Papers by Alireza Shirazi
BMC Oral Health, Jun 16, 2023
Background The application of rubber dams is a widely accepted method of tooth isolation in denta... more Background The application of rubber dams is a widely accepted method of tooth isolation in dental practice. Placement of the rubber dam clamp might be associated with levels of pain and discomfort, especially in younger patients. The purpose of the present systematic review is to evaluate the efficacy of the methods for reducing pain and discomfort associated with rubber dam clamp placement in children and adolescents. Materials and methods English-language literature from inception until September 6 th , 2022 was searched in MEDLINE (via PubMed), SCOPUS, Web of Science, Cochrane, EMBASE, and ProQuest Dissertations & Theses Database Global for articles. Randomized controlled trials (RCTs) comparing methods of reducing the pain and/or discomfort associated with rubber dam clamp placement in children and adolescents were retrieved. Risk of bias assessment was performed using a Cochrane risk of bias-2 (RoB-2) risk assessment tool and the certainty of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) evidence profile. Studies were summarized and pooled estimates of pain intensity scores and incidence of pain were calculated. The meta-analysis was conducted in the following groups according to type of interventions (LA, audiovisual (AV) distraction, behavior management (BM), electronic dental anesthesia (EDA), mandibular infiltration, inferior alveolar nerve block (IANB), TA), outcome (intensity or incidence of pain), and assessment tool (face-legs-activity-cry-consolability (FLACC), color scale, sounds-motor-ocular changes, and faces pain scale (FPS)): (a) pain intensity using (LA + AV) vs (LA + BM), (b) pain intensity using EDA vs LA (c) presence or absence of pain using EDA vs LA (d) presence or absence of pain using mandibular infiltration vs IANB (e) Comparing pain intensity using TA vs placebo (f) Presence or absence of pain using TA vs placebo. Meta-analysis was conducted using StataMP software, version 17.0 (StataCorp, College Station, Texas). Restricted maximum-likelihood random effect model (REML), Mean difference (MD) with 95% confidence interval, and log odds ratio (OR) with 95% CI were calculated were calculated. Results Initially, 1452 articles were retrieved. Sixteen RCTs were finally included for reviewing and summarizing. Nine articles with a total of 867 patients were included for quantitative meta-analysis. The differences in pain intensity
Background The application of rubber dams is a widely accepted method of tooth isolation in denta... more Background The application of rubber dams is a widely accepted method of tooth isolation in dental practice. Placement of the rubber dam clamp might be associated with levels of pain and discomfort, especially in younger patients. The purpose of the present study is to systematically review and meta-analyze the efficacy of the proposed methods for reducing pain and discomfort associated with rubber dam clamp placement in children. Materials and Methods English-language literature from inception until September 6th, 2022 was searched in MEDLINE (via PubMed), SCOPUS, Web of Science, Cochrane, EMBASE, and ProQuest Dissertations & Theses Database Global for articles. Randomized controlled trials (RCTs) were retrieved and risk of bias assessment was performed. Studies were summarized and pooled estimates of pain intensity scores and incidence of pain were calculated. The meta-analysis was conducted in four comparison groups. Results Initially, 1452 articles were retrieved. Sixteen RCTs w...
Journal of dental research, dental clinics, dental prospects, 2010
In spite of their enormous importance, permanent first molars might be affected by caries in chil... more In spite of their enormous importance, permanent first molars might be affected by caries in children in developing countries. The aim of this study was to evaluate the treatment needs of first permanent molars in a group of schoolchildren in Mashhad. This cross-sectional descriptive study was carried out on 700, 7-9 year-old students in primary schools in Mashhad. The schools were randomly selected from each district. Treatment needs and DMFT of first perma-nent molars were calculated. Data was analyzed using ANOVA, Chi-Square and t-test. A total of 95.3% of the children required dental treatment. Fissure sealant application and filling were the treat-ments most required in all age groups. The mean DMFT of first permanent molars was 1.31±1.4. It was significantly higher in girls than boys (P=0.040). Great treatment needs and caries prevalence in permanent first molars in Mashhad schoolchildren show that dental caries is still a serious problem in the children of our society; theref...
Journal of Babol University of Medical Sciences, 2018
1.Department of Pediatric Dentistry, Faculty of Dentistry, Mashhad University of Medical Sciences... more 1.Department of Pediatric Dentistry, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, I.R.Iran. 2.Dental Research Center, Mashhad University of Medical Sciences, Mashhad, I.R.Iran. 3.Department of Restorative Dentistry, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, I.R.Iran. 4.Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, I.R.Iran
Introduction: Given the importance of randomized clinical trials (RCTs) in the evidence-based app... more Introduction: Given the importance of randomized clinical trials (RCTs) in the evidence-based approach in dentistry, the study aimed to conduct critical appraisal of dentistry RCTs of Iran published in English from 1999 until 2012. Materials and Methods: In total, databases of PubMED, ISI web of science and Scopus were searched using specific keywords (i.e., dental, dentistry, critical appraisal, clinical trial, evidence-based RCT, randomized clinical trial, Iran). After the elimination of duplicate articles, the 433 remaining articles were assessed, which led to the selection of 86 studies by employing the inclusion and exclusion criteria. Following that, the articles were evaluated using the revised version of Jadad scale. Results: In this research, mean jadad score was 5.33±1.73, and articles were at a moderate level (4 < jadad score <= 6). In total, 97.7 of the articles received the complete score for the eighth item (statistical analysis), whereas only 38 articles describ...
Iranian Journal of …, 2009
Address: 1Assistant Professor, Department of Pediatric Dentistry and Dental research Center, Mash... more Address: 1Assistant Professor, Department of Pediatric Dentistry and Dental research Center, Mashhad University of Medical Sciences, 91735, Mashhad, Iran 2Postgraduate Student, Department of Pediatric Dentistry and Dental research Center, Mashhad ...
Nowadays, in order to prevent the early loss of cariously or traumatically damaged teeth in paedi... more Nowadays, in order to prevent the early loss of cariously or traumatically damaged teeth in paediatric dentistry, different types of endodontic treatments are considered. Over the past decade, paediatric dentistry has primarily shifted its focus towards the preservation of vital tissues and improvement of treatment outcomes, and has benefitted immensely from the introduction of effective and safe bioactive endodontic materials. Since 1993, the year in which mineral trioxide aggregate was introduced, hydraulic calcium silicate–based biomaterials have made a significant impact on endodontic treatments. There is a growing body of evidence demonstrating that hydraulic calcium silicate cements are beneficial for both the least aggressive and most invasive type of vital pulp therapies, as well as for the management of non-vital primary/permanent young teeth. Moreover, clinicians’ skills and knowledge regarding the applications of hydraulic calcium silicate–based biomaterials play a crucia...
Journal of Conservative Dentistry, 2018
The purpose of this study was to systematically evaluate the dentin bond strength of etch-and-rin... more The purpose of this study was to systematically evaluate the dentin bond strength of etch-and-rinse and self-etch adhesives to primary teeth. In this study, PubMed, ISI (all databases), Scopus, and Cochrane Database were searched according to the selected keywords up to May 11, 2016. The full texts of published articles that appeared to meet the primary criteria for inclusion in this study were obtained. Due to the variation in the methods used, the studies were divided into 2 groups: Group 1-studies that evaluated the micro-tensile bond strengths (MTBSs) of two-step etch-and-rinse adhesives and two-step self-etch adhesives and Group 2-studies that evaluated the MTBSs of two-step etch-and-rinse adhesives and one-step selfetch adhesives. The initial search yielded 1447 publications. After a methodological assessment, 8 publications were selected. The results of this study showed that the MTBS of the etch-and-rinse adhesives and the two-step self-etch adhesives were similar (P = 0.34), and both were significantly higher than that of the one-step self-etch adhesive (P = 0.001). This meta-analysis showed that the application of two-step self-etch adhesives performs well when used for primary dentin and can be used to save time in pediatric dentistry.
Frontiers in Dentistry, 2022
Objectives: Incorporation of fillers might improve the physical properties of sealants. This syst... more Objectives: Incorporation of fillers might improve the physical properties of sealants. This systematic review and meta-analysis evaluated the retention and caries development rate of filled and unfilled fissure sealants. Materials and Methods: This study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The PubMed, Scopus, Embase, Cochrane Database of Systematic Reviews, and ISI Web of Knowledge were searched until October 24, 2019. The risk of bias (ROB) was assessed for the included studies based on the Cochrane collaboration common scheme for bias, and the meta-analysis was performed through a random effects model. Results: The search resulted in 6,336 unrepeated relevant studies. After the title, abstract and full-text screening, 19 studies with 26 comparing groups were finally included in this systematic review and meta-analysis. According to the included studies, both retention rate and caries development in filled a...
iranian endodontic journal, 2018
External inflammatory root resorption (EIRR) is one of the common complications following dental ... more External inflammatory root resorption (EIRR) is one of the common complications following dental trauma which when remained untreated, may lead to tooth loss. Successful treatment outcomes depend on elimination of bacteria from root canal system and apical sealing. This case presents the endodontic management of an EIRR that was nonresponsive to calcium hydroxide (CH) therapy. An 11-year-old boy was referred for management of a traumatized maxillary central incisor. Tooth #8 was symptom-free, nonresponsive to vitality pulp tests and had an immature root with sever EIRR. Using chemomechanical debridement and CH dressing, the treatment was initiated. The tooth was remained asymptomatic; however, after five weeks the size of periradicular lesion increased and intracanal exudate was present, signifying a resistant endodontic infection. In second appointment, double antibiotic paste (DAP; ciprofloxacin/metronidazole) was applied to the canal. Eight weeks later, the tooth continued to be ...
Translational Biomedicine, 2017
Background and purpose: Due to the large number of studies on traditional and herbal treatments f... more Background and purpose: Due to the large number of studies on traditional and herbal treatments for oral aphthous and lack of comprehensive studies on these cases, the purpose of this research was to study and careful analysis of the effectiveness of herbal medicines used in the treatment of these lesions and reported the final outcome that one of the best study methods in these cases is a systematic review. Methods: Five electronic databases (PubMed, ISI web of science, Scopus, Cochrane and OVID) by keywords based on the PICO were searched to identify all the clinical trials with topical and systemic therapeutic interventions aimed at treating or preventing recurrence published in Persian or English that related to the effects of drugs of natural herbal origin for the treatment of recurrent aphthous stomatitis from 2010 to 2015. A structured and standardized form has been used to extract data. Title, journal, year of publication and the field of the first author and corresponding author were recorded. Standard tools of risk of bias used in the systematic review studies that has been developed by the Cochrane (Last update 2011) was applied to investigate bias in the studies. Results: In the current study a total of 33 trials were analyzed. These studies were assessed the effectiveness of 29 different herbal drugs for RAS treatment. Only five studies were assessed as being at medium risk of bias. No study had a low risk of bias. There were insufficient evidences to support or refute the use of these interventions. Conclusion: In summary, current data suggested that there was a beneficial effect in using topical treatments with plant origin for RAS and no study did not report any side effects. Though due to very weak report and disparate studies, acknowledging the fact that which herbal treatment was the best and most effective treatment was not possible.
Pediatric dentistry, 2020
Purposes: The purposes of this prospective trial were to: (1) compare the clinical and radiograph... more Purposes: The purposes of this prospective trial were to: (1) compare the clinical and radiographic outcomes of three restorative methods -modified atraumatic restorative treatment (mART), the Hall technique (HT), and stainless steel crown (SSC)-in primary molars with multi-surface carious lesions; and (2) assess child behavior throughout these treatments. Methods: In this randomized controlled trial (RCT), 123 primary molars in four- to nine-year-old children were randomly divided into treatment groups (HT, mART, and SSC). Variables, including signs of failure, treatment time, child's discomfort, child's behavior, and canine overbite relationship in HT, were recorded immediately after the treatment and at six- and 12-month recalls. Results: Failures occurred most significantly for mART at all recalls (P=0.001). The treatment time was significantly higher in SSC. There was no significant difference in the child-assessment of discomfort (P=0.814). The child's behavior, as...
Journal of Dental Materials and Techniques, 2018
Introduction: Citation analysis is a suitable way to help us to identify research trends within a... more Introduction: Citation analysis is a suitable way to help us to identify research trends within a specific topic. The purpose of this study was to identify the 100 most cited articles in the field of dentistry published over the past 67 years. Methods: A comprehensive list of the most cited articles in dentistry was compiled using ISI Web of Science. The characteristics including number of citations, authors and journals were analyzed. Results: The database resulted in 3,831 articles with 100 or more citations published between 1950 and 2017. Most of these articles had been published by the Journal of Clinical Periodontology, followed by the Journal of Periodontology, and Journal of Dental Research. Sokransky SS followed by Lindhe J, Nyman S, and Genco RJ had the most number of citations. Conclusion: The most cited articles in the field of dentistry allows for advances in this field and also provide useful information for direct future studies and patient care.
Introduction: Treatment of immature permanent teeth damaged by caries or trauma is usually a chal... more Introduction: Treatment of immature permanent teeth damaged by caries or trauma is usually a challenge to a dentist. Recently, revascularization process is performed to induce root development in immature necrotic teeth. The purpose of this report was to present a case of pulp revascularization in an immature necrotic tooth. Case Report: An 8-year-old boy was presented to the pediatric Department of Mashhad dental school with the chief Complaint of localized swelling on the anterior region of maxilla and a history of trauma to the maxillary right central incisor. Based on clinical and radiographic Findings, the diagnosis was pulpal necrosis with symptomatic apical abscess. Revascularization therapy was performed over multiple visits. At 6- month follow-up, in addition to complete healing of the periapical lesion, apex had been closed and dentinal wall thickness had been increased. At 12-month follow-up, pulp canal obliteration (PCO) was observed. At 24-month follow-up; tooth was asy...
Clinical Case Reports, 2021
This study suggests that tampon‐based coronal pulpotomy using a calcium silicate–based biomateria... more This study suggests that tampon‐based coronal pulpotomy using a calcium silicate–based biomaterial can be a reliable approach for the treatment of vital primary molars with irreversible pulpitis.
Journal of Clinical and Experimental Dentistry, 2017
Background: Techniques with adequate accuracy of working length determination along with shorter ... more Background: Techniques with adequate accuracy of working length determination along with shorter duration of treatment in pulpectomy procedure seems to be essential in pediatric dentistry. The aim of the present study was to evaluate the accuracy of root canal length measurement with Root ZX II apex locator and rotary system in pulpectomy of primary teeth. Material and Methods: In this randomized control clinical trial complete pulpectomy was performed on 80 mandibular primary molars in 80, 4-6-year-old children. The study population was randomly divided into case and control groups. In control group conventional pulpectomy was performed and in the case group working length was determined by electronic apex locator Root ZXII and instrumented with Mtwo rotary files. Statistical evaluation was performed using Mann-Whitney and Chi-Square tests (P < 0.05). Results: There were no significant differences between electronic apex locator Root ZXII and conventional method in accuracy of root canal length determination. However significantly less time was needed for instrumenting with rotary files (P=0.000). Conclusions: Considering the comparable results in accuracy of root canal length determination and the considerably shorter instrumentation time in Root ZXII apex locator and rotary system, it may be suggested for pulpectomy in primary molar teeth.
The Journal of Contemporary Dental Practice, 2018
Introduction: Modifying the durability of resin bonding systems resulted in introducing materials... more Introduction: Modifying the durability of resin bonding systems resulted in introducing materials with cross-link property, such as chlorhexidine (CHX) that can promote the strength of resindentin bonding. The aim of this study was evaluation of the effect of CHX on shear bond strength (SBS) of self-etch (SE) and etchand-rinse (E&R) bonding systems to the primary teeth dentin. Materials and methods: In this in vitro study, 40 freshly extracted primary molars collected and were cut mesiodistally, and then the buccal and lingual surface enamel was grounded. The specimens were randomly divided into two groups: I: Single Bond adhesive and II: Clearfil SE Bond adhesive. Then, each group was divided into two subgroups: On the buccal surface of each sample (I 1 , II 1), CHX was applied for 30 seconds and on the lingual surface of (I 2 , II 2 groups), CHX was not applied. The SBS (MPa) of samples was assessed using the Zwick universal testing machine. Data were analyzed by paired t-test and independent t-test using Statistical Package for the Social Sciences (SPSS), version 16. Results: The mean SBS was significantly higher in the Single Bond group with CHX (66.45 ± 8.3) than without CHX (25.43 ± 12.94) in the nonaging group (p = 0.002). There was no significant difference in the mean SBS in the Clearfil SE Bond group with CHX and without CHX in the aging and nonaging groups. Conclusion: CHX had positive influence on immediate SBS of Single Bond adhesive to primary teeth dentin. In addition, no positive effect has been seen in the Clearfil SE Bond system.
The Journal of the American Dental Association, 2018
Background. The aim of this systematic review and meta-analysis was to evaluate the ability of gl... more Background. The aim of this systematic review and meta-analysis was to evaluate the ability of glass ionomer cements (GICs) and resin-based sealants (RBSs) to prevent the occurrence of caries and their retention in standards-based clinical studies. Types of Studies Reviewed. The authors conducted a literature search (from database inception through September 20, 2017) to identify studies for inclusion in this systematic review. The authors assessed the quality of the evidence with the modified Jadad scale and performed the meta-analysis by using a random-effects model. Results. The authors considered 20 studies on caries prevention and 28 studies on retention that met the inclusion criteria for the meta-analysis. The results of the meta-analysis for caries development showed no significant difference (odds ratio, 0.938; 95% confidence interval, 0.647 to 1.359; P ¼ .734). However, the result for the retention rate showed the advantage of RBSs (odds ratio, 6.006; 95% confidence interval, 3.226 to 11.183; P ¼ .000). Conclusions and Practical Implications. There was no difference between the percentage of caries development with use of GICs as fissure sealing material compared with that for the conventional RBSs, but the retention rate of conventional RBSs was much higher than that of the GICs.
Pediatric Blood & Cancer, 2018
Background: One of the most common complications of cancer chemotherapy is oral mucositis (OM). O... more Background: One of the most common complications of cancer chemotherapy is oral mucositis (OM). OM affects more than 75% of patients undergoing chemotherapy and represents a significant burden to patients and caregivers. We performed a systematic review and meta-analysis of published studies to investigate the effects of agents and techniques in reducing OM. Procedure: This systematic review investigated, critically appraised, and rated the evidence on agents used to manage OM in children undergoing cancer therapy. A comprehensive search of the relevant literature was performed from January 2006 to December 2017. MEDLINE, Scopus, the Cochrane Database of Systematic Reviews, EMBASE, and the Web of Science were searched. Nine eligible studies were identified. Using random-effects models, standardized mean difference was estimated between treated and control groups across all studies. The Cochran test and the I 2 index were performed for heterogeneity between studies. The significance level was set at P = 0.05. Results: Palifermin reduced the incidence (OR = 4.131, P = 0.000), duration (St diff mean = 0.803, P = 0.000), and severity (St diff mean = 0.637, P = 0.000) of OM in pediatric cancer patients significantly. However, the laser did not show significant efficacy in decreasing the incidence rate of OM (OR = 2.870, P = 0.364). Conclusion: This review provided a comprehensive examination of available options for children who have OM. The results support the possibility of a positive effect of palifermin on reducing OM in children receiving cancer therapy.
Journal of dentistry (Tehran, Iran), 2016
Scientometric methods and the resulting citations have been applied to investigate the scientific... more Scientometric methods and the resulting citations have been applied to investigate the scientific performance of a nation. The present study was designed to collect the statistical information of dental articles by Iranian authors published in PubMed. We searched the PubMed database for dental articles of Iranian authors until June 31, 2015. All abstracts were manually reviewed in order to exclude false retrievals. The number of articles per dental subspecialties, distribution of research designs, Scopus/Google Scholar citation of each article, number of authors and affiliation of the first/corresponding author were extracted and transferred to Microsoft Excel. The data were further analyzed to illustrate the related scientometric indicators. A total of 3,835 articles were retrieved according to the selection criteria. The number of PubMed-indexed publications between 2008 and 2015 showed a seven-fold increase. The majority of articles were written by four authors (24.56%). Systemat...
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Papers by Alireza Shirazi