Papers by Anabela Arminio
Hallazgos endoscopicos del tracto digestivo superior en pacientes con insuficiencia renal cronica terminal
Gen, 1994
Se estudiaron pacientes en hemodialisis (HD) que fueron sometidos a una endoscopia superior como ... more Se estudiaron pacientes en hemodialisis (HD) que fueron sometidos a una endoscopia superior como rutina pre-operatoria. Las historias medicas de 71 pacientes trasplantados entre 1982 y 1989 fueron revisadas retrospectivamente para determinar la presencia de las lesiones gastrointestinales superiores. Para el momento de la endoscopia las variables predictivas estudiadas fueron: edad, sexo, BUN, creatinina, hemoglobina, hematocrito, calcio y duracion en HD. Los pacientes se dividieron en dos grupos: a) pacientes con lesiones y b) grupo control, sin lesiones. La comparacion entre los dos grupos fue hecha usando pruebas de "t" no pareadas (unpaired t-test) para variables continuas, X cuadrado para variables dicotomas y una p
![Research paper thumbnail of [Safety in the switching traditional cyclosporin to microemulsion cyclosporin in stable renal transplant patients: cooperative study]](https://a.academia-assets.com/images/blank-paper.jpg)
[Safety in the switching traditional cyclosporin to microemulsion cyclosporin in stable renal transplant patients: cooperative study]
Investigación clínica, 1995
In an open clinical trial we assessed the tolerance and safety of the 1:1 conversion of tradition... more In an open clinical trial we assessed the tolerance and safety of the 1:1 conversion of traditional cyclosporine A (CyA) to a new cyclosporine formulation based on a microemulsion technology (CyN) in 18 patients with stable renal allografts. 56% patients were female. Median patient age was 40.9 +/- 3.2 years (range 18 to 65). Renal transplantation was performed in 24.1 +/- 4.6 months (range 6 to 67 months), prior to the beginning of the study, and 67% of the transplants were from cadaveric donor. The most frequent underlying renal disease was glomerulonephritis (44.4%). None of the patients entering the study were withdrawn prematurely. After 2 weeks of observation for graft function stability, the study was divided in two phases: I: during 4 weeks the patients received CyA traditional at fixed doses (Mean dose administered 3.056 +/- 0.25 mg/Kg/d) and II: during the consecutive 6 weeks with conversion to CyN, with doses adjustment as required (Mean dose 2.887 +/- 0.21 mg/Kg/d). Clin...
Nephrology Dialysis Transplantation, 1998
adynamic bone disease; bone densitometry; duration of dialysis and the severity of pre-existing b... more adynamic bone disease; bone densitometry; duration of dialysis and the severity of pre-existing bone mass; glucocorticoids and bone; hyperparathyhyperparathyroidism [7,8]. However, most studies roidism; parathyroid hormone; renal transplantation have reported that in the majority of patients, clinical evidence of severe hyperparathyroidism, i.e. hypercalcaemia and increased circulating PTH, subsides after 1 year of successful renal transplantation [9]. Recently, Although the restoration of normal renal function Pischette et al. [10], in a study on the long-term bone corrects most of the abnormalities of mineral metabolmineral status in kidney transplant patients, have ism that lead to renal osteodystrophy, several studies shown a persistent pathological lumbar demineralizahave demonstrated that bone loss persists or increases tion process. Prednisone dosage was the most constant during the early years after renal transplantation. isolated risk factor in these patients. Although in the Prospective studies have shown that bone loss during cross-sectional study PTH was slightly elevated in the the first 6-12 months is rapid, decreasing thereafter whole group, patients with accelerated bone loss in the [1-3]. The pathogenesis of bone lesions appears to be longitudinal study had significantly less PTH, together multifactorial. Most patients have pre-existing secondwith a smaller body mass and greater mean prednisone ary hyperaparathyroidism or other forms of renal dosage [10]. The study suggested that glucocorticoid osteodystrophy that may persist for some time after therapy is one of the main causes of bone disease after transplantation. Secondary effects of corticosteroids transplantation. also constitute a major factor in the development of We have performed preliminary studies of bone post-transplant bone disease [1,4]. In addition, some and mineral metabolism, in 16 men and four women patients may develop de novo secondary hyperparathywith 5.3±1.8 years of renal transplantation, and roidism or acidosis resulting from alterations of renal stable normal renal function (serum creatinine function in the transplanted kidney. Indeed, some 1.3±0.2 mg/dl). Mean age was 39±12 years, and the studies have demonstrated an inverse correlation time on dialysis prior to transplantation was 2.4±1.6 between bone mineral density at the lumbar spine and years. All patients had been treated with variable doses circulating intact parathyroid hormone (PTH) [2,4], of prednisone in association with azathioprine or cyclowhile others found that the cumulative dose of corticossporin. Twelve of these patients had increased serum teroids is the most important risk factor [5]. The intact PTH at the time of the study, and showed a histological lesions most often reported in these positive correlation between serum PTH and the averpatients include features of persistent high turnover age post-transplant serum calcium concentration [11]. bone disease, suggestive of hyperparathyroidism [3,6 ], Bone mineral density, determined by X-ray absorptiand decreased mineral apposition and bone formation, ometry, expressed as the number of standard deviations consistent with a secondary effect of glucocorticod from mean values for age-and gender-matched normal therapy [1]. population (Z-score), demonstrated an important Very few studies have addressed the long-term evolureduction in bone mass. Thus, the Z-score at the tion of the alterations of bone and mineral metabolism lumbar spine showed a decrease of −1.8±0.3 SD, in patients with renal transplantation. Persistent hyperwhereas femoral neck changes were less severe, parathyroidism, resulting from delayed involution of approaching −1.03±0.3 SD. These results were simhyperplasia or adenomatous transformation of parailar to previous studies in patients with renal transthyroid cells, may maintain an altered response to the plantation of long evolution [10,12]. suppressive effect of calcium [4]. It has been shown Although bone densitometry is a good method for that persistent hyperparathyroidism correlates with the evaluating bone mass changes, it lacks specificity for bone turnover, particularly for assessing the bone
Tres años de dialisis peritoneal ambulatoria continua (DPAC) en el Hospital Universitario de Caracas; 3 years of continuous ambulatory peritoneal …
Med. interna ( …, 1985
... Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, ADOLEC, seleciona. para impri... more ... Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, ADOLEC, seleciona. para imprimir. Fotocópia. Id: 33132. Autor: Amair, Pablo; Domínguez, Omar; Fernández, Ricardo; Gutiérrez, Luis; Arminio, Anabela; Ara, Soledad; Tovar, Norka; Garcia, María; Boissiere, Marcos. ...
[Endoscopic findings in the upper digestive tract in patients with terminal chronic kidney failure]
G.E.N
We studied patients undergoing hemodialysis awaiting renal transplantation who had routine endosc... more We studied patients undergoing hemodialysis awaiting renal transplantation who had routine endoscopy as preoperative evaluation. Medical histories of 71 patients transplanted between 1982-1989 were reviewed retrospectively in order to determine the results of the upper gastrointestinal lesions. At the time of the endoscopy the predictive variables studied were: age, sex, BUN, creatinine, hemoglobin, hematocrit, calcium and time on hemodialysis. The patients were divided in two groups: those with lesions and a control group without lesions. The comparison between the two groups was done using unpaired t-test for continual variables, X2 for dichotomous variables and p < 0.05 was considered as statistically significant. Thirty two patients (45%) had lesions in the upper gastrointestinal tract, in the esophagus: 17%, stomach 30% and duodenum: 23%. Age was the only predictive variables statistically significant for gastric lesions. We conclude that gastrointestinal lesions are frequen...
Occult rejection in renal allografts: preconversion biopsies and postconversion rejection in recipients converted from cyclosporine to azathioprine alone at 6 to 12 months after transplantation
Transplantation proceedings, 1994
Occult rejection in renal allografts: preconversion biopsies and postconversion rejection in recipients converted from cyclosporine to azathioprine alone at 6 to 12 months after transplantation
Transplantation proceedings, 1994
Renal osteodystrophy may persist during the early years after renal transplantation. However, inf... more Renal osteodystrophy may persist during the early years after renal transplantation. However, information on bone status after a successful long-term renal transplantation is limited. We examined biochemical parameters, bone mineral density (BMD), and bone histomorphometry in 25 asymptomatic men with normal renal function after 7.5 ؎ 5.7 years of a renal transplantation. Serum calcium, phosphorus, alkaline phosphatase, and 1,25(OH) 2 D 3 levels and urinary calcium level and cyclic andenosine monophosphate excretion were within normal range in all patients. Serum intact parathyroid hormone (PTH) level was elevated in 11 subjects (133.6 ؎ 78 pg/mL) and normal in the other 14 subjects (47.9 ؎ 13.6 pg/mL). Mean BMD at the lumbar spine and femoral neck was low in the entire group. However, it progressively increased as time after transplantation increased, approaching normal values after 10 years. Bone histomorphometric analysis showed bone resorption, osteoid volume, and osteoid surface greater than normal range in the majority of patients. Bone formation rate and mineralization surface were low, and mineralization time was delayed in most patients. These lesions were more severe in patients after 3 to 4 years of transplantation but improved with time and approached normal values after a period of 10 years. PTH values did not correlate with bone histological characteristics or BMD. These results show that the bone alterations observed after long-term renal transplantation consist of a mixed bone disease in which features of high bone turnover coexist with altered bone formation and delayed mineralization. These findings may result from the combined effect of preexisting bone disease and immunosuppressive therapy.
Background: The enzyme inosine monophosphate dehydrogenase-1 (IMPDH-1) is a target for the immuno... more Background: The enzyme inosine monophosphate dehydrogenase-1 (IMPDH-1) is a target for the immunosuppressive agent mycophenolate mofetil (MMF) because it catalyses a key step in de novo purine nucleotide biosynthesis. This is important for the proliferation of lymphocytes (proliferating B and T lymphocytes are singularly dependent on the de novo pathway). The IMPDH-1 gene is highly polymorphic (30 known polymorphisms) and it may be of interest in predicting individual responses to MMF therapy.
Kidney International, 1992
Risk factors for dialysis-associated hepatitis C in Venezuela. Utilizing the first and second gen... more Risk factors for dialysis-associated hepatitis C in Venezuela. Utilizing the first and second generation of enzyme immunoassays which detect antibodies to the C virus we investigated the frequency of anti-HCV antibodies in 315 patients undergoing hemodialysis. Other subpopulations at risk were used as reference groups. One hundred and twenty-three samples (39%) from the hemodialysis group repeatedly showed anti-HCV positive antibodies
Human Immunology, 2003
Background: The enzyme inosine monophosphate dehydrogenase-1 (IMPDH-1) is a target for the immuno... more Background: The enzyme inosine monophosphate dehydrogenase-1 (IMPDH-1) is a target for the immunosuppressive agent mycophenolate mofetil (MMF) because it catalyses a key step in de novo purine nucleotide biosynthesis. This is important for the proliferation of lymphocytes (proliferating B and T lymphocytes are singularly dependent on the de novo pathway). The IMPDH-1 gene is highly polymorphic (30 known polymorphisms) and it may be of interest in predicting individual responses to MMF therapy.
The pathogenesis of osteodystrophy after renal transplantation as detected by early alterations in bone remodeling
Kidney International, 2003
The pathogenesis of osteodystrophy after renal transplantation as detected by early alterations i... more The pathogenesis of osteodystrophy after renal transplantation as detected by early alterations in bone remodeling.BackgroundLoss of bone mass after transplantation begins in the early periods after transplantations and may persist for several years, even in patients with normal renal function. While the pathogenesis of these abnormalities is still unclear, several studies suggest that preexisting bone disease, glucocorticoid therapy, and alterations
American Journal of Kidney Diseases, 2000
Renal osteodystrophy may persist during the early years after renal transplantation. However, inf... more Renal osteodystrophy may persist during the early years after renal transplantation. However, information on bone status after a successful long-term renal transplantation is limited. We examined biochemical parameters, bone mineral density (BMD), and bone histomorphometry in 25 asymptomatic men with normal renal function after 7.5 ؎ 5.7 years of a renal transplantation. Serum calcium, phosphorus, alkaline phosphatase, and 1,25(OH) 2 D 3 levels and urinary calcium level and cyclic andenosine monophosphate excretion were within normal range in all patients. Serum intact parathyroid hormone (PTH) level was elevated in 11 subjects (133.6 ؎ 78 pg/mL) and normal in the other 14 subjects (47.9 ؎ 13.6 pg/mL). Mean BMD at the lumbar spine and femoral neck was low in the entire group. However, it progressively increased as time after transplantation increased, approaching normal values after 10 years. Bone histomorphometric analysis showed bone resorption, osteoid volume, and osteoid surface greater than normal range in the majority of patients. Bone formation rate and mineralization surface were low, and mineralization time was delayed in most patients. These lesions were more severe in patients after 3 to 4 years of transplantation but improved with time and approached normal values after a period of 10 years. PTH values did not correlate with bone histological characteristics or BMD. These results show that the bone alterations observed after long-term renal transplantation consist of a mixed bone disease in which features of high bone turnover coexist with altered bone formation and delayed mineralization. These findings may result from the combined effect of preexisting bone disease and immunosuppressive therapy.
Thesis Chapters by Anabela Arminio
La tesis revisa la figura del consentimiento presunto en el trasplante de órganos y su impacto en... more La tesis revisa la figura del consentimiento presunto en el trasplante de órganos y su impacto en los programas latinoamericanos de trasplantes de órganos procedentes de donantes fallecidos.
Drafts by Anabela Arminio
El SARS-CoV2 nos comenzó a visitar durante el primer trimestre de 2020. Para entonces el país lle... more El SARS-CoV2 nos comenzó a visitar durante el primer trimestre de 2020. Para entonces el país llevaba ya varios años padeciendo una crisis sanitaria que se había ido profundizando y que el virus contribuyó a hacer más visible y a aumentar su gravedad. La crisis estructural, más antigua y la crisis de la pandemia de COVID-19 han significado un quiebre profundo en el modelo sanitario de Venezuela lo que debe llevarnos a cuestionamientos y análisis que vayan más allá de la distribución espasmódica de recursos: debemos analizar, reflexionar, discernir para actuar bien, con criterios de permanencia y sostenibilidad: debemos actuar de manera ética.
El SARS-CoV2 nos comenzó a visitar durante el primer trimestre de 2020. Para entonces el país lle... more El SARS-CoV2 nos comenzó a visitar durante el primer trimestre de 2020. Para entonces el país llevaba ya varios años padeciendo una crisis sanitaria que se había ido profundizando y que el virus contribuyó a hacer más visible y a aumentar su gravedad. La crisis estructural, más antigua y la crisis de la pandemia de COVID-19 han significado un quiebre profundo en el modelo sanitario de Venezuela lo que debe llevarnos a cuestionamientos y análisis que vayan más allá de la distribución espasmódica de recursos: debemos analizar, reflexionar, discernir para actuar bien, con criterios de permanencia y sostenibilidad: debemos actuar de manera ética.
Breve resumen sobre el trasplante de órganos y conceptos relacionados con énfasis en el impacto d... more Breve resumen sobre el trasplante de órganos y conceptos relacionados con énfasis en el impacto de las leyes vigentes en Latinoamérica sobre los programas de trasplante de cada país de la región.
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Papers by Anabela Arminio
Thesis Chapters by Anabela Arminio
Drafts by Anabela Arminio