving complete eradication of intestinal metaplasia (CE-IM) in Barrett's esophagus (BE) patients. (i) To determine the incidence of recurrent IM and dysplasia achieving CE-IM and (ii) to compare recurrence rates between treatment modalities [radiofrequency ablation (RFA) with or without endoscopic mucosal resection (EMR) vs stepwise complete EMR (SRER)]. A systematic search was performed for studies reporting on outcomes and estimates of recurrence rates after achieving CE-IM. Pooled incidence [per 100-patient-years (PY)] and risk ratios with 95 %CI were obtained. Heterogeneity was measured using the I(2) statistic. Subgroup analyses, decided a priori, were performed to explore heterogeneity in results. A total of 39 studies were identified (25-RFA, 13-SRER, and 2 combined). The pooled incidence of any recurrence was 7.5 (95 %CI 6.1 - 9.0)/100 PY with a pooled inciden...
Study aims The goal of our study was to determine the current trends for inpatient utilization fo... more Study aims The goal of our study was to determine the current trends for inpatient utilization for endoscopic retrograde cholangiopancreatography (ERCP) and its economic impact in the United States between 2002 and 2013. Patients and methods A Nationwide Inpatient Sample from 2002 through 2013 was examined. We identified ERCPs using International Classification of Diseases (ICD-9) codes; Procedure codes 51.10, 51.11, 52.13, 51.14, 51.15, 52.14 and 52.92 for diagnostic and 51.84, 51.86, 52.97 were studied. Rate of inpatient ERCP was calculated. The trends for therapeutic ERCPs were compared to the diagnostic ones. We analyzed patient and hospital characteristics, length of hospital stay, and cost of care after adjusting for weighted samples. We used the Cochran-Armitage test for categorical variables and linear regression for continuous variables. Results A total of 411,409 ERCPs were performed from 2002 to 2013. The mean age was 59 ± 19 years; 61 % were female and 57 % were white. T...
Sarcoidosis is a multisystem granulomatous syndrome of unknown etiology with noncaseating epithel... more Sarcoidosis is a multisystem granulomatous syndrome of unknown etiology with noncaseating epithelioid granulomas being the pathognomonic pathological finding. Sarcoidosis most commonly involves the lungs and involvement of the gastrointestinal (GI) tract is uncommon. Pancreatic sarcoidosis is very rare, especially when it is the presenting feature of sarcoidosis and can masquerade as pancreatic cancer. Tissue infiltration in pancreatic sarcoidosis can lead to either a diffuse nodular appearance or a mass-like lesion. We present an interesting case of a 47-year-old woman with a 10-pack-year history of smoking who presented with sharp epigastric pain, weight loss, and elevated lipase level. CT and MRI imaging showed a 4 cm × 5 cm heterogeneous pancreatic mass with a dilated pancreatic duct and peripancreatic lymphadenopathy. Endoscopic ultrasound guided FNA revealed noncaseating granulomas with no evidence of malignancy or atypical infection. CT of the chest revealed bilateral mediast...
A 56-year-old man initially presented for evaluation of iron deficiency anemia. Further evaluatio... more A 56-year-old man initially presented for evaluation of iron deficiency anemia. Further evaluation with esophagogastroduodenoscopy (EGD) and colonoscopy revealed a large, benign-appearing mass in the duodenum (Figure 1). Subsequent endoscopic ultrasound (EUS) revealed a 3 x 4-cm subepithelial mass arising from the submucosa with numerous cystic spaces and mixed echogenicity (Figure 2).
EUS-guided decompression of a large mucinous cyst through an electrocautery-enhanced lumen-apposi... more EUS-guided decompression of a large mucinous cyst through an electrocautery-enhanced lumen-apposing metal stent A 94-year-old woman presented with a 2-month history of dysphagia to solids and a 6.8-kg weight loss. EGD revealed extrinsic compression of the cardia of the stomach (Fig. 1A). Anteroposterior CT demonstrated a large cystic lesion arising from the body of the pancreas, causing extrinsic compression on the stomach (Fig. 1B). EUS with
Antegrade cholangiogram via cholecystoduodenostomy in biliary pancreatitis Figure 1. A, EUS showi... more Antegrade cholangiogram via cholecystoduodenostomy in biliary pancreatitis Figure 1. A, EUS showing gallbladder wall thickening, with common bile duct dilatation and sludge (arrow). B, Endoscopic view of cholecystoduodenostomy via lumen-apposing metal stent. C, Presence of a large periampullary diverticulum leading to failure of location of the papillary orifice and unsuccessful ERCP. D, Antegrade cholangiogram with contrast medium filling the bile duct. E, Expression of contrast medium from papillary orifice.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, Jan 23, 2016
It is not clear exactly how many passes are required to determine whether pancreatic masses are m... more It is not clear exactly how many passes are required to determine whether pancreatic masses are malignant using endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). We aimed to define the per-pass diagnostic yield of EUS-FNA for establishing the malignancy of a pancreatic mass, and identify factors associated with detection of malignancies. In a prospective study, 239 patients with solid pancreatic masses were randomly assigned to groups that underwent EUS-FNA, with the number of passes determined by an on-site cytopathology evaluation or set at 7 passes, at 3 tertiary referral centers. A final diagnosis of pancreatic malignancy was made based on findings from cytology, surgery, or a follow-up evaluation at least 1 year after EUS-FNA. The cumulative sensitivity of detection of malignancy by EUS-FNA was calculated after each pass; in the primary analysis, lesions categorized as malignant or suspicious were considered as positive findings. Pancreatic malignancies were found ...
Background Peptic ulcer disease (PUD) is a major public health burden significantly impacting the... more Background Peptic ulcer disease (PUD) is a major public health burden significantly impacting the cost of hospitalization in the United States (US). We examined the trends, characteristics, complications, cost, and seasonality of PUD-related hospitalizations from 2000 to 2011. Methods With the use of the Nationwide Inpatient Sample from 2000 through 2011, we identified PUD-related hospitalizations using the International Classification of Diseases (ICD-9), 9th Revision, and the Clinical Modification code 531.00 to 534.91 as the principal discharge diagnosis. The total number of hospitalizations for each calendar month of the year were added over a 12-year period, and this number was divided by the number of days in that particular month to obtain the mean hospitalizations per day for each month. Results The study found that 351,921 hospitalizations with the primary discharge diagnosis of peptic ulcer disease (PUD) occurred in the US between 2000 and 2011. This number dropped significantly from 49,524 to 17,499 between 2000 and 2011, and the rate of PUD-related mortality decreased from 4.3% to 3.1%. The mean age of the study population was 66.2 ± 17.4 years; 52.3% were males, and 56.8% were white. The number of hospitalizations in the US peaked in the spring season (916/day), and reached a nadir in the fall season
perceived by each group. The purpose of this study is to compare doctor and patient perceptions o... more perceived by each group. The purpose of this study is to compare doctor and patient perceptions of the same after hours telephone conversations. Methods: Patient-initiated, after hours telephone calls to a university based fellowship program during a 4-month period were included. Each month was covered by one of four 2nd year fellows. Information was recorded about the call. Immediately after the call, the fellow answered a 6 question survey. Within one week, the patient was called and a similar survey was administered. Only calls that had both doctor and patient surveys completed were included in this study. The surveys used a 5-point Likert scale (1-not at all, to 5-very). Ratings for points 1, 2 and 3 were combined and compared to the sum of ratings for points 4 and 5, using McNemars test. The surveys addressed the 1) Seriousness of the problem 2) Disability of the patient 3) Reasonableness of the request 4) Helpfulness of the doctor 5) Satisfaction with the recommendations and 5) Likeability of the doctor/patient. Results: There were 104 patient telephone calls assessed. Mean age of patients was 42 (range 17-85). Patients were 69% female, 83% European American, 11% African American and 6% other.
Aadam A Aziz et al. EUS FNA and FNB for pancreatic/non-pancreatic masses … Endoscopy Internationa... more Aadam A Aziz et al. EUS FNA and FNB for pancreatic/non-pancreatic masses … Endoscopy International Open 2016; 04: E497-E505 This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.
Rates of progression to esophageal adenocarcinoma in subjects with Barrett's esophagus (BE) a... more Rates of progression to esophageal adenocarcinoma in subjects with Barrett's esophagus (BE) are lower than previously estimated. Identification of predictors of progression will enable risk stratification of BE subjects, potentially making current surveillance programs more efficient. We aimed to assess the potential of demographic and lifestyle factors, obesity and medications in predicting progression in BE. BE subjects were identified from the General Practice Research Database using validated diagnostic codes. BE subjects developing esophageal cancer (EC) 12 months after their index BE diagnosis were defined as progressors. Time to event analysis was used to assess the overall risk of progression to EC. Cox proportional hazards models and time varying marginal structural models were used to assess predictors of progression. 9,660 BE patients were included in the analysis. The mean age (SD) of the study subjects was 63 (13.5) years. 62.6 % were males. 103 subjects (1.1%) prog...
perceived by each group. The purpose of this study is to compare doctor and patient perceptions o... more perceived by each group. The purpose of this study is to compare doctor and patient perceptions of the same after hours telephone conversations. Methods: Patient-initiated, after hours telephone calls to a university based fellowship program during a 4-month period were included. Each month was covered by one of four 2nd year fellows. Information was recorded about the call. Immediately after the call, the fellow answered a 6 question survey. Within one week, the patient was called and a similar survey was administered. Only calls that had both doctor and patient surveys completed were included in this study. The surveys used a 5-point Likert scale (1-not at all, to 5-very). Ratings for points 1, 2 and 3 were combined and compared to the sum of ratings for points 4 and 5, using McNemars test. The surveys addressed the 1) Seriousness of the problem 2) Disability of the patient 3) Reasonableness of the request 4) Helpfulness of the doctor 5) Satisfaction with the recommendations and 5) Likeability of the doctor/patient. Results: There were 104 patient telephone calls assessed. Mean age of patients was 42 (range 17-85). Patients were 69% female, 83% European American, 11% African American and 6% other.
VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy, 2018
These articles are available on the VideoGIE website by clicking on the "Articles in Press" tab. ... more These articles are available on the VideoGIE website by clicking on the "Articles in Press" tab. Articles in Press represent the final edited text of articles that are accepted for publication but not yet scheduled to appear in a specific issue. They are considered officially published as of the date of Web publication, which means readers can access the information and authors can cite the research months prior to its availability in an issue. To cite Articles in Press, include the journal title, year, and the article's Digital Object Identifier (DOI), located in the article footnote. Visit the website today to stay current on the latest research in the field of gastrointestinal endoscopy.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, Jan 15, 2018
There have been few studies of abdominal imaging screening of individuals at high risk for pancre... more There have been few studies of abdominal imaging screening of individuals at high risk for pancreatic cancer (based on family history or genetic variants). We performed a meta-analysis of prospective cohort studies to determine the diagnostic yield and outcomes of abdominal imaging screening for asymptomatic individuals at high risk. Through a systematic review of multiple electronic databases and conference proceedings through July 2017, we identified prospective cohort studies (>20 patients) of asymptomatic adults determined to be at high-risk of pancreatic cancer (lifetime risk >5%, including specific genetic-associated conditions) who were screened by endoscopic ultrasound (EUS) and/or magnetic resonance imaging (MRI) to detect pancreatic lesions. Our primary outcome was identification of high-risk pancreatic lesions (high-grade pancreatic intraepithelial neoplasia, high-grade dysplasia, or adenocarcinoma) at initial screening, and overall incidence during follow up. Summa...
Unresectable malignant biliary strictures are generally managed by palliative stent placement for... more Unresectable malignant biliary strictures are generally managed by palliative stent placement for drainage of biliary tree. Recently, radiofrequency ablation (RFA) has been used to improve the patency of biliary stents in these patients. Several studies have evaluated the effectiveness of biliary stent placement with RFA on stent patency and patient survival with variable results. We performed this meta-analysis to evaluate the efficacy and safety of biliary stent placement with RFA compared with stent placement alone in patients with malignant biliary strictures. We performed a comprehensive search of electronic databases for all the studies comparing RFA with biliary stent placement versus stent placement-only. Measured outcomes included patient survival, stent patency and procedure-related adverse events. Inverse variance method was used to pool data on stent patency into random-effects model. Cox-regression analysis was used to calculate Hazard ratio (HR) for survival analysis. ...
Conflicting data exist with regard to recurrence rates of intestinal metaplasia (IM) and dysplas... more Conflicting data exist with regard to recurrence rates of intestinal metaplasia (IM) and dysplasia after achieving complete eradication of intestinal metaplasia (CE-IM) in Barrett's esophagus (BE) patients. (i) To determine the incidence of recurrent IM and dysplasia achieving CE-IM and (ii) to compare recurrence rates between treatment modalities [radiofrequency ablation (RFA) with or without endoscopic mucosal resection (EMR) vs stepwise complete EMR (SRER)]. A systematic search was performed for studies reporting on outcomes and estimates of recurrence rates after achieving CE-IM. Pooled incidence [per 100-patient-years (PY)] and risk ratios with 95 %CI were obtained. Heterogeneity was measured using the I(2) statistic. Subgroup analyses, decided a priori, were performed to explore heterogeneity in results. A total of 39 studies were identified (25-RFA, 13-SRER, and 2 combined). The pooled incidence of any recurrence was 7.5 (95 %CI 6.1 - 9.0)/100 PY with a pooled inciden...
Study aims The goal of our study was to determine the current trends for inpatient utilization fo... more Study aims The goal of our study was to determine the current trends for inpatient utilization for endoscopic retrograde cholangiopancreatography (ERCP) and its economic impact in the United States between 2002 and 2013. Patients and methods A Nationwide Inpatient Sample from 2002 through 2013 was examined. We identified ERCPs using International Classification of Diseases (ICD-9) codes; Procedure codes 51.10, 51.11, 52.13, 51.14, 51.15, 52.14 and 52.92 for diagnostic and 51.84, 51.86, 52.97 were studied. Rate of inpatient ERCP was calculated. The trends for therapeutic ERCPs were compared to the diagnostic ones. We analyzed patient and hospital characteristics, length of hospital stay, and cost of care after adjusting for weighted samples. We used the Cochran-Armitage test for categorical variables and linear regression for continuous variables. Results A total of 411,409 ERCPs were performed from 2002 to 2013. The mean age was 59 ± 19 years; 61 % were female and 57 % were white. T...
Sarcoidosis is a multisystem granulomatous syndrome of unknown etiology with noncaseating epithel... more Sarcoidosis is a multisystem granulomatous syndrome of unknown etiology with noncaseating epithelioid granulomas being the pathognomonic pathological finding. Sarcoidosis most commonly involves the lungs and involvement of the gastrointestinal (GI) tract is uncommon. Pancreatic sarcoidosis is very rare, especially when it is the presenting feature of sarcoidosis and can masquerade as pancreatic cancer. Tissue infiltration in pancreatic sarcoidosis can lead to either a diffuse nodular appearance or a mass-like lesion. We present an interesting case of a 47-year-old woman with a 10-pack-year history of smoking who presented with sharp epigastric pain, weight loss, and elevated lipase level. CT and MRI imaging showed a 4 cm × 5 cm heterogeneous pancreatic mass with a dilated pancreatic duct and peripancreatic lymphadenopathy. Endoscopic ultrasound guided FNA revealed noncaseating granulomas with no evidence of malignancy or atypical infection. CT of the chest revealed bilateral mediast...
A 56-year-old man initially presented for evaluation of iron deficiency anemia. Further evaluatio... more A 56-year-old man initially presented for evaluation of iron deficiency anemia. Further evaluation with esophagogastroduodenoscopy (EGD) and colonoscopy revealed a large, benign-appearing mass in the duodenum (Figure 1). Subsequent endoscopic ultrasound (EUS) revealed a 3 x 4-cm subepithelial mass arising from the submucosa with numerous cystic spaces and mixed echogenicity (Figure 2).
EUS-guided decompression of a large mucinous cyst through an electrocautery-enhanced lumen-apposi... more EUS-guided decompression of a large mucinous cyst through an electrocautery-enhanced lumen-apposing metal stent A 94-year-old woman presented with a 2-month history of dysphagia to solids and a 6.8-kg weight loss. EGD revealed extrinsic compression of the cardia of the stomach (Fig. 1A). Anteroposterior CT demonstrated a large cystic lesion arising from the body of the pancreas, causing extrinsic compression on the stomach (Fig. 1B). EUS with
Antegrade cholangiogram via cholecystoduodenostomy in biliary pancreatitis Figure 1. A, EUS showi... more Antegrade cholangiogram via cholecystoduodenostomy in biliary pancreatitis Figure 1. A, EUS showing gallbladder wall thickening, with common bile duct dilatation and sludge (arrow). B, Endoscopic view of cholecystoduodenostomy via lumen-apposing metal stent. C, Presence of a large periampullary diverticulum leading to failure of location of the papillary orifice and unsuccessful ERCP. D, Antegrade cholangiogram with contrast medium filling the bile duct. E, Expression of contrast medium from papillary orifice.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, Jan 23, 2016
It is not clear exactly how many passes are required to determine whether pancreatic masses are m... more It is not clear exactly how many passes are required to determine whether pancreatic masses are malignant using endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). We aimed to define the per-pass diagnostic yield of EUS-FNA for establishing the malignancy of a pancreatic mass, and identify factors associated with detection of malignancies. In a prospective study, 239 patients with solid pancreatic masses were randomly assigned to groups that underwent EUS-FNA, with the number of passes determined by an on-site cytopathology evaluation or set at 7 passes, at 3 tertiary referral centers. A final diagnosis of pancreatic malignancy was made based on findings from cytology, surgery, or a follow-up evaluation at least 1 year after EUS-FNA. The cumulative sensitivity of detection of malignancy by EUS-FNA was calculated after each pass; in the primary analysis, lesions categorized as malignant or suspicious were considered as positive findings. Pancreatic malignancies were found ...
Background Peptic ulcer disease (PUD) is a major public health burden significantly impacting the... more Background Peptic ulcer disease (PUD) is a major public health burden significantly impacting the cost of hospitalization in the United States (US). We examined the trends, characteristics, complications, cost, and seasonality of PUD-related hospitalizations from 2000 to 2011. Methods With the use of the Nationwide Inpatient Sample from 2000 through 2011, we identified PUD-related hospitalizations using the International Classification of Diseases (ICD-9), 9th Revision, and the Clinical Modification code 531.00 to 534.91 as the principal discharge diagnosis. The total number of hospitalizations for each calendar month of the year were added over a 12-year period, and this number was divided by the number of days in that particular month to obtain the mean hospitalizations per day for each month. Results The study found that 351,921 hospitalizations with the primary discharge diagnosis of peptic ulcer disease (PUD) occurred in the US between 2000 and 2011. This number dropped significantly from 49,524 to 17,499 between 2000 and 2011, and the rate of PUD-related mortality decreased from 4.3% to 3.1%. The mean age of the study population was 66.2 ± 17.4 years; 52.3% were males, and 56.8% were white. The number of hospitalizations in the US peaked in the spring season (916/day), and reached a nadir in the fall season
perceived by each group. The purpose of this study is to compare doctor and patient perceptions o... more perceived by each group. The purpose of this study is to compare doctor and patient perceptions of the same after hours telephone conversations. Methods: Patient-initiated, after hours telephone calls to a university based fellowship program during a 4-month period were included. Each month was covered by one of four 2nd year fellows. Information was recorded about the call. Immediately after the call, the fellow answered a 6 question survey. Within one week, the patient was called and a similar survey was administered. Only calls that had both doctor and patient surveys completed were included in this study. The surveys used a 5-point Likert scale (1-not at all, to 5-very). Ratings for points 1, 2 and 3 were combined and compared to the sum of ratings for points 4 and 5, using McNemars test. The surveys addressed the 1) Seriousness of the problem 2) Disability of the patient 3) Reasonableness of the request 4) Helpfulness of the doctor 5) Satisfaction with the recommendations and 5) Likeability of the doctor/patient. Results: There were 104 patient telephone calls assessed. Mean age of patients was 42 (range 17-85). Patients were 69% female, 83% European American, 11% African American and 6% other.
Aadam A Aziz et al. EUS FNA and FNB for pancreatic/non-pancreatic masses … Endoscopy Internationa... more Aadam A Aziz et al. EUS FNA and FNB for pancreatic/non-pancreatic masses … Endoscopy International Open 2016; 04: E497-E505 This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.
Rates of progression to esophageal adenocarcinoma in subjects with Barrett's esophagus (BE) a... more Rates of progression to esophageal adenocarcinoma in subjects with Barrett's esophagus (BE) are lower than previously estimated. Identification of predictors of progression will enable risk stratification of BE subjects, potentially making current surveillance programs more efficient. We aimed to assess the potential of demographic and lifestyle factors, obesity and medications in predicting progression in BE. BE subjects were identified from the General Practice Research Database using validated diagnostic codes. BE subjects developing esophageal cancer (EC) 12 months after their index BE diagnosis were defined as progressors. Time to event analysis was used to assess the overall risk of progression to EC. Cox proportional hazards models and time varying marginal structural models were used to assess predictors of progression. 9,660 BE patients were included in the analysis. The mean age (SD) of the study subjects was 63 (13.5) years. 62.6 % were males. 103 subjects (1.1%) prog...
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