Amelia Santoro

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Oleg Yu Vorobyev

Siberian Federal University

Syafruddin Rauf

Hasanuddin University

DR.ABHITOSH DEBATA

Rajiv Gandhi University of Health Sciences

Larry Schooler

The University of Texas at Austin

David Schwebel

University of Alabama at Birmingham

Mirza Firnanda

Universitas Airlangga

د.نعمان النجار

Ust Yemen

CLEMENT C AZODO

University of Benin

B. Giraldo

Universitat Politecnica de Catalunya

Emad Ebbini

University of Minnesota - Twin Cities

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Psychopathological aspects of dysphagia: a systematic review on correlations with eating disorders and other psychiatric conditions

Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity

The effect of psychopathology on swallowing ability tends to be an overlooked issue in the assess... more The effect of psychopathology on swallowing ability tends to be an overlooked issue in the assessment of dysphagic patients, possibly overshadowed by the given prominence to organic pathologies and the difficulties on the management of these patients. In addition, it should also be kept in mind that a great number of psychotropic drugs can affect swallowing adding problematic clinical issues in this area. Despite this, assessment of dysphagia should be considered as an extremely important issue, due to its impact on basic symptomatology, course of illness and quality of life. This review aims to be an overview of relevant data on psychopathology associated with dysphagia and impairment of swallowing function. An extensive bibliographic search was carried out in different medical databases (PubMed and Psycharticles) to comprehensively identify the most relevant publications available on dysphagia in eating disorders published until December 2020, according to the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analysis) method. Research articles, either theoretical or empirical-based, published in peer-reviewed journals and in English language, were included. Case reports were also considered in the analysis when it was appropriate for completeness purposes. Titles and abstracts were reviewed according to the eligibility criteria. In total, 260 published studies were identified and 40 were finally selected after removal of duplicates and relevance. Primarily we investigated the correlation between dysphagia and eating disorders, analysing the complex relationship between the two conditions. Then we provided an overview of the assessment of dysphagic symptoms in other psychiatric syndromes. No exclusion criteria or statistical methods were applied nor was an assessment of study-level or outcome-level bias applicable for our purpose. The topic is vast and research bias could not be excluded; moreover, data available are heterogeneous and lacking systematic approach. With this review, the authors want to provide an overview of the most considerable and clinically useful information about the topic, focusing on some key points to disentangle psychiatric components from the complexity of patient with dysphagia. It should be a relevant concern for all clinicians and should be always thoroughly assessed, considered its frequency in clinical practice and its implications in every kind of patients’ morbidity, mortality and quality of life. Special attention should be paid to mentally ill patients, who might display complex and multiple comorbidities, as well as consequences of abnormal eating behaviours, occasionally exacerbated by psychotropic medications. More systematic studies are needed, while it seems clear that a multidisciplinary approach is pivotal in the assessment and management of dysphagic patients. Level I (evidence obtained from at least one properly designed randomized controlled trials; systematic reviews and meta-analyses; experimental studies).

Espressione dei recettori TAARs (trace amine-associated receptors) nella mucosa nasale umana

I trace amine associated receptors (TAARs) sono stati identificati recentemente nel neuroepitelio... more I trace amine associated receptors (TAARs) sono stati identificati recentemente nel neuroepitelio olfattorio (EO) di topo e si pensa possano essere implicati nella detezione delle amine volatili, inclusi i ferormoni. Scopo di questo studio è stato quello di ricercare l’espressione dei TAARs nel neuroepitelio olfattivo presente nella mucosa nasale umana, valutando 32 biopsie di mucosa nasale prelevate da 16 pazienti sani, con olfatto normale, che venivano sottoposti a chirurgia nasale per altri motivi. La presenza di EO nei prelievi è stata verificata sulla base dell’espressione genica di proteine marker di tipo olfattorio (Olfactory Marker Protein - OMP) ed è stato rilevato in 11 campioni su 32. I TAARs sono stati ricercati sia nel EO che nell’epitelio respiratorio (ER), e, ad eccezione del TAAR1, che è stato individuato in tracce in poche biopsie di entrambi i gruppi, l’espressione dei TAARs e stata riscontrata solo nell’EO. Il TAAR5 è espresso i tutti i campioni EO+ a livelli comp...

Amelia Santoro

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