Adsorption was deliberate as a meaning of quantity of adsorbent and pH with contact time. It was ... more Adsorption was deliberate as a meaning of quantity of adsorbent and pH with contact time. It was found that the percentage of adsorption changed linearly with the quantity of dosage and time nonetheless varienon-linearly by pH. The Langmuir and Freundlich isotherm models were verified and adsorption was found in appropriate healthy into these models. The removal of oil content in oilfield produced water was inspected by kiwi peels. Kiwi peels were preserved with 0.1 M sodium hydroxide, followed by sulfuric acid with 0.1 M, and washed methodically. The got correlation coefficient (R 2) for different dose optional suitable of the experimental data to Freundlich model for oil content in producing water .Results presented that modified kiwi peels were active and low cost adsorbent can be productively rummage-sale for the elimination of oil content in produced water.
The potentially many software system input combinations make exhaustive testing practically impos... more The potentially many software system input combinations make exhaustive testing practically impossible. To address this issue, combinatorial t-way testing (where t indicates the interaction strength, i.e. the number of interacting parameters (input)) was adopted to minimize the number of cases for testing. Complimentary to existing testing techniques (e.g. boundary value, equivalence partitioning, cause and effect graphing), combinatorial testing helps to detect faults caused by the faulty interaction between input parameters. In the last 15 years, applications of meta-heuristics as the backbone of t-way test suite generation have shown promising results (e.g. Particle Swarm Optimization, Cuckoo Search, Flower Pollination Algorithm, and Hyper-Heuristics (HHH), to name a few). Supporting the No Free Lunch theorem, as well as potentially offering new insights into the whole process of t-way generation, this article proposes a new strategy with constraint support based on the Whale Optimization Algorithm (WOA). Our work is the first attempt to adopt the WOA as part of a search-based software engineering (SBSE) initiative for t-way test suite generation with constraint support. The experimental results of the test-suite generation indicate that WOA produces competitive outcomes compared to some selected single-based and population-based metaheuristic algorithms. INDEX TERMS Search-based software engineering (SBSE), T-way testing, combinatorial testing, software testing, meta-heuristic.
This article discusses fostering social capital as the result of interaction between Public Relat... more This article discusses fostering social capital as the result of interaction between Public Relations and democracy. Social capital is a collective benefit which results from the close cooperation of individuals or group of individuals through mutual interaction. Burt (2002) defined social capital as “the actual and potential resource that is embedded in available through, derived from social networks of relationships”. This present study mainly focuses on “What does interaction between public relations and democracy contributes to enhancing the Social Capital, i.e., benefits for individuals in society after mutual cooperation. Public relations and democracy are part and parcel in any society now a day. This paper also argues about the interplay between Public Relations and democracy for the betterment of society. This article ends with the implications of Public Relations on creating social capital and development of democracy.
The current software systems and their corresponding deployment environments are highly com- plex... more The current software systems and their corresponding deployment environments are highly com- plex and demanding. Multiple and unstable network technologies, resource-restricted devices, and mobility, are few examples of these complexities. In this paper we propose a new component model, called Cloud Component (CC), that copes with the challenges posed by mobile and pervasive en- vironments. Traditional distributed applications are based on distribution transparency, where a middleware layer is expected to handle and hide all remote communication. Cloud component model is the result of a paradigm shift from distribution transparency to localization acknowledg- ment, where all details of the deployment environment including networks and communication, mobile devices, constrained devices, and sensors, are considered a first class concern. The cloud component model is presented informally and formally with a mathematical notation. The infor- mal notation allows for faster comprehension ...
The study examines the psychological effects of TV News violence on youth. This research analyzes... more The study examines the psychological effects of TV News violence on youth. This research analyzes Desensitization, Catharsis, Imitation and Fear as effects of TV News violence. Survey methodology has been chosen by the researcher to accomplish this purpose. Results of the study reveal that 59 % percent viewers affect psychologically from TV News violence. 76 % percent become desensitize due to exposure of TV News violence. Study also proved that 71 % percent viewers feel fear after the exposure of TV News violence. The findings also indicate 52% percent viewers become aggressive after watching TV news violence. And for 39% percent viewers, TV News violence becomes a cause of catharsis and their aggressive impulses discharged due to violence.
Background: For implant overdenture therapy, implant positions are diverse and seemingly arbitrar... more Background: For implant overdenture therapy, implant positions are diverse and seemingly arbitrary; many based their evidence upon empirical information without evidence-based dental theory.
Bimanual motor actions, such as threading a needle, require coordination of the movements of each... more Bimanual motor actions, such as threading a needle, require coordination of the movements of each hand according to the state of the other hand. By connecting homologous cortical regions between the two cerebral hemispheres, the corpus callosum is thought to play a key role in such bimanual coordination. However, direct experimental evidence of the contribution of the corpus callosum to natural behaviors requiring bimanual coordination, such as feeding, is lacking. We investigated the hypothesis that the corpus callosum mediates bimanual movements during food-handling behavior. We first traced the forelimb-related components of the motor corpus callosum in Long-Evans rats, and found that the callosal fiber bundle from the forelimb motor areas passes through the anterior part of the corpus callosum. We then confirmed by electrophysiological recordings that blocking the axonal conduction of fibers in the anterior corpus callosum reduced neural transmission between cortical forelimb ar...
Ankylosing spondylitis (AS) is a chronic, progressive inflammatory rheumatic disease that leads t... more Ankylosing spondylitis (AS) is a chronic, progressive inflammatory rheumatic disease that leads to structural damage, functional impairment, and decrease in the quality of life. Red cell distribution width (RDW) is a part of the complete blood count (CBC) and estimates erythrocyte variability. To analyse RDW in patients with AS and to evaluate the relationships with acute phase reactants (APRs) and disease activity index. A total of 100 patients with AS (78 males and 22 females) were diagnosed according to the modified New York classification criteria for AS and 146 (99 males: 47 females) healthy individuals matched in age and sex as controls enrolled in the study. Demographic data, disease activity scores using Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), medical history, C-reactive protein (CRP), erythrocytes sedimentation rate (ESR), and complete blood count (CBC) were measured. The mean age for patients and controls was 38.0 ± 9.0 and 35.8 ± 9.0 years, respective...
Oral health-related quality of life (OHRQoL) involves many aspects such as chewing ability, sleep... more Oral health-related quality of life (OHRQoL) involves many aspects such as chewing ability, sleeping, social interactions, self-esteem, and satisfaction with life and oral health. The increasing research interest in OHRQoL began only after the shortcomings of previous approaches of treating symptoms only and neglecting the patient's self-perception were revealed. The current study design is a cross-sectional study of patients who attended King Abdulaziz University Dental Hospital (Jeddah, Saudi Arabia) and King Saud University Dental Hospital (Riyadh, Saudi Arabia). After obtaining their verbal consent, young adult and adult patients (mean age 25.19±7.29 years old) with anterior spacing or crowding were recruited to participate in the study. They filled the Arabic short version of the oral-health impact profile-14 questionnaire after a clinical evaluation of the severity of their spacing or crowding. Parameters of spacing/crowding severity assessment were as follows: <4, mild...
Toxicity as well as chemical instability issues of halide perovskites based on organic-inorganic ... more Toxicity as well as chemical instability issues of halide perovskites based on organic-inorganic lead-containing materials still remains the main drawbacks for perovskite solar cells (PSCs). Herein, we discuss the preparation of copper (Cu)-based hybrid materials, where we replace lead (Pb) with non-toxic Cu metal for lead free perovskite solar cells; investigate of its potential towards solar cells applications based on experimental and theoretical studies. The formation of (CH3NH3)2CuX4 [(CH3NH3)2CuCl4, (CH3NH3)2CuCl2I2, and (CH3NH3)2CuCl2Br2] were discussed in details. Furthermore, founding chlorine (Cl-) in the structure is critical for the stabilization of the formed compounds. Cu-based perovskite-like materials illustrated attractive absorbance features extended to the near-infrared, with appropriate band gaps. Green photoluminescence of these materials obtained due to Cu+ ions. The power conversion efficiency (PCE) measured experimentally and estimated theoretically for diffe...
The treatment of severe skeletal anterior open bite is extremely difficult in adults, and orthogn... more The treatment of severe skeletal anterior open bite is extremely difficult in adults, and orthognathic surgery is generally selected for its treatment. We report the case of an 18-year-old adult patient with skeletal anterior open bite and temporomandibular disorders who was successfully treated using temporary anchorage devices. She had an open bite of -2.0 mm and an increased facial height. Miniplates were implanted in both the maxilla and mandible, and molar intrusion resulted in counterclockwise rotation of the mandible over a period of 12 months. After active treatment, her upper and lower first molars were intruded by approximately 2 mm and her overbite became +2.5 mm. Her retrognathic profile improved with counterclockwise rotation of the mandible. Orthodontic treatment aided with skeletal anchorage is beneficial for intrusion of bimaxillary molars in patients with anterior open bite.
In barley endosperm arabinoxylan (AX) is the second most abundant cell wall polysaccharide and in... more In barley endosperm arabinoxylan (AX) is the second most abundant cell wall polysaccharide and in wheat it is the most abundant polysaccharide in the starchy endosperm walls of the grain. AX is one of the main contributors to grain dietary fibre content providing several health benefits including cholesterol and glucose lowering effects, and antioxidant activities. Due to its complex structural features, AX might also affect the downstream applications of barley grain in malting and brewing. Using a high pressure liquid chromatography (HPLC) method we quantified AX amounts in mature grain in 128 spring 2-row barley accessions. Amounts ranged from ~ 5.2 μg/g to ~ 9 μg/g. We used this data for a Genome Wide Association Study (GWAS) that revealed three significant quantitative trait loci (QTL) associated with grain AX levels which passed a false discovery threshold (FDR) and are located on two of the seven barley chromosomes. Regions underlying the QTLs were scanned for genes likely to...
Vitreous cysts are rare ocular malformations. We report an unusual case of a pigmented free-float... more Vitreous cysts are rare ocular malformations. We report an unusual case of a pigmented free-floating vitreous cyst incidentally detected in a highly myopic 28-year-old woman who was referred by her optometrist.
The new G protein-coupled estrogen receptor 1 (GPER/GPR30) plays important roles in many organ sy... more The new G protein-coupled estrogen receptor 1 (GPER/GPR30) plays important roles in many organ systems. The plasma membrane Ca2+-ATPase (PMCA) is essential for removal of cytoplasmic Ca2+ and for shaping the time courses of Ca2+-dependent activities. Here we show that PMCA and GPER/GPR30 physically interact and functionally influence each other. In primary endothelial cells, GPER/GPR30 agonist G-1 decreases PMCA-mediated Ca2+ extrusion by promoting PMCA tyrosine phosphorylation. GPER/GPR30 overexpression decreases PMCA activity, and G-1 further potentiates this effect. GPER/GPR30 knockdown increases PMCA activity, while PMCA knockdown substantially reduces GPER/GPR30-mediated phosphorylation of the extracellular signal related kinase (ERK1/2). GPER/GPR30 coimmunoprecipitates with PMCA with or without treatment with 17beta-estradiol, thapsigargin or G-1. Heterologously expressed GPER/GPR30 in HEK 293 cells colocalizes with PMCA4b, the main endothelial PMCA isoform. Endothelial cells ...
The aim of the present work was to establish a bioequivalence-indicating dissolution specificatio... more The aim of the present work was to establish a bioequivalence-indicating dissolution specification for candesartan cilexetil tablets. The discriminating power of the selected medium (0.25% Polysorbate 20 in pH 6.5 phosphate buffer) was assessed relative to that of 0.35% Polysorbate 20 in pH 6.5 phosphate buffer, a medium recommended by the U.S. FDA. Plasma concentration-time profiles of candesartan cilexetil tablets were derived from in vitro dissolution data by a convolution model. In solubility studies, 0.25% Polysorbate 20 in pH 6.5 phosphate buffer provided sink conditions for candesartan cilexetil 16-mg tablets. The method was more sensitive to the concentration of Polysorbate 20 than to paddle rotation speed and was able to distinguish depressed dissolution of mismanufactured tablets in samples taken at 20-and 30-min intervals. Verification of the model performed on innovator samples revealed the closeness of the predicted C max and AUC 0-α values to the reported values. A two-point dissolution specification is proposed for post-approval changes, and a one-point dissolution specification for quality control release of production batches.
2009 Chinese Control and Decision Conference, 2009
Fractional Order Control (FOC) is still an unfamiliar concept. But it is actually a natural gener... more Fractional Order Control (FOC) is still an unfamiliar concept. But it is actually a natural generalization of classical Integer Order Control (IOC) theory, in which the orders of controlled systems and/or controllers can be any real numbers including the conventional integer numbers. This generalization provides insight and more flexibility for robust control design. This paper reviews the applications of various FOC approaches including fractional order filter and disturbance observer into the gear backlash vibration control of a torsion test bench, in which a trade-off exists between stability and the strength of vibration suppression. The theoretical analysis and implementation results show FOC's superior robustness against gear backlash nonlinearity and more importantly its possibility of enabling a clear-cut robust control design.
1986 IEEE International Solid-State Circuits Conference. Digest of Technical Papers
This paper will describe a 32b digital signal processor with 0.5 to 1.5μs instruction cycle times... more This paper will describe a 32b digital signal processor with 0.5 to 1.5μs instruction cycle times for motor position control, A 4.04×4.83mm2chip containing 25,000 transistors has been made in 3μm NMOS technology and dissipates 250mW.
2011 International Conference on Infrared, Millimeter, and Terahertz Waves, 2011
We present a metamaterial based terahertz (THz) detector. The detector design, which combines met... more We present a metamaterial based terahertz (THz) detector. The detector design, which combines metamaterials and MEMs, is frequency selective, and we have fabricated and tested detectors at 95 GHz and 693 GHz with noise equivalent powers of 1.13 x 10-8 W/√Hz and 2.96 x 10-8 W/√Hz and responsivities of 16,500 V/W and 6,800 V/W, respectively. These values were achieved at room temperature and pressure.
Adsorption was deliberate as a meaning of quantity of adsorbent and pH with contact time. It was ... more Adsorption was deliberate as a meaning of quantity of adsorbent and pH with contact time. It was found that the percentage of adsorption changed linearly with the quantity of dosage and time nonetheless varienon-linearly by pH. The Langmuir and Freundlich isotherm models were verified and adsorption was found in appropriate healthy into these models. The removal of oil content in oilfield produced water was inspected by kiwi peels. Kiwi peels were preserved with 0.1 M sodium hydroxide, followed by sulfuric acid with 0.1 M, and washed methodically. The got correlation coefficient (R 2) for different dose optional suitable of the experimental data to Freundlich model for oil content in producing water .Results presented that modified kiwi peels were active and low cost adsorbent can be productively rummage-sale for the elimination of oil content in produced water.
The potentially many software system input combinations make exhaustive testing practically impos... more The potentially many software system input combinations make exhaustive testing practically impossible. To address this issue, combinatorial t-way testing (where t indicates the interaction strength, i.e. the number of interacting parameters (input)) was adopted to minimize the number of cases for testing. Complimentary to existing testing techniques (e.g. boundary value, equivalence partitioning, cause and effect graphing), combinatorial testing helps to detect faults caused by the faulty interaction between input parameters. In the last 15 years, applications of meta-heuristics as the backbone of t-way test suite generation have shown promising results (e.g. Particle Swarm Optimization, Cuckoo Search, Flower Pollination Algorithm, and Hyper-Heuristics (HHH), to name a few). Supporting the No Free Lunch theorem, as well as potentially offering new insights into the whole process of t-way generation, this article proposes a new strategy with constraint support based on the Whale Optimization Algorithm (WOA). Our work is the first attempt to adopt the WOA as part of a search-based software engineering (SBSE) initiative for t-way test suite generation with constraint support. The experimental results of the test-suite generation indicate that WOA produces competitive outcomes compared to some selected single-based and population-based metaheuristic algorithms. INDEX TERMS Search-based software engineering (SBSE), T-way testing, combinatorial testing, software testing, meta-heuristic.
This article discusses fostering social capital as the result of interaction between Public Relat... more This article discusses fostering social capital as the result of interaction between Public Relations and democracy. Social capital is a collective benefit which results from the close cooperation of individuals or group of individuals through mutual interaction. Burt (2002) defined social capital as “the actual and potential resource that is embedded in available through, derived from social networks of relationships”. This present study mainly focuses on “What does interaction between public relations and democracy contributes to enhancing the Social Capital, i.e., benefits for individuals in society after mutual cooperation. Public relations and democracy are part and parcel in any society now a day. This paper also argues about the interplay between Public Relations and democracy for the betterment of society. This article ends with the implications of Public Relations on creating social capital and development of democracy.
The current software systems and their corresponding deployment environments are highly com- plex... more The current software systems and their corresponding deployment environments are highly com- plex and demanding. Multiple and unstable network technologies, resource-restricted devices, and mobility, are few examples of these complexities. In this paper we propose a new component model, called Cloud Component (CC), that copes with the challenges posed by mobile and pervasive en- vironments. Traditional distributed applications are based on distribution transparency, where a middleware layer is expected to handle and hide all remote communication. Cloud component model is the result of a paradigm shift from distribution transparency to localization acknowledg- ment, where all details of the deployment environment including networks and communication, mobile devices, constrained devices, and sensors, are considered a first class concern. The cloud component model is presented informally and formally with a mathematical notation. The infor- mal notation allows for faster comprehension ...
The study examines the psychological effects of TV News violence on youth. This research analyzes... more The study examines the psychological effects of TV News violence on youth. This research analyzes Desensitization, Catharsis, Imitation and Fear as effects of TV News violence. Survey methodology has been chosen by the researcher to accomplish this purpose. Results of the study reveal that 59 % percent viewers affect psychologically from TV News violence. 76 % percent become desensitize due to exposure of TV News violence. Study also proved that 71 % percent viewers feel fear after the exposure of TV News violence. The findings also indicate 52% percent viewers become aggressive after watching TV news violence. And for 39% percent viewers, TV News violence becomes a cause of catharsis and their aggressive impulses discharged due to violence.
Background: For implant overdenture therapy, implant positions are diverse and seemingly arbitrar... more Background: For implant overdenture therapy, implant positions are diverse and seemingly arbitrary; many based their evidence upon empirical information without evidence-based dental theory.
Bimanual motor actions, such as threading a needle, require coordination of the movements of each... more Bimanual motor actions, such as threading a needle, require coordination of the movements of each hand according to the state of the other hand. By connecting homologous cortical regions between the two cerebral hemispheres, the corpus callosum is thought to play a key role in such bimanual coordination. However, direct experimental evidence of the contribution of the corpus callosum to natural behaviors requiring bimanual coordination, such as feeding, is lacking. We investigated the hypothesis that the corpus callosum mediates bimanual movements during food-handling behavior. We first traced the forelimb-related components of the motor corpus callosum in Long-Evans rats, and found that the callosal fiber bundle from the forelimb motor areas passes through the anterior part of the corpus callosum. We then confirmed by electrophysiological recordings that blocking the axonal conduction of fibers in the anterior corpus callosum reduced neural transmission between cortical forelimb ar...
Ankylosing spondylitis (AS) is a chronic, progressive inflammatory rheumatic disease that leads t... more Ankylosing spondylitis (AS) is a chronic, progressive inflammatory rheumatic disease that leads to structural damage, functional impairment, and decrease in the quality of life. Red cell distribution width (RDW) is a part of the complete blood count (CBC) and estimates erythrocyte variability. To analyse RDW in patients with AS and to evaluate the relationships with acute phase reactants (APRs) and disease activity index. A total of 100 patients with AS (78 males and 22 females) were diagnosed according to the modified New York classification criteria for AS and 146 (99 males: 47 females) healthy individuals matched in age and sex as controls enrolled in the study. Demographic data, disease activity scores using Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), medical history, C-reactive protein (CRP), erythrocytes sedimentation rate (ESR), and complete blood count (CBC) were measured. The mean age for patients and controls was 38.0 ± 9.0 and 35.8 ± 9.0 years, respective...
Oral health-related quality of life (OHRQoL) involves many aspects such as chewing ability, sleep... more Oral health-related quality of life (OHRQoL) involves many aspects such as chewing ability, sleeping, social interactions, self-esteem, and satisfaction with life and oral health. The increasing research interest in OHRQoL began only after the shortcomings of previous approaches of treating symptoms only and neglecting the patient's self-perception were revealed. The current study design is a cross-sectional study of patients who attended King Abdulaziz University Dental Hospital (Jeddah, Saudi Arabia) and King Saud University Dental Hospital (Riyadh, Saudi Arabia). After obtaining their verbal consent, young adult and adult patients (mean age 25.19±7.29 years old) with anterior spacing or crowding were recruited to participate in the study. They filled the Arabic short version of the oral-health impact profile-14 questionnaire after a clinical evaluation of the severity of their spacing or crowding. Parameters of spacing/crowding severity assessment were as follows: <4, mild...
Toxicity as well as chemical instability issues of halide perovskites based on organic-inorganic ... more Toxicity as well as chemical instability issues of halide perovskites based on organic-inorganic lead-containing materials still remains the main drawbacks for perovskite solar cells (PSCs). Herein, we discuss the preparation of copper (Cu)-based hybrid materials, where we replace lead (Pb) with non-toxic Cu metal for lead free perovskite solar cells; investigate of its potential towards solar cells applications based on experimental and theoretical studies. The formation of (CH3NH3)2CuX4 [(CH3NH3)2CuCl4, (CH3NH3)2CuCl2I2, and (CH3NH3)2CuCl2Br2] were discussed in details. Furthermore, founding chlorine (Cl-) in the structure is critical for the stabilization of the formed compounds. Cu-based perovskite-like materials illustrated attractive absorbance features extended to the near-infrared, with appropriate band gaps. Green photoluminescence of these materials obtained due to Cu+ ions. The power conversion efficiency (PCE) measured experimentally and estimated theoretically for diffe...
The treatment of severe skeletal anterior open bite is extremely difficult in adults, and orthogn... more The treatment of severe skeletal anterior open bite is extremely difficult in adults, and orthognathic surgery is generally selected for its treatment. We report the case of an 18-year-old adult patient with skeletal anterior open bite and temporomandibular disorders who was successfully treated using temporary anchorage devices. She had an open bite of -2.0 mm and an increased facial height. Miniplates were implanted in both the maxilla and mandible, and molar intrusion resulted in counterclockwise rotation of the mandible over a period of 12 months. After active treatment, her upper and lower first molars were intruded by approximately 2 mm and her overbite became +2.5 mm. Her retrognathic profile improved with counterclockwise rotation of the mandible. Orthodontic treatment aided with skeletal anchorage is beneficial for intrusion of bimaxillary molars in patients with anterior open bite.
In barley endosperm arabinoxylan (AX) is the second most abundant cell wall polysaccharide and in... more In barley endosperm arabinoxylan (AX) is the second most abundant cell wall polysaccharide and in wheat it is the most abundant polysaccharide in the starchy endosperm walls of the grain. AX is one of the main contributors to grain dietary fibre content providing several health benefits including cholesterol and glucose lowering effects, and antioxidant activities. Due to its complex structural features, AX might also affect the downstream applications of barley grain in malting and brewing. Using a high pressure liquid chromatography (HPLC) method we quantified AX amounts in mature grain in 128 spring 2-row barley accessions. Amounts ranged from ~ 5.2 μg/g to ~ 9 μg/g. We used this data for a Genome Wide Association Study (GWAS) that revealed three significant quantitative trait loci (QTL) associated with grain AX levels which passed a false discovery threshold (FDR) and are located on two of the seven barley chromosomes. Regions underlying the QTLs were scanned for genes likely to...
Vitreous cysts are rare ocular malformations. We report an unusual case of a pigmented free-float... more Vitreous cysts are rare ocular malformations. We report an unusual case of a pigmented free-floating vitreous cyst incidentally detected in a highly myopic 28-year-old woman who was referred by her optometrist.
The new G protein-coupled estrogen receptor 1 (GPER/GPR30) plays important roles in many organ sy... more The new G protein-coupled estrogen receptor 1 (GPER/GPR30) plays important roles in many organ systems. The plasma membrane Ca2+-ATPase (PMCA) is essential for removal of cytoplasmic Ca2+ and for shaping the time courses of Ca2+-dependent activities. Here we show that PMCA and GPER/GPR30 physically interact and functionally influence each other. In primary endothelial cells, GPER/GPR30 agonist G-1 decreases PMCA-mediated Ca2+ extrusion by promoting PMCA tyrosine phosphorylation. GPER/GPR30 overexpression decreases PMCA activity, and G-1 further potentiates this effect. GPER/GPR30 knockdown increases PMCA activity, while PMCA knockdown substantially reduces GPER/GPR30-mediated phosphorylation of the extracellular signal related kinase (ERK1/2). GPER/GPR30 coimmunoprecipitates with PMCA with or without treatment with 17beta-estradiol, thapsigargin or G-1. Heterologously expressed GPER/GPR30 in HEK 293 cells colocalizes with PMCA4b, the main endothelial PMCA isoform. Endothelial cells ...
The aim of the present work was to establish a bioequivalence-indicating dissolution specificatio... more The aim of the present work was to establish a bioequivalence-indicating dissolution specification for candesartan cilexetil tablets. The discriminating power of the selected medium (0.25% Polysorbate 20 in pH 6.5 phosphate buffer) was assessed relative to that of 0.35% Polysorbate 20 in pH 6.5 phosphate buffer, a medium recommended by the U.S. FDA. Plasma concentration-time profiles of candesartan cilexetil tablets were derived from in vitro dissolution data by a convolution model. In solubility studies, 0.25% Polysorbate 20 in pH 6.5 phosphate buffer provided sink conditions for candesartan cilexetil 16-mg tablets. The method was more sensitive to the concentration of Polysorbate 20 than to paddle rotation speed and was able to distinguish depressed dissolution of mismanufactured tablets in samples taken at 20-and 30-min intervals. Verification of the model performed on innovator samples revealed the closeness of the predicted C max and AUC 0-α values to the reported values. A two-point dissolution specification is proposed for post-approval changes, and a one-point dissolution specification for quality control release of production batches.
2009 Chinese Control and Decision Conference, 2009
Fractional Order Control (FOC) is still an unfamiliar concept. But it is actually a natural gener... more Fractional Order Control (FOC) is still an unfamiliar concept. But it is actually a natural generalization of classical Integer Order Control (IOC) theory, in which the orders of controlled systems and/or controllers can be any real numbers including the conventional integer numbers. This generalization provides insight and more flexibility for robust control design. This paper reviews the applications of various FOC approaches including fractional order filter and disturbance observer into the gear backlash vibration control of a torsion test bench, in which a trade-off exists between stability and the strength of vibration suppression. The theoretical analysis and implementation results show FOC's superior robustness against gear backlash nonlinearity and more importantly its possibility of enabling a clear-cut robust control design.
1986 IEEE International Solid-State Circuits Conference. Digest of Technical Papers
This paper will describe a 32b digital signal processor with 0.5 to 1.5μs instruction cycle times... more This paper will describe a 32b digital signal processor with 0.5 to 1.5μs instruction cycle times for motor position control, A 4.04×4.83mm2chip containing 25,000 transistors has been made in 3μm NMOS technology and dissipates 250mW.
2011 International Conference on Infrared, Millimeter, and Terahertz Waves, 2011
We present a metamaterial based terahertz (THz) detector. The detector design, which combines met... more We present a metamaterial based terahertz (THz) detector. The detector design, which combines metamaterials and MEMs, is frequency selective, and we have fabricated and tested detectors at 95 GHz and 693 GHz with noise equivalent powers of 1.13 x 10-8 W/√Hz and 2.96 x 10-8 W/√Hz and responsivities of 16,500 V/W and 6,800 V/W, respectively. These values were achieved at room temperature and pressure.
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Papers by Ali Hassan